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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1affects expressionISOMap2k1 (Mus musculus)6480464CTDEstradiol affects the expression of MAP2K1 mRNAPMID:15598610
Map2k1affects expressionISOMAP2K1 (Homo sapiens)6480464CTDEstradiol affects the expression of MAP2K1 mRNAPMID:22574217
Map2k1increases activityISOMAP2K1 (Homo sapiens)6480464CTDEstradiol results in increased activity of MAP2K1 proteinPMID:15615701
Map2k1increases expressionISOMap2k1 (Mus musculus)6480464CTDEstradiol results in increased expression of MAP2K1 mRNAPMID:14664709 PMID:25210133 PMID:25575267
Map2k1increases expressionISOMAP2K1 (Homo sapiens)6480464CTDEstradiol results in increased expression of MAP2K1 mRNAPMID:12154049 PMID:23094148
Map2k1multiple interactionsISOMap2k1 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of MAP2K1 mRNA]PMID:25210133
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTDIGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAP2K1 mRNA]PMID:23094148
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