Adh1c (alcohol dehydrogenase 1C (class I), gamma polypeptide) - Rat Genome Database

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Gene: Adh1c (alcohol dehydrogenase 1C (class I), gamma polypeptide) Rattus norvegicus
Analyze
Symbol: Adh1c
Name: alcohol dehydrogenase 1C (class I), gamma polypeptide
RGD ID: 2044
Description: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in several processes, including animal organ regeneration; response to ethanol; and response to progesterone. Predicted to be located in several cellular components, including ciliary basal body; mitochondrion; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in alcohol dependence; late onset Parkinson's disease; and pancreatic cancer. Orthologous to human ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide); INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adh; Adh1; Adh1a; Alcohol dehydrogenase (class I), alpha polypeptide; alcohol dehydrogenase 1; alcohol dehydrogenase 1 (class I); alcohol dehydrogenase 1 (class I), gamma polypeptide; alcohol dehydrogenase 1, complex; alcohol dehydrogenase A subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Adh1-ps1  
Is Marker For: Strains:   SS.MNS-(D2Mit6-Adh1)/Ayd   SS.MNS-(Adh1-D2Mit5)/Mco   SS.MNS-(D2Wox27-Adh1)/Ayd  
QTLs:   Bp239   Kidm36  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,470,703 - 229,482,291 (+)NCBIGRCr8
mRatBN7.22226,797,303 - 226,808,892 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,797,303 - 226,808,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,543,562 - 234,555,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,443,298 - 232,454,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,307,972 - 227,319,527 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,550,655 - 243,562,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,550,627 - 243,687,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,090,818 - 262,102,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,799,396 - 235,811,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,786,135 - 235,797,838 (+)NCBI
Celera2218,954,198 - 218,965,645 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetone  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amitrole  (EXP)
Aroclor 1254  (EXP)
atazanavir sulfate  (ISO)
Azoxymethane  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
cimetidine  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crotonaldehyde  (EXP)
cyanamide  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disulfiram  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethylene glycol  (ISO)
etomoxir  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
fluconazole  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
ketoconazole  (EXP)
methamphetamine  (ISO)
methanol  (ISO)
methimazole  (EXP)
mifepristone  (EXP)
milrinone  (EXP)
Monobutylphthalate  (ISO)
Muconic dialdehyde  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalene  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oleanolic acid  (EXP)
omeprazole  (ISO)
ouabain  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
raloxifene  (EXP)
rifampicin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
taraxerone  (ISO)
tartrazine  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
ciliary basal body  (ISO)
cilium  (ISO)
cytoplasm  (IEA)
cytosol  (IBA,ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, etal., Addict Biol. 2017 Nov;22(6):1475-1485. doi: 10.1111/adb.12402. Epub 2016 May 5.
2. Distribution of alcohol dehydrogenase and the low Km form of aldehyde dehydrogenase in isolated perivenous and periportal hepatocytes in rats. Chen L, etal., Alcohol Clin Exp Res. 1992 Feb;16(1):23-9.
3. Structure and expression of the rat class I alcohol dehydrogenase gene. Crabb DW, etal., Genomics 1989 Nov;5(4):906-14.
4. High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. Galli A, etal., Hepatology. 1999 Apr;29(4):1164-70.
5. Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Galter D, etal., Eur J Biochem 2003 Mar;270(6):1316-26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Methanol metabolism and embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase. Harris C, etal., Reprod Toxicol. 2003 May-Jun;17(3):349-57.
9. Ocular alcohol dehydrogenase in the rat: regional distribution and kinetics of the ADH-1 isoenzyme with retinol and retinal. Julia P, etal., Exp Eye Res. 1986 Apr;42(4):305-14.
10. Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. Kanda J, etal., Cancer Sci. 2008 Dec 4.
11. Involvement of alcohol and aldehyde dehydrogenase activities on hepatic retinoid metabolism and its possible participation in the progression of rat liver regeneration. Lopez-Valencia V, etal., Biochem Pharmacol. 2007 Feb 15;73(4):586-96. Epub 2006 Oct 26.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Interactions of alcohol dehydrogenase to p-hydroxyacetophenone-sepharose and p-acetamidophenol-sepharose. Negoro M and Wakabayashi I, Alcohol Clin Exp Res. 2005 Dec;29(12 Suppl):304S-8S.
14. Evidence for the expression of alcohol dehydrogenase class I gene in rat uterus and its up-regulation by progesterone. Ohno T, etal., Endocr J. 2008 Mar;55(1):83-90. Epub 2008 Jan 24.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9982   PMID:518534   PMID:2881847   PMID:3996732   PMID:4673366   PMID:6370228   PMID:6391957   PMID:6816803   PMID:7026729   PMID:7748347   PMID:8119157   PMID:8344317  
PMID:8973327   PMID:9002638   PMID:10358022   PMID:12027900   PMID:12213809   PMID:12787032   PMID:12851412   PMID:15123720   PMID:15193143   PMID:15489334   PMID:16109828   PMID:16421892  
PMID:17257171   PMID:17488809   PMID:22214999  


Genomics

Comparative Map Data
Adh1c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,470,703 - 229,482,291 (+)NCBIGRCr8
mRatBN7.22226,797,303 - 226,808,892 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,797,303 - 226,808,892 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,543,562 - 234,555,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,443,298 - 232,454,851 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,307,972 - 227,319,527 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,550,655 - 243,562,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,550,627 - 243,687,857 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,090,818 - 262,102,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,799,396 - 235,811,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,786,135 - 235,797,838 (+)NCBI
Celera2218,954,198 - 218,965,645 (+)NCBICelera
Cytogenetic Map2q44NCBI
ADH1C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,336,497 - 99,352,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,336,497 - 99,352,746 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,257,654 - 100,273,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,476,672 - 100,492,940 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,614,828 - 100,631,081NCBI
Celera497,554,804 - 97,571,075 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,995,418 - 96,011,667 (-)NCBIHuRef
CHM1_14100,234,034 - 100,250,392 (-)NCBICHM1_1
T2T-CHM13v2.04102,651,250 - 102,667,501 (-)NCBIT2T-CHM13v2.0
Adh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393137,983,346 - 137,996,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3137,966,752 - 137,996,459 (+)EnsemblGRCm39 Ensembl
GRCm383138,277,585 - 138,290,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,260,991 - 138,290,698 (+)EnsemblGRCm38mm10GRCm38
MGSCv373137,940,609 - 137,953,655 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,215,032 - 138,228,078 (+)NCBIMGSCv36mm8
Celera3144,684,702 - 144,697,775 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.16NCBI
Adh1c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554968,136,279 - 8,149,496 (+)NCBIChiLan1.0ChiLan1.0
LOC100970753
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,415,305 - 97,432,225 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,698,981 - 97,715,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,756,817 - 91,773,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,418,515 - 102,435,079 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,388,575 - 102,435,079 (-)Ensemblpanpan1.1panPan2
LOC100512795
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,020,969 - 121,041,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,020,683 - 121,041,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,164,997 - 130,185,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Adh1c
111 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat

Markers in Region
D2Mco31  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q44UniSTS
RH127331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22226,808,361 - 226,808,574 (+)MAPPERmRatBN7.2
Rnor_6.02243,561,713 - 243,561,925NCBIRnor6.0
Rnor_5.02262,102,447 - 262,102,659UniSTSRnor5.0
RGSC_v3.42235,811,054 - 235,811,266UniSTSRGSC3.4
Celera2218,965,115 - 218,965,327UniSTS
Cytogenetic Map2q44UniSTS
RH94448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22226,804,370 - 226,804,497 (+)MAPPERmRatBN7.2
mRatBN7.22226,925,460 - 226,925,587 (+)MAPPERmRatBN7.2
Rnor_6.02243,678,784 - 243,678,910NCBIRnor6.0
Rnor_6.02243,557,722 - 243,557,848NCBIRnor6.0
Rnor_5.02262,215,552 - 262,215,678UniSTSRnor5.0
Rnor_5.02262,098,456 - 262,098,582UniSTSRnor5.0
RGSC_v3.42235,806,700 - 235,806,826UniSTSRGSC3.4
RGSC_v3.42235,929,773 - 235,929,899UniSTSRGSC3.4
Celera2219,082,133 - 219,082,259UniSTS
Celera2218,961,124 - 218,961,250UniSTS
RH 3.4 Map21605.6UniSTS
Cytogenetic Map2q44UniSTS
AI233003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22226,808,694 - 226,808,846 (+)MAPPERmRatBN7.2
Rnor_6.02243,562,046 - 243,562,197NCBIRnor6.0
Rnor_5.02262,102,780 - 262,102,931UniSTSRnor5.0
RGSC_v3.42235,811,387 - 235,811,538UniSTSRGSC3.4
Celera2218,965,448 - 218,965,599UniSTS
RH 3.4 Map21595.4UniSTS
Cytogenetic Map2q44UniSTS


Related Rat Strains
The following Strains have been annotated to Adh1c
SS.MNS-(Adh1-D2Mit5)/Mco     SS.MNS-(D2Mit6-Adh1)/Ayd     SS.MNS-(D2Wox27-Adh1)/Ayd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 29 70 57 60 41 19 41 146 59 62 35 39 19

