(+)-catechin decreases expression ISO RGD:732023 6480464 Catechin results in decreased expression of MAP2K1 mRNA, Catechin results in decreased expression of MAP2K1 protein CTD PMID:15465739 (+)-catechin multiple interactions ISO RGD:732023 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 (+)-catechin increases expression ISO RGD:732023 6480464 Catechin results in increased expression of MAP2K1 mRNA CTD PMID:15465739 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 (20R)-protopanaxadiol increases expression ISO RGD:732023 6480464 protopanaxadiol results in increased expression of MAP2K1 mRNA CTD PMID:31805304 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expression ISO RGD:1550208 6480464 2 more ... CTD PMID:25575267 1,2-dimethylhydrazine multiple interactions ISO RGD:1550208 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1550208 6480464 1, 2-Dimethylhydrazine results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions ISO RGD:1550208 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 1-(5-isoquinolinesulfonyl)-2-methylpiperazine decreases phosphorylation ISO RGD:1550208 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 17alpha-ethynylestradiol affects expression ISO RGD:1550208 6480464 Ethinyl Estradiol affects the expression of MAP2K1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:17108234 17beta-estradiol multiple interactions ISO RGD:1550208 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:25210133 17beta-estradiol multiple interactions ISO RGD:732023 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:23094148 17beta-estradiol increases expression ISO RGD:732023 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 , PMID:23094148 17beta-estradiol affects expression ISO RGD:732023 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:22574217 17beta-estradiol affects expression ISO RGD:1550208 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:15598610 17beta-estradiol increases activity ISO RGD:732023 6480464 Estradiol results in increased activity of MAP2K1 protein CTD PMID:15615701 17beta-estradiol increases expression ISO RGD:1550208 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:14664709 more ... 17beta-estradiol 3-benzoate decreases phosphorylation EXP 6480464 estradiol 3-benzoate results in decreased phosphorylation of MAP2K1 protein CTD PMID:15778002 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:732023 6480464 2 more ... CTD PMID:31675489 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:732023 6480464 Tetrachlorodibenzodioxin results in increased activity of MAP2K1 protein CTD PMID:15313166 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550208 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]] more ... CTD PMID:12213569 more ... 2,4,6-tribromophenol decreases expression ISO RGD:732023 6480464 2 more ... CTD PMID:31675489 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of MAP2K1 mRNA CTD PMID:21346803 2-arachidonoylglycerol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 2-methylcholine affects expression ISO RGD:732023 6480464 beta-methylcholine affects the expression of MAP2K1 mRNA CTD PMID:21179406 3',5'-cyclic GMP multiple interactions ISO RGD:732023 6480464 Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K1 protein] CTD PMID:18225537 3',5'-cyclic GMP decreases phosphorylation ISO RGD:732023 6480464 Cyclic GMP results in decreased phosphorylation of MAP2K1 protein CTD PMID:18225537 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:732023 6480464 tetrabromobisphenol A results in decreased expression of MAP2K1 protein CTD PMID:31675489 3,7-dihydropurine-6-thione decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:732023 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:11861786 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] CTD PMID:21177760 3-methylcholanthrene increases expression ISO RGD:1550208 6480464 Methylcholanthrene results in increased expression of MAP2K1 mRNA CTD PMID:25926378 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of MAP2K1 mRNA CTD PMID:19162173 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:732023 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein, Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 5-(2-methylpiperazine-1-sulfonyl)isoquinoline decreases phosphorylation ISO RGD:1550208 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions ISO RGD:1550208 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-aza-2'-deoxycytidine increases expression ISO RGD:732023 6480464 Decitabine results in increased expression of MAP2K1 mRNA CTD PMID:17785578 5-fluorouracil multiple interactions ISO RGD:732023 6480464 [U 0126 results in decreased activity of MAP2K1 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin], MAP2K1 protein results in decreased susceptibility to [Cisplatin co-treated with Fluorouracil] CTD PMID:21444628 9-cis,11-trans-octadecadienoic acid