Gstm5 (glutathione S-transferase, mu 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gstm5 (glutathione S-transferase, mu 5) Rattus norvegicus
Analyze
Symbol: Gstm5
Name: glutathione S-transferase, mu 5
RGD ID: 61964
Description: Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; nitrobenzene metabolic process; and response to estrogen. Predicted to be located in cytosol and sperm fibrous sheath. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase mu 3; glutathione S-transferase Mu 5; GST class-mu 5; Gstm3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,219,769 - 198,222,732 (+)NCBIGRCr8
mRatBN7.22195,531,599 - 195,534,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,173,992 - 203,176,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,056,113 - 201,058,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,873,066 - 195,875,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,685,338 - 210,688,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,154,305 - 230,157,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,456,122 - 203,458,917 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,418,875 - 203,421,671 (+)NCBI
Celera2188,178,084 - 188,180,884 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (EXP)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (EXP,ISO)
cumene hydroperoxide  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-penicillamine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibenzofurans  (ISO)
dibenzoylmethane  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinous acid  (ISO)
dinophysistoxin 1  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (EXP,ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
gliclazide  (EXP)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
graphite  (ISO)
GW 4064  (ISO)
homocysteine  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
kojic acid  (EXP,ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
microcystin  (EXP)
microcystin-LR  (EXP,ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naloxone  (EXP)
naphthalene  (ISO)
nickel atom  (EXP,ISO)
nicotinamide  (EXP)
non-2-enal  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (EXP,ISO)
prostaglandin E2  (ISO)
prostaglandin H2  (ISO)
prostaglandins E  (ISO)
pyrene  (ISO)
quercetin  (ISO)
quinidine  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rifampicin  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
spironolactone  (ISO)
stilbene oxide  (EXP)
streptozocin  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
sperm fibrous sheath  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. DNA methylation is associated with altered gene expression in AMD. Hunter A, etal., Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105. doi: 10.1167/iovs.11-8449.
3. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Maes OC, etal., Neurobiol Aging. 2010 Jan;31(1):34-45. Epub 2008 Apr 17.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. Rao AV and Shaha C, FEBS Lett. 2001 Oct 26;507(2):174-80.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis. Rowe JD, etal., J Biol Chem 1998 Apr 17;273(16):9593-601.
11. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:6822548   PMID:8373352   PMID:8512323   PMID:10037815   PMID:10067818   PMID:10587441   PMID:10680782   PMID:11470996   PMID:15115915   PMID:15621212   PMID:16189514   PMID:16598069  
PMID:16687649   PMID:17550934   PMID:19060904   PMID:19723343   PMID:19889946   PMID:20577141   PMID:21516116   PMID:21630459   PMID:23012479   PMID:23376485   PMID:23533145   PMID:25931508  
PMID:31515488  


