(+)-catechin decreases expression ISO RGD:732023 6480464 Catechin results in decreased expression of MAP2K1 mRNA, Catechin results in decreased expression of MAP2K1 protein CTD PMID:15465739 (+)-catechin multiple interactions ISO RGD:732023 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 (+)-catechin increases expression ISO RGD:732023 6480464 Catechin results in increased expression of MAP2K1 mRNA CTD PMID:15465739 (+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expression ISO RGD:1550208 6480464 2 more ... CTD PMID:25575267 1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions ISO RGD:1550208 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 1-(5-isoquinolinesulfonyl)-2-methylpiperazine decreases phosphorylation ISO RGD:1550208 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 17alpha-ethynylestradiol affects expression ISO RGD:1550208 6480464 Ethinyl Estradiol affects the expression of MAP2K1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:17108234 17beta-estradiol multiple interactions ISO RGD:1550208 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:25210133 17beta-estradiol multiple interactions ISO RGD:732023 6480464 IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K1 mRNA] CTD PMID:23094148 17beta-estradiol increases expression ISO RGD:732023 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 , PMID:23094148 17beta-estradiol affects expression ISO RGD:732023 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:22574217 17beta-estradiol affects expression ISO RGD:1550208 6480464 Estradiol affects the expression of MAP2K1 mRNA CTD PMID:15598610 17beta-estradiol increases activity ISO RGD:732023 6480464 Estradiol results in increased activity of MAP2K1 protein CTD PMID:15615701 17beta-estradiol increases expression ISO RGD:1550208 6480464 Estradiol results in increased expression of MAP2K1 mRNA CTD PMID:14664709 more ... 17beta-estradiol 3-benzoate decreases phosphorylation EXP 6480464 estradiol 3-benzoate results in decreased phosphorylation of MAP2K1 protein CTD PMID:15778002 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:732023 6480464 Tetrachlorodibenzodioxin results in increased activity of MAP2K1 protein CTD PMID:15313166 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550208 6480464 Tetrachlorodibenzodioxin affects the expression of MAP2K1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein modified form binds to ARNT protein modified form]] more ... CTD PMID:12213569 more ... 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of MAP2K1 mRNA CTD PMID:21346803 2-arachidonoylglycerol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 2-methylcholine affects expression ISO RGD:732023 6480464 beta-methylcholine affects the expression of MAP2K1 mRNA CTD PMID:21179406 3',5'-cyclic GMP multiple interactions ISO RGD:732023 6480464 Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K1 protein] CTD PMID:18225537 3',5'-cyclic GMP decreases phosphorylation ISO RGD:732023 6480464 Cyclic GMP results in decreased phosphorylation of MAP2K1 protein CTD PMID:18225537 3,7-dihydropurine-6-thione decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:732023 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:11861786 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] CTD PMID:21177760 3-methylcholanthrene increases expression ISO RGD:1550208 6480464 Methylcholanthrene results in increased expression of MAP2K1 mRNA CTD PMID:25926378 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of MAP2K1 mRNA CTD PMID:19162173 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:732023 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein, Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 5-(2-methylpiperazine-1-sulfonyl)isoquinoline decreases phosphorylation ISO RGD:1550208 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions ISO RGD:1550208 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with TNF protein] results in decreased phosphorylation of MAP2K1 protein CTD PMID:14654170 5-aza-2'-deoxycytidine increases expression ISO RGD:732023 6480464 Decitabine results in increased expression of MAP2K1 mRNA CTD PMID:17785578 5-fluorouracil multiple interactions ISO RGD:732023 6480464 [U 0126 results in decreased activity of MAP2K1 protein] results in increased susceptibility to [Fluorouracil co-treated with Cisplatin], MAP2K1 protein results in decreased susceptibility to [Cisplatin co-treated with Fluorouracil] CTD PMID:21444628 9-cis,11-trans-octadecadienoic acid multiple interactions EXP 6480464 [cis-9, trans-11-conjugated linoleic acid co-treated with trans-10 more ... CTD PMID:17869086 acetylsalicylic acid increases expression ISO RGD:732023 6480464 Aspirin results in increased expression of MAP2K1 mRNA CTD PMID:20457246 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of MAP2K1 mRNA CTD PMID:28959563 afimoxifene increases expression ISO RGD:732023 6480464 afimoxifene results in increased expression of MAP2K1 mRNA CTD PMID:12154049 aflatoxin B1 increases expression ISO RGD:732023 6480464 Aflatoxin B1 results in increased expression of MAP2K1 mRNA CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:732023 6480464 Aflatoxin B1 results in increased methylation of MAP2K1 intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:18098270 , PMID:20615082 all-trans-retinoic acid increases phosphorylation ISO RGD:732023 6480464 Tretinoin results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 all-trans-retinoic acid decreases expression ISO RGD:732023 6480464 Tretinoin results in decreased expression of MAP2K1 protein CTD PMID:18098270 all-trans-retinol multiple interactions EXP 6480464 6-hydroxy-2 more ... CTD PMID:16510265 all-trans-retinol increases phosphorylation EXP 6480464 Vitamin A results in increased phosphorylation of MAP2K1 protein CTD PMID:16510265 alpha-mangostin increases phosphorylation ISO RGD:732023 6480464 mangostin analog results in increased phosphorylation of MAP2K1 protein CTD PMID:28722351 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MAP2K1 mRNA CTD PMID:16483693 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of MAP2K1 mRNA CTD PMID:12420312 anandamide multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:12657697 anethole multiple interactions ISO RGD:732023 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 anthranilic acid decreases activity ISO RGD:732023 6480464 anthranilic acid results in decreased activity of MAP2K1 protein CTD PMID:18393446 arachidonic acid multiple interactions ISO RGD:732023 