multiple interactions EXP 6480464 [cis-9 more ... CTD PMID:17869086 acetylsalicylic acid increases expression ISO RGD:732023 6480464 Aspirin results in increased expression of MAP2K1 mRNA CTD PMID:20457246 acrolein multiple interactions ISO RGD:732023 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MAP2K1 mRNA CTD PMID:32699268 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of MAP2K1 mRNA CTD PMID:28959563 afimoxifene increases expression ISO RGD:732023 6480464 afimoxifene results in increased expression of MAP2K1 mRNA CTD PMID:12154049 aflatoxin B1 increases expression ISO RGD:732023 6480464 Aflatoxin B1 results in increased expression of MAP2K1 mRNA CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:732023 6480464 Aflatoxin B1 results in increased methylation of MAP2K1 intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:18098270 , PMID:20615082 all-trans-retinoic acid increases phosphorylation ISO RGD:732023 6480464 Tretinoin results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 all-trans-retinoic acid decreases expression ISO RGD:732023 6480464 Tretinoin results in decreased expression of MAP2K1 protein CTD PMID:18098270 all-trans-retinol multiple interactions EXP 6480464 6-hydroxy-2 more ... CTD PMID:16510265 all-trans-retinol increases phosphorylation EXP 6480464 Vitamin A results in increased phosphorylation of MAP2K1 protein CTD PMID:16510265 alpha-mangostin increases phosphorylation ISO RGD:732023 6480464 mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 alpha-pinene multiple interactions ISO RGD:732023 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MAP2K1 mRNA CTD PMID:32699268 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MAP2K1 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MAP2K1 mRNA CTD PMID:12420312 anandamide multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 anethole multiple interactions ISO RGD:732023 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 anthranilic acid decreases activity ISO RGD:732023 6480464 anthranilic acid results in decreased activity of MAP2K1 protein CTD PMID:18393446 antimonite multiple interactions ISO RGD:732023 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of MAP2K1 mRNA CTD PMID:32076005 arachidonic acid multiple interactions ISO RGD:732023 6480464 FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] more ... CTD PMID:19720122 Aroclor 1254 decreases expression ISO RGD:1550208 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of MAP2K1 mRNA CTD PMID:23650126 arsenic acid increases activity ISO RGD:732023 6480464 arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenite(3-) increases activity ISO RGD:732023 6480464 arsenite results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenous acid increases expression ISO RGD:732023 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 arsenous acid decreases phosphorylation ISO RGD:732023 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 arsenous acid decreases phosphorylation ISO RGD:1550208 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 arsenous acid decreases activity ISO RGD:732023 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 ATP affects binding ISO RGD:1550208 6480464 Adenosine Triphosphate binds to MAP2K1 protein CTD PMID:17693661 atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of MAP2K1 mRNA CTD PMID:30580161 azathioprine decreases phosphorylation ISO RGD:732023 6480464 Azathioprine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 benzo[a]pyrene multiple interactions ISO RGD:1550208 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAP2K1 mRNA] CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:732023 6480464 Benzo(a)pyrene affects the methylation of MAP2K1 intron CTD PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:732023 6480464 Benzo(a)pyrene results in increased methylation of MAP2K1 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:732023 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein, Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 benzo[a]pyrene increases expression ISO RGD:1550208 6480464 Benzo(a)pyrene results in increased expression of MAP2K1 mRNA CTD PMID:22228805 beryllium difluoride increases phosphorylation ISO RGD:1550208 6480464 beryllium fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:11867686 bicalutamide multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 bis(2-chloroethyl) sulfide increases expression ISO RGD:1550208 6480464 Mustard Gas results in increased expression of MAP2K1 mRNA CTD PMID:18955075 bisphenol A increases expression ISO RGD:1550208 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25575267 , PMID:33221593 bisphenol A decreases methylation ISO RGD:732023 6480464 bisphenol A results in decreased methylation of MAP2K1 gene CTD PMID:31601247 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA CTD PMID:30816183 more ... bisphenol A decreases expression ISO RGD:732023 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA, bisphenol A results in decreased expression of MAP2K1 protein CTD PMID:29275510 , PMID:31675489 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25181051 bortezomib multiple interactions ISO RGD:732023 6480464 [Bortezomib co-treated with Butyrates] results in decreased expression of MAP2K1 protein, [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein CTD PMID:12893773 cadmium atom increases phosphorylation ISO RGD:732023 6480464 Cadmium results in increased phosphorylation of MAP2K1 protein CTD PMID:14499349 cadmium atom multiple interactions ISO RGD:732023 6480464 GPER1 mutant form inhibits the reaction [Cadmium results in increased activity of MAP2K1 protein], MAP2K1 protein affects the reaction [Cadmium results in increased expression of PLAUR mRNA] CTD PMID:20153348 , PMID:25069788 cadmium atom increases activity ISO RGD:732023 6480464 Cadmium results in increased activity of MAP2K1 protein CTD PMID:20153348 cadmium dichloride multiple interactions ISO RGD:1550208 6480464 1 more ... CTD PMID:11858940 cadmium dichloride increases expression ISO RGD:732023 6480464 Cadmium Chloride results in increased expression of MAP2K1 mRNA CTD PMID:32512071 cadmium dichloride increases phosphorylation ISO RGD:732023 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride multiple interactions ISO RGD:732023 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride increases phosphorylation ISO RGD:1550208 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:11858940 calcium atom multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 calcium(0) multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 cannabidiol affects methylation EXP 6480464 Cannabidiol affects the methylation of MAP2K1 gene CTD PMID:30521419 cannabidiol multiple interactions ISO RGD:732023 6480464 [Cannabidiol co-treated with moringin] results in increased expression of MAP2K1 mRNA more ... CTD PMID:30096889 , PMID:32992648 cannabidiol decreases expression ISO RGD:732023 6480464 Cannabidiol results in decreased expression of MAP2K1 mRNA CTD PMID:32992648 capsaicin increases expression ISO RGD:732023 6480464 Capsaicin results in increased expression of MAP2K1 mRNA CTD PMID:19502594 carbon nanotube increases expression ISO RGD:1550208 6480464 Nanotubes more ... CTD PMID:25554681 celecoxib decreases phosphorylation ISO RGD:732023 6480464 Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 chenodeoxycholic acid multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 chloropicrin decreases expression ISO RGD:732023 6480464 chloropicrin results in decreased expression of MAP2K1 mRNA CTD PMID:28476498 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of MAP2K1 mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:1550208 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 choline increases expression ISO RGD:1550208 6480464 Choline results in increased expression of MAP2K1 mRNA CTD PMID:27664006 cisplatin multiple interactions ISO RGD:732023 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA more ... CTD PMID:21444628 , PMID:27514524 cisplatin multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein], MAP2K1 protein promotes the reaction [Cisplatin results in increased phosphorylation of SHC1 protein] CTD PMID:20547441 cisplatin increases phosphorylation ISO RGD:732023 6480464 Cisplatin results in increased phosphorylation of MAP2K1 protein CTD PMID:21444628 clobetasol increases expression ISO RGD:1550208 6480464 Clobetasol results in increased expression of MAP2K1 mRNA CTD PMID:27462272 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 cobalt dichloride multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [cobaltous chloride results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]], [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] which results in decreased susceptibility to cobaltous chloride CTD PMID:14536030 cobalt dichloride increases expression ISO RGD:732023 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:19376846 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:24386269 cocaine decreases expression ISO RGD:732023 6480464 Cocaine results in decreased expression of MAP2K1 mRNA CTD PMID:12629581 cocaine multiple interactions ISO RGD:1550208 6480464 CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein] CTD PMID:15665076 cocaine increases phosphorylation ISO RGD:1550208 6480464 Cocaine results in increased phosphorylation of MAP2K1 protein CTD PMID:15665076 copper atom multiple interactions ISO RGD:732023 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K1 mRNA CTD PMID:30911355 copper(0) multiple interactions ISO RGD:732023 6480464 [Chelating Agents binds to Copper] which results in increased expression of MAP2K1 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO RGD:732023 6480464 Copper Sulfate results in increased