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Gene: PTPRC (protein tyrosine phosphatase receptor type C) Homo sapiens
Symbol: PTPRC
Name: protein tyrosine phosphatase receptor type C
Description: Exhibits cytoskeletal protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of cell population proliferation; and regulation of protein kinase activity. Localizes to the bleb and external side of plasma membrane. Implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B220; CD45; CD45 antigen; CD45R; glycoprotein; GP180; L-CA; LCA; leukocyte common antigen; leukocyte-common antigen; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
Mus musculus (house mouse) : Ptprc (protein tyrosine phosphatase, receptor type, C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptprc (protein tyrosine phosphatase, receptor type, C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprc (protein tyrosine phosphatase receptor type C)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRC (protein tyrosine phosphatase receptor type C)
Canis lupus familiaris (dog) : PTPRC (protein tyrosine phosphatase receptor type C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprc (protein tyrosine phosphatase receptor type C)
Sus scrofa (pig) : PTPRC (protein tyrosine phosphatase receptor type C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381198,638,968 - 198,757,476 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371198,608,098 - 198,726,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361196,874,760 - 196,993,168 (+)NCBINCBI36hg18NCBI36
Build 341195,339,881 - 195,393,989NCBI
Celera1171,730,687 - 171,849,073 (+)NCBI
Cytogenetic Map1q31.3-q32.1NCBI
HuRef1169,775,326 - 169,893,838 (+)NCBIHuRef
CHM1_11200,030,413 - 200,148,903 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPRC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736371
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.