Map2k1 (mitogen activated protein kinase kinase 1) - Rat Genome Database

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Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
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Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
RGD ID: 70495
Description: Enables ATP binding activity; MAP kinase kinase activity; and enzyme binding activity. Involved in several processes, including regulation of gene expression; regulation of intracellular signal transduction; and regulation of muscle contraction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,683,449 - 64,754,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,683,449 - 64,755,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx870,198,296 - 70,269,639 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0868,470,887 - 68,542,228 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0866,340,874 - 66,412,220 (-)NCBIRnor_WKY
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(20R)-protopanaxadiol  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (EXP)
2-methylcholine  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anandamide  (EXP)
anethole  (ISO)
anthranilic acid  (ISO)
antimonite  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beryllium difluoride  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-mannitol  (EXP)
daunorubicin  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
geraniol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP)
heparin  (EXP)
heptachlor  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketamine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP)
maneb  (ISO)
melatonin  (ISO)
mercaptopurine  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perifosine  (ISO)
phenylephrine  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (ISO)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
purine-6-thiol  (ISO)
pyocyanine  (ISO)
quercetin  (ISO)
quinoline  (ISO)
quinomethionate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
SCH772984  (EXP)
serpentine asbestos  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP,ISO)
sulfates  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
teriflunomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toosendanin  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
vanadyl sulfate  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
Bergmann glial cell differentiation  (IEA,ISO)
cell motility  (IEA,ISO)
cell population proliferation  (IDA)
cellular senescence  (IEA,ISO)
cerebellar cortex formation  (IEA,ISO)
endodermal cell differentiation  (IEA,ISO)
epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
glucose homeostasis  (IDA)
Golgi inheritance  (IMP)
heart development  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intracellular signal transduction  (TAS)
keratinocyte differentiation  (IEA,ISO)
labyrinthine layer development  (IEA,ISO)
lung morphogenesis  (ISO)
MAPK cascade  (IBA)
melanosome transport  (IDA)
mitotic cell cycle  (IDA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of gene expression  (IGI)
negative regulation of homotypic cell-cell adhesion  (IMP)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IGI,IMP)
neuron differentiation  (IBA,IEA,IMP,ISO)
neuron projection morphogenesis  (IMP)
peptidyl-tyrosine phosphorylation  (IEA)
placenta blood vessel development  (IEA,ISO)
positive regulation of ATP biosynthetic process  (IGI,IMP)
positive regulation of autophagy  (IDA)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endodermal cell differentiation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,IGI,IMP,ISO)
positive regulation of GTPase activity  (IMP)
positive regulation of MAPK cascade  (IDA,ISO)
positive regulation of miRNA maturation  (ISO)
positive regulation of muscle contraction  (IGI,IMP)
positive regulation of protein serine/threonine kinase activity  (IEA,ISO)
positive regulation of Ras protein signal transduction  (IMP)
positive regulation of transcription elongation by RNA polymerase II  (IMP)
protein phosphorylation  (IDA,IEA,ISO,TAS)
regulation of axon regeneration  (IEA,ISO)
regulation of early endosome to late endosome transport  (TAS)
regulation of ERK1 and ERK2 cascade  (IDA)
regulation of Golgi inheritance  (TAS)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (EXP,IDA)
regulation of stress-activated MAPK cascade  (TAS)
regulation of vascular associated smooth muscle contraction  (IMP)
response to axon injury  (IMP)
response to glucocorticoid  (IDA)
response to oxidative stress  (IDA)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)
triglyceride homeostasis  (IDA)
type B pancreatic cell proliferation  (IEA,ISO)
vesicle transport along microtubule  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway  (IEA)
colorectal cancer pathway  (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
Hedgehog signaling pathway  (ISO)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA,ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway  (IEA)
mitogen activated protein kinase signaling pathway  (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
non-small cell lung carcinoma pathway  (IEA,ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway  (IEA)
prostate cancer pathway  (IEA)
renal cell carcinoma pathway  (IEA)
T cell receptor signaling pathway  (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IMP,TAS)
thyroid cancer pathway  (IEA)
Toll-like receptor signaling pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis. Acharya U, etal., Cell. 1998 Jan 23;92(2):183-92.
2. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Alessandrini A, etal., Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12866-9.
3. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Blasco RB, etal., Cancer Cell. 2011 May 17;19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.
4. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras. Brassard DL, etal., Exp Cell Res. 2002 Feb 15;273(2):138-46.
5. A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. Catling AD, etal., Mol Cell Biol. 1995 Oct;15(10):5214-25.
6. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
7. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y and Borlak J, Oncotarget. 2017 Oct 23;8(60):101808-101831. doi: 10.18632/oncotarget.21981. eCollection 2017 Nov 24.
8. RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis. Colanzi A, etal., J Cell Biol. 2003 Apr 14;161(1):27-32.
9. Regulation of bidirectional melanosome transport by organelle bound MAP kinase. Deacon SW, etal., Curr Biol. 2005 Mar 8;15(5):459-63.
10. Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator. Doring F, etal., Gene 1993 Sep 15;131(2):303-4.
11. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Duan RD, etal., Am J Physiol. 1995 Jun;268(6 Pt 1):G1060-5.
12. Insulin receptor, insulin receptor substrate-1, Raf-1, and Mek-1 during hormonal hepatocarcinogenesis by intrahepatic pancreatic islet transplantation in diabetic rats. Evert M, etal., Cancer Res. 2004 Nov 1;64(21):8093-100.
13. Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. Flood DG, etal., J Comp Neurol. 1998 Aug 31;398(3):373-92.
14. Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells. Fujita T, etal., Mol Cell Biol. 2008 Mar;28(5):1630-43. Epub 2007 Dec 17.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Giroux S, etal., Curr Biol 1999 Apr 8;9(7):369-72.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Gong X, etal., Invest Ophthalmol Vis Sci. 2001 Mar;42(3):539-48.
19. Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis. Guan Z, etal., Mol Med Rep. 2017 Oct;16(4):4784-4790. doi: 10.3892/mmr.2017.7213. Epub 2017 Aug 10.
20. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Halbrook CJ, etal., Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):99-118. doi: 10.1016/j.jcmgh.2016.09.009.
21. Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Huang D, etal., Cancer Res. 2008 Jan 1;68(1):81-8.
22. DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. Kelly PA and Rahmani Z, Mol Biol Cell. 2005 Aug;16(8):3562-73. Epub 2005 May 25.
23. Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells. Kim BW and Son H, Exp Mol Med. 2006 Dec 31;38(6):732-8.
24. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
25. Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen. Kupryjanczyk J, etal., Br J Cancer. 2003 Mar 24;88(6):848-54.
26. Insulin and oxidative stress modulate proliferation of rat ovarian theca-interstitial cells through diverse signal transduction pathways. Kwintkiewicz J, etal., Biol Reprod. 2006 Jun;74(6):1034-40. Epub 2006 Feb 15.
27. Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries. Lagaud GJ, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):523-7.
28. Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway. MacInnis BL and Campenot RB, Mol Cell Neurosci. 2005 Mar;28(3):430-9.
29. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. Marinovic AC, etal., J Biol Chem 2002 May 10;277(19):16673-81.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. Mizukami Y, etal., J Biol Chem. 2004 Nov 26;279(48):50120-31. Epub 2004 Sep 30.
32. Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf. Moodie SA, etal., Mol Cell Biol. 1994 Nov;14(11):7153-62.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Oka H, etal., Cancer Res. 1995 Sep 15;55(18):4182-7.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Isolation of two members of the rat MAP kinase kinase gene family. Otsu M, etal., FEBS Lett 1993 Apr 12;320(3):246-50.
37. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. MEK/ERK regulates adherens junctions and migration through Rac1. Ray RM, etal., Cell Motil Cytoskeleton. 2007 Mar;64(3):143-56.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo. Robinson JP, etal., Oncogene. 2011 Mar 17;30(11):1341-50. doi: 10.1038/onc.2010.513. Epub 2010 Nov 8.
46. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Rodriguez-Viciana P, etal., Science. 2006 Mar 3;311(5765):1287-90. Epub 2006 Jan 26.
47. Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. Salh B, etal., Anticancer Res. 1999 Jan-Feb;19(1B):731-40.
48. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
49. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
50. The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells. Schipper HM, etal., Neuroscience. 1999;93(2):585-95.
51. PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. Slack-Davis JK, etal., J Cell Biol. 2003 Jul 21;162(2):281-91.
52. Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells. Su F, etal., J Cancer Res Clin Oncol. 2009 Dec;135(12):1655-63. doi: 10.1007/s00432-009-0612-6. Epub 2009 Jun 10.
53. Involvement of ERK1/2 in invasiveness and metastatic development of rat prostatic adenocarcinoma. Suthiphongchai T, etal., Oncol Res. 2003;13(5):253-9.
54. ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain. Suzuki T, etal., Neurosci Res. 1995 Jun;22(3):277-85.
