Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Description: ENCODES a protein that exhibits ATP binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; INVOLVED IN activation of MAPK activity; cell population proliferation; glucose homeostasis; PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; ASSOCIATED WITH impaired smooth muscle contractility; ASSOCIATED WITH cataract; Experimental Liver Neoplasms; prostate adenocarcinoma; FOUND IN axon; cell cortex; cytosol; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,6-dinitrotoluene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
Homo sapiens (human) : MAP2K1 (mitogen-activated protein kinase kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Map2k1 (mitogen-activated protein kinase kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k1 (mitogen-activated protein kinase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Canis lupus familiaris (dog) : MAP2K1 (mitogen-activated protein kinase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k1 (mitogen-activated protein kinase kinase 1)
Sus scrofa (pig) : MAP2K1 (mitogen-activated protein kinase kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70495
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE