(+)-catechin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Catechin results in decreased expression of MAP2K1 mRNA and Catechin results in decreased expression of MAP2K1 protein CTD PMID:15465739 (+)-catechin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 (+)-catechin increases expression ISO MAP2K1 (Homo sapiens) 6480464 Catechin results in increased expression of MAP2K1 mRNA CTD PMID:15465739 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 (20R)-protopanaxadiol increases expression ISO MAP2K1 (Homo sapiens) 6480464 protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expression ISO Map2k1 (Mus musculus) 6480464 2 more ... CTD PMID:25575267 1,2-dimethylhydrazine multiple interactions ISO Map2k1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO Map2k1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions ISO Map2k1 (Mus musculus) 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 1-(5-isoquinolinesulfonyl)-2-methylpiperazine decreases phosphorylation ISO Map2k1 (Mus musculus) 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 17alpha-ethynylestradiol affects expression ISO Map2k1 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of MAP2K1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:17108234 17beta-estradiol multiple interactions ISO Map2k1 (Mus musculus) 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:25210133 17beta-estradiol multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:23094148 17beta-estradiol increases expression ISO MAP2K1 (Homo sapiens) 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 and PMID:23094148 17beta-estradiol affects expression ISO MAP2K1 (Homo sapiens) 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:22574217 17beta-estradiol affects expression ISO Map2k1 (Mus musculus) 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:15598610 17beta-estradiol increases activity ISO MAP2K1 (Homo sapiens) 6480464 Estradiol results in increased activity of MAP2K1 protein CTD PMID:15615701 17beta-estradiol increases expression ISO Map2k1 (Mus musculus) 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:14664709 more ... 17beta-estradiol 3-benzoate decreases phosphorylation EXP 6480464 estradiol 3-benzoate results in decreased phosphorylation of MAP2K1 protein CTD PMID:15778002 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO MAP2K1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO MAP2K1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased activity of MAP2K1 protein CTD PMID:15313166 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Map2k1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Map2k1 (Mus musculus) 6480464 MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]] more ... CTD PMID:12213569 more ... 2,4,6-tribromophenol decreases expression ISO MAP2K1 (Homo sapiens) 6480464 2 more ... CTD PMID:31675489 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of MAP2K1 mRNA CTD PMID:21346803 2-arachidonoylglycerol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 2-methylcholine affects expression ISO MAP2K1 (Homo sapiens) 6480464 beta-methylcholine affects the expression of MAP2K1 mRNA CTD PMID:21179406 3',5'-cyclic GMP multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K1 protein] CTD PMID:18225537 3',5'-cyclic GMP decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Cyclic GMP results in decreased phosphorylation of MAP2K1 protein CTD PMID:18225537 3,3',5,5'-tetrabromobisphenol A decreases expression ISO MAP2K1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of MAP2K1 protein CTD PMID:31675489 3,7-dihydropurine-6-thione decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:11861786 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] CTD PMID:21177760 3-methylcholanthrene increases expression ISO Map2k1 (Mus musculus) 6480464 Methylcholanthrene results in increased expression of MAP2K1 mRNA CTD PMID:25926378 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1 and 2-dithiol-3-thione results in decreased expression of MAP2K1 mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO MAP2K1 (Homo sapiens) 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of MAP2K1 protein CTD PMID:34186270 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein and Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 5-(2-methylpiperazine-1-sulfonyl)isoquinoline decreases phosphorylation ISO Map2k1 (Mus musculus) 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions ISO Map2k1 (Mus musculus) 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-aza-2'-deoxycytidine increases expression ISO MAP2K1 (Homo sapiens) 6480464 Decitabine results in increased expression of MAP2K1 mRNA CTD PMID:17785578 5-fluorouracil multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [U 0126 results in decreased activity of MAP2K1 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin] and MAP2K1 protein results in decreased susceptibility to [Cisplatin co-treated with Fluorouracil] CTD PMID:21444628 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of MAP2K1 mRNA CTD PMID:30047161 9-cis,11-trans-octadecadienoic acid multiple interactions EXP 6480464 [cis-9 more ... CTD PMID:17869086 acetylsalicylic acid increases expression ISO MAP2K1 (Homo sapiens) 6480464 Aspirin results in increased expression of MAP2K1 mRNA CTD PMID:20457246 acrolein multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MAP2K1 mRNA CTD PMID:32699268 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of MAP2K1 mRNA CTD PMID:28959563 afimoxifene increases expression ISO MAP2K1 (Homo sapiens) 6480464 afimoxifene results in increased expression of MAP2K1 mRNA CTD PMID:12154049 aflatoxin B1 