6480464 FOS protein affects the reaction [MAP2K1 protein inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]] more ... CTD PMID:19720122 Aroclor 1254 decreases expression ISO RGD:1550208 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of MAP2K1 mRNA CTD PMID:23650126 arsenic acid increases activity ISO RGD:732023 6480464 arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenite(3-) increases activity ISO RGD:732023 6480464 arsenite results in increased activity of MAP2K1 protein CTD PMID:14674888 arsenous acid increases expression ISO RGD:732023 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 arsenous acid decreases phosphorylation ISO RGD:732023 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 arsenous acid decreases phosphorylation ISO RGD:1550208 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 arsenous acid decreases activity ISO RGD:732023 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 ATP affects binding ISO RGD:1550208 6480464 Adenosine Triphosphate binds to MAP2K1 protein CTD PMID:17693661 azathioprine decreases phosphorylation ISO RGD:732023 6480464 Azathioprine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 benzo[a]pyrene multiple interactions ISO RGD:1550208 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAP2K1 mRNA] CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:732023 6480464 Benzo(a)pyrene affects the methylation of MAP2K1 intron CTD PMID:30157460 benzo[a]pyrene multiple interactions ISO RGD:732023 6480464 [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein, Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein] CTD PMID:21882252 benzo[a]pyrene increases expression ISO RGD:1550208 6480464 Benzo(a)pyrene results in increased expression of MAP2K1 mRNA CTD PMID:22228805 beryllium difluoride increases phosphorylation ISO RGD:1550208 6480464 beryllium fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:11867686 bicalutamide multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bicalutamide results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:15466214 bis(2-chloroethyl) sulfide increases expression ISO RGD:1550208 6480464 Mustard Gas results in increased expression of MAP2K1 mRNA CTD PMID:18955075 bisphenol A increases expression ISO RGD:1550208 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25575267 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA CTD PMID:30816183 bisphenol A decreases expression ISO RGD:732023 6480464 bisphenol A results in decreased expression of MAP2K1 mRNA CTD PMID:29275510 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MAP2K1 mRNA CTD PMID:25181051 bortezomib multiple interactions ISO RGD:732023 6480464 [Bortezomib co-treated with Butyrates] results in decreased expression of MAP2K1 protein, [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein CTD PMID:12893773 cadmium atom increases phosphorylation ISO RGD:732023 6480464 Cadmium results in increased phosphorylation of MAP2K1 protein CTD PMID:14499349 cadmium atom multiple interactions ISO RGD:732023 6480464 GPER1 mutant form inhibits the reaction [Cadmium results in increased activity of MAP2K1 protein], MAP2K1 protein affects the reaction [Cadmium results in increased expression of PLAUR mRNA] CTD PMID:20153348 , PMID:25069788 cadmium atom increases activity ISO RGD:732023 6480464 Cadmium results in increased activity of MAP2K1 protein CTD PMID:20153348 cadmium dichloride multiple interactions ISO RGD:1550208 6480464 1 more ... CTD PMID:11858940 cadmium dichloride increases phosphorylation ISO RGD:732023 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:18703135 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride multiple interactions ISO RGD:732023 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 cadmium dichloride increases phosphorylation ISO RGD:1550208 6480464 Cadmium Chloride results in increased phosphorylation of MAP2K1 protein CTD PMID:11858940 calcium atom multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 calcium(0) multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Calcium inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 cannabidiol affects methylation EXP 6480464 Cannabidiol affects the methylation of MAP2K1 gene CTD PMID:30521419 capsaicin increases expression ISO RGD:732023 6480464 Capsaicin results in increased expression of MAP2K1 mRNA CTD PMID:19502594 carbon nanotube increases expression ISO RGD:1550208 6480464 Nanotubes, Carbon analog results in increased expression of MAP2K1 mRNA, Nanotubes, Carbon results in increased expression of MAP2K1 mRNA CTD PMID:25554681 celecoxib decreases phosphorylation ISO RGD:732023 6480464 Celecoxib results in decreased phosphorylation of MAP2K1 protein CTD PMID:16123214 chloropicrin decreases expression ISO RGD:732023 6480464 chloropicrin results in decreased expression of MAP2K1 mRNA CTD PMID:28476498 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of MAP2K1 mRNA CTD PMID:18668222 choline multiple interactions ISO RGD:1550208 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 choline increases expression ISO RGD:1550208 6480464 Choline results in increased expression of MAP2K1 mRNA CTD PMID:27664006 cisplatin multiple interactions ISO RGD:732023 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA more ... CTD PMID:21444628 , PMID:27514524 cisplatin multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Cisplatin results in increased activity of CASP3 protein], MAP2K1 protein promotes the reaction [Cisplatin results in increased phosphorylation of SHC1 protein] CTD PMID:20547441 cisplatin increases phosphorylation ISO RGD:732023 6480464 Cisplatin results in increased phosphorylation of MAP2K1 protein CTD PMID:21444628 clobetasol increases expression ISO RGD:1550208 6480464 Clobetasol results in increased expression of MAP2K1 mRNA CTD PMID:27462272 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 cobalt dichloride multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [cobaltous chloride results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]], [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] which results in decreased susceptibility to cobaltous chloride CTD PMID:14536030 cobalt dichloride increases expression ISO RGD:732023 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:19376846 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of MAP2K1 mRNA CTD PMID:24386269 cocaine decreases expression ISO RGD:732023 6480464 Cocaine results in decreased expression of MAP2K1 mRNA CTD PMID:12629581 cocaine multiple