Dlk1 (delta like non-canonical Notch ligand 1) - Rat Genome Database

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Gene: Dlk1 (delta like non-canonical Notch ligand 1) Rattus norvegicus
Analyze
Symbol: Dlk1
Name: delta like non-canonical Notch ligand 1
RGD ID: 619931
Description: Predicted to enable calcium ion binding activity. Involved in cell differentiation. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in membrane. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1); PARTICIPATES IN forkhead class A signaling pathway; Notch signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delta-like 1; delta-like 1 homolog; delta-like 1 homolog (Drosophila); delta-like homolog (Drosophila); DLK-1; preadipocyte factor 1; preadipocyte factor-1; Pref-1; protein delta homolog 1; Zog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,192,491 - 134,199,779 (+)NCBIGRCr8
mRatBN7.26128,410,216 - 128,417,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,410,316 - 128,417,522 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,550,763 - 128,557,963 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,846,606 - 128,853,806 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,207,854 - 128,215,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,576,513 - 133,583,751 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,552,821 - 133,583,751 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,742,149 - 142,749,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46134,022,016 - 134,043,058 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16134,028,202 - 134,035,262 (+)NCBI
Celera6125,960,411 - 125,967,475 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
baicalein  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP,ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triflumizole  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas. Carlsson C, etal., Endocrinology 1997 Sep;138(9):3940-8.
2. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
3. Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. Fang JZ, etal., PLoS One. 2015 Nov 16;10(11):e0143042. doi: 10.1371/journal.pone.0143042. eCollection 2015.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells. Halder SK, etal., Endocrinology 1998 Jul;139(7):3316-28.
7. The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia. Huang CC, etal., J Pathol. 2004 Feb;202(2):172-9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene. Stridh P, etal., PLoS Genet. 2014 Mar 27;10(3):e1004265. doi: 10.1371/journal.pgen.1004265. eCollection 2014 Mar.
16. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.
17. DLK1: increased expression in gliomas and associated with oncogenic activities. Yin D, etal., Oncogene. 2006 Mar 23;25(13):1852-61.
Additional References at PubMed
PMID:7925474   PMID:8500166   PMID:12477932   PMID:12655782   PMID:18751720   PMID:18988804   PMID:19084046   PMID:19247431   PMID:19515692   PMID:19661059   PMID:21308776   PMID:21419176  
PMID:22298767   PMID:23387476   PMID:24584117   PMID:24913911   PMID:25093684   PMID:25268256   PMID:25342302   PMID:25723595   PMID:27044861   PMID:29453913   PMID:30145985   PMID:31091532  
PMID:33472171   PMID:35050550  


Genomics

Comparative Map Data
Dlk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,192,491 - 134,199,779 (+)NCBIGRCr8
mRatBN7.26128,410,216 - 128,417,518 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,410,316 - 128,417,522 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,550,763 - 128,557,963 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,846,606 - 128,853,806 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,207,854 - 128,215,027 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,576,513 - 133,583,751 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,552,821 - 133,583,751 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06142,742,149 - 142,749,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46134,022,016 - 134,043,058 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16134,028,202 - 134,035,262 (+)NCBI
Celera6125,960,411 - 125,967,475 (+)NCBICelera
Cytogenetic Map6q32NCBI
DLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,726,892 - 100,738,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,725,705 - 100,738,224 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,193,229 - 101,204,561 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,263,006 - 100,271,213 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414100,263,005 - 100,271,210NCBI
Celera1481,247,286 - 81,255,551 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1481,373,717 - 81,381,968 (+)NCBIHuRef
CHM1_114101,130,974 - 101,139,248 (+)NCBICHM1_1
T2T-CHM13v2.01494,961,805 - 94,973,139 (+)NCBIT2T-CHM13v2.0
Dlk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,418,411 - 109,429,262 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,418,749 - 109,429,262 (+)EnsemblGRCm39 Ensembl
GRCm3812109,452,485 - 109,463,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,452,823 - 109,463,336 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,691,033 - 110,701,546 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,901,030 - 109,908,498 (+)NCBIMGSCv36mm8
Celera12110,648,411 - 110,658,915 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.17NCBI
Dlk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495562738,128 - 43,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495562737,886 - 43,730 (-)NCBIChiLan1.0ChiLan1.0
DLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,879,300 - 101,887,554 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114101,095,796 - 101,104,047 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01481,348,380 - 81,356,607 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,654,965 - 100,668,020 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14100,654,965 - 100,668,019 (+)Ensemblpanpan1.1panPan2
DLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,961,975 - 68,970,106 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,961,744 - 68,972,761 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,479,790 - 68,487,872 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,245,619 - 69,253,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl869,245,491 - 69,256,384 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,906,950 - 68,915,034 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,973,041 - 68,981,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,370,948 - 69,379,035 (+)NCBIUU_Cfam_GSD_1.0
Dlk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086405,567,786 - 5,578,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366044,504,503 - 4,511,910 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366044,504,519 - 4,511,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,565,854 - 121,576,654 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,565,844 - 121,577,493 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27132,339,547 - 132,345,907 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,687,542 - 78,695,782 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,687,668 - 78,695,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,824,853 - 65,833,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,363,001 - 3,372,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,363,084 - 3,372,790 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlk1
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000006339
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat

Markers in Region
BE115497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26128,417,114 - 128,417,264 (+)MAPPERmRatBN7.2
Rnor_6.06133,583,346 - 133,583,495NCBIRnor6.0
Rnor_5.06142,748,927 - 142,749,076UniSTSRnor5.0
RGSC_v3.46134,028,833 - 134,028,982UniSTSRGSC3.4
Celera6125,967,189 - 125,967,338UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:259449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26128,416,706 - 128,417,270 (+)MAPPERmRatBN7.2
Rnor_6.06133,582,938 - 133,583,501NCBIRnor6.0
Rnor_5.06142,748,519 - 142,749,082UniSTSRnor5.0
RGSC_v3.46134,028,425 - 134,028,988UniSTSRGSC3.4
Celera6125,966,781 - 125,967,344UniSTS
Cytogenetic Map6q32UniSTS
Dlk1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26128,416,794 - 128,417,010 (+)MAPPERmRatBN7.2
Rnor_6.06133,583,026 - 133,583,241NCBIRnor6.0
Rnor_5.06142,748,607 - 142,748,822UniSTSRnor5.0
RGSC_v3.46134,028,513 - 134,028,728UniSTSRGSC3.4
Celera6125,966,869 - 125,967,084UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6 1
Medium 20 24 16 16 2 3 52 18 27 4 2
Low 12 9 5 6 5 5 7 22 2 11 7 5
Below cutoff 3 10 15 11 12 11 1 1 9 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000006339   ⟹   ENSRNOP00000006339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,410,969 - 128,417,522 (+)Ensembl
Rnor_6.0 Ensembl6133,552,821 - 133,583,498 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085933   ⟹   ENSRNOP00000069391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,410,316 - 128,417,522 (+)Ensembl
Rnor_6.0 Ensembl6133,576,568 - 133,583,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107076   ⟹   ENSRNOP00000086145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,410,316 - 128,417,267 (+)Ensembl
RefSeq Acc Id: NM_053744   ⟹   NP_446196
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,192,597 - 134,199,779 (+)NCBI
mRatBN7.26128,410,335 - 128,417,518 (+)NCBI
Rnor_6.06133,576,568 - 133,583,751 (+)NCBI
Rnor_5.06142,742,149 - 142,749,166 (+)NCBI
RGSC_v3.46134,022,016 - 134,043,058 (+)RGD
Celera6125,960,411 - 125,967,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764917   ⟹   XP_008763139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,192,491 - 134,199,777 (+)NCBI
mRatBN7.26128,410,216 - 128,417,397 (+)NCBI
Rnor_6.06133,576,513 - 133,583,742 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063261397   ⟹   XP_063117467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,192,503 - 134,199,777 (+)NCBI
RefSeq Acc Id: NP_446196   ⟸   NM_053744
- Peptide Label: precursor
- UniProtKB: Q62779 (UniProtKB/Swiss-Prot),   O70534 (UniProtKB/TrEMBL),   A6KBJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763139   ⟸   XM_008764917
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GDQ5 (UniProtKB/TrEMBL),   A6KBJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006339   ⟸   ENSRNOT00000006339
RefSeq Acc Id: ENSRNOP00000069391   ⟸   ENSRNOT00000085933
RefSeq Acc Id: ENSRNOP00000086145   ⟸   ENSRNOT00000107076
RefSeq Acc Id: XP_063117467   ⟸   XM_063261397
- Peptide Label: isoform X2
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70534-F1-model_v2 AlphaFold O70534 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694825
Promoter ID:EPDNEW_R5349
Type:single initiation site
Name:Dlk1_1
Description:delta like non-canonical Notch ligand 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06133,576,535 - 133,576,595EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619931 AgrOrtholog
BioCyc Gene G2FUF-36264 BioCyc
Ensembl Genes ENSRNOG00000019584 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055028031 UniProtKB/Swiss-Prot
  ENSRNOG00060017366 UniProtKB/Swiss-Prot
  ENSRNOG00065026096 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006339.7 UniProtKB/TrEMBL
  ENSRNOT00000085933 ENTREZGENE
  ENSRNOT00000085933.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107076.1 UniProtKB/TrEMBL
  ENSRNOT00055048579 UniProtKB/Swiss-Prot
  ENSRNOT00060029726 UniProtKB/Swiss-Prot
  ENSRNOT00065045038 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8365650 IMAGE-MGC_LOAD
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114587 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187346 IMAGE-MGC_LOAD
NCBI Gene 114587 ENTREZGENE
PANTHER DELTA-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1 UniProtKB/Swiss-Prot
  PROTEIN DELTA HOMOLOG 1 UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlk1 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019584 RatGTEx
  ENSRNOG00055028031 RatGTEx
  ENSRNOG00060017366 RatGTEx
  ENSRNOG00065026096 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GDQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3B5_RAT UniProtKB/TrEMBL
  A6KBJ4 ENTREZGENE, UniProtKB/TrEMBL
  DLK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62779 ENTREZGENE
UniProt Secondary Q62779 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Dlk1  delta like non-canonical Notch ligand 1  Dlk1  delta-like 1 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Dlk1  delta-like 1 homolog (Drosophila)    delta-like homolog (Drosophila)  Name updated 1299863 APPROVED
2002-08-07 Dlk1  delta-like homolog (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in both differentiation and growth of beta-cells 632566