increases expression ISO MAP2K1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of MAP2K1 mRNA CTD PMID:27153756 and PMID:34396909 aflatoxin B1 increases methylation ISO MAP2K1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of MAP2K1 intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:18098270 and PMID:20615082 all-trans-retinoic acid increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Tretinoin results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 all-trans-retinoic acid decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of MAP2K1 protein CTD PMID:18098270 all-trans-retinol multiple interactions EXP 6480464 6-hydroxy-2 more ... CTD PMID:16510265 all-trans-retinol increases phosphorylation EXP 6480464 Vitamin A results in increased phosphorylation of MAP2K1 protein CTD PMID:16510265 alpha-mangostin increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 alpha-pinene multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MAP2K1 mRNA CTD PMID:32699268 amiodarone multiple interactions ISO Map2k1 (Mus musculus) 6480464 MAP2K1 protein inhibits the reaction [Amiodarone results in decreased expression of SNAI1 protein] CTD PMID:26515726 amitrole increases expression EXP 6480464 Amitrole results in increased expression of MAP2K1 mRNA CTD PMID:30047161 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MAP2K1 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MAP2K1 mRNA CTD PMID:12420312 anandamide multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 anethole multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 anthranilic acid decreases activity ISO MAP2K1 (Homo sapiens) 6480464 anthranilic acid results in decreased activity of MAP2K1 protein CTD PMID:18393446 antimonite multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of MAP2K1 mRNA CTD PMID:32076005 arachidonic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] more ... CTD PMID:19720122 Aroclor 1254 decreases expression ISO Map2k1 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of MAP2K1 mRNA CTD PMID:23650126 arsenic acid increases activity ISO MAP2K1 (Homo sapiens) 6480464 arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenite(3-) increases activity ISO MAP2K1 (Homo sapiens) 6480464 arsenite results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenous acid increases expression ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 arsenous acid decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 arsenous acid decreases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 arsenous acid decreases activity ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 ATP affects binding ISO Map2k1 (Mus musculus) 6480464 Adenosine Triphosphate binds to MAP2K1 protein CTD PMID:17693661 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of MAP2K1 mRNA CTD PMID:30580161 azathioprine decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Azathioprine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 benzo[a]pyrene multiple interactions ISO Map2k1 (Mus musculus) 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAP2K1 mRNA] CTD PMID:22228805 benzo[a]pyrene affects methylation ISO MAP2K1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of MAP2K1 intron CTD PMID:30157460 benzo[a]pyrene increases methylation ISO MAP2K1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of MAP2K1 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein and Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 benzo[a]pyrene increases expression ISO Map2k1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of MAP2K1 mRNA CTD PMID:22228805 beryllium difluoride increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 beryllium fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:11867686 bicalutamide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 bis(2-chloroethyl) sulfide increases expression ISO Map2k1 (Mus musculus) 6480464 Mustard Gas results in increased expression of MAP2K1 mRNA CTD PMID:18955075 bisphenol A increases expression ISO Map2k1 (Mus musculus) 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25575267 and PMID:33221593 bisphenol A decreases methylation ISO MAP2K1 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of MAP2K1 gene CTD PMID:31601247 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA CTD PMID:30816183 more ... bisphenol A decreases expression ISO MAP2K1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA and bisphenol A results in decreased expression of MAP2K1 protein CTD PMID:29275510 and PMID:31675489 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25181051 Bisphenol B increases expression ISO MAP2K1 (Homo sapiens) 6480464 bisphenol B results in increased expression of MAP2K1 protein CTD PMID:34186270 bortezomib multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Bortezomib co-treated with Butyrates] results in decreased expression of MAP2K1 protein and [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein CTD PMID:12893773 cadmium atom increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Cadmium results in increased phosphorylation of MAP2K1 protein CTD PMID:14499349 cadmium atom multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 GPER1 mutant form inhibits the reaction [Cadmium results in increased activity of MAP2K1 protein] and MAP2K1 protein affects the reaction [Cadmium results in increased expression of PLAUR mRNA] CTD PMID:20153348 and PMID:25069788 cadmium atom increases activity ISO MAP2K1 (Homo sapiens) 6480464 Cadmium results in increased activity of MAP2K1 protein CTD PMID:20153348 cadmium dichloride multiple interactions ISO Map2k1 (Mus musculus) 6480464 1 more ... CTD