interactions ISO RGD:1550208 6480464 CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein] CTD PMID:15665076 cocaine increases phosphorylation ISO RGD:1550208 6480464 Cocaine results in increased phosphorylation of MAP2K1 protein CTD PMID:15665076 copper(II) sulfate increases expression ISO RGD:732023 6480464 Copper Sulfate results in increased expression of MAP2K1 mRNA CTD PMID:19549813 copper(II) sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 crocidolite asbestos multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein affects the reaction [Asbestos, Crocidolite results in increased expression of SCGB1A1 mRNA] more ... CTD PMID:18192500 crocidolite asbestos affects expression ISO RGD:732023 6480464 Asbestos, Crocidolite affects the expression of MAP2K1 mRNA CTD PMID:24160326 crocidolite asbestos increases phosphorylation ISO RGD:732023 6480464 Asbestos, Crocidolite results in increased phosphorylation of MAP2K1 protein CTD PMID:18314537 cumene multiple interactions ISO RGD:1550208 6480464 [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA, [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein CTD PMID:18648096 curcumin multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 cycloheximide multiple interactions ISO RGD:1550208 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cycloheximide results in increased expression of MAP2K1 mRNA] CTD PMID:23237828 cycloheximide increases activity ISO RGD:1550208 6480464 Cycloheximide results in increased activity of MAP2K1 protein CTD PMID:23237828 cyclosporin A increases expression ISO RGD:732023 6480464 Cyclosporine results in increased expression of MAP2K1 mRNA CTD PMID:25562108 D-mannitol multiple interactions EXP 6480464 Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 Deguelin decreases expression ISO RGD:732023 6480464 deguelin metabolite results in decreased expression of MAP2K1 protein, deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008 , PMID:19336726 dexamethasone multiple interactions ISO RGD:732023 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 dexamethasone increases expression ISO RGD:1550208 6480464 Dexamethasone results in increased expression of MAP2K1 mRNA CTD PMID:21041162 diarsenic trioxide decreases activity ISO RGD:732023 6480464 Arsenic Trioxide results in decreased activity of MAP2K1 protein CTD PMID:11304686 diarsenic trioxide increases expression ISO RGD:732023 6480464 Arsenic Trioxide results in increased expression of MAP2K1 mRNA CTD PMID:22521957 diarsenic trioxide decreases phosphorylation ISO RGD:732023 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:20592496 diarsenic trioxide multiple interactions ISO RGD:732023 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAP2K1 protein]] more ... CTD PMID:20615082 diarsenic trioxide decreases phosphorylation ISO RGD:1550208 6480464 Arsenic Trioxide results in decreased phosphorylation of MAP2K1 protein CTD PMID:28454374 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of MAP2K1 mRNA CTD PMID:21266533 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 dichlorine increases expression EXP 6480464 Chlorine results in increased expression of MAP2K1 mRNA CTD PMID:18636392 dieldrin multiple interactions ISO RGD:732023 6480464 Dieldrin results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 diethylstilbestrol increases expression ISO RGD:732023 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:15766595 diethylstilbestrol increases expression ISO RGD:1550208 6480464 Diethylstilbestrol results in increased expression of MAP2K1 mRNA CTD PMID:16636312 , PMID:25575267 dimethyl sulfoxide increases expression ISO RGD:732023 6480464 Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA CTD PMID:31265865 dimethyl sulfoxide multiple interactions ISO RGD:732023 6480464 cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA] CTD PMID:31265865 dioxygen increases response to substance EXP 6480464 MAP2K1 protein results in increased susceptibility to Oxygen CTD PMID:10780954 disodium selenite decreases expression ISO RGD:732023 6480464 Sodium Selenite results in decreased expression of MAP2K1 mRNA CTD PMID:16705456 doxorubicin increases phosphorylation ISO RGD:732023 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 doxorubicin decreases expression ISO RGD:732023 6480464 Doxorubicin results in decreased expression of MAP2K1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin] more ... CTD PMID:18594523 doxorubicin increases phosphorylation ISO RGD:1550208 6480464 Doxorubicin results in increased phosphorylation of MAP2K1 protein CTD PMID:17974986 emodin multiple interactions EXP 6480464 Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 endosulfan multiple interactions ISO RGD:732023 6480464 Endosulfan results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of MAP2K1 mRNA CTD PMID:29391264 estriol increases expression ISO RGD:1550208 6480464 Estriol results in increased expression of MAP2K1 mRNA CTD PMID:25575267 etacrynic acid increases expression ISO RGD:732023 6480464 Ethacrynic Acid results in increased expression of MAP2K1 protein CTD PMID:14556662 ethanol affects expression EXP 6480464 Ethanol affects the expression of MAP2K1 mRNA CTD PMID:11772933 ethanol affects splicing ISO RGD:1550208 6480464 Ethanol affects the splicing of MAP2K1 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MAP2K1 protein CTD PMID:23702218 ethanol multiple interactions EXP 6480464 N-methyl-N-(6-methoxy-1-phenyl-1 more ... CTD PMID:20655511 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of MAP2K1 mRNA CTD PMID:20655511 ethyl methanesulfonate decreases expression ISO RGD:732023 6480464 Ethyl Methanesulfonate results in decreased expression of MAP2K1 mRNA CTD PMID:23649840 fipronil decreases activity ISO RGD:1550208 6480464 fipronil results in decreased activity of MAP2K1 protein CTD PMID:21167920 flavonoids decreases expression ISO RGD:732023 6480464 Flavonoids results in decreased expression of MAP2K1 mRNA CTD PMID:15465739 flutamide increases expression EXP 6480464 Flutamide results in increased expression of MAP2K1 mRNA CTD PMID:24136188 gallic acid multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]] more ... CTD PMID:21420233 more ... gamma-hexachlorocyclohexane multiple interactions ISO RGD:732023 6480464 Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 geldanamycin multiple interactions ISO RGD:1550208 6480464 geldanamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:8816498 geldanamycin decreases phosphorylation ISO