Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Adh1 (alcohol dehydrogenase 1 (class I)) Rattus norvegicus
Symbol: Adh1
Name: alcohol dehydrogenase 1 (class I)
Description: Exhibits NAD binding activity; ethanol binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including acetaldehyde biosynthetic process; ethanol oxidation; and response to progesterone. Localizes to the cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide) and ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adh; Adh1a; Adh1c; Alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1; alcohol dehydrogenase 1, complex; alcohol dehydrogenase 1C (class I), gamma polypeptide; alcohol dehydrogenase A subunit
Is Marker For: Strains:   SS.MNS-(D2Mit6-Adh1)/Ayd   SS.MNS-(Adh1-D2Mit5)/Mco   SS.MNS-(D2Wox27-Adh1)/Ayd  
QTLs:   Bp239   Kidm36  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02243,550,655 - 243,562,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,550,627 - 243,687,857 (+)Ensembl
Rnor_5.02262,090,818 - 262,102,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,799,396 - 235,811,584 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12235,786,135 - 235,797,838 (+)NCBI
Celera2218,954,198 - 218,965,645 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Adh1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2044
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.