PMID:11858940 cadmium dichloride increases expression ISO MAP2K1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of MAP2K1 mRNA CTD PMID:32512071 cadmium dichloride increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:11858940 calcium atom multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] and Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 calcium(0) multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] and Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 cannabidiol affects methylation EXP 6480464 Cannabidiol affects the methylation of MAP2K1 gene CTD PMID:30521419 cannabidiol multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in increased expression of MAP2K1 mRNA more ... CTD PMID:30096889 and PMID:32992648 cannabidiol decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of MAP2K1 mRNA CTD PMID:32992648 capsaicin increases expression ISO MAP2K1 (Homo sapiens) 6480464 Capsaicin results in increased expression of MAP2K1 mRNA CTD PMID:19502594 carbon nanotube increases expression ISO Map2k1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 celecoxib decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 chenodeoxycholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 chloropicrin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 chloropicrin results in decreased expression of MAP2K1 mRNA CTD PMID:28476498 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of MAP2K1 mRNA CTD PMID:18668222 choline multiple interactions ISO Map2k1 (Mus musculus) 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 choline increases expression ISO Map2k1 (Mus musculus) 6480464 Choline results in increased expression of MAP2K1 mRNA CTD PMID:27664006 cisplatin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA more ... CTD PMID:21444628 and PMID:27514524 cisplatin multiple interactions ISO Map2k1 (Mus musculus) 6480464 MAP2K1 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein] and MAP2K1 protein promotes the reaction [Cisplatin results in increased phosphorylation of SHC1 protein] CTD PMID:20547441 cisplatin increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Cisplatin results in increased phosphorylation of MAP2K1 protein CTD PMID:21444628 clobetasol increases expression ISO Map2k1 (Mus musculus) 6480464 Clobetasol results in increased expression of MAP2K1 mRNA CTD PMID:27462272 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 cobalt dichloride multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [cobaltous chloride results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] and [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] which results in decreased susceptibility to cobaltous chloride CTD PMID:14536030 cobalt dichloride increases expression ISO MAP2K1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:19376846 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:24386269 cocaine decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Cocaine results in decreased expression of MAP2K1 mRNA CTD PMID:12629581 cocaine multiple interactions ISO Map2k1 (Mus musculus) 6480464 CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein] CTD PMID:15665076 cocaine increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Cocaine results in increased phosphorylation of MAP2K1 protein CTD PMID:15665076 copper atom multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K1 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K1 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO MAP2K1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of MAP2K1 mRNA CTD PMID:19549813 copper(II) sulfate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 corn oil increases expression ISO Map2k1 (Mus musculus) 6480464 Corn Oil results in increased expression of MAP2K1 mRNA CTD PMID:33263755 crocidolite asbestos multiple interactions ISO Map2k1 (Mus musculus) 6480464 MAP2K1 protein affects the reaction [Asbestos more ... CTD PMID:18192500 crocidolite asbestos affects expression ISO MAP2K1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of MAP2K1 mRNA CTD PMID:24160326 crocidolite asbestos increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased phosphorylation of MAP2K1 protein CTD PMID:18314537 cumene multiple interactions ISO Map2k1 (Mus musculus) 6480464 [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA and [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein CTD PMID:18648096 curcumin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 cycloheximide multiple interactions ISO Map2k1 (Mus musculus) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cycloheximide results in increased expression of MAP2K1 mRNA] CTD PMID:23237828 cycloheximide increases activity ISO Map2k1 (Mus musculus) 6480464 Cycloheximide results in increased activity of MAP2K1 protein CTD PMID:23237828 cyclosporin A increases expression ISO MAP2K1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of MAP2K1 mRNA CTD PMID:25562108 cyclosporin A multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 D-mannitol multiple interactions EXP 6480464 Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 daunorubicin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] more ... CTD PMID:34963561 deguelin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 deguelin metabolite results in decreased expression of MAP2K1 protein and deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008 and PMID:19336726 deoxycholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 dexamethasone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein] and Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 dexamethasone increases expression ISO