RGD:732023 6480464 geldanamycin results in decreased phosphorylation of MAP2K1 protein CTD PMID:19167484 genistein decreases phosphorylation EXP 6480464 Genistein results in decreased phosphorylation of MAP2K1 protein CTD PMID:15781664 genistein increases phosphorylation ISO RGD:732023 6480464 Genistein results in increased phosphorylation of MAP2K1 protein CTD PMID:19038232 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 gold atom multiple interactions ISO RGD:732023 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]], MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 gold(0) multiple interactions ISO RGD:732023 6480464 MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]], MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]] CTD PMID:27634460 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of MAP2K1 mRNA CTD PMID:15860345 heparin multiple interactions EXP 6480464 Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein], Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:14966081 heptachlor multiple interactions ISO RGD:732023 6480464 Heptachlor results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:15888667 heptachlor decreases expression ISO RGD:732023 6480464 Heptachlor results in decreased expression of MAP2K1 protein CTD PMID:9704902 hyaluronic acid increases phosphorylation ISO RGD:732023 6480464 Hyaluronic Acid analog results in increased phosphorylation of MAP2K1 protein CTD PMID:12402308 hydrogen peroxide increases activity ISO RGD:732023 6480464 Hydrogen Peroxide results in increased activity of MAP2K1 protein CTD PMID:15242773 , PMID:19038233 hydrogen peroxide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein affects the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA] CTD PMID:26514923 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of MAP2K1 mRNA CTD PMID:18299717 ionomycin multiple interactions EXP 6480464 Ionomycin inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 isoprenaline multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Isoproterenol results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 isoprenaline multiple interactions ISO RGD:1550208 6480464 MAP2K1 protein promotes the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA] more ... CTD PMID:21177286 ketamine multiple interactions ISO RGD:1550208 6480464 Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein] CTD PMID:19540866 lead diacetate multiple interactions ISO RGD:732023 6480464 bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein] more ... CTD PMID:11861786 lead(0) increases phosphorylation ISO RGD:732023 6480464 Lead results in increased phosphorylation of MAP2K1 protein CTD PMID:19133285 lead(0) decreases expression EXP 6480464 Lead results in decreased expression of MAP2K1 mRNA, Lead results in decreased expression of MAP2K1 protein CTD PMID:24960059 lead(2+) increases phosphorylation ISO RGD:732023 6480464 Lead results in increased phosphorylation of MAP2K1 protein CTD PMID:19133285 lead(2+) decreases expression EXP 6480464 Lead results in decreased expression of MAP2K1 mRNA, Lead results in decreased expression of MAP2K1 protein CTD PMID:24960059 letrozole increases expression ISO RGD:1550208 6480464 letrozole results in increased expression of MAP2K1 protein CTD PMID:15967659 lipopolysaccharide increases phosphorylation ISO RGD:732023 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:19010997 lipopolysaccharide increases phosphorylation EXP 6480464 Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein CTD PMID:21247645 lipopolysaccharide multiple interactions EXP 6480464 MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] more ... CTD PMID:10469353 , PMID:21247645 lipopolysaccharide increases expression ISO RGD:1550208 6480464 Lipopolysaccharides results in increased expression of MAP2K1 mRNA CTD PMID:10975854 lipopolysaccharide multiple interactions ISO RGD:1550208 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein more ... CTD PMID:19540866 more ... lipopolysaccharide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:18209571 lipoteichoic acid increases phosphorylation ISO RGD:1550208 6480464 lipoteichoic acid results in increased phosphorylation of MAP2K1 protein CTD PMID:19573522 lipoteichoic acid multiple interactions ISO RGD:1550208 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 lithium atom multiple interactions ISO RGD:1550208 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithium hydride multiple interactions ISO RGD:1550208 6480464 [Lithium results in increased phosphorylation of and results in increased activity of MAP3K8 protein] which results in increased phosphorylation of MAP2K1 protein CTD PMID:19159680 lithocholic acid multiple interactions ISO RGD:732023 6480464 MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 LY294002 multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein] CTD PMID:15850772 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 lycopene increases expression ISO RGD:732023 6480464 lycopene results in increased expression of MAP2K1 mRNA CTD PMID:16886892 maneb multiple interactions ISO RGD:1550208 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 melatonin multiple interactions ISO RGD:1550208 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 mercaptopurine decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of MAP2K1 protein CTD PMID:19826936 methamphetamine decreases expression ISO RGD:1550208 6480464 Methamphetamine results in decreased expression of MAP2K1 protein CTD PMID:16192988 methylmercury chloride affects expression ISO RGD:1550208 6480464 methylmercuric chloride affects the expression of MAP2K1 mRNA CTD PMID:21613230 methylseleninic acid decreases expression ISO RGD:732023 6480464 methylselenic acid results in decreased expression of MAP2K1 mRNA CTD PMID:11830524 methylseleninic acid increases expression ISO RGD:732023 6480464 methylselenic acid results in increased expression of MAP2K1 mRNA CTD PMID:12517777 mifepristone multiple interactions ISO RGD:732023 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]] CTD PMID:10807665 mitomycin C multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] more ... CTD PMID:21810436 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of MAP2K1 mRNA CTD PMID:28954212 myricetin multiple interactions ISO RGD:1550208 6480464 myricetin binds to and results in decreased activity of MAP2K1 protein, myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein] CTD PMID:17693661 N-acetyl-L-cysteine multiple interactions