expression of MAP2K1 mRNA CTD PMID:19549813 copper(II) sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 crocidolite asbestos multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein affects the reaction [Asbestos more ... CTD PMID:18192500 crocidolite asbestos affects expression ISO RGD:732023 6480464 Asbestos, Crocidolite affects the expression of MAP2K1 mRNA CTD PMID:24160326 crocidolite asbestos increases phosphorylation ISO RGD:732023 6480464 Asbestos, Crocidolite results in increased phosphorylation of MAP2K1 protein CTD PMID:18314537 cumene multiple interactions ISO RGD:1550208 6480464 [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA, [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein CTD PMID:18648096 curcumin multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 cycloheximide multiple interactions ISO RGD:1550208 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cycloheximide results in increased expression of MAP2K1 mRNA] CTD PMID:23237828 cycloheximide increases activity ISO RGD:1550208 6480464 Cycloheximide results in increased activity of MAP2K1 protein CTD PMID:23237828 cyclosporin A increases expression ISO RGD:732023 6480464 Cyclosporine results in increased expression of MAP2K1 mRNA CTD PMID:25562108 cyclosporin A multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 D-mannitol multiple interactions EXP 6480464 Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 daunorubicin multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] more ... CTD PMID:34963561 deguelin decreases expression ISO RGD:732023 6480464 deguelin metabolite results in decreased expression of MAP2K1 protein, deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008 , PMID:19336726 deoxycholic acid multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 dexamethasone multiple interactions ISO RGD:732023 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 dexamethasone increases expression ISO RGD:1550208 6480464 Dexamethasone results in increased expression of MAP2K1 mRNA CTD PMID:21041162 diarsenic trioxide decreases activity ISO RGD:732023 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 diarsenic trioxide increases expression ISO RGD:732023 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 diarsenic trioxide decreases phosphorylation ISO RGD:732023 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 diarsenic trioxide multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 diarsenic trioxide decreases phosphorylation ISO RGD:1550208 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of MAP2K1 mRNA CTD PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 dichlorine increases expression EXP 6480464 Chlorine results in increased expression of MAP2K1 mRNA CTD PMID:18636392 dieldrin multiple interactions ISO RGD:732023 6480464 Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 diethylstilbestrol increases expression ISO RGD:732023 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:15766595 diethylstilbestrol increases expression ISO RGD:1550208 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:16636312 , PMID:25575267 dimethyl sulfoxide increases expression ISO RGD:732023 6480464 Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA CTD PMID:31265865 dimethyl sulfoxide multiple interactions ISO RGD:732023 6480464 cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA] CTD PMID:31265865 dioxygen increases response to substance EXP 6480464 MAP2K1 protein results in increased susceptibility to Oxygen CTD PMID:10780954 dioxygen multiple interactions ISO RGD:732023 6480464 [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:32992648 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO RGD:732023 6480464 [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in increased expression of MAP2K1 mRNA CTD PMID:32076005 disodium selenite decreases expression ISO RGD:732023 6480464 Sodium Selenite results in decreased expression of MAP2K1 mRNA CTD PMID:16705456 doxorubicin increases phosphorylation ISO RGD:732023 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 doxorubicin decreases expression ISO RGD:732023 6480464 Doxorubicin results in decreased expression of MAP2K1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin] more ... CTD PMID:18594523 doxorubicin increases phosphorylation ISO RGD:1550208 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 emodin multiple interactions EXP 6480464 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 endosulfan multiple interactions ISO RGD:732023 6480464 Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MAP2K1 mRNA CTD PMID:29391264 estriol increases expression ISO RGD:1550208 6480464 Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 etacrynic acid increases expression ISO RGD:732023 6480464 Ethacrynic Acid results in increased expression of MAP2K1 protein CTD PMID:14556662 ethanol affects expression EXP 6480464 Ethanol