Genomics

Comparative Map Data
Gstm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,219,769 - 198,222,732 (+)NCBIGRCr8
mRatBN7.22195,531,599 - 195,534,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,173,992 - 203,176,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,056,113 - 201,058,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,873,066 - 195,875,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,685,338 - 210,688,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,154,305 - 230,157,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,456,122 - 203,458,917 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,418,875 - 203,421,671 (+)NCBI
Celera2188,178,084 - 188,180,884 (+)NCBICelera
Cytogenetic Map2q34NCBI
GSTM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,733,937 - 109,741,038 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,733,932 - 109,741,038 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,276,559 - 110,283,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,078,077 - 110,084,563 (-)NCBINCBI36Build 36hg18NCBI36
Build 341109,988,595 - 109,995,082NCBI
Celera1108,523,169 - 108,530,274 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,146,319 - 108,153,420 (-)NCBIHuRef
CHM1_11110,391,373 - 110,398,478 (-)NCBICHM1_1
T2T-CHM13v2.01109,744,083 - 109,751,183 (-)NCBIT2T-CHM13v2.0
Gstm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,803,240 - 107,806,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,803,137 - 107,806,002 (+)EnsemblGRCm39 Ensembl
GRCm383107,895,854 - 107,898,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,895,821 - 107,898,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,698,772 - 107,701,603 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,023,910 - 108,026,741 (+)NCBIMGSCv36mm8
Celera3110,228,602 - 110,231,433 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Gstm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,253,947 - 13,256,965 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,253,947 - 13,256,965 (-)NCBIChiLan1.0ChiLan1.0
GSTM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,304,765 - 117,308,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,452,825 - 116,456,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,380,890 - 112,384,988 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,956,485 - 127,960,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,957,008 - 127,960,578 (+)Ensemblpanpan1.1panPan2
GSTM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,187,869 - 42,191,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,187,967 - 42,191,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,963,499 - 44,966,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,519,524 - 42,522,915 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,519,762 - 42,523,399 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,252,336 - 42,255,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,210,095 - 42,213,500 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,645,471 - 42,648,416 (+)NCBIUU_Cfam_GSD_1.0
Gstm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,877,269 - 18,880,232 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,233,780 - 1,237,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,233,909 - 1,236,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,330,028 - 110,332,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,330,027 - 110,332,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,827,568 - 120,830,517 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,797,794 - 23,802,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,799,177 - 23,802,921 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,656,028 - 34,661,589 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gstm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,495,452 - 5,498,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,495,452 - 5,498,714 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gstm5
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:97
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000072342, ENSRNOT00000073649
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
RH129596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,534,369 - 195,534,551 (+)MAPPERmRatBN7.2
Rnor_6.02210,688,081 - 210,688,262NCBIRnor6.0
Rnor_5.02230,157,048 - 230,157,229UniSTSRnor5.0
Rnor_5.02228,699,710 - 228,699,891UniSTSRnor5.0
RGSC_v3.42203,458,865 - 203,459,046UniSTSRGSC3.4
Celera2188,180,832 - 188,181,013UniSTS
RH 3.4 Map21390.7UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 60 56 48 24 12 24 12 99 48 36 15 43 24

Sequence


Ensembl Acc Id: ENSRNOT00000072342   ⟹   ENSRNOP00000065389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)Ensembl
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090430   ⟹   ENSRNOP00000070934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,916 - 195,534,553 (+)Ensembl
RefSeq Acc Id: NM_172038   ⟹   NP_742035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,219,769 - 198,222,732 (+)NCBI
mRatBN7.22195,531,599 - 195,534,562 (+)NCBI
Rnor_6.02210,685,338 - 210,688,133 (+)NCBI
Rnor_5.02230,154,305 - 230,157,100 (+)NCBI
RGSC_v3.42203,456,122 - 203,458,917 (+)RGD
Celera2188,178,084 - 188,180,884 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103048   ⟹   XP_038958976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,220,145 - 198,222,732 (+)NCBI
mRatBN7.22195,531,970 - 195,534,562 (+)NCBI
Protein Sequences
Protein RefSeqs NP_742035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD00603 (Get FASTA)   NCBI Sequence Viewer  
  EDL81893 (Get FASTA)   NCBI Sequence Viewer  
  EDL81894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065389
  ENSRNOP00000065389.1
  ENSRNOP00000070934.2
GenBank Protein Q9Z1B2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742035   ⟸   NM_172038
- UniProtKB: Q9Z1B2 (UniProtKB/Swiss-Prot),   A6HUV7 (UniProtKB/TrEMBL),   A0A8L2R3A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065389   ⟸   ENSRNOT00000072342
RefSeq Acc Id: XP_038958976   ⟸   XM_039103048
- Peptide Label: isoform X1
- UniProtKB: A6HUV8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000070934   ⟸   ENSRNOT00000090430
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1B2-F1-model_v2 AlphaFold Q9Z1B2 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691665
Promoter ID:EPDNEW_R2189
Type:initiation region
Name:Gstm3_1
Description:glutathione S-transferase mu 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,685,310 - 210,685,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61964 AgrOrtholog
BioCyc Gene G2FUF-51655 BioCyc
Ensembl Genes ENSRNOG00000049743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072342 ENTREZGENE
  ENSRNOT00000072342.3 UniProtKB/Swiss-Prot
  ENSRNOT00000090430.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_mu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_superfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64352 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64352 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gstm5 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049743 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230112
UniProt A0A8L2R3A5 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV7 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV8 ENTREZGENE, UniProtKB/TrEMBL
  GSTM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gstm5  glutathione S-transferase, mu 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed mainly in testis 61624