ISO RGD:732023 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein] CTD PMID:18703135 N-methyl-4-phenylpyridinium increases expression ISO RGD:1550208 6480464 1-Methyl-4-phenylpyridinium results in increased expression of MAP2K1 protein CTD PMID:26558463 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA] CTD PMID:28428697 N-methyl-N-nitrosourea multiple interactions EXP 6480464 Methylnitrosourea results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-Nitroso-N-methylurethane multiple interactions EXP 6480464 Nitrosomethylurethane results in increased phosphorylation of and results in increased activity of MAP2K1 protein CTD PMID:12693035 N-nitrosodiethylamine affects phosphorylation ISO RGD:1550208 6480464 Diethylnitrosamine affects the phosphorylation of MAP2K1 protein CTD PMID:24535843 N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of MAP2K1 protein CTD PMID:21411721 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of MAP2K1 mRNA CTD PMID:24136188 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of MAP2K1 mRNA CTD PMID:22110744 ochratoxin A increases phosphorylation ISO RGD:732023 6480464 ochratoxin A results in increased phosphorylation of MAP2K1 protein CTD PMID:25002221 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA CTD PMID:18636392 p-menthan-3-ol decreases expression ISO RGD:732023 6480464 Menthol results in decreased expression of MAP2K1 mRNA CTD PMID:26760959 paclitaxel multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel] more ... CTD PMID:18098270 , PMID:18594523 paraquat multiple interactions ISO RGD:1550208 6480464 [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA more ... CTD PMID:23963992 pentachlorophenol increases expression ISO RGD:1550208 6480464 Pentachlorophenol results in increased expression of MAP2K1 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of MAP2K1 mRNA CTD PMID:20136073 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of MAP2K1 mRNA CTD PMID:19162173 perifosine multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates] more ... CTD PMID:15781658 phenylephrine multiple interactions EXP 6480464 MAP2K1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA] more ... CTD PMID:10888249 PhIP increases phosphorylation ISO RGD:732023 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased phosphorylation of MAP2K1 protein CTD PMID:22307971 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:11861786 more ... phorbol 13-acetate 12-myristate increases activity ISO RGD:1550208 6480464 Tetradecanoylphorbol Acetate results in increased activity of MAP2K1 protein CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1550208 6480464 3 more ... CTD PMID:17693661 more ... phorbol 13-acetate 12-myristate increases phosphorylation ISO RGD:732023 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein CTD PMID:20479004 propiconazole increases expression ISO RGD:1550208 6480464 propiconazole results in increased expression of MAP2K1 mRNA CTD PMID:21278054 propofol multiple interactions ISO RGD:1550208 6480464 Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] CTD PMID:19573522 prostaglandin F2alpha increases phosphorylation ISO RGD:1550208 6480464 Dinoprost results in increased phosphorylation of MAP2K1 protein CTD PMID:24333336 prostaglandin F2alpha multiple interactions ISO RGD:1550208 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein], SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 purine-6-thiol decreases phosphorylation ISO RGD:732023 6480464 Mercaptopurine results in decreased phosphorylation of MAP2K1 protein CTD PMID:12697733 pyocyanine increases phosphorylation ISO RGD:732023 6480464 Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 quercetin multiple interactions ISO RGD:732023 6480464 [Cisplatin co-treated with Quercetin] results in increased expression of MAP2K1 mRNA CTD PMID:27514524 quercetin multiple interactions ISO RGD:1550208 6480464 Quercetin binds to and results in decreased activity of MAP2K1 protein CTD PMID:18245498 quinoline decreases activity ISO RGD:732023 6480464 quinoline results in decreased activity of MAP2K1 protein CTD PMID:18393446 quinomethionate affects expression ISO RGD:732023 6480464 quinomethionate affects the expression of MAP2K1 mRNA CTD PMID:15387888 reactive oxygen species multiple interactions ISO RGD:732023 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Reactive Oxygen Species] CTD PMID:16945329 resveratrol decreases phosphorylation ISO RGD:732023 6480464 resveratrol results in decreased phosphorylation of MAP2K1 protein CTD PMID:16761963 resveratrol multiple interactions ISO RGD:1550208 6480464 resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein] CTD PMID:24333336 resveratrol multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [resveratrol results in decreased expression of XRCC1 protein] CTD PMID:26046675 resveratrol increases expression ISO RGD:732023 6480464 resveratrol results in increased expression of MAP2K1 mRNA CTD PMID:12154049 resveratrol increases activity ISO RGD:732023 6480464 resveratrol results in increased activity of MAP2K1 protein CTD PMID:15615701 resveratrol decreases activity ISO RGD:732023 6480464 resveratrol results in decreased activity of MAP2K1 protein CTD PMID:15698585 rottlerin decreases phosphorylation ISO RGD:732023 6480464 rottlerin results in decreased phosphorylation of MAP2K1 protein CTD PMID:15949478 serpentine asbestos affects expression ISO RGD:732023 6480464 Asbestos, Serpentine affects the expression of MAP2K1 mRNA CTD PMID:24160326 sirolimus multiple interactions ISO RGD:732023 6480464 [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of MAP2K1 protein, [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of MAP2K1 protein CTD PMID:15767555 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein], Sirolimus inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:12411397 sodium arsenite multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 more ... sodium arsenite decreases expression ISO RGD:1550208 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:31233874 sodium arsenite increases phosphorylation ISO RGD:732023 6480464 sodium arsenite results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 sodium arsenite increases expression ISO RGD:732023 6480464 sodium arsenite results in increased expression of MAP2K1 mRNA CTD PMID:24431212 sodium arsenite decreases expression ISO RGD:732023 6480464 sodium arsenite results in decreased expression of MAP2K1 mRNA CTD PMID:12016162 sodium arsenite