affects the expression of MAP2K1 mRNA CTD PMID:11772933 ethanol affects splicing ISO RGD:1550208 6480464 Ethanol affects the splicing of MAP2K1 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MAP2K1 protein CTD PMID:23702218 ethanol multiple interactions EXP 6480464 N-methyl-N-(6-methoxy-1-phenyl-1 more ... CTD PMID:20655511 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of MAP2K1 mRNA CTD PMID:20655511 ethyl methanesulfonate decreases expression ISO RGD:732023 6480464 Ethyl Methanesulfonate results in decreased expression of MAP2K1 mRNA CTD PMID:23649840 fipronil decreases activity ISO RGD:1550208 6480464 fipronil results in decreased activity of MAP2K1 protein CTD PMID:21167920 flavonoids decreases expression ISO RGD:732023 6480464 Flavonoids results in decreased expression of MAP2K1 mRNA CTD PMID:15465739 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MAP2K1 mRNA CTD PMID:24136188 folic acid decreases expression ISO RGD:1550208 6480464 Folic Acid results in decreased expression of MAP2K1 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:1550208 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAP2K1 mRNA CTD PMID:22206623 gallic acid multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] more ... CTD PMID:21420233 more ... gamma-hexachlorocyclohexane multiple interactions ISO RGD:732023 6480464 Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 geldanamycin multiple interactions ISO RGD:1550208 6480464 geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:8816498 geldanamycin decreases phosphorylation ISO RGD:732023 6480464 geldanamycin results in decreased phosphorylation of MAP2K1 protein CTD PMID:19167484 genistein decreases phosphorylation EXP 6480464 Genistein results in decreased phosphorylation of MAP2K1 protein CTD PMID:15781664 genistein increases phosphorylation ISO RGD:732023 6480464 Genistein results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 glycochenodeoxycholic acid multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glycocholic acid multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glycodeoxycholic acid multiple interactions ISO RGD:732023 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP2K1 mRNA CTD PMID:32152650 glyphosate decreases expression ISO RGD:732023 6480464 glyphosate results in decreased expression of MAP2K1 mRNA CTD PMID:31295307 gold atom multiple interactions ISO RGD:732023 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]], MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 gold(0) multiple interactions ISO RGD:732023 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]], MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 heparin multiple interactions EXP 6480464 Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein], Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:14966081 heptachlor multiple interactions ISO RGD:732023 6480464 Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 heptachlor decreases expression ISO RGD:732023 6480464 Heptachlor results in decreased expression of MAP2K1 protein CTD PMID:9704902 hyaluronic acid increases phosphorylation ISO RGD:732023 6480464 Hyaluronic Acid analog results in increased phosphorylation of MAP2K1 protein CTD PMID:12402308 hydrogen peroxide increases activity ISO RGD:732023 6480464 Hydrogen Peroxide results in increased activity of MAP2K1 protein CTD PMID:15242773 , PMID:19038233 hydrogen peroxide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein affects the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA] CTD PMID:26514923 hydroquinone multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [hydroquinone results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:23288922 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of MAP2K1 mRNA CTD PMID:18299717 ionomycin multiple interactions EXP 6480464 Ionomycin inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 isoprenaline multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 isoprenaline multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] more ... CTD PMID:21177286 ivermectin decreases expression ISO RGD:732023 6480464 Ivermectin results in decreased expression of MAP2K1 protein CTD PMID:32959892 ketamine multiple interactions ISO RGD:1550208 6480464 Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:19540866 lead diacetate multiple interactions ISO RGD:732023 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:11861786 lead(0) increases phosphorylation ISO RGD:732023 6480464 Lead results in increased phosphorylation of MAP2K1 protein CTD PMID:19133285 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of MAP2K1 mRNA, Lead results in decreased expression of MAP2K1 protein CTD PMID:24960059 lead(2+) increases phosphorylation ISO RGD:732023 6480464 Lead results in increased phosphorylation of MAP2K1 protein CTD PMID:19133285 lead(2+) decreases expression EXP 6480464 Lead results in