Map2k1 (Mus musculus) 6480464 Dexamethasone results in increased expression of MAP2K1 mRNA CTD PMID:21041162 diarsenic trioxide decreases activity ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 diarsenic trioxide increases expression ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 diarsenic trioxide decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 diarsenic trioxide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 diarsenic trioxide decreases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of MAP2K1 mRNA CTD PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 dichlorine increases expression EXP 6480464 Chlorine results in increased expression of MAP2K1 mRNA CTD PMID:18636392 dieldrin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 diethylstilbestrol increases expression ISO MAP2K1 (Homo sapiens) 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:15766595 diethylstilbestrol increases expression ISO Map2k1 (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:16636312 and PMID:25575267 dimethyl sulfoxide increases expression ISO MAP2K1 (Homo sapiens) 6480464 Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA CTD PMID:31265865 dimethyl sulfoxide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA] CTD PMID:31265865 dioxygen increases response to substance EXP 6480464 MAP2K1 protein results in increased susceptibility to Oxygen CTD PMID:10780954 dioxygen multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:32992648 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of MAP2K1 mRNA CTD PMID:32076005 diquat increases expression ISO Map2k1 (Mus musculus) 6480464 Diquat results in increased expression of MAP2K1 protein CTD PMID:36851058 disodium selenite decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Sodium Selenite results in decreased expression of MAP2K1 mRNA CTD PMID:16705456 diuron decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Diuron results in decreased expression of MAP2K1 mRNA CTD PMID:35967413 doxorubicin increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 doxorubicin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of MAP2K1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin] more ... CTD PMID:18594523 doxorubicin increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 emodin multiple interactions EXP 6480464 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 endosulfan multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MAP2K1 mRNA CTD PMID:29391264 estriol increases expression ISO Map2k1 (Mus musculus) 6480464 Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 etacrynic acid increases expression ISO MAP2K1 (Homo sapiens) 6480464 Ethacrynic Acid results in increased expression of MAP2K1 protein CTD PMID:14556662 ethanol affects expression EXP 6480464 Ethanol affects the expression of MAP2K1 mRNA CTD PMID:11772933 ethanol affects splicing ISO Map2k1 (Mus musculus) 6480464 Ethanol affects the splicing of MAP2K1 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MAP2K1 protein CTD PMID:23702218 ethanol multiple interactions EXP 6480464 N-methyl-N-(6-methoxy-1-phenyl-1 more ... CTD PMID:20655511 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of MAP2K1 mRNA CTD PMID:20655511 ethyl methanesulfonate decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in decreased expression of MAP2K1 mRNA CTD PMID:23649840 fipronil decreases activity ISO Map2k1 (Mus musculus) 6480464 fipronil results in decreased activity of MAP2K1 protein CTD PMID:21167920 flavonoids decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Flavonoids results in decreased expression of MAP2K1 mRNA CTD PMID:15465739 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MAP2K1 mRNA CTD PMID:24136188 folic acid decreases expression ISO Map2k1 (Mus musculus) 6480464 Folic Acid results in decreased expression of MAP2K1 mRNA CTD PMID:25629700 folic acid multiple interactions ISO Map2k1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 gallic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] more ... CTD PMID:21420233 more ... gamma-hexachlorocyclohexane multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 geldanamycin multiple interactions ISO Map2k1 (Mus musculus) 6480464 geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:8816498 geldanamycin decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 geldanamycin results in decreased phosphorylation of MAP2K1 protein CTD PMID:19167484 genistein decreases phosphorylation EXP 6480464 Genistein results in decreased phosphorylation of MAP2K1 protein CTD PMID:15781664 genistein increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Genistein results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 glycochenodeoxycholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glycocholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glycodeoxycholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glyphosate decreases expression ISO MAP2K1 (Homo sapiens) 6480464 glyphosate results in decreased expression of MAP2K1 mRNA CTD PMID:31295307 gold atom multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] and MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 gold(0) multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] and MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 heparin multiple interactions EXP 6480464 Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein] and Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:14966081 heptachlor multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 heptachlor decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Heptachlor results in decreased expression of MAP2K1 