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Gene: PTPRC (protein tyrosine phosphatase receptor type C) Homo sapiens
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Symbol: PTPRC
Name: protein tyrosine phosphatase receptor type C
Description: Exhibits cytoskeletal protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of cell population proliferation; and regulation of protein kinase activity. Localizes to the bleb and external side of plasma membrane. Implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B220; CD45; CD45 antigen; CD45R; glycoprotein; GP180; L-CA; LCA; leukocyte common antigen; leukocyte-common antigen; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
Orthologs:
Mus musculus (house mouse) : Ptprc (protein tyrosine phosphatase, receptor type, C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptprc (protein tyrosine phosphatase, receptor type, C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprc (protein tyrosine phosphatase receptor type C)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRC (protein tyrosine phosphatase receptor type C)
Canis lupus familiaris (dog) : PTPRC (protein tyrosine phosphatase receptor type C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprc (protein tyrosine phosphatase receptor type C)
Sus scrofa (pig) : PTPRC (protein tyrosine phosphatase receptor type C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381198,638,968 - 198,757,476 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371198,608,098 - 198,726,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361196,874,760 - 196,993,168 (+)NCBINCBI36hg18NCBI36
Build 341195,339,881 - 195,393,989NCBI
Celera1171,730,687 - 171,849,073 (+)NCBI
Cytogenetic Map1q31.3-q32.1NCBI
HuRef1169,775,326 - 169,893,838 (+)NCBIHuRef
CHM1_11200,030,413 - 200,148,903 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PTPRC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736371
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.