55. A subdomain of MEKK1 that is critical for binding to MKK4. Tu Z, etal., Cell Signal. 2003 Jan;15(1):65-77.
56. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ and Strack S, Mol Cell Biol. 2009 Feb;29(3):662-74. doi: 10.1128/MCB.01242-08. Epub 2008 Nov 24.
57. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. Voisin L, etal., BMC Cancer. 2008 Nov 17;8:337. doi: 10.1186/1471-2407-8-337.
58. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
59. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
60. Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. Wu J, etal., Biochem J 1992 Aug 1;285 ( Pt 3):701-5.
61. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Wu J, etal., Mol Cell Biol 1993 Aug;13(8):4539-48.
62. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Wu J, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):173-7.
63. Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy. Xiao Y, etal., Diabetes. 2016 Feb;65(2):393-405. doi: 10.2337/db15-1024. Epub 2015 Nov 18.
64. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. Xu J, etal., J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.
65. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Xu S, etal., Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6808-12.
66. The ERK signaling cascade--views from different subcellular compartments. Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
67. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Zhu JJ, etal., Cell. 2002 Aug 23;110(4):443-55.
Additional References at PubMed
PMID:8026469   PMID:8388392   PMID:8889548   PMID:9765203   PMID:10407019   PMID:10409742   PMID:10644344   PMID:11841548   PMID:12477932   PMID:12624112   PMID:14963006   PMID:15145949  
PMID:15155804   PMID:15469737   PMID:15782137   PMID:15896720   PMID:16737746   PMID:16908534   PMID:17498664   PMID:18006605   PMID:18270979   PMID:18952847   PMID:19047410   PMID:19249349  
PMID:19340459   PMID:19447520   PMID:19453943   PMID:19462441   PMID:20001965   PMID:20942268   PMID:21263381   PMID:21777515   PMID:22294037   PMID:22572157   PMID:23096919   PMID:23376485  
PMID:23626836   PMID:24126801   PMID:24375836   PMID:24431450   PMID:24610459   PMID:24733831   PMID:25100655   PMID:26272725   PMID:26514923   PMID:28166211   PMID:28975447   PMID:29433126  
PMID:29476059   PMID:30053369   PMID:30206251   PMID:30876692   PMID:31505169   PMID:32357304  


Genomics

Comparative Map Data
Map2k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,683,449 - 64,754,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,683,449 - 64,755,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx870,198,296 - 70,269,639 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0868,470,887 - 68,542,228 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0866,340,874 - 66,412,220 (-)NCBIRnor_WKY
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
MAP2K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381566,386,912 - 66,491,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1566,386,837 - 66,491,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371566,679,250 - 66,783,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,466,679 - 64,570,936 (+)NCBINCBI36Build 36hg18NCBI36
Build 341564,466,678 - 64,570,935NCBI
Celera1543,568,908 - 43,673,089 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,515,493 - 43,620,002 (+)NCBIHuRef
CHM1_11566,797,173 - 66,901,898 (+)NCBICHM1_1
T2T-CHM13v2.01564,208,363 - 64,313,019 (+)NCBIT2T-CHM13v2.0
Map2k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,093,051 - 64,160,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,093,052 - 64,160,913 (-)EnsemblGRCm39 Ensembl
GRCm38964,185,769 - 64,253,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,185,770 - 64,253,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37964,033,600 - 64,101,412 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,983,794 - 64,051,338 (-)NCBIMGSCv36mm8
Celera961,410,935 - 61,478,604 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.55NCBI
Map2k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,181,851 - 9,239,648 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,181,851 - 9,205,277 (-)NCBIChiLan1.0ChiLan1.0
MAP2K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11563,613,988 - 63,714,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,613,961 - 63,714,161 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01545,337,117 - 45,438,826 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAP2K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,683,192 - 30,760,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,683,107 - 30,760,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,613,296 - 30,690,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,879,701 - 30,957,083 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,878,118 - 30,957,083 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,809,219 - 30,886,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,868,842 - 30,945,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,110,222 - 31,187,514 (+)NCBIUU_Cfam_GSD_1.0
