Map2k1 (mitogen activated protein kinase kinase 1) - Rat Genome Database
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Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
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Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
RGD ID: 70495
Description: Exhibits ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including establishment of vesicle localization; positive regulation of cellular metabolic process; and regulation of intracellular signal transduction. Localizes to several cellular components, including dendrite cytoplasm; glutamatergic synapse; and perikaryon. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in bone disease (multiple); carcinoma (multiple); and cardiofaciocutaneous syndrome 3. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,683,449 - 64,754,900 (-)NCBI
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(20R)-protopanaxadiol  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anandamide  (EXP)
anethole  (ISO)
anthranilic acid  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beryllium difluoride  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (EXP)
Deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
heparin  (EXP)
heptachlor  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perifosine  (ISO)
phenylephrine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (ISO)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
purine-6-thiol  (ISO)
pyocyanine  (ISO)
quercetin  (ISO)
quinoline  (ISO)
quinomethionate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
serpentine asbestos  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP,ISO)
sulfates  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trametinib  (ISO)
trans-anethole  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
vanadyl sulfate  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (IBA,IDA,IEA,ISO,TAS)
Bergmann glial cell differentiation  (IEA,ISO)
cell cycle arrest  (IEA,ISO)
cell motility  (IEA,ISO)
cell population proliferation  (IDA)
cellular senescence  (IEA,ISO)
cerebellar cortex formation  (IEA,ISO)
epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
glucose homeostasis  (IDA)
Golgi inheritance  (IMP)
heart development  (IEA,ISO)
intracellular signal transduction  (TAS)
keratinocyte differentiation  (IEA,ISO)
labyrinthine layer development  (IEA,ISO)
lung morphogenesis  (ISO)
melanosome transport  (IDA)
mitotic cell cycle  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of gene expression  (IEA,IGI,ISO)
negative regulation of homotypic cell-cell adhesion  (IMP)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IGI,IMP)
neuron differentiation  (IBA,IEA,IMP,ISO)
neuron projection morphogenesis  (IMP)
peptidyl-threonine phosphorylation  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA)
placenta blood vessel development  (IEA,ISO)
positive regulation of ATP biosynthetic process  (IGI,IMP)
positive regulation of autophagy  (IDA)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IGI,IMP,ISO)
positive regulation of GTPase activity  (IMP)
positive regulation of muscle contraction  (IGI,IMP)
positive regulation of production of miRNAs involved in gene silencing by miRNA  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (IMP)
positive regulation of transcription elongation from RNA polymerase II promoter  (IMP)
positive regulation of transcription, DNA-templated  (IEA,ISO)
protein phosphorylation  (IDA,ISO,TAS)
regulation of axon regeneration  (IEA,ISO)
regulation of early endosome to late endosome transport  (TAS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of Golgi inheritance  (TAS)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (EXP,IDA)
regulation of stress-activated MAPK cascade  (TAS)
regulation of vascular associated smooth muscle contraction  (IMP)
response to axon injury  (IMP)
response to glucocorticoid  (IDA)
response to oxidative stress  (IDA)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)
triglyceride homeostasis  (IDA)
vesicle transport along microtubule  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA,ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA,ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway  (IEA)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IMP,TAS)
thyroid cancer pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Acharya U, etal., Cell. 1998 Jan 23;92(2):183-92.
2. Alessandrini A, etal., Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12866-9.
3. Brassard DL, etal., Exp Cell Res. 2002 Feb 15;273(2):138-46.
4. Catling AD, etal., Mol Cell Biol. 1995 Oct;15(10):5214-25.
5. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
6. Colanzi A, etal., J Cell Biol. 2003 Apr 14;161(1):27-32.
7. Deacon SW, etal., Curr Biol. 2005 Mar 8;15(5):459-63.
8. Doring F, etal., Gene 1993 Sep 15;131(2):303-4.
9. Duan RD, etal., Am J Physiol. 1995 Jun;268(6 Pt 1):G1060-5.
10. Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100.
11. Flood DG, etal., J Comp Neurol. 1998 Aug 31;398(3):373-92.
12. Fujita T, etal., Mol Cell Biol. 2008 Mar;28(5):1630-43. Epub 2007 Dec 17.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Giroux S, etal., Curr Biol 1999 Apr 8;9(7):369-72.
