PTPRC (protein tyrosine phosphatase receptor type C) - Rat Genome Database

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Gene: PTPRC (protein tyrosine phosphatase receptor type C) Sus scrofa
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Symbol: PTPRC
Name: protein tyrosine phosphatase receptor type C
RGD ID: 14039555
Description: ENCODES a protein that exhibits ankyrin binding (inferred); heparan sulfate proteoglycan binding (inferred); heparin binding (inferred); INVOLVED IN B cell differentiation (ortholog); B cell receptor signaling pathway (ortholog); defense response to virus (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendocrine Tumor (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cell surface (ortholog); integral component of membrane (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: CD45; CD45 antigen; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1021,466,373 - 21,764,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11021,482,984 - 21,601,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21026,308,772 - 26,332,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA,ISO)
B cell proliferation  (IEA)
B cell receptor signaling pathway  (IEA,ISO)
bone marrow development  (IEA)
calcium-mediated signaling using intracellular calcium source  (IEA)
cell cycle phase transition  (IEA)
cellular response to extracellular stimulus  (IEA)
defense response to virus  (IEA,ISO)
dephosphorylation  (IEA)
hematopoietic progenitor cell differentiation  (IEA)
heterotypic cell-cell adhesion  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA,ISO)
natural killer cell differentiation  (IEA)
negative regulation of cell adhesion involved in substrate-bound cell migration  (IEA)
negative regulation of cytokine-mediated signaling pathway  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of interleukin-2 production  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
negative regulation of protein autophosphorylation  (IEA,ISO)
negative regulation of protein kinase activity  (IBA,IEA)
negative regulation of protein tyrosine kinase activity  (IEA)
negative regulation of T cell mediated cytotoxicity  (IEA)
negative thymic T cell selection  (IEA,ISO)
peptidyl-tyrosine dephosphorylation  (IEA)
plasma membrane raft distribution  (IEA)
positive regulation of alpha-beta T cell proliferation  (IEA,ISO)
positive regulation of antigen receptor-mediated signaling pathway  (IEA)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis  (IEA)
positive regulation of gamma-delta T cell differentiation  (IEA,ISO)
positive regulation of hematopoietic stem cell migration  (IEA)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of interleukin-2 production  (IEA)
positive regulation of isotype switching to IgG isotypes  (IEA,ISO)
positive regulation of MAP kinase activity  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IBA,IEA)
positive regulation of protein tyrosine phosphatase activity  (IEA)
positive regulation of stem cell proliferation  (IEA)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO)
positive regulation of T cell mediated immunity  (IEA,ISO)
positive regulation of T cell proliferation  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive thymic T cell selection  (IEA,ISO)
protein dephosphorylation  (IBA,IEA)
regulation of cell cycle  (IEA)
regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of humoral immune response mediated by circulating immunoglobulin  (IEA,ISO)
regulation of interleukin-8 production  (IEA)
regulation of phagocytosis  (IEA)
regulation of protein tyrosine kinase activity  (IEA)
regulation of receptor signaling pathway via JAK-STAT  (IEA)
release of sequestered calcium ion into cytosol  (IEA)
response to gamma radiation  (ISO)
stem cell development  (IEA)
T cell differentiation  (IEA)
T cell proliferation  (IEA,ISO)
T cell receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:17163576  