protein CTD PMID:9704902 hyaluronic acid increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Hyaluronic Acid analog results in increased phosphorylation of MAP2K1 protein CTD PMID:12402308 hydrogen peroxide increases activity ISO MAP2K1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased activity of MAP2K1 protein CTD PMID:15242773 and PMID:19038233 hydrogen peroxide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein affects the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA] CTD PMID:26514923 hydroquinone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [hydroquinone results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:23288922 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of MAP2K1 mRNA CTD PMID:18299717 ionomycin multiple interactions EXP 6480464 Ionomycin inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 isoprenaline multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 isoprenaline multiple interactions ISO Map2k1 (Mus musculus) 6480464 MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] more ... CTD PMID:21177286 ivermectin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of MAP2K1 protein CTD PMID:32959892 ketamine multiple interactions ISO Map2k1 (Mus musculus) 6480464 Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:19540866 lead diacetate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:11861786 lead(0) increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Lead results in increased phosphorylation of MAP2K1 protein CTD PMID:19133285 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of MAP2K1 mRNA and Lead results in decreased expression of MAP2K1 protein CTD PMID:24960059 letrozole increases expression ISO Map2k1 (Mus musculus) 6480464 letrozole results in increased expression of MAP2K1 protein CTD PMID:15967659 lipopolysaccharide increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:19010997 lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:21247645 lipopolysaccharide multiple interactions EXP 6480464 MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] more ... CTD PMID:10469353 and PMID:21247645 lipopolysaccharide increases expression ISO Map2k1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of MAP2K1 mRNA CTD PMID:10975854 lipopolysaccharide multiple interactions ISO Map2k1 (Mus musculus) 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein more ... CTD PMID:19540866 more ... lipopolysaccharide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:18209571 lipoteichoic acid increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 lipoteichoic acid results in increased phosphorylation of MAP2K1 protein CTD PMID:19573522 lipoteichoic acid multiple interactions ISO Map2k1 (Mus musculus) 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 lithium atom multiple interactions ISO Map2k1 (Mus musculus) 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithium hydride multiple interactions ISO Map2k1 (Mus musculus) 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithocholic acid multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 LY294002 multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein] CTD PMID:15850772 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 lycopene increases expression ISO MAP2K1 (Homo sapiens) 6480464 lycopene results in increased expression of MAP2K1 mRNA CTD PMID:16886892 Maduramicin multiple interactions EXP 6480464 MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein] and MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein] CTD PMID:29241734 Maduramicin decreases response to substance EXP 6480464 MAP2K1 protein results in decreased susceptibility to maduramicin CTD PMID:29241734 maneb multiple interactions ISO Map2k1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 melatonin multiple interactions ISO Map2k1 (Mus musculus) 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 mercaptopurine decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of MAP2K1 protein CTD PMID:19826936 methamphetamine decreases expression ISO Map2k1 (Mus musculus) 6480464 Methamphetamine results in decreased expression of MAP2K1 protein CTD PMID:16192988 methimazole increases expression EXP 6480464 Methimazole results in increased expression of MAP2K1 mRNA CTD PMID:30047161 methylmercury chloride affects expression ISO Map2k1 (Mus musculus) 6480464 methylmercuric chloride affects the expression of MAP2K1 mRNA CTD PMID:21613230 methylseleninic acid decreases expression ISO MAP2K1 (Homo sapiens) 6480464 methylselenic acid results in decreased expression of MAP2K1 mRNA CTD PMID:11830524 methylseleninic acid increases expression ISO MAP2K1 (Homo sapiens) 6480464 methylselenic acid results in increased expression of MAP2K1 mRNA CTD PMID:12517777 mifepristone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 mitomycin C multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of MAP2K1 mRNA CTD PMID:28954212 myricetin multiple interactions ISO Map2k1 (Mus musculus) 6480464 myricetin binds to and results in decreased activity of MAP2K1 protein and myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:17693661 N-acetyl-L-cysteine multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-methyl-4-phenylpyridinium increases expression ISO Map2k1 (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of MAP2K1 protein CTD PMID:26558463 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-Nitroso-N-methylurethane multiple interactions EXP 6480464 Nitrosomethylurethane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-nitrosodiethylamine affects phosphorylation ISO Map2k1 (Mus musculus) 6480464 Diethylnitrosamine affects the