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Gene: Ptprc (protein tyrosine phosphatase, receptor type, C) Rattus norvegicus
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Symbol: Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Description: Exhibits protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Localizes to the cell surface and integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD45; L-CA; Lca; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Protein tyrosine phosphatase, receptor-type, c polypeptide; receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein
Orthologs:
Homo sapiens (human) : PTPRC (protein tyrosine phosphatase receptor type C)  HGNC  Alliance
Mus musculus (house mouse) : Ptprc (protein tyrosine phosphatase, receptor type, C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprc (protein tyrosine phosphatase receptor type C)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRC (protein tyrosine phosphatase receptor type C)
Canis lupus familiaris (dog) : PTPRC (protein tyrosine phosphatase receptor type C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprc (protein tyrosine phosphatase receptor type C)
Sus scrofa (pig) : PTPRC (protein tyrosine phosphatase receptor type C)
more info ...
Is Marker For: Strains:   BBDP.WF-(D13Rat124-D13Mgh5)/Sunn   BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01355,061,561 - 55,174,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1355,061,562 - 55,173,692 (-)Ensembl
Rnor_5.01360,094,038 - 60,205,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41351,246,163 - 51,357,995 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11351,261,097 - 51,309,893 (-)NCBI
Celera1349,881,478 - 49,993,142 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ptprc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3451
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.