MAP2K1 (mitogen-activated protein kinase kinase 1) - Rat Genome Database

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Gene: MAP2K1 (mitogen-activated protein kinase kinase 1) Canis lupus familiaris
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Symbol: MAP2K1
Name: mitogen-activated protein kinase kinase 1
RGD ID: 12140765
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase kinase activity (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN Bergmann glial cell differentiation (ortholog); cell motility (ortholog); cerebellar cortex formation (ortholog); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive Alport syndrome (ortholog); Bloom syndrome (ortholog); FOUND IN axon (ortholog); cell cortex (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,683,192 - 30,760,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,683,107 - 30,760,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,613,296 - 30,690,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,879,701 - 30,957,083 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,878,118 - 30,957,083 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,809,219 - 30,886,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,868,842 - 30,945,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,110,222 - 31,187,514 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
Bergmann glial cell differentiation  (IEA,ISO)
cell motility  (IEA,ISO)
cellular senescence  (IEA)
cerebellar cortex formation  (IEA,ISO)
endodermal cell differentiation  (IEA,ISO)
epithelial cell proliferation involved in lung morphogenesis  (IEA,ISO)
ERBB2-ERBB3 signaling pathway  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
Golgi inheritance  (ISO)
heart development  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA)
keratinocyte differentiation  (IEA,ISO)
labyrinthine layer development  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
MAPK cascade  (IEA)
melanosome transport  (ISO)
myelination  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of homotypic cell-cell adhesion  (ISO)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (ISO)
neuron differentiation  (IEA,ISO)
neuron projection morphogenesis  (ISO)
placenta blood vessel development  (IEA,ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of axonogenesis  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endodermal cell differentiation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of GTPase activity  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of muscle contraction  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of transcription elongation by RNA polymerase II  (ISO)
protein phosphorylation  (ISO)
regulation of axon regeneration  (IEA,ISO)
regulation of early endosome to late endosome transport  (IEA)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of Golgi inheritance  (IEA)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of stress-activated MAPK cascade  (IEA)
regulation of vascular associated smooth muscle contraction  (ISO)
response to axon injury  (ISO)
response to glucocorticoid  (ISO)
response to oxidative stress  (ISO)
Schwann cell development  (IEA)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)
triglyceride homeostasis  (ISO)
type B pancreatic cell proliferation  (IEA,ISO)
vesicle transport along microtubule  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MAP2K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13030,683,192 - 30,760,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3030,683,107 - 30,760,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3030,613,296 - 30,690,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03030,879,701 - 30,957,083 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3030,878,118 - 30,957,083 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13030,809,219 - 30,886,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03030,868,842 - 30,945,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,110,222 - 31,187,514 (+)NCBIUU_Cfam_GSD_1.0
MAP2K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381566,386,912 - 66,491,544 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1566,386,837 - 66,491,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371566,679,250 - 66,783,882 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361564,466,679 - 64,570,936 (+)NCBINCBI36Build 36hg18NCBI36
Build 341564,466,678 - 64,570,935NCBI
Celera1543,568,908 - 43,673,089 (+)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1543,515,493 - 43,620,002 (+)NCBIHuRef
CHM1_11566,797,173 - 66,901,898 (+)NCBICHM1_1
T2T-CHM13v2.01564,208,363 - 64,313,019 (+)NCBIT2T-CHM13v2.0
Map2k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39964,093,066 - 64,160,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl964,093,052 - 64,160,913 (-)EnsemblGRCm39 Ensembl
GRCm38964,185,769 - 64,253,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl964,185,770 - 64,253,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv37964,033,600 - 64,101,412 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,983,794 - 64,051,338 (-)NCBIMGSCv36mm8
Celera961,410,935 - 61,478,604 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.55NCBI
Map2k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,578,747 - 73,650,184 (-)NCBIGRCr8
mRatBN7.2864,683,449 - 64,754,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,683,449 - 64,755,147 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx870,198,296 - 70,269,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0868,470,887 - 68,542,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0866,340,874 - 66,412,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl869,134,223 - 69,164,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBICelera
Cytogenetic Map8q24NCBI
Map2k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554509,181,851 - 9,239,648 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554509,181,851 - 9,205,277 (-)NCBIChiLan1.0ChiLan1.0
MAP2K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21655,642,226 - 55,744,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11559,814,985 - 59,916,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01545,337,117 - 45,438,826 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11563,613,988 - 63,714,928 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1563,613,961 - 63,714,161 (+)Ensemblpanpan1.1panPan2
Map2k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640108,704,376 - 108,780,234 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647126,589,161 - 26,628,302 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647126,589,251 - 26,628,302 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,381,845 - 164,471,226 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,381,892 - 164,469,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,187,631 - 182,196,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12617,059,122 - 17,168,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2617,060,054 - 17,168,782 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048124,281,623 - 124,391,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247816,222,365 - 6,285,531 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247816,222,365 - 6,285,398 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP2K1
806 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 20 4 6 4 6 6 12 8 10 6
Low 2 2 2
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000027411   ⟹   ENSCAFP00000025491
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3030,719,965 - 30,759,560 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000043934   ⟹   ENSCAFP00000041046
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3030,683,107 - 30,759,560 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000061644   ⟹   ENSCAFP00000045279
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3030,683,107 - 30,759,472 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000090797   ⟹   ENSCAFP00000049758
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3030,683,192 - 30,760,479 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027504   ⟹   ENSCAFP00845021639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3030,878,118 - 30,957,083 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027561   ⟹   ENSCAFP00845021684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3030,879,432 - 30,956,127 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027576   ⟹   ENSCAFP00845021698
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3030,890,260 - 30,957,083 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845027624   ⟹   ENSCAFP00845021738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3030,916,543 - 30,956,164 (+)Ensembl
RefSeq Acc Id: NM_001048094   ⟹   NP_001041559
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13030,683,192 - 30,760,479 (+)NCBI
Dog10K_Boxer_Tasha3030,613,296 - 30,690,593 (+)NCBI
ROS_Cfam_1.03030,879,701 - 30,957,083 (+)NCBI
UMICH_Zoey_3.13030,809,219 - 30,886,485 (+)NCBI
UNSW_CanFamBas_1.03030,868,842 - 30,945,867 (+)NCBI
UU_Cfam_GSD_1.03031,110,222 - 31,187,514 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001041559   ⟸   NM_001048094
- UniProtKB: A0A8C0QXB7 (UniProtKB/TrEMBL),   A0A8I3NMM5 (UniProtKB/TrEMBL),   A0A8P0NS89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041046   ⟸   ENSCAFT00000043934
RefSeq Acc Id: ENSCAFP00000025491   ⟸   ENSCAFT00000027411
RefSeq Acc Id: ENSCAFP00000049758   ⟸   ENSCAFT00000090797
RefSeq Acc Id: ENSCAFP00000045279   ⟸   ENSCAFT00000061644
RefSeq Acc Id: ENSCAFP00845021698   ⟸   ENSCAFT00845027576
RefSeq Acc Id: ENSCAFP00845021684   ⟸   ENSCAFT00845027561
RefSeq Acc Id: ENSCAFP00845021738   ⟸   ENSCAFT00845027624
RefSeq Acc Id: ENSCAFP00845021639   ⟸   ENSCAFT00845027504
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017298 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013407 UniProtKB/TrEMBL
  ENSCAFG00040025663 UniProtKB/TrEMBL
  ENSCAFG00845015371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027411.5 UniProtKB/TrEMBL
  ENSCAFT00000043934.4 UniProtKB/TrEMBL
  ENSCAFT00000090797.2 UniProtKB/TrEMBL
  ENSCAFT00030024899.1 UniProtKB/TrEMBL
  ENSCAFT00030025001.1 UniProtKB/TrEMBL
  ENSCAFT00040047911.1 UniProtKB/TrEMBL
  ENSCAFT00040047924.1 UniProtKB/TrEMBL
  ENSCAFT00040047935.1 UniProtKB/TrEMBL
  ENSCAFT00845027504.1 UniProtKB/TrEMBL
  ENSCAFT00845027561.1 UniProtKB/TrEMBL
  ENSCAFT00845027576 ENTREZGENE
  ENSCAFT00845027576.1 UniProtKB/TrEMBL
  ENSCAFT00845027624.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAP2K1 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0NAT7_CANLF UniProtKB/TrEMBL
  A0A8C0NFJ4_CANLF UniProtKB/TrEMBL
  A0A8C0QXB7 ENTREZGENE
  A0A8C0TUG3_CANLF UniProtKB/TrEMBL
  A0A8C0Z792_CANLF UniProtKB/TrEMBL
  A0A8I3NMM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P5D5_CANLF UniProtKB/TrEMBL
  A0A8I3RYU6_CANLF UniProtKB/TrEMBL
  A0A8I3RYV5_CANLF UniProtKB/TrEMBL
  A0A8P0NS89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NZL9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:42960 ENTREZGENE