phosphorylation of MAP2K1 protein CTD PMID:24535843 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MAP2K1 protein CTD PMID:21411721 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MAP2K1 mRNA CTD PMID:24136188 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MAP2K1 mRNA CTD PMID:22110744 ochratoxin A increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 ochratoxin A results in increased phosphorylation of MAP2K1 protein CTD PMID:25002221 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 ozone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA more ... CTD PMID:32699268 more ... p-menthan-3-ol decreases expression ISO MAP2K1 (Homo sapiens) 6480464 Menthol results in decreased expression of MAP2K1 mRNA CTD PMID:26760959 paclitaxel multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel] more ... CTD PMID:18098270 and PMID:18594523 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of MAP2K1 mRNA CTD PMID:33387578 paraquat multiple interactions ISO Map2k1 (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 PD 0325901 multiple interactions EXP 6480464 mirdametinib inhibits the reaction [polyphyllin I inhibits the reaction [Dietary Fats results in decreased expression of MAP2K1 protein]] CTD PMID:36120828 pentachlorophenol increases expression ISO Map2k1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of MAP2K1 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of MAP2K1 mRNA CTD PMID:20136073 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MAP2K1 mRNA CTD PMID:19162173 perifosine multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates] more ... CTD PMID:15781658 phenylephrine multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 PhIP increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased phosphorylation of MAP2K1 protein CTD PMID:22307971 phorbol 13-acetate 12-myristate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:11861786 more ... phorbol 13-acetate 12-myristate increases activity ISO Map2k1 (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate multiple interactions ISO Map2k1 (Mus musculus) 6480464 3 more ... CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein CTD PMID:20479004 propiconazole increases expression ISO Map2k1 (Mus musculus) 6480464 propiconazole results in increased expression of MAP2K1 mRNA CTD PMID:21278054 propofol multiple interactions ISO Map2k1 (Mus musculus) 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 prostaglandin F2alpha increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Dinoprost results in increased phosphorylation of MAP2K1 protein CTD PMID:24333336 prostaglandin F2alpha multiple interactions ISO Map2k1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] and SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 purine-6-thiol decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 pyocyanine increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 quercetin multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA CTD PMID:27514524 quercetin multiple interactions ISO Map2k1 (Mus musculus) 6480464 Quercetin binds to and results in decreased activity of MAP2K1 protein CTD PMID:18245498 quinoline decreases activity ISO MAP2K1 (Homo sapiens) 6480464 quinoline results in decreased activity of MAP2K1 protein CTD PMID:18393446 quinomethionate affects expression ISO MAP2K1 (Homo sapiens) 6480464 quinomethionate affects the expression of MAP2K1 mRNA CTD PMID:15387888 reactive oxygen species multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] CTD PMID:16945329 resveratrol decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 resveratrol results in decreased phosphorylation of MAP2K1 protein CTD PMID:16761963 resveratrol multiple interactions ISO Map2k1 (Mus musculus) 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 resveratrol multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [resveratrol results in decreased expression of XRCC1 protein] CTD PMID:26046675 resveratrol increases expression ISO MAP2K1 (Homo sapiens) 6480464 resveratrol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 resveratrol increases activity ISO MAP2K1 (Homo sapiens) 6480464 resveratrol results in increased activity of MAP2K1 protein CTD PMID:15615701 resveratrol decreases activity ISO MAP2K1 (Homo sapiens) 6480464 resveratrol results in decreased activity of MAP2K1 protein CTD PMID:15698585 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of MAP2K1 protein CTD PMID:35544339 rottlerin decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 SCH772984 increases phosphorylation EXP 6480464 SCH772984 results in increased phosphorylation of MAP2K1 protein CTD PMID:28087833 serpentine asbestos affects expression ISO MAP2K1 (Homo sapiens) 6480464 Asbestos and Serpentine affects the expression of MAP2K1 mRNA CTD PMID:24160326 sirolimus multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MAP2K1 protein and [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K1 protein CTD PMID:15767555 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein] and Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 sodium arsenite multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 more ... sodium arsenite decreases expression ISO Map2k1 (Mus musculus) 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:31233874 sodium arsenite increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 sodium arsenite results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 sodium arsenite increases expression ISO MAP2K1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of MAP2K1 mRNA CTD PMID:24431212 sodium arsenite decreases expression ISO