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Gene: Adh1 (alcohol dehydrogenase 1 (class I)) Rattus norvegicus
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Symbol: Adh1
Name: alcohol dehydrogenase 1 (class I)
Description: Exhibits NAD binding activity; ethanol binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including acetaldehyde biosynthetic process; ethanol oxidation; and response to progesterone. Localizes to the cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide) and ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adh; Adh1a; Adh1c; Alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1; alcohol dehydrogenase 1, complex; alcohol dehydrogenase 1C (class I), gamma polypeptide; alcohol dehydrogenase A subunit
Orthologs:
Is Marker For: Strains:   SS.MNS-(D2Mit6-Adh1)/Ayd   SS.MNS-(Adh1-D2Mit5)/Mco   SS.MNS-(D2Wox27-Adh1)/Ayd  
QTLs:   Bp239   Kidm36  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02243,550,655 - 243,562,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02262,090,818 - 262,102,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,799,396 - 235,811,584 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12235,786,135 - 235,797,838 (+)NCBI
Celera2218,954,198 - 218,965,645 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Adh1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2044
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.