decreased expression of MAP2K1 mRNA, Lead results in decreased expression of MAP2K1 protein CTD PMID:24960059 letrozole increases expression ISO RGD:1550208 6480464 letrozole results in increased expression of MAP2K1 protein CTD PMID:15967659 lipopolysaccharide increases phosphorylation ISO RGD:732023 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:19010997 lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:21247645 lipopolysaccharide multiple interactions EXP 6480464 MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] more ... CTD PMID:10469353 , PMID:21247645 lipopolysaccharide increases expression ISO RGD:1550208 6480464 Lipopolysaccharides results in increased expression of MAP2K1 mRNA CTD PMID:10975854 lipopolysaccharide multiple interactions ISO RGD:1550208 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein more ... CTD PMID:19540866 more ... lipopolysaccharide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:18209571 lipoteichoic acid increases phosphorylation ISO RGD:1550208 6480464 lipoteichoic acid results in increased phosphorylation of MAP2K1 protein CTD PMID:19573522 lipoteichoic acid multiple interactions ISO RGD:1550208 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 lithium atom multiple interactions ISO RGD:1550208 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithium hydride multiple interactions ISO RGD:1550208 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithocholic acid multiple interactions ISO RGD:732023 6480464 MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 LY294002 multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein] CTD PMID:15850772 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 lycopene increases expression ISO RGD:732023 6480464 lycopene results in increased expression of MAP2K1 mRNA CTD PMID:16886892 Maduramicin multiple interactions EXP 6480464 MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein], MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein] CTD PMID:29241734 Maduramicin decreases response to substance EXP 6480464 MAP2K1 protein results in decreased susceptibility to maduramicin CTD PMID:29241734 maneb multiple interactions ISO RGD:1550208 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 melatonin multiple interactions ISO RGD:1550208 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 mercaptopurine decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of MAP2K1 protein CTD PMID:19826936 methamphetamine decreases expression ISO RGD:1550208 6480464 Methamphetamine results in decreased expression of MAP2K1 protein CTD PMID:16192988 methylmercury chloride affects expression ISO RGD:1550208 6480464 methylmercuric chloride affects the expression of MAP2K1 mRNA CTD PMID:21613230 methylseleninic acid decreases expression ISO RGD:732023 6480464 methylselenic acid results in decreased expression of MAP2K1 mRNA CTD PMID:11830524 methylseleninic acid increases expression ISO RGD:732023 6480464 methylselenic acid results in increased expression of MAP2K1 mRNA CTD PMID:12517777 mifepristone multiple interactions ISO RGD:732023 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 mitomycin C multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of MAP2K1 mRNA CTD PMID:28954212 myricetin multiple interactions ISO RGD:1550208 6480464 myricetin binds to and results in decreased activity of MAP2K1 protein, myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:17693661 N-acetyl-L-cysteine multiple interactions ISO RGD:732023 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-methyl-4-phenylpyridinium increases expression ISO RGD:1550208 6480464 1-Methyl-4-phenylpyridinium results in increased expression of MAP2K1 protein CTD PMID:26558463 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-Nitroso-N-methylurethane multiple interactions EXP 6480464 Nitrosomethylurethane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-nitrosodiethylamine affects phosphorylation ISO RGD:1550208 6480464 Diethylnitrosamine affects the phosphorylation of MAP2K1 protein CTD PMID:24535843 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MAP2K1 protein CTD PMID:21411721 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MAP2K1 mRNA CTD PMID:24136188 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MAP2K1 mRNA CTD PMID:22110744 ochratoxin A increases phosphorylation ISO RGD:732023 6480464 ochratoxin A results in increased phosphorylation of MAP2K1 protein CTD PMID:25002221 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 ozone multiple interactions ISO RGD:732023 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MAP2K1 mRNA more ... CTD PMID:32699268 , PMID:32992648 p-menthan-3-ol decreases expression ISO RGD:732023 6480464 Menthol results in decreased expression of MAP2K1 mRNA CTD PMID:26760959 paclitaxel multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel] more ... CTD PMID:18098270 , PMID:18594523 