MAP2K1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:12016162 sodium arsenite affects expression ISO MAP2K1 (Homo sapiens) 6480464 sodium arsenite affects the expression of MAP2K1 mRNA and sodium arsenite affects the expression of MAP2K1 protein modified form CTD PMID:17384772 more ... sodium fluoride increases phosphorylation EXP 6480464 Sodium Fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:19900517 sodium fluoride multiple interactions ISO Map2k1 (Mus musculus) 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 sodium fluoride decreases expression ISO Map2k1 (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of MAP2K1 mRNA CTD PMID:27664006 sorafenib multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [MAP2K1 protein results in increased phosphorylation of MAPK1 protein] which results in decreased susceptibility to sorafenib more ... CTD PMID:20117835 and PMID:21187475 sorafenib decreases phosphorylation EXP 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 sorafenib decreases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 more ... sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of MAP2K1 mRNA CTD PMID:30047161 sulfates multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Soot co-treated with Sulfates] affects the methylation of MAP2K1 promoter CTD PMID:25395096 sulindac sulfide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 and PMID:16079301 sulindac sulfone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 sumatriptan multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] and Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 sunitinib increases expression ISO MAP2K1 (Homo sapiens) 6480464 Sunitinib results in increased expression of MAP2K1 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein] CTD PMID:20479004 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of MAP2K1 protein modified form CTD PMID:17901229 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of MAP2K1 protein modified form CTD PMID:17901229 teriflunomide multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 teriflunomide inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:9973483 testosterone increases activity ISO MAP2K1 (Homo sapiens) 6480464 [Testosterone results in increased activity of RAF1 protein] which results in increased activity of MAP2K1 protein CTD PMID:20372086 testosterone multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] more ... CTD PMID:21177760 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of MAP2K1 mRNA CTD PMID:17805973 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MAP2K1 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 tetrachloromethane multiple interactions ISO Map2k1 (Mus musculus) 6480464 Silymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:32956689 tetrachloromethane increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased phosphorylation of MAP2K1 protein CTD PMID:32956689 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MAP2K1 mRNA CTD PMID:34492290 titanium dioxide increases phosphorylation ISO Map2k1 (Mus musculus) 6480464 titanium dioxide analog results in increased phosphorylation of MAP2K1 protein CTD PMID:25111187 toluene affects expression EXP 6480464 Toluene affects the expression of MAP2K1 mRNA CTD PMID:21827849 toosendanin decreases expression ISO MAP2K1 (Homo sapiens) 6480464 toosendanin results in decreased expression of MAP2K1 protein modified form CTD PMID:23111283 trametinib decreases response to substance ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein mutant form results in decreased susceptibility to trametinib CTD PMID:29768711 trametinib multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein] and [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:29768711 trans-anethole multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 trichostatin A multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A] CTD PMID:15781658 trichostatin A affects expression ISO MAP2K1 (Homo sapiens) 6480464 trichostatin A affects the expression of MAP2K1 mRNA CTD PMID:28542535 trimethyltin increases expression ISO Map2k1 (Mus musculus) 6480464 trimethyltin results in increased expression of MAP2K1 mRNA CTD PMID:20833246 troglitazone multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 MAP2K1 protein promotes the reaction [troglitazone results in increased expression of ATF3 mRNA] CTD PMID:16079301 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein] CTD PMID:16269455 urethane increases expression ISO MAP2K1 (Homo sapiens) 6480464 Urethane results in increased expression of MAP2K1 mRNA CTD PMID:28818685 vanadyl sulfate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 and PMID:11943669 vanadyl sulfate increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 vanadyl sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 vorinostat multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein and MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:12893773 and PMID:15781658 vorinostat decreases expression ISO MAP2K1 (Homo sapiens) 6480464 vorinostat results in decreased expression of MAP2K1 protein CTD PMID:12893773 wogonin multiple interactions ISO Map2k1 (Mus musculus) 6480464 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 zearalenone decreases expression ISO Map2k1 (Mus musculus) 6480464 Zearalenone results in decreased expression of MAP2K1 protein CTD PMID:36252740 zinc sulfate multiple interactions ISO MAP2K1 (Homo sapiens) 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 and PMID:11943669 zinc sulfate increases phosphorylation ISO MAP2K1 (Homo sapiens) 6480464 Zinc Sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669