Map2k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,704,376 - 108,780,234 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647126,589,251 - 26,628,302 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,381,845 - 164,471,226 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,381,892 - 164,469,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,187,631 - 182,196,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,059,122 - 17,168,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,060,054 - 17,168,782 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048124,281,623 - 124,391,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,222,365 - 6,285,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,222,365 - 6,285,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH140096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,693,122 - 64,693,339 (+)MAPPERmRatBN7.2
Rnor_6.0869,143,892 - 69,144,108NCBIRnor6.0
Rnor_5.0868,850,128 - 68,850,344UniSTSRnor5.0
RGSC_v3.4868,388,746 - 68,388,962UniSTSRGSC3.4
Celera864,099,862 - 64,100,078UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH143905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,754,956 - 64,755,187 (+)MAPPERmRatBN7.2
Rnor_6.0869,722,309 - 69,722,539NCBIRnor6.0
Rnor_5.0869,431,673 - 69,431,903UniSTSRnor5.0
Celera864,161,371 - 64,161,600UniSTS
RH 3.4 Map8808.2UniSTS
Cytogenetic Map8q24UniSTS
RH137806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,729,870 - 64,730,025 (+)MAPPERmRatBN7.2
Rnor_6.0869,179,742 - 69,179,896NCBIRnor6.0
Rnor_5.0868,886,035 - 68,886,189UniSTSRnor5.0
RGSC_v3.4868,426,345 - 68,426,499UniSTSRGSC3.4
Celera864,136,284 - 64,136,438UniSTS
RH 3.4 Map8806.9UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000013933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013933   ⟹   ENSRNOP00000013933
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,683,490 - 64,755,147 (-)Ensembl
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097110   ⟹   ENSRNOP00000092766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,684,351 - 64,715,956 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097536   ⟹   ENSRNOP00000081692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,683,449 - 64,715,956 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102833   ⟹   ENSRNOP00000086602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,683,449 - 64,743,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120242   ⟹   ENSRNOP00000084527
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,683,449 - 64,715,723 (-)Ensembl
RefSeq Acc Id: NM_031643   ⟹   NP_113831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2864,683,449 - 64,754,900 (-)NCBI
Rnor_6.0869,134,218 - 69,722,252 (-)NCBI
Rnor_5.0868,840,454 - 68,877,679 (-)NCBI
RGSC_v3.4868,379,074 - 68,451,554 (-)RGD
Celera864,090,188 - 64,161,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080739   ⟹   XP_038936667
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2864,683,449 - 64,742,332 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113831   ⟸   NM_031643
- UniProtKB: Q5EBD5 (UniProtKB/Swiss-Prot),   Q01986 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013933   ⟸   ENSRNOT00000013933
RefSeq Acc Id: XP_038936667   ⟸   XM_039080739
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084527   ⟸   ENSRNOT00000120242
RefSeq Acc Id: ENSRNOP00000086602   ⟸   ENSRNOT00000102833
RefSeq Acc Id: ENSRNOP00000092766   ⟸   ENSRNOT00000097110
RefSeq Acc Id: ENSRNOP00000081692   ⟸   ENSRNOT00000097536
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01986-F1-model_v2 AlphaFold Q01986 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70495 AgrOrtholog
BioCyc Gene G2FUF-30104 BioCyc
Ensembl Genes ENSRNOG00000010176 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013933 ENTREZGENE
  ENSRNOP00000013933.5 UniProtKB/TrEMBL
  ENSRNOP00000081692.1 UniProtKB/TrEMBL
  ENSRNOP00000084527.1 UniProtKB/TrEMBL
  ENSRNOP00000086602 ENTREZGENE
  ENSRNOP00000086602.1 UniProtKB/TrEMBL
  ENSRNOP00000092766.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013933 ENTREZGENE
  ENSRNOT00000013933.7 UniProtKB/TrEMBL
  ENSRNOT00000097110.1 UniProtKB/TrEMBL
  ENSRNOT00000097536.1 UniProtKB/TrEMBL
  ENSRNOT00000102833 ENTREZGENE
  ENSRNOT00000102833.1 UniProtKB/TrEMBL
  ENSRNOT00000120242.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7382030 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170851 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108573 IMAGE-MGC_LOAD
NCBI Gene 170851 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAP2K1 RGD
PhenoGen Map2k1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHI2_RAT UniProtKB/TrEMBL
  A0A8I5ZT77_RAT UniProtKB/TrEMBL
  A0A8I6A048_RAT UniProtKB/TrEMBL
  A0A8I6A1J3_RAT UniProtKB/TrEMBL
  A0A8I6AEA6_RAT UniProtKB/TrEMBL
  MP2K1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBD5 ENTREZGENE
UniProt Secondary Q5EBD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to approved 629479 APPROVED
2002-06-10 Map2k1  mitogen activated protein kinase kinase 1      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression high in brain, lung, and liver 70317
gene_expression expression decreases in cardiac ventricles after birth 70317
gene_expression expression decreases in cardiac ventricles after birth; expression high in brain, lung, and liver 70317
gene_function phosphorylates and activates Mapk1 and Mapk3 70317
gene_protein contains 393 amino acids 729191
gene_regulation phosphorylated by Raf; nitric oxide enhances phosphorylation 70317