Ptprc (protein tyrosine phosphatase receptor type C) - Rat Genome Database

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Gene: Ptprc (protein tyrosine phosphatase receptor type C) Chinchilla lanigera
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Symbol: Ptprc
Name: protein tyrosine phosphatase receptor type C
RGD ID: 9060585
Description: ENCODES a protein that exhibits ankyrin binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN B cell differentiation (ortholog); B cell proliferation (ortholog); B cell receptor signaling pathway (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendocrine Tumor (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN bleb (ortholog); cell periphery (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: receptor-type tyrosine-protein phosphatase C
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540635,005,214 - 35,129,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (ISO)
B cell proliferation  (ISO)
B cell receptor signaling pathway  (ISO)
bone marrow development  (ISO)
calcium-mediated signaling using intracellular calcium source  (ISO)
cell cycle phase transition  (ISO)
cellular response to extracellular stimulus  (ISO)
defense response to virus  (ISO)
dephosphorylation  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
heterotypic cell-cell adhesion  (ISO)
leukocyte cell-cell adhesion  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of cell adhesion involved in substrate-bound cell migration  (ISO)
negative regulation of cytokine-mediated signaling pathway  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein tyrosine kinase activity  (ISO)
negative regulation of T cell mediated cytotoxicity  (ISO)
negative thymic T cell selection  (ISO)
plasma membrane raft distribution  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of antigen receptor-mediated signaling pathway  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of hematopoietic stem cell migration  (ISO)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of isotype switching to IgG isotypes  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein tyrosine phosphatase activity  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T cell mediated immunity  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive thymic T cell selection  (ISO)
protein dephosphorylation  (ISO)
regulation of cell cycle  (ISO)
regulation of extrinsic apoptotic signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of humoral immune response mediated by circulating immunoglobulin  (ISO)
regulation of interleukin-8 production  (ISO)
regulation of phagocytosis  (ISO)
regulation of protein tyrosine kinase activity  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to gamma radiation  (ISO)
stem cell development  (ISO)
T cell differentiation  (ISO)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Ptprc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540635,005,214 - 35,129,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBIChiLan1.0ChiLan1.0
PTPRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1198,638,457 - 198,757,476 (+)EnsemblGRCh38hg38GRCh38
GRCh381198,639,025 - 198,757,476 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371198,608,170 - 198,726,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361196,874,760 - 196,993,168 (+)NCBINCBI36hg18NCBI36
Build 341195,339,881 - 195,393,989NCBI
Celera1171,730,687 - 171,849,073 (+)NCBI
Cytogenetic Map1q31.3-q32.1NCBI
HuRef1169,775,326 - 169,893,838 (+)NCBIHuRef
CHM1_11200,030,413 - 200,148,903 (+)NCBICHM1_1
Ptprc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391137,990,597 - 138,103,491 (-)NCBIGRCm39mm39
GRCm39 Ensembl1137,990,599 - 138,103,446 (-)Ensembl
GRCm381138,062,859 - 138,175,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1138,062,861 - 138,175,708 (-)EnsemblGRCm38mm10GRCm38
MGSCv371139,959,438 - 140,071,882 (-)NCBIGRCm37mm9NCBIm37
MGSCv361139,879,826 - 139,991,677 (-)NCBImm8
Celera1140,702,480 - 140,816,534 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map160.73NCBI
Ptprc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21349,596,193 - 49,708,283 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1355,061,562 - 55,173,692 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01355,061,561 - 55,174,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01360,094,038 - 60,205,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41351,246,163 - 51,357,995 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11351,261,097 - 51,309,893 (-)NCBI
Celera1349,881,478 - 49,993,142 (-)NCBICelera
Cytogenetic Map13q13NCBI
PTPRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11178,555,803 - 178,674,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1178,556,104 - 178,672,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01174,246,389 - 174,364,893 (+)NCBIMhudiblu_PPA_v0panPan3
PTPRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.174,155,876 - 4,282,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl74,137,728 - 4,282,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha73,841,036 - 3,967,333 (-)NCBI
ROS_Cfam_1.073,809,638 - 3,848,816 (-)NCBI
ROS_Cfam_1.073,851,043 - 3,967,973 (-)NCBI
UMICH_Zoey_3.173,787,560 - 3,913,845 (-)NCBI
UNSW_CanFamBas_1.073,889,732 - 4,015,907 (-)NCBI
UU_Cfam_GSD_1.073,921,322 - 4,047,618 (-)NCBI
Ptprc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934476,032,103 - 76,143,785 (-)NCBI
SpeTri2.0NW_0049365675,266,653 - 5,378,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1021,466,373 - 21,764,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11021,482,984 - 21,601,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21026,308,772 - 26,332,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12530,655,014 - 30,777,367 (-)NCBI
ChlSab1.1 Ensembl2530,653,044 - 30,777,303 (-)Ensembl
Vero_WHO_p1.0NW_02366605531,544,354 - 31,666,237 (-)NCBI
Ptprc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247981,700,732 - 1,814,603 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000024140   ⟹   ENSCLAP00000023913
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540635,005,214 - 35,129,552 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000024141   ⟹   ENSCLAP00000023914
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540635,005,214 - 35,129,552 (+)Ensembl
RefSeq Acc Id: XM_013521946   ⟹   XP_013377400
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521949   ⟹   XP_013377403
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521953   ⟹   XP_013377407
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521962   ⟹   XP_013377416
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521970   ⟹   XP_013377424
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013521971   ⟹   XP_013377425
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013377400   ⟸   XM_013521946
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013377403   ⟸   XM_013521949
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013377407   ⟸   XM_013521953
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013377416   ⟸   XM_013521962
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013377424   ⟸   XM_013521970
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013377425   ⟸   XM_013521971
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSCLAP00000023914   ⟸   ENSCLAT00000024141
RefSeq Acc Id: ENSCLAP00000023913   ⟸   ENSCLAT00000024140


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016409 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000023914 ENTREZGENE
Ensembl Transcript ENSCLAT00000024141 ENTREZGENE
NCBI Gene Ptprc ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Ptprc  protein tyrosine phosphatase receptor type C    protein tyrosine phosphatase, receptor type C  Symbol and/or name change 5135510 APPROVED
2016-08-03 Ptprc  protein tyrosine phosphatase, receptor type C    protein tyrosine phosphatase, receptor type, C  Symbol and/or name change 5135510 APPROVED