15. GOA data from the GO Consortium
16. Gong X, etal., Invest Ophthalmol Vis Sci. 2001 Mar;42(3):539-48.
17. Guan Z, etal., Mol Med Rep. 2017 Oct;16(4):4784-4790. doi: 10.3892/mmr.2017.7213. Epub 2017 Aug 10.
18. Halbrook CJ, etal., Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):99-118. doi: 10.1016/j.jcmgh.2016.09.009.
19. Huang D, etal., Cancer Res. 2008 Jan 1;68(1):81-8.
20. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
21. Kim BW and Son H, Exp Mol Med. 2006 Dec 31;38(6):732-8.
22. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
23. Kupryjanczyk J, etal., Br J Cancer. 2003 Mar 24;88(6):848-54.
24. Kwintkiewicz J, etal., Biol Reprod. 2006 Jun;74(6):1034-40. Epub 2006 Feb 15.
25. Lagaud GJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):523-7.
26. MacInnis BL and Campenot RB, Mol Cell Neurosci. 2005 Mar;28(3):430-9.
27. Marinovic AC, etal., J Biol Chem 2002 May 10;277(19):16673-81.
28. MGD data from the GO Consortium
29. Mizukami Y, etal., J Biol Chem. 2004 Nov 26;279(48):50120-31. Epub 2004 Sep 30.
30. Moodie SA, etal., Mol Cell Biol. 1994 Nov;14(11):7153-62.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Oka H, etal., Cancer Res. 1995 Sep 15;55(18):4182-7.
33. OMIM Disease Annotation Pipeline
34. Otsu M, etal., FEBS Lett 1993 Apr 12;320(3):246-50.
35. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
36. Pipeline to import KEGG annotations from KEGG into RGD
37. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. Pipeline to import SMPDB annotations from SMPDB into RGD
39. Ray RM, etal., Cell Motil Cytoskeleton. 2007 Mar;64(3):143-56.
40. RGD automated data pipeline
41. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. RGD automated import pipeline for gene-chemical interactions
