Ndc80 (NDC80 kinetochore complex component)

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Gene: Ndc80 (NDC80 kinetochore complex component) Rattus norvegicus

Analyze

Symbol:

Ndc80

Name:

NDC80 kinetochore complex component

RGD ID:

1310154

Description:

Predicted to enable cyclin binding activity; identical protein binding activity; and kinetochore adaptor activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization involved in mitosis; and positive regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within several processes, including centrosome duplication; meiosis I cell cycle process; and skeletal muscle satellite cell proliferation. Predicted to be located in several cellular components, including centrosome; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Orthologous to human NDC80 (NDC80 kinetochore complex component); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

kinetochore associated 2; kinetochore protein NDC80 homolog; Kntc2; LOC301701; NDC80 homolog, kinetochore complex component; NDC80 homolog, kinetochore complex component (S. cerevisiae)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NDC80 (NDC80 kinetochore complex component)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ndc80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ndc80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NDC80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NDC80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ndc80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NDC80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NDC80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ndc80 (NDC80 kinetochore complex component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NDC80 (NDC80 kinetochore complex component)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ndc80 (NDC80 kinetochore complex component)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ndc80 (NDC80 kinetochore complex component)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NDC80	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	ndc-80	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ndc80	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ndc80	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	111,407,191 - 111,440,921 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	111,407,191 - 111,440,924 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	119,805,258 - 119,842,593 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,934,621 - 124,971,844 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	123,271,148 - 123,308,405 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,837,857 - 119,871,435 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,839,016 - 119,871,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	119,291,271 - 119,324,839 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,702,935 - 110,718,894 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,912,517 - 110,945,708 (-)	NCBI
Celera	9	108,536,354 - 108,552,152 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal cancer (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

intellectual disability (ISO)

lung non-small cell carcinoma (ISO)

Neoplasm Metastasis (ISO)

stomach cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cytarabine (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibenz[a,h]anthracene (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dioxygen (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

flutamide (EXP)

fluvastatin (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

glycidol (EXP)

hydrogen peroxide (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

indometacin (ISO)

ivermectin (ISO)

leflunomide (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

lucanthone (ISO)

menadione (ISO)

methamphetamine (EXP)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

naphthalene (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenanthrene (ISO)

phenformin (EXP)

phytoestrogen (ISO)

piroxicam (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sirolimus (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

attachment of mitotic spindle microtubules to kinetochore (IBA,ISO)

attachment of spindle microtubules to kinetochore (ISO)

biological_process (ND)

cell division (IEA)

centrosome duplication (ISO)

chromosome segregation (ISO)

establishment of mitotic spindle orientation (ISO)

G2/MI transition of meiotic cell cycle (ISO)

kinetochore organization (ISO)

metaphase chromosome alignment (ISO)

mitotic spindle organization (ISO)

positive regulation of mitotic cell cycle spindle assembly checkpoint (ISO)

regulation of protein stability (ISO)

skeletal muscle satellite cell proliferation (ISO)

spindle assembly involved in female meiosis I (ISO)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

kinetochore (ISO)

Ndc80 complex (IBA,ISO)

nucleoplasm (IEA,ISO)

outer kinetochore (ISO)

Molecular Function

cyclin binding (ISO)

identical protein binding (ISO)

kinetochore adaptor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis.	Hayama S, etal., Cancer Res. 2006 Nov 1;66(21):10339-48. doi: 10.1158/0008-5472.CAN-06-2137.
4.	siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.	Kaneko N, etal., Biochem Biophys Res Commun. 2009 Dec 25;390(4):1235-40. doi: 10.1016/j.bbrc.2009.10.127. Epub 2009 Oct 28.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:14699129	PMID:17363900	PMID:18195732	PMID:19468067	PMID:19946888	PMID:20360068	PMID:22581055	PMID:23891108	PMID:24752407	PMID:25416956	PMID:25743205

Genomics

Comparative Map Data

Ndc80
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	111,407,191 - 111,440,921 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	111,407,191 - 111,440,924 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	119,805,258 - 119,842,593 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,934,621 - 124,971,844 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	123,271,148 - 123,308,405 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	119,837,857 - 119,871,435 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,839,016 - 119,871,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	119,291,271 - 119,324,839 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	110,702,935 - 110,718,894 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	110,912,517 - 110,945,708 (-)	NCBI
Celera	9	108,536,354 - 108,552,152 (-)	NCBI		Celera
Cytogenetic Map	9	q38	NCBI