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of MAP2K1 mRNA CTD PMID:33387578 paraquat multiple interactions ISO RGD:1550208 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 pentachlorophenol increases expression ISO RGD:1550208 6480464 Pentachlorophenol results in increased expression of MAP2K1 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of MAP2K1 mRNA CTD PMID:20136073 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MAP2K1 mRNA CTD PMID:19162173 perifosine multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates] more ... CTD PMID:15781658 phenylephrine multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 PhIP increases phosphorylation ISO RGD:732023 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of MAP2K1 protein CTD PMID:22307971 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:11861786 more ... phorbol 13-acetate 12-myristate increases activity ISO RGD:1550208 6480464 Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1550208 6480464 3 more ... CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate increases phosphorylation ISO RGD:732023 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein CTD PMID:20479004 propiconazole increases expression ISO RGD:1550208 6480464 propiconazole results in increased expression of MAP2K1 mRNA CTD PMID:21278054 propofol multiple interactions ISO RGD:1550208 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 prostaglandin F2alpha increases phosphorylation ISO RGD:1550208 6480464 Dinoprost results in increased phosphorylation of MAP2K1 protein CTD PMID:24333336 prostaglandin F2alpha multiple interactions ISO RGD:1550208 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein], SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 purine-6-thiol decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 pyocyanine increases phosphorylation ISO RGD:732023 6480464 Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 quercetin multiple interactions ISO RGD:732023 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA CTD PMID:27514524 quercetin multiple interactions ISO RGD:1550208 6480464 Quercetin binds to and results in decreased activity of MAP2K1 protein CTD PMID:18245498 quinoline decreases activity ISO RGD:732023 6480464 quinoline results in decreased activity of MAP2K1 protein CTD PMID:18393446 quinomethionate affects expression ISO RGD:732023 6480464 quinomethionate affects the expression of MAP2K1 mRNA CTD PMID:15387888 reactive oxygen species multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] CTD PMID:16945329 resveratrol decreases phosphorylation ISO RGD:732023 6480464 resveratrol results in decreased phosphorylation of MAP2K1 protein CTD PMID:16761963 resveratrol multiple interactions ISO RGD:1550208 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 resveratrol multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [resveratrol results in decreased expression of XRCC1 protein] CTD PMID:26046675 resveratrol increases expression ISO RGD:732023 6480464 resveratrol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 resveratrol increases activity ISO RGD:732023 6480464 resveratrol results in increased activity of MAP2K1 protein CTD PMID:15615701 resveratrol decreases activity ISO RGD:732023 6480464 resveratrol results in decreased activity of MAP2K1 protein CTD PMID:15698585 rottlerin decreases phosphorylation ISO RGD:732023 6480464 rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 SCH772984 increases phosphorylation EXP 6480464 SCH772984 results in increased phosphorylation of MAP2K1 protein CTD PMID:28087833 serpentine asbestos affects expression ISO RGD:732023 6480464 Asbestos, Serpentine affects the expression of MAP2K1 mRNA CTD PMID:24160326 sirolimus multiple interactions ISO RGD:732023 6480464 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MAP2K1 protein, [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K1 protein CTD PMID:15767555 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein], Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 sodium arsenite multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 more ... sodium arsenite decreases expression ISO RGD:1550208 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:31233874 sodium arsenite increases phosphorylation ISO RGD:732023 6480464 sodium arsenite results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 sodium arsenite increases expression ISO RGD:732023 6480464 sodium arsenite results in increased expression of MAP2K1 mRNA CTD PMID:24431212 sodium arsenite decreases expression ISO RGD:732023 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:12016162 sodium arsenite affects expression ISO RGD:732023 6480464 sodium arsenite affects the expression of MAP2K1 mRNA, sodium arsenite affects the expression of MAP2K1 protein modified form CTD PMID:17384772 more ... sodium fluoride increases phosphorylation EXP 6480464 Sodium Fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:19900517 sodium fluoride multiple interactions ISO RGD:1550208 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 sodium fluoride decreases expression ISO RGD:1550208 6480464 Sodium Fluoride results in decreased expression of MAP2K1 mRNA CTD PMID:27664006 sorafenib multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein results in increased phosphorylation of MAPK1 protein] which results in decreased susceptibility to sorafenib more ... CTD PMID:20117835 , PMID:21187475 sorafenib decreases phosphorylation EXP 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 sorafenib decreases phosphorylation ISO RGD:732023 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 more ... sulfates multiple interactions ISO RGD:732023 6480464 [Soot co-treated with Sulfates] affects the methylation of MAP2K1 promoter CTD PMID:25395096 sulindac sulfide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 , PMID:16079301 sulindac sulfone multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 sumatriptan multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 sunitinib increases expression ISO RGD:732023 6480464 Sunitinib results in increased expression of MAP2K1 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:732023 6480464 Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein] CTD PMID:20479004 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of MAP2K1 protein modified form CTD PMID:17901229 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of MAP2K1 protein modified form CTD PMID:17901229 teriflunomide multiple interactions ISO RGD:732023 6480464 teriflunomide inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:9973483 testosterone increases activity ISO RGD:732023 6480464 [Testosterone results in increased activity of RAF1 protein] which results in increased activity of MAP2K1 protein CTD PMID:20372086 testosterone multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] more ... CTD PMID:21177760 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of MAP2K1 mRNA CTD PMID:17805973 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MAP2K1 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1550208 6480464 Silymarin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:32956689 tetrachloromethane increases phosphorylation ISO RGD:1550208 6480464 Carbon Tetrachloride results in increased phosphorylation of MAP2K1 protein CTD PMID:32956689 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MAP2K1 mRNA CTD PMID:34492290 titanium dioxide increases phosphorylation ISO RGD:1550208 6480464 titanium dioxide analog results in increased phosphorylation of MAP2K1 protein CTD PMID:25111187 toluene affects expression EXP 6480464 Toluene affects the expression of MAP2K1 mRNA CTD PMID:21827849 toosendanin decreases expression ISO RGD:732023 6480464 toosendanin results in decreased expression of MAP2K1 protein modified form CTD PMID:23111283 trametinib decreases response to substance ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased susceptibility to trametinib CTD PMID:29768711 trametinib multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein], [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:29768711 trans-anethole multiple interactions ISO RGD:732023 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 trichostatin A multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A] CTD PMID:15781658 trichostatin A affects expression ISO RGD:732023 6480464 trichostatin A affects the expression of MAP2K1 mRNA CTD PMID:28542535 trimethyltin increases expression ISO RGD:1550208 6480464 trimethyltin results in increased expression of MAP2K1 mRNA CTD PMID:20833246 troglitazone multiple interactions ISO RGD:732023 6480464 MAP2K1 protein promotes the reaction [troglitazone results in increased expression of ATF3 mRNA] CTD PMID:16079301 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein] CTD PMID:16269455 urethane increases expression ISO RGD:732023 6480464 Urethane results in increased expression of MAP2K1 mRNA CTD PMID:28818685 vanadyl sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 , PMID:11943669 vanadyl sulfate increases phosphorylation ISO RGD:732023 6480464 vanadyl sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 vorinostat multiple interactions ISO RGD:732023 6480464 [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein, MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:12893773 , PMID:15781658 vorinostat decreases expression ISO RGD:732023 6480464 vorinostat results in decreased expression of MAP2K1 protein CTD PMID:12893773 wogonin multiple interactions ISO RGD:1550208 6480464 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 zinc sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 , PMID:11943669 zinc sulfate increases phosphorylation ISO RGD:732023 6480464 Zinc Sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669
