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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1increases activityISOMAP2K1 (Homo sapiens)6480464CTDCadmium results in increased activity of MAP2K1 proteinPMID:20153348
Map2k1increases phosphorylationISOMAP2K1 (Homo sapiens)6480464CTDCadmium results in increased phosphorylation of MAP2K1 proteinPMID:14499349
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTDGPER1 mutant form inhibits the reaction [Cadmium results in increased activity of MAP2K1 protein]; MAP2K1 protein affects the reaction [Cadmium results in increased expression of PLAUR mRNA]PMID:20153348 PMID:25069788
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