NDC80
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	2,571,557 - 2,616,635 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	2,571,557 - 2,616,635 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	2,571,556 - 2,616,634 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	2,561,605 - 2,606,629 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	2,561,604 - 2,606,626	NCBI
Celera	18	2,446,814 - 2,491,757 (+)	NCBI		Celera
Cytogenetic Map	18	p11.32	NCBI
HuRef	18	2,532,999 - 2,577,942 (+)	NCBI		HuRef
CHM1_1	18	2,570,883 - 2,615,800 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	2,727,304 - 2,772,223 (+)	NCBI		T2T-CHM13v2.0

Ndc80
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	71,803,095 - 71,833,852 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	71,803,095 - 71,833,852 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	71,496,100 - 71,526,857 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	71,496,100 - 71,526,857 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	71,845,440 - 71,876,197 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	71,400,962 - 71,431,714 (-)	NCBI		MGSCv36	mm8
Celera	17	75,767,449 - 75,800,160 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	41.87	NCBI

Ndc80
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	7,691,937 - 7,729,690 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	7,692,009 - 7,728,876 (-)	NCBI	ChiLan1.0	ChiLan1.0

NDC80
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	18	21,521,776 - 21,567,360 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	11,666,099 - 11,711,456 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,972,637 - 14,018,261 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,972,637 - 14,018,261 (-)	Ensembl	panpan1.1		panPan2

NDC80
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,268,218 - 69,317,126 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	69,268,242 - 69,317,072 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	68,723,201 - 68,772,189 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,329,940 - 69,378,870 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,329,990 - 69,378,835 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	69,012,589 - 69,061,471 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	69,032,710 - 69,081,627 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,329,927 - 69,378,829 (+)	NCBI		UU_Cfam_GSD_1.0

Ndc80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	65,630,900 - 65,669,747 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,872,193 - 1,909,675 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936672	1,872,205 - 1,910,956 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NDC80
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	103,999,034 - 104,055,760 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	104,000,794 - 104,055,785 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	97,024,076 - 97,061,162 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NDC80
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	61,835,027 - 61,882,660 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	61,835,064 - 61,881,627 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	36,694,925 - 36,740,902 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ndc80
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	12,939,763 - 12,974,162 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	12,937,887 - 12,974,352 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ndc80
271 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	69
Interacting mature miRNAs:	71
Transcripts:	ENSRNOT00000018644
Prediction methods:	Microtar, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	29	22	14	22			37	20	36
Low	1	15	22	13	5	13	4	5	35	11	5	11	4
Below cutoff		2	6	6		6	4	6	2	4			4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001126270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018644 ⟹ ENSRNOP00000018644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	119,840,326 - 119,871,382 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080498 ⟹ ENSRNOP00000072111

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	111,407,191 - 111,440,924 (-)	Ensembl
Rnor_6.0 Ensembl	9	119,839,016 - 119,869,639 (-)	Ensembl

RefSeq Acc Id:

NM_001126270 ⟹ NP_001119742

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	111,407,191 - 111,440,921 (-)	NCBI
Rnor_6.0	9	119,840,326 - 119,856,147 (-)	NCBI
Rnor_5.0	9	119,291,271 - 119,324,839 (-)	NCBI
RGSC_v3.4	9	110,702,935 - 110,718,894 (-)	RGD
Celera	9	108,536,354 - 108,552,152 (-)	RGD

Sequence:

show sequence

GCTTCCTTACAAGCAGATGTTCAAAACTATAAAGCATACATGAGCAATTTGGAGTCTCATTCAT
CCATTCTGGAGCAGAAACTGAGCAGTCTTGATGAAGAGATTGGTAGACTGGAGCTAGAATGTGA
GACAGTTAAACAGGAAAACACTCGACTACAGAGTGTTGTTGATAACCAGAAGTATTCGATCGCT
GACATTGAGAGAATAAATCATGAGAAAAATGAATTGCAGCAGACTATAAATAAATTAACCAAAG
ACCTGGAAGCCGAACAACAACAAATGTGGAATGAGGAATTAAAATATGCCAGAGGCAAAGAGGC
GATTGAAGCACAGTTAGCAGAGTACCACAAGTTGGCTAGAAAACTGAAGCTTATCCCCAAGGGT
GCTGAGAATTCCAAAGGTTATGACTTTGAAATTAAGTTTAATCCTGAGGCTGGTGCCAACTGCC
TTGTCAAATACAGGACTCAAGTGTATGCACCTCTCAAAGAACTCTTGAATGAAATCGAAGAAGA
AATTAACAAAGCTCTGAATAAAAAGATGGGTCTGGAGGATACTTTAGAACAACTGAACACCGTG
AAAACAGAAAGCAAGAGGGCTGTGAGAATGCTGAAGGAAGAGGTTCAAAAGCTGGACGACCTTT
ACCAACAAAAAGTTAAGGAAGCTGAGGAAGAAGACAAGAAGTGTGCCAGTGAGCTTGACTCCCT
GGAGAAACACAAGCACCTGCTGGAAAGCGCAGTGAACGAGGGTCTCAGCGAGGCCATGGGCGAG
CTGGACGCCGTCCAGCGGGAATACCAGTTAGCTGTGCAGACCACAACTGAAGAAAGAAGAAAGG
TGGGAAACAACTTACAACGTCTTTTGGAGATGGTTGCTACACATGTAGGGTCTTTGGAGAAACA
CCTTGAAGAGCAGATTGTTAAAGCTGACAGAGAGTATGAGGAATGCACGTCTGAAGATCTCTTG
GAAAACATCAGAAGGATCGCAGAGAAGTATAAGAGCAACGCTGCCCAACTGAAGGCCCCCGACA
AATGAAGATAAATTAATTAATCTTTCAAAGACATAACAGTATTTTATCCCAAAATTATGGTAAC
ATGGTAGATTAGATGTGACAGATAGTTAATAAAGTGTACTAGTG

hide sequence

RefSeq Acc Id:

XM_008767423 ⟹ XP_008765645

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	111,407,191 - 111,440,898 (-)	NCBI
Rnor_6.0	9	119,837,857 - 119,871,435 (-)	NCBI

Sequence:

show sequence

AAATTTTAAAATTCAAACCGCCCAAGGTTGGCCTAGACTAAAGCTCTTGTTTTGGCGGCTGTTT
TCGCGTGCAGTCGTGGAGTTTACTGAAAGCTGGGCGCTGGGTCTCGTTGAGAAGCCGAGAGAAA
GGTAACTGCTGAGGTTACAAGCATGAAGCGCAGTTCGGTTTCCAGCTGTGGTGCTGGCCGCCTC
TCTATGCAGGAGTTAAGATCCCTGGACCTCAATAAACCTGGCCTTCATACCCCTCAAACCAGAG
AGAGGTCAACCTTTGGAAAACTGAGTACTCACAAGCCTACATCTGAAAGAAAAGTCTCAATATT
TGGGAAAAGGACTAGCGAACATGGGTCCAGGAATAGTCAACTTGGTATATTTTCCAGTTCTGAG
AAAATCAAGGACCCAAGACCCCTTAATGACAAAGCATTCATTCAGCAGTGTATTCGACAACTCT
ATGAGTTTCTTACAGAAAACGGTTATGTATATAGTGTATCCATGAAGTCTCTACAAGCTCCATC
TACCAAAGATTTCCTAAAGATCTTCGCCTTTCTTTATGGCTTTCTGTGCCCATCATATGAACTT
CCTGATACAAAATGTGAAGAAGAGGTCCCAAGAATTTTTAAAGAACTTGGGTATCCCTTTGCAC
TGTCCAAGAGCTCCATGTACACAGTGGGAGCCCCTCACACGTGGCCTCACATTGTGGCCGCCTT
GGTGTGGCTAACAGACTGCATCAAGATTCATGATGCCATGAAACAAAGCTCACCTTTGTTTGAT
GATGGGCAGGCTTGGGGAGAAGAAACTGAAGATGGAATTAAGCATAATAAGTTGTTTTTGGACT
ACACAAAAAAATGCTATGAGAAGTTCATGACTGGAGCTGACACCTTCGAAGACGTGGATGCTGA
ACTGCAGGCGAAGCTGAAGGACTTGTATAAGGTAGATGCGTCCAAGCTGGAATCACTCGTGGAG
GAAAACAAAGCACTGAATGAACAGATTGCAAGACTGGAGCAGGAAAGAGAAAAAGAACCGAACC
GTCTGATATCATTGAGGAAACTGAAAGCTTCCTTACAAGCAGATGTTCAAAACTATAAAGCATA
CATGAGCAATTTGGAGTCTCATTCATCCATTCTGGAGCAGAAACTGAGCAGTCTTGATGAAGAG
ATTGGTAGACTGGAGCTAGAATGTGAGACAGTTAAACAGGAAAACACTCGACTACAGAGTGTTG
TTGATAACCAGAAGTATTCGATCGCTGACATTGAGAGAATAAATCATGAGAAAAATGAATTGCA
GCAGACTATAAATAAATTAACCAAAGACCTGGAAGCCGAACAACAACAAATGTGGAATGAGGAA
TTAAAATATGCCAGAGGCAAAGAGGCGATTGAAGCACAGTTAGCAGAGTACCACAAGTTGGCTA
GAAAACTGAAGCTTATCCCCAAGGGTGCTGAGAATTCCAAAGGTTATGACTTTGAAATTAAGTT
TAATCCTGAGGCTGGTGCCAACTGCCTTGTCAAATACAGGACTCAAGTGTATGCACCTCTCAAA
GAACTCTTGAATGAAATCGAAGAAGAAATTAACAAAGCTCTGAATAAAAAGATGGGTCTGGAGG
ATACTTTAGAACAACTGAACACCGTGAAAACAGAAAGCAAGAGGGCTGTGAGAATGCTGAAGGA
AGAGGTTCAAAAGCTGGACGACCTTTACCAACAAAAAGTTAAGGAAGCTGAGGAAGAAGACAAG
AAGTGTGCCAGTGAGCTTGACTCCCTGGAGAAACACAAGCACCTGCTGGAAAGCGCAGTGAACG
AGGGTCTCAGCGAGGCCATGGGCGAGCTGGACGCCGTCCAGCGGGAATACCAGTTAGCTGTGCA
GACCACAACTGAAGAAAGAAGAAAGGTGGGAAACAACTTACAACGTCTTTTGGAGATGGTTGCT
ACACATGTAGGGTCTTTGGAGAAACACCTTGAAGAGCAGATTGTTAAAGCTGACAGAGAGTATG
AGGAATGCACGTCTGAAGATCTCTTGGAAAACATCAGAAGGATCGCAGAGAAGTATAAGAGCAA
CGCTGCCCAACTGAAGGCCCCCGACAAATGAAGATAAATTAATTAATCTTTCAAAGACATAACA
GTATTTTATCCCAAAATTATGGTAACATGGTAGATTAGATGTGACAGATAGTTAATAAAGTGTA
CTAGTGAAGCGTGGGCGTCCCCTCCCATTTCCATGACTCACTTCTGACCTGAGGAGAAGATATG
TGGCATGGGCTGTACTGGGAGTTAGCAAATCCAGTCTGAATATGTCAGGCACACCCACTCACTG