affects expression ISO RGD:732023 6480464 sodium arsenite affects the expression of MAP2K1 mRNA, sodium arsenite affects the expression of MAP2K1 protein modified form CTD PMID:17384772 , PMID:29319823 sodium fluoride increases phosphorylation EXP 6480464 Sodium Fluoride results in increased phosphorylation of MAP2K1 protein CTD PMID:19900517 sodium fluoride multiple interactions ISO RGD:1550208 6480464 Choline inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA] CTD PMID:27664006 sodium fluoride decreases expression ISO RGD:1550208 6480464 Sodium Fluoride results in decreased expression of MAP2K1 mRNA CTD PMID:27664006 sorafenib multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein results in increased phosphorylation of MAPK1 protein] which results in decreased susceptibility to sorafenib more ... CTD PMID:20117835 , PMID:21187475 sorafenib decreases phosphorylation EXP 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 sorafenib decreases phosphorylation ISO RGD:732023 6480464 sorafenib results in decreased phosphorylation of MAP2K1 protein CTD PMID:17341847 more ... sulfates multiple interactions ISO RGD:732023 6480464 [Soot co-treated with Sulfates] affects the methylation of MAP2K1 promoter CTD PMID:25395096 sulindac sulfide multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 , PMID:16079301 sulindac sulfone multiple interactions ISO RGD:732023 6480464 MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] more ... CTD PMID:15548677 sumatriptan multiple interactions EXP 6480464 [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA], Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] CTD PMID:12574409 sunitinib increases expression ISO RGD:732023 6480464 Sunitinib results in increased expression of MAP2K1 mRNA CTD PMID:31533062 tamoxifen multiple interactions ISO RGD:732023 6480464 Tamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein] CTD PMID:20479004 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of MAP2K1 protein modified form CTD PMID:17901229 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of MAP2K1 protein modified form CTD PMID:17901229 teriflunomide multiple interactions ISO RGD:732023 6480464 A 771726 inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:9973483 testosterone increases activity ISO RGD:732023 6480464 [Testosterone results in increased activity of RAF1 protein] which results in increased activity of MAP2K1 protein CTD PMID:20372086 testosterone multiple interactions EXP 6480464 [FSHB protein co-treated with 1-Methyl-3-isobutylxanthine] inhibits the reaction [Testosterone promotes the reaction [RAF1 results in increased phosphorylation of MAP2K1 protein]] more ... CTD PMID:21177760 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of MAP2K1 mRNA CTD PMID:17805973 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MAP2K1 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K1 mRNA] CTD PMID:31150632 titanium dioxide increases phosphorylation ISO RGD:1550208 6480464 titanium dioxide analog results in increased phosphorylation of MAP2K1 protein CTD PMID:25111187 toluene affects expression EXP 6480464 Toluene affects the expression of MAP2K1 mRNA CTD PMID:21827849 trametinib decreases response to substance ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased susceptibility to trametinib CTD PMID:29768711 trametinib multiple interactions ISO RGD:732023 6480464 [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK1 protein], [MAP2K1 protein mutant form results in decreased susceptibility to trametinib] inhibits the reaction [trametinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:29768711 trans-anethole multiple interactions ISO RGD:732023 6480464 anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 trichostatin A multiple interactions ISO RGD:732023 6480464 MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A] CTD PMID:15781658 trichostatin A affects expression ISO RGD:732023 6480464 trichostatin A affects the expression of MAP2K1 mRNA CTD PMID:28542535 trimethyltin increases expression ISO RGD:1550208 6480464 trimethyltin results in increased expression of MAP2K1 mRNA CTD PMID:20833246 troglitazone multiple interactions ISO RGD:732023 6480464 MAP2K1 protein promotes the reaction [troglitazone results in increased expression of ATF3 mRNA] CTD PMID:16079301 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [Oleylethanolamide results in increased phosphorylation of MAP2K1 protein] CTD PMID:16269455 urethane increases expression ISO RGD:732023 6480464 Urethane results in increased expression of MAP2K1 mRNA CTD PMID:28818685 vanadyl sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 , PMID:11943669 vanadyl sulfate increases phosphorylation ISO RGD:732023 6480464 vanadyl sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669 vorinostat multiple interactions ISO RGD:732023 6480464 [Bortezomib co-treated with vorinostat] results in decreased expression of MAP2K1 protein, MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:12893773 , PMID:15781658 vorinostat decreases expression ISO RGD:732023 6480464 vorinostat results in decreased expression of MAP2K1 protein CTD PMID:12893773 wogonin multiple interactions ISO RGD:1550208 6480464 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 zinc sulfate multiple interactions ISO RGD:732023 6480464 4-((3-bromophenyl)amino)-6 more ... CTD PMID:10564177 , PMID:11943669 zinc sulfate increases phosphorylation ISO RGD:732023 6480464 Zinc Sulfate results in increased phosphorylation of MAP2K1 protein CTD PMID:11943669
Biological Process activation of MAPK activity ISO RGD:732023 1624291 (PMID:10644344) RGD PMID:10644344 activation of MAPK activity IBA FB:FBgn0010269 more ... 13792537 PMID:21873635 GO_Central activation of MAPK activity IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 activation of MAPK activity IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 activation of MAPK activity TAS 8553538 PMID:19565474 UniProt activation of MAPK activity ISO RGD:1550208 1624291 (MGI:MGI:3579196, PMID:15896720) RGD MGI:MGI:3579196 , PMID:15896720 activation of MAPK activity IDA 2293305 RGD activation of protein kinase activity IBA FB:FBgn0261524 more ... 