43. Robinson JP, etal., Oncogene. 2011 Mar 17;30(11):1341-50. doi: 10.1038/onc.2010.513. Epub 2010 Nov 8.
44. Rodriguez-Viciana P, etal., Science. 2006 Mar 3;311(5765):1287-90. Epub 2006 Jan 26.
45. Salh B, etal., Anticancer Res. 1999 Jan-Feb;19(1B):731-40.
46. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
47. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
48. Schipper HM, etal., Neuroscience. 1999;93(2):585-95.
49. Slack-Davis JK, etal., J Cell Biol. 2003 Jul 21;162(2):281-91.
50. Su F, etal., J Cancer Res Clin Oncol. 2009 Dec;135(12):1655-63. doi: 10.1007/s00432-009-0612-6. Epub 2009 Jun 10.
51. Suthiphongchai T, etal., Oncol Res. 2003;13(5):253-9.
52. Suzuki T, etal., Neurosci Res. 1995 Jun;22(3):277-85.
53. Tu Z, etal., Cell Signal. 2003 Jan;15(1):65-77.
54. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
55. Voisin L, etal., BMC Cancer. 2008 Nov 17;8:337. doi: 10.1186/1471-2407-8-337.
56. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
57. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
58. Wu J, etal., Biochem J 1992 Aug 1;285 ( Pt 3):701-5.
59. Wu J, etal., Mol Cell Biol 1993 Aug;13(8):4539-48.
60. Wu J, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):173-7.
61. Xiao Y, etal., Diabetes. 2016 Feb;65(2):393-405. doi: 10.2337/db15-1024. Epub 2015 Nov 18.
62. Xu J, etal., J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.
63. Xu S, etal., Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6808-12.
64. Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
65. Zhu JJ, etal., Cell. 2002 Aug 23;110(4):443-55.
Additional References at PubMed
PMID:8026469   PMID:8388392   PMID:8889548   PMID:9765203   PMID:10407019   PMID:10409742   PMID:10644344   PMID:11841548   PMID:12477932   PMID:12624112   PMID:14963006   PMID:15145949  
PMID:15155804   PMID:15469737   PMID:15782137   PMID:15896720   PMID:16737746   PMID:16908534   PMID:17498664   PMID:18006605   PMID:18270979   PMID:18305109   PMID:18952847   PMID:19047410  
PMID:19249349   PMID:19340459   PMID:19447520   PMID:19453943   PMID:19462441   PMID:20001965   PMID:20942268   PMID:21263381   PMID:21777515   PMID:22294037   PMID:22572157   PMID:23096919  
PMID:23376485   PMID:23626836   PMID:24126801   PMID:24375836   PMID:24431450   PMID:24610459   PMID:24733831   PMID:25100655   PMID:26272725   PMID:26514923   PMID:28166211   PMID:28975447  
PMID:29433126   PMID:29476059   PMID:30053369   PMID:30206251   PMID:30876692   PMID:31505169  


Genomics

Comparative Map Data
Map2k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,683,449 - 64,754,900 (-)NCBI
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
MAP2K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1566,386,837 - 66,491,544 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1566,386,817 - 66,492,312 (+)EnsemblGRCh38hg38GRCh38
GRCh381566,386,912 - 66,491,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371566,679,250 - 66,783,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,466,679 - 64,570,936 (+)NCBINCBI36hg18NCBI36
Build 341564,466,678 - 64,570,935NCBI
Celera1543,568,908 - 43,673,089 (+)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1543,515,493 - 43,620,002 (+)NCBIHuRef
CHM1_11566,797,173 - 66,901,898 (+)NCBICHM1_1
Map2k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,093,051 - 64,160,887 (-)NCBIGRCm39mm39
GRCm39 Ensembl964,093,052 - 64,160,913 (-)Ensembl
GRCm38964,185,769 - 64,253,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,185,770 - 64,253,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37964,033,600 - 64,101,412 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,983,794 - 64,051,338 (-)NCBImm8
Celera961,410,935 - 61,478,604 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.55NCBI
Map2k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,181,851 - 9,239,648 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,181,851 - 9,205,277 (-)NCBIChiLan1.0ChiLan1.0
MAP2K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11563,613,988 - 63,714,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,613,961 - 63,714,161 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01545,337,117 - 45,438,826 (+)NCBIMhudiblu_PPA_v0panPan3
MAP2K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3030,683,107 - 30,760,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13030,683,192 - 30,760,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Map2k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647126,589,251 - 26,628,302 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,381,845 - 164,471,226 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,381,892 - 164,469,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,187,631 - 182,196,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,059,122 - 17,168,787 (-)NCBI
ChlSab1.1 Ensembl2617,060,054 - 17,168,782 (-)Ensembl
Map2k1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247816,222,365 - 6,285,398 (-)NCBI

Position Markers
RH140096  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0869,143,892 - 69,144,108NCBIRnor6.0
Rnor_5.0868,850,128 - 68,850,344UniSTSRnor5.0
RGSC_v3.4868,388,746 - 68,388,962UniSTSRGSC3.4
Celera864,099,862 - 64,100,078UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH143905  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0869,722,309 - 69,722,539NCBIRnor6.0
Rnor_5.0869,431,673 - 69,431,903UniSTSRnor5.0
Celera864,161,371 - 64,161,600UniSTS
RH 3.4 Map8808.2UniSTS
Cytogenetic Map8q24UniSTS
RH137806  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0869,179,742 - 69,179,896NCBIRnor6.0
Rnor_5.0868,886,035 - 68,886,189UniSTSRnor5.0
RGSC_v3.4868,426,345 - 68,426,499UniSTSRGSC3.4
Celera864,136,284 - 64,136,438UniSTS
RH 3.4 Map8806.9UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84571247575971259Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85406504489058369Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85406504489058369Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85406504489058369Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)858230766106394378Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85842551091990535Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85842551091990535Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)858425510106526740Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)859234112108068306Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000013933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013933   ⟹   ENSRNOP00000013933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)Ensembl
RefSeq Acc Id: NM_031643   ⟹   NP_113831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2864,683,449 - 64,754,900 (-)NCBI
Rnor_6.0869,134,218 - 69,722,252 (-)NCBI
Rnor_5.0868,840,454 - 68,877,679 (-)NCBI
RGSC_v3.4868,379,074 - 68,451,554 (-)RGD
Celera864,090,188 - 64,161,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595427   ⟹   XP_017450916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0869,136,210 - 69,722,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080739   ⟹   XP_038936667
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2864,683,449 - 64,742,332 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113831   ⟸   NM_031643
- UniProtKB: Q01986 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450916   ⟸   XM_017595427
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000013933   ⟸   ENSRNOT00000013933
RefSeq Acc Id: XP_038936667   ⟸   XM_039080739
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70495 AgrOrtholog
Ensembl Genes ENSRNOG00000010176 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013933 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013933 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7382030 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170851 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108573 IMAGE-MGC_LOAD
NCBI Gene 170851 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAP2K1 RGD
PhenoGen Map2k1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHI2_RAT UniProtKB/TrEMBL
  MP2K1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5EBD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression high in brain, lung, and liver 70317
gene_expression expression decreases in cardiac ventricles after birth 70317
gene_expression expression decreases in cardiac ventricles after birth; expression high in brain, lung, and liver 70317
gene_function phosphorylates and activates Mapk1 and Mapk3 70317
gene_protein contains 393 amino acids 729191
gene_regulation phosphorylated by Raf; nitric oxide enhances phosphorylation 70317