Pdpk1 (3-phosphoinositide dependent protein kinase-1) - Rat Genome Database

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Gene: Pdpk1 (3-phosphoinositide dependent protein kinase-1) Rattus norvegicus
Analyze
Symbol: Pdpk1
Name: 3-phosphoinositide dependent protein kinase-1
RGD ID: 620307
Description: Enables 3-phosphoinositide-dependent protein kinase activity; insulin receptor binding activity; and protein kinase binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; focal adhesion assembly; and negative regulation of neuron apoptotic process. Located in perikaryon. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1); PARTICIPATES IN angiotensin II signaling pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-phosphoinositide-dependent protein kinase 1; pkB kinase; protein kinase B kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,610,000 - 13,687,226 (-)NCBIGRCr8
mRatBN7.21013,105,435 - 13,182,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,105,498 - 13,174,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,855,532 - 17,919,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,344,364 - 17,408,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,842,927 - 12,906,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,446,373 - 13,525,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,451,624 - 13,515,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,262,177 - 13,339,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,329,708 - 13,394,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,329,707 - 13,394,080 (-)NCBI
Celera1012,796,598 - 12,860,647 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Asiaticoside  (EXP)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
finasteride  (EXP)
folic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
icariside II  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
maleic acid  (ISO)
mechlorethamine  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
microcystin-LR  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-succinylsulfathiazole  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
ochratoxin A  (EXP)
OSU-03012  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling  (IEA,ISO)
cell migration  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IEP)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to insulin stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
focal adhesion assembly  (IMP)
hyperosmotic response  (IEA,ISO)
insulin receptor signaling pathway  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of toll-like receptor signaling pathway  (IEA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of sprouting angiogenesis  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
regulation of endothelial cell migration  (ISO)
regulation of mast cell degranulation  (IEA,ISO)
type B pancreatic cell development  (IEA,ISO)

Cellular Component
cell projection  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA,ISO)
focal adhesion  (IEA)
nucleus  (IEA)
perikaryon  (IDA)
plasma membrane  (IEA,ISO,TAS)
postsynaptic density  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. Fiory F, etal., Mol Cell Biol. 2005 Dec;25(24):10803-14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Prognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer. Han L, etal., Med Oncol. 2014 Sep;31(9):129. doi: 10.1007/s12032-014-0129-y. Epub 2014 Jul 27.
5. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
6. Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival. Kharebava G, etal., J Neurosci. 2008 Oct 29;28(44):11409-20. doi: 10.1523/JNEUROSCI.2135-08.2008.
7. A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo. Maemets-Allas K, etal., Mol Cancer Ther. 2015 Nov;14(11):2486-96. doi: 10.1158/1535-7163.MCT-15-0281. Epub 2015 Aug 20.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Sargeant AM, etal., Toxicol Pathol. 2007 Jun;35(4):549-61. doi: 10.1080/01926230701338966.
17. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Stephens L, etal., Science 1998 Jan 30;279(5351):710-4.
18. Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Taniyama Y, etal., Mol Cell Biol. 2003 Nov;23(22):8019-29.
Additional References at PubMed
PMID:9368760   PMID:9373175   PMID:9637919   PMID:9768361   PMID:10075713   PMID:10567711   PMID:12783890   PMID:14711829   PMID:14749367   PMID:15007074   PMID:16207722   PMID:17114649  
PMID:17327236   PMID:17371830   PMID:18559349   PMID:19276999   PMID:19429709   PMID:19635472   PMID:19717727   PMID:20584979   PMID:21063107   PMID:21069435   PMID:21736902   PMID:22134004  
PMID:22232248   PMID:22454520   PMID:23802567   PMID:26235810   PMID:32373981   PMID:33199822   PMID:34133802   PMID:35061720   PMID:37162681  


Genomics

Comparative Map Data
Pdpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,610,000 - 13,687,226 (-)NCBIGRCr8
mRatBN7.21013,105,435 - 13,182,664 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,105,498 - 13,174,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,855,532 - 17,919,448 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,344,364 - 17,408,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,842,927 - 12,906,749 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,446,373 - 13,525,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,451,624 - 13,515,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,262,177 - 13,339,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,329,708 - 13,394,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,329,707 - 13,394,080 (-)NCBI
Celera1012,796,598 - 12,860,647 (-)NCBICelera
Cytogenetic Map10q12NCBI
PDPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,538,021 - 2,603,188 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,537,979 - 2,603,188 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,588,022 - 2,653,189 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,527,971 - 2,593,190 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,527,970 - 2,593,189NCBI
Cytogenetic Map16p13.3NCBI
HuRef162,533,939 - 2,579,217 (+)NCBIHuRef
CHM1_1162,587,908 - 2,653,167 (+)NCBICHM1_1
T2T-CHM13v2.0162,560,174 - 2,625,339 (+)NCBIT2T-CHM13v2.0
Pdpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,292,654 - 24,370,957 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,292,654 - 24,369,898 (-)EnsemblGRCm39 Ensembl
GRCm381724,073,680 - 24,155,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,073,680 - 24,150,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,210,647 - 24,278,561 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,806,503 - 23,869,181 (-)NCBIMGSCv36mm8
Celera1724,579,774 - 24,646,541 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.23NCBI
Pdpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,685,153 - 14,772,870 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,685,089 - 14,772,870 (-)NCBIChiLan1.0ChiLan1.0
PDPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,039,537 - 3,108,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,820,580 - 6,889,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,394,447 - 1,463,735 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,426,464 - 38,506,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,431,600 - 38,499,295 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,665,293 - 39,744,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,736,122 - 38,815,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,739,163 - 38,809,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,421,263 - 38,500,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,393,915 - 38,473,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,869,968 - 38,949,380 (-)NCBIUU_Cfam_GSD_1.0
Pdpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,173,175 - 105,264,644 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,526,653 - 1,537,386 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049366941,444,880 - 1,488,265 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,444,819 - 1,487,628 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,432,058 - 39,512,601 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,429,928 - 39,512,623 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,792,968 - 42,830,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDPK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606828,533,894 - 28,612,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824293,374 - 383,156 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824279,893 - 383,220 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdpk1
285 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:84
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000067660
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
D10Rat258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,145,824 - 13,146,036 (+)MAPPERmRatBN7.2
Rnor_6.01013,486,760 - 13,486,971NCBIRnor6.0
Rnor_5.01013,301,821 - 13,302,032UniSTSRnor5.0
RGSC_v3.41013,365,691 - 13,365,903RGDRGSC3.4
RGSC_v3.41013,365,692 - 13,365,903UniSTSRGSC3.4
RGSC_v3.11013,365,577 - 13,366,139RGD
Celera1012,831,751 - 12,831,952UniSTS
SHRSP x BN Map108.07UniSTS
SHRSP x BN Map108.07RGD
Cytogenetic Map10q12UniSTS
D10Arb29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,170,590 - 13,170,801 (+)MAPPERmRatBN7.2
Rnor_6.01013,511,414 - 13,511,624NCBIRnor6.0
Rnor_5.01013,326,711 - 13,326,921UniSTSRnor5.0
RGSC_v3.41013,390,051 - 13,390,262RGDRGSC3.4
RGSC_v3.41013,390,052 - 13,390,262UniSTSRGSC3.4
RGSC_v3.11013,390,051 - 13,390,262RGD
Celera1012,856,627 - 12,856,837UniSTS
Cytogenetic Map10q12UniSTS
BF397060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,128,631 - 13,128,753 (+)MAPPERmRatBN7.2
Rnor_6.01013,469,567 - 13,469,688NCBIRnor6.0
Rnor_5.01013,284,628 - 13,284,749UniSTSRnor5.0
RGSC_v3.41013,348,524 - 13,348,645UniSTSRGSC3.4
Celera1012,814,558 - 12,814,679UniSTS
Cytogenetic Map10q12UniSTS
BF417221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,162,297 - 13,162,523 (+)MAPPERmRatBN7.2
Rnor_6.01013,503,230 - 13,503,455NCBIRnor6.0
Rnor_5.01013,318,635 - 13,318,860UniSTSRnor5.0
RGSC_v3.41013,381,976 - 13,382,201UniSTSRGSC3.4
Celera1012,848,383 - 12,848,608UniSTS
RH 3.4 Map10147.5UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 46 30 19 30 8 8 74 35 41 11 8
Low 5 11 11 11 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000067660   ⟹   ENSRNOP00000061683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,110,688 - 13,174,623 (-)Ensembl
