Ces2e (carboxylesterase 2E) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ces2e (carboxylesterase 2E) Rattus norvegicus
Analyze
Symbol: Ces2e
Name: carboxylesterase 2E
RGD ID: 621563
Description: Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Located in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH 17beta-estradiol; acetamide; beta-naphthoflavone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 5; carboxylic ester hydrolase; Ces5; Loc192257; phenobarbital-inducible carboxylesterase (liver); pyrethroid hydrolase Ces2e
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819163,899 - 179,274 (+)NCBIGRCr8
mRatBN7.219157,447 - 172,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19157,407 - 172,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19162,415 - 177,795 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.019896,113 - 911,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019171,345 - 186,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01985,679 - 100,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1985,606 - 100,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01986,201 - 100,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41965,698 - 82,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11965,705 - 82,042 (+)NCBI
Celera19153,546 - 166,005 (+)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.

Genomics

Comparative Map Data
Ces2e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819163,899 - 179,274 (+)NCBIGRCr8
mRatBN7.219157,447 - 172,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19157,407 - 172,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19162,415 - 177,795 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.019896,113 - 911,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019171,345 - 186,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01985,679 - 100,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1985,606 - 100,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01986,201 - 100,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41965,698 - 82,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11965,705 - 82,042 (+)NCBI
Celera19153,546 - 166,005 (+)NCBICelera
Cytogenetic Map19p14NCBI
Ces2e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,652,892 - 105,661,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,652,892 - 105,661,304 (+)EnsemblGRCm39 Ensembl
GRCm388104,926,260 - 104,934,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,926,260 - 104,934,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,450,160 - 107,458,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,815,399 - 107,823,796 (+)NCBIMGSCv36mm8
Celera8109,148,515 - 109,156,927 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI

Variants

.
Variants in Ces2e
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000015724
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system renal system reproductive system respiratory system appendage
High
Medium 19 19 19
Low 1 4 4 4 3
Below cutoff 1 12 10 10 3 3 3 8 5 3

Sequence


RefSeq Acc Id: ENSRNOT00000015724   ⟹   ENSRNOP00000015724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19157,407 - 172,856 (+)Ensembl
Rnor_6.0 Ensembl1985,606 - 100,424 (+)Ensembl
RefSeq Acc Id: NM_001100477   ⟹   NP_001093947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819163,899 - 179,274 (+)NCBI
mRatBN7.219157,447 - 172,822 (+)NCBI
Rnor_6.01985,679 - 100,386 (+)NCBI
Rnor_5.01986,201 - 100,908 (+)NCBI
RGSC_v3.41965,698 - 82,042 (+)RGD
Celera19153,546 - 166,005 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001093947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA23607 (Get FASTA)   NCBI Sequence Viewer  
  EDL87215 (Get FASTA)   NCBI Sequence Viewer  
  EDL87216 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015724.5
GenBank Protein G3V7J5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001093947   ⟸   NM_001100477
- Peptide Label: precursor
- UniProtKB: O35535 (UniProtKB/Swiss-Prot),   G3V7J5 (UniProtKB/Swiss-Prot),   A6JXT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015724   ⟸   ENSRNOT00000015724
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7J5-F1-model_v2 AlphaFold G3V7J5 1-567 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700903
Promoter ID:EPDNEW_R11427
Type:initiation region
Name:Ces2e_1
Description:carboxylesterase 2E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01985,639 - 85,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621563 AgrOrtholog
BioCyc Gene G2FUF-6674 BioCyc
Ensembl Genes ENSRNOG00000011635 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015724.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192257 UniProtKB/TrEMBL
NCBI Gene 192257 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COCAINE ESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces2e PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011635 RatGTEx
Superfamily-SCOP alpha/beta-Hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JXT7 ENTREZGENE, UniProtKB/TrEMBL
  EST2E_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O35535 ENTREZGENE
UniProt Secondary O35535 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces2e  carboxylesterase 2E  Ces5  carboxylesterase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ces5  carboxylesterase 5  Loc192257  phenobarbital-inducible carboxylesterase (liver)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc192257  phenobarbital-inducible carboxylesterase (liver)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in metabolizing tissues, including lung, small intestine, liver, stomach, kidney, skin, and testis 724430