Sequence


Ensembl Acc Id: ENSRNOT00000036993   ⟹   ENSRNOP00000030638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2243,656,579 - 243,687,857 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083682   ⟹   ENSRNOP00000072955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,799,121 - 226,807,597 (+)Ensembl
Rnor_6.0 Ensembl2243,550,639 - 243,561,757 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085067   ⟹   ENSRNOP00000069797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,797,303 - 226,808,892 (+)Ensembl
Rnor_6.0 Ensembl2243,550,627 - 243,687,383 (+)Ensembl
RefSeq Acc Id: NM_019286   ⟹   NP_062159
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,470,703 - 229,482,291 (+)NCBI
mRatBN7.22226,797,303 - 226,808,892 (+)NCBI
Rnor_6.02243,550,655 - 243,562,243 (+)NCBI
Rnor_5.02262,090,818 - 262,102,977 (+)NCBI
RGSC_v3.42235,799,396 - 235,811,584 (+)RGD
Celera2218,954,198 - 218,965,645 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062159   ⟸   NM_019286
- UniProtKB: P06757 (UniProtKB/Swiss-Prot),   Q8K571 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069797   ⟸   ENSRNOT00000085067
Ensembl Acc Id: ENSRNOP00000030638   ⟸   ENSRNOT00000036993
Ensembl Acc Id: ENSRNOP00000072955   ⟸   ENSRNOT00000083682
Protein Domains
Alcohol dehydrogenase-like C-terminal   Alcohol dehydrogenase-like N-terminal   Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06757-F1-model_v2 AlphaFold P06757 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691785
Promoter ID:EPDNEW_R2310
Type:multiple initiation site
Name:Adh6_1
Description:alcohol dehydrogenase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02243,550,657 - 243,550,717EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2044 AgrOrtholog
BioCyc Gene G2FUF-51076 BioCyc
BioCyc Pathway PWY66-21 [ethanol degradation II] BioCyc
BioCyc Pathway Image PWY66-21 BioCyc
Ensembl Genes ENSRNOG00000012436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085067 ENTREZGENE
  ENSRNOT00000085067.2 UniProtKB/Swiss-Prot
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621394 IMAGE-MGC_LOAD
InterPro ADH_C UniProtKB/Swiss-Prot
  ADH_N UniProtKB/Swiss-Prot
  ADH_Zn_CS UniProtKB/Swiss-Prot
  GroES-like_sf UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  PKS_ER UniProtKB/Swiss-Prot
KEGG Report rno:24172 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72255 IMAGE-MGC_LOAD
NCBI Gene 24172 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/Swiss-Prot
  ALCOHOL DEHYDROGENASE 1A UniProtKB/Swiss-Prot
Pfam ADH_N UniProtKB/Swiss-Prot
  ADH_zinc_N UniProtKB/Swiss-Prot
PharmGKB ADH1C RGD
PhenoGen Adh1c PhenoGen
PROSITE ADH_ZINC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012436 RatGTEx
SMART PKS_ER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
UniProt A0A0G2JW98_RAT UniProtKB/TrEMBL
  A0A8L2R817_RAT UniProtKB/TrEMBL
  ADH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K571 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-19 Adh1c  alcohol dehydrogenase 1C (class I), gamma polypeptide  Adh1c  alcohol dehydrogenase 1 (class I), gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-06-09 Adh1c  alcohol dehydrogenase 1 (class I), gamma polypeptide  Adh1  alcohol dehydrogenase 1C (class I), gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-08 Adh1  alcohol dehydrogenase 1C (class I), gamma polypeptide  Adh1  alcohol dehydrogenase 1 (class I)  Name changed 629549 APPROVED
2013-03-07 Adh1  alcohol dehydrogenase 1 (class I)  Adh1c  alcohol dehydrogenase 1C (class I), gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-01 Adh1c  alcohol dehydrogenase 1C (class I), gamma polypeptide  Adh1  alcohol dehydrogenase 1 (class I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-28 Adh1c  alcohol dehydrogenase 1C (class I), gamma polypeptide  Adh1  alcohol dehydrogenase 1 (class I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-28 Adh1  alcohol dehydrogenase 1 (class I)  Adh1c  alcohol dehydrogenase 1C (class I), gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adh1  alcohol dehydrogenase 1 (class I)    alcohol dehydrogenase 1  Name updated 1299863 APPROVED
2002-11-06 Adh1  alcohol dehydrogenase 1    Alcohol dehydrogenase (class I), alpha polypeptide  Name updated 625702 APPROVED
2002-06-10 Adh1  Alcohol dehydrogenase (class I), alpha polypeptide      Symbol and Name status set to approved 70586 APPROVED