CCTACAAGTTCTTTCCTGCTGTAATGGTAGTTAAGCATATGCAGCAGAGGCTACTCAGCCTGCA
AAGCCAGAGGTATTGCTCCCCAGGTCCCTGTTAGGTGTCTTTTCCTGGGGAGATGTGAAGAAGC
ATCTGTTCACGCACATGGAAAAGATAACAACTAAAGGATTCCATCCAAGTCCAGCTGAATCAAT
AAGTTCATCAGGCTTACTGGCAGATCAAAAATGGCCACCAGGAAATCCCCTGGACAAGTACAGG
CATTATACCATGAAAAGTCCCACCTACTGGATAACTCACAGCAACACCACTTGAGAGTCTTGGA
CACCTTGAGGGAGGCTATTCTACCACAAATTTTCCTTGTCAGCTATGTGCCTTTTGTATAACCT
CGGGGCAGGGCACTTCTGAGGACTCAGGGCTGAACACCGTAAGCCTCCCTCCTCCATCCAGGGG
GGAATGAAGTGAGCTGCTTCACTTAAGCCTAGAGGAGACTTACACAGTCCTTTAATAAAAAATT
TGTTTGATTAAAGACTGCCTACTTTTAAAAGTTCTTGCTCTGGGATGTATCCCAAGTAGAGAAC
TTGCCCAGCATATTCAAAGTTATAGATTCAGTCCCCAGCTCCCAAGAATAAGCAGTTAAAAGAT
AGTTGTAGGTTTAGATTTAAATAAAAAATAAAAAAAAAACTGCTTTAATAAGGGTTTTTAAACA
TTTTGATTCCCCTTGTAGCCCACCGTCCAAAGGTAGGGGAGAAGAAAATGGTAAATAGGACAAG
AGGATGTGGACCCATTTAGTAGACCTGTTTAGTAATTCTTTGGAGCAATTTAATCTCTGCAGTC
CAGTTTAGTAGTGTCAGAATACCAAACACAAATCAGTAGCAGGGGTACGATCCAACAGAAACTG
CCAGGCCTCCTCAGAATTGACAGGAGTCCGTGGGAGTGACTAGGACTAGCCAGAATGCCTTGAG
AACTTCTCTGCTGTGCCTCTCAATGAAGTGAAGATCAGCCAAGATGTGAGCCATTGAAGTGTTG
CAAGACTCGCTGTGCAAGGACCCTGTCATTGTCCATTGGGTCCTAGTTATACTCTCCAAACACA
TGTCCTCCGCAAAACACAAGGAGACTCTGCATCACATGATACAGCCAGAAACTTATACTTCAGA
CAGTTATCTTCAGACAGTATGGAGGTAAAAAAGTAAAATAAAATAAATAAAAAAAACCTCAAGT
TGCTATTTAGAGCCTAGACAAAATTTCAGTTTTAAATCTATTTTTTAAAAATAATCTCATGTAA
TACATGGTAGTGGTGTGTTAAGAGTAGGCTACTGCTAGAGTGCTTGTCTAGCCTGTCACGGCCC
TTGGGTTTGATCCCAGAACCGAGGGGAGAAAAAACAAAACTATTAAAGCAAACACACAGCCTCA
ATCTAGCTCAGTGAGGGATGCTGAGAGAGAGGCAAAGGTCTGGAGGTCACGGCCAGCCTAACGT
ACATAGCAGGATAAGGGGATCTAGCCCAGGCTGGCCTCAAACCCCTGCATAGCTGAAGATGACC
GTGAACTTCTAACCCTCCCACTTCCACCTCTTTGTGAGATTACAGTTTGTCTCCGTGTCTGGAT
TATGTGTTATGGAGACCAAACTCAAAACCTCCTACATGCTAGGCAAGACAACTATCACCAGCCC
CCCAAAAGCAAAACATTAATTAGAAGAGAAGCTGGCATTTTAGTGCATGATCCATCCTTTCAGC
AACTGAATAAGAGGATCAAGAGACCCTGTTAAAGCTAAAGAGAAAAAGGAACAAGGCAGAAAGA
CACTCAGTGGACATGCCCTTCCCTGTCCATAAACTATCAGTTCTCATAACTCATTATCTGGGGC
ATAAAGAGGCCCTGATCACAGGCACAAAGTTCCACATACACAGCTAAAGAATGAGAATAACAGC
TTGTGTGATGACTTAACATTTAACAAATTTCAAAAGTACCCCCCCCCTTTTTTTTTTTTTTTTT
TGTATTGGTTTGTTTGGTTTTTGAAGACAAGGTTTCTTTGTTTAACAGCCCTGGTTGCTCTGAA
ACTCTCTTTGTATACCAGGCTGGCCTGAAAATCAGAGGGAGAAATCCACCTGCCTCTGCCTCCT
GAGCACTGGGATTAAAGGCGTGAACCACCACCCTTGGCTTGACTGTTAAATTTTATCAAATGAC
TTGTAGGGATTTAGACATGAATTGTGACTTTTTTCTAAGTATTTTCATATGATCACTTTCTCAG
GCTGGGACTGTAACTCATTGCATCTGGGCCCAGATTCAATTTGAAGTTCTGTCAGAAAAACAAA
AGTACATGTACACATTTCTAGAATAAATACCATTTGGTCATGA