Genomics

Comparative Map Data
PTPRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1021,466,373 - 21,764,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11021,482,984 - 21,601,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21026,308,772 - 26,332,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1198,638,457 - 198,757,476 (+)EnsemblGRCh38hg38GRCh38
GRCh381198,639,025 - 198,757,476 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371198,608,170 - 198,726,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361196,874,760 - 196,993,168 (+)NCBINCBI36hg18NCBI36
Build 341195,339,881 - 195,393,989NCBI
Celera1171,730,687 - 171,849,073 (+)NCBI
Cytogenetic Map1q31.3-q32.1NCBI
HuRef1169,775,326 - 169,893,838 (+)NCBIHuRef
CHM1_11200,030,413 - 200,148,903 (+)NCBICHM1_1
Ptprc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391137,990,597 - 138,103,491 (-)NCBIGRCm39mm39
GRCm39 Ensembl1137,990,599 - 138,103,446 (-)Ensembl
GRCm381138,062,859 - 138,175,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1138,062,861 - 138,175,708 (-)EnsemblGRCm38mm10GRCm38
MGSCv371139,959,438 - 140,071,882 (-)NCBIGRCm37mm9NCBIm37
MGSCv361139,879,826 - 139,991,677 (-)NCBImm8
Celera1140,702,480 - 140,816,534 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map160.73NCBI
Ptprc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21349,596,193 - 49,708,283 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1349,596,193 - 49,708,692 (-)Ensembl
Rnor_6.01355,061,561 - 55,174,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1355,061,562 - 55,173,692 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01360,094,038 - 60,205,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41351,246,163 - 51,357,995 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11351,261,097 - 51,309,893 (-)NCBI
Celera1349,881,478 - 49,993,142 (-)NCBICelera
Cytogenetic Map13q13NCBI
Ptprc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540635,005,214 - 35,129,552 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540635,005,577 - 35,127,395 (+)NCBIChiLan1.0ChiLan1.0
PTPRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11178,555,803 - 178,674,089 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1178,556,104 - 178,672,994 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01174,246,389 - 174,364,893 (+)NCBIMhudiblu_PPA_v0panPan3
PTPRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.174,155,876 - 4,282,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl74,137,728 - 4,282,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha73,841,036 - 3,967,333 (-)NCBI
ROS_Cfam_1.073,809,638 - 3,848,816 (-)NCBI
ROS_Cfam_1.073,851,043 - 3,967,973 (-)NCBI
ROS_Cfam_1.0 Ensembl73,809,641 - 3,967,858 (-)Ensembl
UMICH_Zoey_3.173,787,560 - 3,913,845 (-)NCBI
UNSW_CanFamBas_1.073,889,732 - 4,015,907 (-)NCBI
UU_Cfam_GSD_1.073,921,322 - 4,047,618 (-)NCBI
Ptprc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934476,032,103 - 76,143,785 (-)NCBI
SpeTri2.0NW_0049365675,266,653 - 5,378,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12530,655,014 - 30,777,367 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2530,653,044 - 30,777,303 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605531,544,354 - 31,666,237 (-)NCBIVero_WHO_p1.0
Ptprc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247981,700,732 - 1,814,603 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 1 3
Low 2 2 3 2 23 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003130596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY444871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ318544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ318546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ318548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ318551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ437865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP067416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01116813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000011934   ⟹   ENSSSCP00000011627
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,546,375 - 21,764,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000011937   ⟹   ENSSSCP00000011630
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,483,061 - 21,600,215 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034423   ⟹   ENSSSCP00000029209
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,559,585 - 21,764,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037090   ⟹   ENSSSCP00000038572
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,483,061 - 21,601,627 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048012   ⟹   ENSSSCP00000040401
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,483,275 - 21,764,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066711   ⟹   ENSSSCP00000072671
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,466,373 - 21,537,022 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085971   ⟹   ENSSSCP00000067591
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,559,585 - 21,764,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087706   ⟹   ENSSSCP00000066391
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1021,546,375 - 21,764,560 (+)Ensembl
RefSeq Acc Id: XM_003130596   ⟹   XP_003130644
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11021,482,984 - 21,601,627 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003130644   ⟸   XM_003130596
- Sequence:
RefSeq Acc Id: ENSSSCP00000029209   ⟸   ENSSSCT00000034423
RefSeq Acc Id: ENSSSCP00000011627   ⟸   ENSSSCT00000011934
RefSeq Acc Id: ENSSSCP00000011630   ⟸   ENSSSCT00000011937
RefSeq Acc Id: ENSSSCP00000072671   ⟸   ENSSSCT00000066711
RefSeq Acc Id: ENSSSCP00000038572   ⟸   ENSSSCT00000037090
RefSeq Acc Id: ENSSSCP00000067591   ⟸   ENSSSCT00000085971
RefSeq Acc Id: ENSSSCP00000040401   ⟸   ENSSSCT00000048012
RefSeq Acc Id: ENSSSCP00000066391   ⟸   ENSSSCT00000087706

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010908 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011627 UniProtKB/TrEMBL
  ENSSSCP00000011630 UniProtKB/TrEMBL
  ENSSSCP00000029209 UniProtKB/TrEMBL
  ENSSSCP00000038572 UniProtKB/TrEMBL
  ENSSSCP00000040401 UniProtKB/TrEMBL
  ENSSSCP00000066391 UniProtKB/TrEMBL
  ENSSSCP00000067591 UniProtKB/TrEMBL
  ENSSSCP00000072671 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011934 UniProtKB/TrEMBL
  ENSSSCT00000011937 UniProtKB/TrEMBL
  ENSSSCT00000034423 UniProtKB/TrEMBL
  ENSSSCT00000037090 UniProtKB/TrEMBL
  ENSSSCT00000048012 UniProtKB/TrEMBL
  ENSSSCT00000066711 UniProtKB/TrEMBL
  ENSSSCT00000085971 UniProtKB/TrEMBL
  ENSSSCT00000087706 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_recept_N UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Ptprc UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPRC ENTREZGENE
Pfam CD45 UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PTP_N UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A287A482_PIG UniProtKB/TrEMBL
  A0A287A9D0_PIG UniProtKB/TrEMBL
  A0A5G2R067_PIG UniProtKB/TrEMBL
  A0A5G2R602_PIG UniProtKB/TrEMBL
  A0A5G2R711_PIG UniProtKB/TrEMBL
  F1S5D8_PIG UniProtKB/TrEMBL
  F1S5F1_PIG UniProtKB/TrEMBL
  K7GMW0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:108280 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPRC  protein tyrosine phosphatase receptor type C    protein tyrosine phosphatase, receptor type C  Symbol and/or name change 5135510 APPROVED