Rnor_6.0 Ensembl1013,451,624 - 13,515,448 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095623   ⟹   ENSRNOP00000083884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,105,498 - 13,174,623 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097563   ⟹   ENSRNOP00000081448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,110,688 - 13,142,280 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100601   ⟹   ENSRNOP00000078834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,110,688 - 13,174,623 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101162   ⟹   ENSRNOP00000090187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,110,924 - 13,174,623 (-)Ensembl
RefSeq Acc Id: NM_031081   ⟹   NP_112343
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,615,251 - 13,679,175 (-)NCBI
mRatBN7.21013,110,688 - 13,174,617 (-)NCBI
Rnor_6.01013,451,624 - 13,515,442 (-)NCBI
Rnor_5.01013,262,177 - 13,339,277 (-)NCBI
RGSC_v3.41013,329,708 - 13,394,080 (-)RGD
Celera1012,796,598 - 12,860,647 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246036   ⟹   XP_006246098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,610,000 - 13,687,188 (-)NCBI
mRatBN7.21013,105,435 - 13,182,621 (-)NCBI
Rnor_6.01013,446,373 - 13,525,248 (-)NCBI
Rnor_5.01013,262,177 - 13,339,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086936   ⟹   XP_038942864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,610,000 - 13,687,226 (-)NCBI
mRatBN7.21013,105,435 - 13,182,664 (-)NCBI
RefSeq Acc Id: XM_039086937   ⟹   XP_038942865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,610,000 - 13,646,545 (-)NCBI
mRatBN7.21013,105,435 - 13,141,985 (-)NCBI
RefSeq Acc Id: XM_063269947   ⟹   XP_063126017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,610,000 - 13,678,797 (-)NCBI
RefSeq Acc Id: XM_063269948   ⟹   XP_063126018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,610,000 - 13,679,244 (-)NCBI
RefSeq Acc Id: XM_063269949   ⟹   XP_063126019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,620,312 - 13,679,244 (-)NCBI
RefSeq Acc Id: XM_063269950   ⟹   XP_063126020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,620,312 - 13,679,244 (-)NCBI
RefSeq Acc Id: NP_112343   ⟸   NM_031081
- UniProtKB: O55173 (UniProtKB/Swiss-Prot),   G3V9W3 (UniProtKB/Swiss-Prot),   A0A8I5ZS05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246098   ⟸   XM_006246036
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061683   ⟸   ENSRNOT00000067660
RefSeq Acc Id: XP_038942864   ⟸   XM_039086936
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942865   ⟸   XM_039086937
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000083884   ⟸   ENSRNOT00000095623
RefSeq Acc Id: ENSRNOP00000081448   ⟸   ENSRNOT00000097563
RefSeq Acc Id: ENSRNOP00000078834   ⟸   ENSRNOT00000100601
RefSeq Acc Id: ENSRNOP00000090187   ⟸   ENSRNOT00000101162
RefSeq Acc Id: XP_063126018   ⟸   XM_063269948
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126017   ⟸   XM_063269947
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063126020   ⟸   XM_063269950
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063126019   ⟸   XM_063269949
- Peptide Label: isoform X3
Protein Domains
PDK1-type PH   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55173-F1-model_v2 AlphaFold O55173 1-559 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697002
Promoter ID:EPDNEW_R7527
Type:multiple initiation site
Name:Pdpk1_1
Description:3-phosphoinositide dependent protein kinase-1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,515,482 - 13,515,542EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620307 AgrOrtholog
BioCyc Gene G2FUF-25879 BioCyc
Ensembl Genes ENSRNOG00000006136 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026228 UniProtKB/Swiss-Prot
  ENSRNOG00060009727 UniProtKB/Swiss-Prot
  ENSRNOG00065010212 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067660 ENTREZGENE
  ENSRNOT00000067660.2 UniProtKB/Swiss-Prot
  ENSRNOT00000095623.1 UniProtKB/TrEMBL
  ENSRNOT00000097563.1 UniProtKB/TrEMBL
  ENSRNOT00000100601.1 UniProtKB/TrEMBL
  ENSRNOT00000101162.1 UniProtKB/TrEMBL
  ENSRNOT00055045426 UniProtKB/Swiss-Prot
  ENSRNOT00060016542 UniProtKB/Swiss-Prot
  ENSRNOT00065016490 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDK1-typ_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDPK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81745 UniProtKB/Swiss-Prot
NCBI Gene 81745 ENTREZGENE
PANTHER 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdpk1 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006136 RatGTEx
  ENSRNOG00055026228 RatGTEx
  ENSRNOG00060009727 RatGTEx
  ENSRNOG00065010212 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPJ2_RAT UniProtKB/TrEMBL
  A0A8I5ZS05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A046_RAT UniProtKB/TrEMBL
  A0A8I6GHZ8_RAT UniProtKB/TrEMBL
  A6HCQ1_RAT UniProtKB/TrEMBL
  G3V9W3 ENTREZGENE
  O55173 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V9W3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-08-06 Pdpk1  3-phosphoinositide dependent protein kinase-1      Symbol and Name status set to provisional 70820 PROVISIONAL