13792537 PMID:21873635 GO_Central Bergmann glial cell differentiation ISO RGD:1550208 1624291 MGI:MGI:99511 (MGI:MGI:5545830 , PMID:24431450) RGD MGI:MGI:5545830 , PMID:24431450 Bergmann glial cell differentiation IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell cycle arrest ISO RGD:732023 1624291 (PMID:9765203) RGD PMID:9765203 cell cycle arrest IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell motility ISO RGD:1550208 1624291 MGI:MGI:2178132 (MGI:MGI:1334781 , PMID:10209122) RGD MGI:MGI:1334781 , PMID:10209122 cell motility IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell population proliferation IDA 1582172 RGD cellular senescence ISO RGD:732023 1624291 (PMID:9765203) RGD PMID:9765203 cellular senescence IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 cerebellar cortex formation ISO RGD:1550208 1624291 MGI:MGI:99511 (MGI:MGI:5545830 , PMID:24431450) RGD MGI:MGI:5545830 , PMID:24431450 cerebellar cortex formation IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 epithelial cell proliferation involved in lung morphogenesis ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:5588044 , PMID:25100655) RGD MGI:MGI:5588044 , PMID:25100655 epithelial cell proliferation involved in lung morphogenesis IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 ERK1 and ERK2 cascade ISO RGD:732023 1624291 (PMID:18305109) RGD PMID:18305109 ERK1 and ERK2 cascade IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 ERK1 and ERK2 cascade IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 ERK1 and ERK2 cascade ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:5588044 , PMID:25100655) RGD MGI:MGI:5588044 , PMID:25100655 face development ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:3832113 , PMID:18952847) RGD MGI:MGI:3832113 , PMID:18952847 face development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 glucose homeostasis IDA 12879823 RGD Golgi inheritance IMP 2293212 Golgi fragmentation during mitosis RGD heart development ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:3832113 , PMID:18952847) RGD MGI:MGI:3832113 , PMID:18952847 heart development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 intracellular signal transduction TAS 70317 RGD keratinocyte differentiation ISO RGD:1550208 1624291 (MGI:MGI:2176412, PMID:11841548) RGD MGI:MGI:2176412 , PMID:11841548 keratinocyte differentiation IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 labyrinthine layer development ISO RGD:1550208 1624291 MGI:MGI:2178132 (MGI:MGI:1334781 , PMID:10209122) RGD MGI:MGI:1334781 , PMID:10209122 labyrinthine layer development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 lung morphogenesis ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:5588044 , PMID:25100655) RGD MGI:MGI:5588044 , PMID:25100655 melanosome transport IDA 2293208 positive regulation of bidirectional melanosome transport along microtubules RGD mitotic cell cycle IDA 1582173 RGD negative regulation of cell population proliferation ISO RGD:732023 1624291 (PMID:9765203) RGD PMID:9765203 negative regulation of cell population proliferation IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression ISO RGD:732023 1624291 UniProtKB:P36507 (PMID:23626836) RGD PMID:23626836 negative regulation of gene expression IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression IGI UniProtKB:P36506 13524616 PMID:28947594 BHF-UCL negative regulation of homotypic cell-cell adhesion IMP 2292641 IEC6 cells RGD negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IGI UniProtKB:P06733 12793039 PMID:15459207 CAFA negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP 12793039 PMID:15459207 CAFA neuron differentiation IMP 2292642 RGD neuron differentiation IBA MGI:MGI:1346866 more ... 13792537 PMID:21873635 GO_Central neuron differentiation IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuron differentiation ISO RGD:1550208 1624291 (MGI:MGI:3050703, PMID:15145949) RGD MGI:MGI:3050703 , PMID:15145949 neuron projection morphogenesis IMP 2292642 RGD peptidyl-threonine phosphorylation ISO RGD:732023 1624291 (PMID:18305109) RGD PMID:18305109 peptidyl-threonine phosphorylation IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-tyrosine phosphorylation IEA GO:0004713 1600115 GO_REF:0000108 GOC GO_REF:0000108 placenta blood vessel development ISO RGD:1550208 1624291 MGI:MGI:2178132 (MGI:MGI:1334781 , PMID:10209122) RGD MGI:MGI:1334781 , PMID:10209122 placenta blood vessel development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of ATP biosynthetic process IMP 12793039 PMID:15459207 CAFA positive regulation of ATP biosynthetic process IGI UniProtKB:P06733 12793039 PMID:15459207 CAFA positive regulation of autophagy IDA 12879823 RGD positive regulation of axonogenesis ISO RGD:1550208 1624291 MGI:MGI:1346867 more ... RGD MGI:MGI:5582953 , PMID:24733831 positive regulation of axonogenesis IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell differentiation ISO RGD:1550208 1624291 (MGI:MGI:3689690, PMID:16908534) RGD MGI:MGI:3689690 , PMID:16908534 positive regulation of cell migration IMP 2292641 IEC6 cells RGD positive regulation of ERK1 and ERK2 cascade ISO RGD:732023 1624291 (PMID:24375836) RGD PMID:24375836 positive regulation of ERK1 and ERK2 cascade IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:732023 1624291 (PMID:15155804) RGD PMID:15155804 positive regulation of gene expression IMP 12793039 PMID:15459207 CAFA positive regulation of gene expression IGI UniProtKB:P09416 12793039 PMID:15459207 CAFA positive regulation of GTPase activity IMP 2292641 basal and EGF-activated Rac1 RGD positive regulation of muscle contraction IGI UniProtKB:P06733 12793039 PMID:15459207 CAFA positive regulation of muscle contraction IMP 12793039 PMID:15459207 CAFA positive regulation of production of miRNAs involved in gene silencing by miRNA ISO RGD:732023 1624291 (PMID:24375836) RGD PMID:24375836 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of protein serine/threonine kinase activity ISO RGD:732023 1624291 (PMID:8388392) RGD PMID:8388392 positive regulation of Ras protein signal transduction IMP 8553977 PMID:19029245 MGI positive regulation of transcription elongation from RNA polymerase II promoter IMP 2292639 RGD positive regulation of transcription, DNA-templated ISO RGD:732023 1624291 (PMID:24375836), (PMID:26514923) RGD PMID:24375836 , PMID:26514923 positive regulation of transcription, DNA-templated IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation IDA 61657 ; 2298674 RGD protein phosphorylation ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:3579196 more ... RGD MGI:MGI:3579196 more ... protein phosphorylation ISO RGD:732023 1624291 (PMID:28166211) RGD PMID:28166211 protein phosphorylation IDA 2293209 MAPK K52R mutant RGD protein phosphorylation TAS 70317 RGD regulation of axon regeneration