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GENE - TERM ANNOTATION REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: DOID:1909
Term: melanoma
Definition: A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Melanoma "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/22123420 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1 ISOMAP2K1 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:22197931
Map2k1 ISOMAP2K1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Malignant melanoma, somatic | ClinVar Annotator: match by term: MelanomaPMID:17366577 PMID:17551924 PMID:17704260 PMID:18060073 PMID:18456719 PMID:18632602 PMID:19344873 PMID:19411838 PMID:19915144 PMID:20301365 PMID:21107320 PMID:21383288 PMID:22197931 PMID:22327936 PMID:22588879 PMID:22622578 PMID:23444215 PMID:23569304 PMID:23614898 PMID:24033266 PMID:24448821 PMID:24803665 PMID:25049390 PMID:25157968 PMID:25741868 PMID:26343583 PMID:26619011 PMID:27862862 PMID:28049852 PMID:28492532 PMID:28495673 PMID:29402968 PMID:29643386 PMID:30763456 PMID:31487502 PMID:32005694 PMID:32978145 PMID:7651428
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