hide sequence

RefSeq Acc Id:

XM_039083429 ⟹ XP_038939357

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	111,407,191 - 111,440,761 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001119742	(Get FASTA)	NCBI Sequence Viewer
	XP_008765645	(Get FASTA)	NCBI Sequence Viewer
	XP_038939357	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61935	(Get FASTA)	NCBI Sequence Viewer
	EDL90957	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001119742 ⟸ NM_001126270

- UniProtKB:

B1WBY4 (UniProtKB/TrEMBL), F7F189 (UniProtKB/TrEMBL), A0A0G2K254 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSNLESHSSILEQKLSSLDEEIGRLELECETVKQENTRLQSVVDNQKYSIADIERINHEKNELQ
QTINKLTKDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLKLIPKGAENSKGYDFEIKF
NPEAGANCLVKYRTQVYAPLKELLNEIEEEINKALNKKMGLEDTLEQLNTVKTESKRAVRMLKE
EVQKLDDLYQQKVKEAEEEDKKCASELDSLEKHKHLLESAVNEGLSEAMGELDAVQREYQLAVQ
TTTEERRKVGNNLQRLLEMVATHVGSLEKHLEEQIVKADREYEECTSEDLLENIRRIAEKYKSN
AAQLKAPDK

hide sequence

RefSeq Acc Id:	XP_008765645 ⟸ XM_008767423
- Peptide Label:	isoform X1
- UniProtKB:	F7F189 (UniProtKB/TrEMBL), B1WBY4 (UniProtKB/TrEMBL), A0A0G2K254 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKRSSVSSCGAGRLSMQELRSLDLNKPGLHTPQTRERSTFGKLSTHKPTSERKVSIFGKRTSEH GSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLYEFLTENGYVYSVSMKSLQAPSTKDFLKI FAFLYGFLCPSYELPDTKCEEEVPRIFKELGYPFALSKSSMYTVGAPHTWPHIVAALVWLTDCI KIHDAMKQSSPLFDDGQAWGEETEDGIKHNKLFLDYTKKCYEKFMTGADTFEDVDAELQAKLKD LYKVDASKLESLVEENKALNEQIARLEQEREKEPNRLISLRKLKASLQADVQNYKAYMSNLESH SSILEQKLSSLDEEIGRLELECETVKQENTRLQSVVDNQKYSIADIERINHEKNELQQTINKLT KDLEAEQQQMWNEELKYARGKEAIEAQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGAN CLVKYRTQVYAPLKELLNEIEEEINKALNKKMGLEDTLEQLNTVKTESKRAVRMLKEEVQKLDD LYQQKVKEAEEEDKKCASELDSLEKHKHLLESAVNEGLSEAMGELDAVQREYQLAVQTTTEERR KVGNNLQRLLEMVATHVGSLEKHLEEQIVKADREYEECTSEDLLENIRRIAEKYKSNAAQLKAP DK hide sequence

RefSeq Acc Id:

ENSRNOP00000072111 ⟸ ENSRNOT00000080498

RefSeq Acc Id:

ENSRNOP00000018644 ⟸ ENSRNOT00000018644

RefSeq Acc Id:	XP_038939357 ⟸ XM_039083429
- Peptide Label:	isoform X1
- UniProtKB:	B1WBY4 (UniProtKB/TrEMBL), F7F189 (UniProtKB/TrEMBL), A0A0G2K254 (UniProtKB/TrEMBL)

Protein Domains

DUF5595

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7F189-F1-model_v2	AlphaFold	F7F189	1-642	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310154	AgrOrtholog
BioCyc Gene	G2FUF-26325	BioCyc
Ensembl Genes	ENSRNOG00000013727	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000072111	ENTREZGENE
	ENSRNOP00000072111.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000080498	ENTREZGENE
	ENSRNOT00000080498.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.30	UniProtKB/TrEMBL
	6.10.250.1950	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9022458	IMAGE-MGC_LOAD
InterPro	DUF5595	UniProtKB/TrEMBL
	Kinetochore_Ndc80	UniProtKB/TrEMBL
	Ndc80_sf	UniProtKB/TrEMBL
KEGG Report	rno:301701	UniProtKB/TrEMBL
MGC_CLONE	MGC:187716	IMAGE-MGC_LOAD
NCBI Gene	301701	ENTREZGENE
PANTHER	KINETOCHORE PROTEIN NDC80 HOMOLOG	UniProtKB/TrEMBL
	PTHR10643	UniProtKB/TrEMBL
Pfam	DUF5595	UniProtKB/TrEMBL
	Ndc80_HEC	UniProtKB/TrEMBL
PhenoGen	Ndc80	PhenoGen
UniProt	A0A0G2K254	ENTREZGENE, UniProtKB/TrEMBL
	A6KFA5_RAT	UniProtKB/TrEMBL
	B1WBY4	ENTREZGENE
	F7F189	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B1WBY4	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-27	Ndc80	NDC80 kinetochore complex component	Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	Kntc2_predicted	kinetochore associated 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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