ISO RGD:1550208 1624291 MGI:MGI:1346867 more ... RGD MGI:MGI:5582953 , PMID:24733831 regulation of axon regeneration IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of early endosome to late endosome transport TAS 8553538 PMID:19565474 UniProt regulation of ERK1 and ERK2 cascade IDA 12879823 RGD regulation of Golgi inheritance TAS 8553538 PMID:19565474 UniProt regulation of mitotic cell cycle IBA PANTHER:PTN000684825 , PomBase:SPAC9G1.0913792537 PMID:21873635 GO_Central regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP 13702166 PMID:12202034 SynGO regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA 13702166 PMID:12202034 SynGO regulation of stress-activated MAPK cascade TAS 8553538 PMID:19565474 UniProt regulation of vascular smooth muscle contraction IMP 2293329 inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001) RGD response to axon injury IMP 2293210 protection from axon degeneration following transection or NGF deprivation RGD response to glucocorticoid IDA 625388 RGD response to oxidative stress IDA 1582172 RGD signal transduction by protein phosphorylation IBA CGD:CAL0000198103 more ... 13792537 PMID:21873635 GO_Central stress-activated protein kinase signaling cascade IBA PANTHER:PTN000684825 more ... 13792537 PMID:21873635 GO_Central thymus development ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:3832113 , PMID:18952847) RGD MGI:MGI:3832113 , PMID:18952847 thymus development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 thyroid gland development ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:3832113 , PMID:18952847) RGD MGI:MGI:3832113 , PMID:18952847 thyroid gland development IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 trachea formation ISO RGD:1550208 1624291 MGI:MGI:1346867 (MGI:MGI:5588044 , PMID:25100655) RGD MGI:MGI:5588044 , PMID:25100655 trachea formation IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 triglyceride homeostasis IDA 12879823 RGD vesicle transport along microtubule IDA 2293208 positive regulation of bidirectional melanosome transport along microtubules RGD Cellular Component axon IDA 2293331 cytoplasm RGD cell cortex IDA 2298675 RGD cytoplasm IBA FB:FBgn0010909 more ... 13792537 PMID:21873635 GO_Central cytosol IDA 2298675 ; 70317 RGD cytosol ISO RGD:732023 1624291 RGD GO_REF:0000052 cytosol TAS 8553538 PMID:19565474 UniProt cytosol IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IEA UniProtKB:A4QPA9 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 dendrite IDA 2293321 RGD dendrite cytoplasm IDA 2293331 RGD early endosome TAS 8553538 PMID:19565474 UniProt endoplasmic reticulum ISO RGD:732023 1624291 (PMID:22572157) RGD PMID:22572157 endoplasmic reticulum IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 focal adhesion TAS 8553538 PMID:19565474 UniProt glutamatergic synapse IDA 13702166 PMID:12202034 SynGO glutamatergic synapse EXP 13702166 PMID:12202034 SynGO Golgi apparatus IDA 1582173 RGD Golgi apparatus TAS 8553538 PMID:19565474 UniProt late endosome TAS 8553538 PMID:19565474 UniProt microtubule colocalizes_with IDA 2293321 partial colocalization RGD microtubule organizing center IEA UniProtKB-SubCell:SL-0048 1600115 GO_REF:0000044 UniProt GO_REF:0000044 mitochondrion TAS 8553538 PMID:19565474 UniProt nucleus TAS 8553538 PMID:19565474 UniProt perikaryon IDA 2293331 ; 2293321 RGD perinuclear region of cytoplasm IDA 2293211 phosphorylated (p-S298) Map2k1 during cell adhesion RGD plasma membrane IDA 2293211 phosphorylated (p-S298) Map2k1 during cell adhesion RGD plasma membrane IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IEA UniProtKB:A4QPA9 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISO RGD:732023 1624291 RGD GO_REF:0000052 postsynaptic density IDA 13702331 PMID:7478291 SynGO Molecular Function ATP binding IDA 2298674 RGD ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 MAP kinase kinase activity IDA 2298674 ; 2293305 ; 1582177 ; 61657 RGD MAP kinase kinase activity IBA FB:FBgn0010269 more ... 13792537 PMID:21873635 GO_Central MAP kinase kinase activity ISO RGD:732023 1624291 (PMID:28166211), (PMID:8388392) RGD PMID:28166211 , PMID:8388392 MAP kinase kinase activity IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 MAP kinase kinase activity IEA UniProtKB:P31938 , ensembl:ENSMUSP000000050661600115 GO_REF:0000107 Ensembl GO_REF:0000107 MAP kinase kinase activity ISO RGD:1550208 1624291 (MGI:MGI:2176412, PMID:11841548) RGD MGI:MGI:2176412 , PMID:11841548 MAP kinase kinase activity TAS 70317 RGD MAP-kinase scaffold activity ISO RGD:732023 1624291 (PMID:29433126) RGD PMID:29433126 MAP-kinase scaffold activity IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitogen-activated protein kinase kinase kinase binding IPI RGD:620966 2293486 RGD mitogen-activated protein kinase kinase kinase binding IDA 2293209 Chinese hamster c-Raf-1 RGD protein binding IPI RGD:1308105 2298675 RGD protein binding ISO RGD:732023 1624291 UniProtKB:O15519-1 more ... RGD PMID:15299019 more ... protein binding ISO RGD:1550208 1624291 UniProtKB:Q13526 more ... RGD MGI:MGI:1890011 more ... protein C-terminus binding ISO RGD:732023 1624291 (PMID:22572157) RGD PMID:22572157 protein C-terminus binding IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding IPI RGD:737237 2292643 RGD protein N-terminus binding ISO RGD:732023 1624291 (PMID:22572157) RGD PMID:22572157 protein N-terminus binding IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein serine/threonine kinase activator activity ISO RGD:732023 1624291 (PMID:8388392) RGD PMID:8388392 protein serine/threonine kinase activator activity IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein serine/threonine kinase activity ISO RGD:732023 1624291 (PMID:18305109) RGD PMID:18305109 protein serine/threonine kinase activity IBA CGD:CAL0000192143 more ... 13792537 PMID:21873635 GO_Central protein serine/threonine kinase activity IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein serine/threonine/tyrosine kinase activity TAS 8553538 PMID:19565474 UniProt protein tyrosine kinase activity IEA UniProtKB-KW:KW-0829 1600115 GO_REF:0000043 UniProt GO_REF:0000043 protein-containing complex binding IPI RGD:737237 more ... 2292643 heterooligomerization RGD Ras GTPase binding IPI RGD:730881 2293305 RGD scaffold protein binding IEA UniProtKB:Q02750 , ensembl:ENSP000003024861600115 GO_REF:0000107 Ensembl GO_REF:0000107 scaffold protein binding ISO RGD:732023 1624291 UniProtKB:Q61097 (PMID:10409742) RGD PMID:10409742
Gene-Chemical Interaction Annotations
