Gclm (glutamate cysteine ligase, modifier subunit) - Rat Genome Database

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Gene: Gclm (glutamate cysteine ligase, modifier subunit) Rattus norvegicus
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
RGD ID: 619871
Description: Enables glutamate-cysteine ligase activity and glutamate-cysteine ligase catalytic subunit binding activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to thyroxine stimulus; and response to gonadotropin. Part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
Previously known as: gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase) regulatory; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase modifier subunit
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82213,032,135 - 213,052,192 (+)NCBIGRCr8
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,020,579 - 218,040,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,928,345 - 215,948,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,770,305 - 210,790,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-Ethylhexyl acrylate  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrobenzyl bromide  (ISO)
4-phenyl-3-furoxancarbonitrile  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,8-dihydroxycoumarin  (ISO)
7beta-aminocephalosporanic acid  (ISO)
[6]-Shogaol  (ISO)
abietic acid  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
Aescin  (ISO)
aflatoxin B1  (EXP,ISO)
AL 8810  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha,alpha-trehalose  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-Solamarine  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
astilbin  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
benfotiamine  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
benzoquinones  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beta-naphthoflavone  (ISO)
beta-tocopherol  (EXP)
Betanin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP,ISO)
Carnosol  (ISO)
celastrol  (EXP,ISO)
ceric oxide  (EXP)
cerium trichloride  (ISO)
chalcone  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
citral  (ISO)
clavulanic acid  (ISO)
Clivoline  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
deguelin  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
diethyl malate  (ISO)
diethyl maleate  (EXP,ISO)
dihydrogen  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dinoseb  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dodecan-1-ol  (ISO)
domoic acid  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
emodin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epichlorohydrin  (ISO)
Epomediol  (EXP)
erastin  (EXP)
erdosteine  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylene glycol dimethacrylate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fluprostenol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fumonisin B1  (ISO)
furosemide  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gedunin  (ISO)
genistein  (EXP)
gentamycin  (EXP)
geranial  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyoxal  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hemin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
hexane  (ISO)
homoeriodictyol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iodixanol  (EXP)
iohexol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoprofen  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
limonene  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithocholic acid  (ISO)
luteolin  (EXP)
LY294002  (ISO)
lycopene  (ISO)
malonaldehyde  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methidathion  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylene blue  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (ISO)
mifepristone  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naphthalene  (ISO)
naproxen  (ISO)
nefazodone  (EXP)
neoastilbin  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nilotinib  (ISO)
nimesulide  (EXP)
nitisinone  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (EXP)
Nonidet P-40  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenoxymethylpenicillin  (ISO)
phenyl benzoate  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosgene  (ISO)
picoxystrobin  (ISO)
plumbagin  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B3  (ISO)
propan-2-ol  (ISO)
prostaglandin J2  (EXP)
purine-6-thiol  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-(1,2-Dichlorovinyl)glutathione  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
spermidine  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
suprofen  (ISO)
T-2 toxin  (ISO)
tartrazine  (ISO)
tebufenpyrad  (ISO)
tectorigenin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
triacsin C  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
undecanal  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
wortmannin  (ISO)
XAV939  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Polymorphisms and vascular cognitive impairment after ischemic stroke. Baum L, etal., J Geriatr Psychiatry Neurol. 2007 Jun;20(2):93-9.
2. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. Chen CN, etal., J Gerontol A Biol Sci Med Sci. 2010 Feb;65(2):129-37. doi: 10.1093/gerona/glp194. Epub 2009 Dec 16.
3. Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Dasgupta A, etal., Free Radic Biol Med. 2007 Mar 1;42(5):617-26. Epub 2006 Dec 15.
4. Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. Diaz-Hernandez JI, etal., J Biol Chem. 2005 Nov 25;280(47):38992-9001. Epub 2005 Sep 23.
5. Curvature of clathrin-coated pits driven by epsin. Ford MG, etal., Nature 2002 Sep 26;419(6905):361-6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. Gualtieri AF, etal., Int J Androl. 2009 Jun;32(3):218-25. Epub 2007 Nov 27.
9. Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. Huang CS, etal., J Biol Chem 1993 Sep 25;268(27):20578-83.
10. HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA. Hui L, etal., Free Radic Biol Med. 2010 Aug 1;49(3):467-73. doi: 10.1016/j.freeradbiomed.2010.05.002. Epub 2010 May 11.
11. Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Jang HI, etal., Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Lee JI, etal., Biochem J. 2006 Jan 1;393(Pt 1):181-90.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. Ramani K, etal., J Biol Chem. 2012 Oct 19;287(43):36341-55. doi: 10.1074/jbc.M112.370775. Epub 2012 Aug 31.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific. Tsai-Turton M and Luderer U, Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E391-402. Epub 2005 Apr 5.
26. Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues. Wu HZ, etal., Anal Bioanal Chem. 2011 Apr;399(10):3431-9. Epub 2010 Dec 9.
27. Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats. Yang L, etal., Life Sci. 2012 Oct 5;91(11-12):389-94. doi: 10.1016/j.lfs.2012.08.003. Epub 2012 Aug 11.
28. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Zhu Y, etal., Brain Res. 2006 May 23;1090(1):35-44. Epub 2006 May 2.
Additional References at PubMed
PMID:9675072   PMID:9841880   PMID:9895302   PMID:10395918   PMID:12081989   PMID:12384496   PMID:12975258   PMID:15288121   PMID:15489334   PMID:16081425   PMID:20439489   PMID:20447326  
PMID:24557597   PMID:27998794  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82213,032,135 - 213,052,192 (+)NCBIGRCr8
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,020,579 - 218,040,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,928,345 - 215,948,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,770,305 - 210,790,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38193,885,199 - 93,909,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,885,199 - 93,909,456 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,350,755 - 94,374,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,467,558 - 94,489,979 (-)NCBICHM1_1
T2T-CHM13v2.0193,733,450 - 93,757,695 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393122,039,206 - 122,060,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,039,206 - 122,064,381 (+)EnsemblGRCm39 Ensembl
GRCm383122,245,487 - 122,267,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,245,557 - 122,270,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,948,510 - 121,969,566 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,237,614 - 122,258,670 (+)NCBIMGSCv36mm8
MGSCv363122,610,732 - 122,631,895 (+)NCBIMGSCv36mm8
Celera3128,652,324 - 128,663,438 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955423782,468 - 805,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423782,468 - 805,384 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21133,110,998 - 133,133,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,267,567 - 132,291,710 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,548,850 - 96,573,273 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,278,665 - 95,298,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,278,665 - 95,297,893 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1655,204,602 - 55,244,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,930,482 - 57,952,133 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,598,315 - 55,619,977 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,598,408 - 55,617,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,278,061 - 55,299,711 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,263,100 - 55,284,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,715,747 - 55,737,399 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405058103,569,105 - 103,591,072 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365375,356,914 - 5,378,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl4123,371,193 - 123,390,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,017,027 - 135,035,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12039,339,948 - 39,359,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,339,908 - 39,359,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603378,685,244 - 78,710,789 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247423,713,250 - 3,743,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gclm
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:55
Interacting mature miRNAs:62
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,366,861 - 210,367,043 (+)MAPPERmRatBN7.2
Rnor_6.02225,847,201 - 225,847,382NCBIRnor6.0
Rnor_5.02243,882,600 - 243,882,781UniSTSRnor5.0
RGSC_v3.42218,914,816 - 218,914,997UniSTSRGSC3.4
Celera2202,796,475 - 202,796,656UniSTS
RH 3.4 Map21501.9UniSTS
Cytogenetic Map2q41UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,367,720 - 210,367,922 (+)MAPPERmRatBN7.2
Rnor_6.02225,848,060 - 225,848,261NCBIRnor6.0
Rnor_5.02243,883,459 - 243,883,660UniSTSRnor5.0
RGSC_v3.42218,915,675 - 218,915,876UniSTSRGSC3.4
Celera2202,797,334 - 202,797,535UniSTS
RH 3.4 Map21520.6UniSTS
Cytogenetic Map2q41UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,367,151 - 210,367,337 (+)MAPPERmRatBN7.2
Rnor_6.02225,847,491 - 225,847,676NCBIRnor6.0
Rnor_5.02243,882,890 - 243,883,075UniSTSRnor5.0
RGSC_v3.42218,915,106 - 218,915,291UniSTSRGSC3.4
Celera2202,796,765 - 202,796,950UniSTS
Cytogenetic Map2q41UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6
Medium 3 41 57 41 19 41 6 8 74 29 41 11 6
Low 2 2 3 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000018343   ⟹   ENSRNOP00000018343
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)Ensembl
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)Ensembl
RefSeq Acc Id: NM_017305   ⟹   NP_059001
Rat AssemblyChrPosition (strand)Source
GRCr82213,032,135 - 213,052,192 (+)NCBI
mRatBN7.22210,347,482 - 210,367,537 (+)NCBI
Rnor_6.02225,827,504 - 225,847,876 (+)NCBI
Rnor_5.02243,862,903 - 243,883,275 (+)NCBI
RGSC_v3.42218,895,434 - 218,915,491 (+)RGD
Celera2202,777,122 - 202,797,150 (+)RGD
RefSeq Acc Id: NP_059001   ⟸   NM_017305
- UniProtKB: P48508 (UniProtKB/Swiss-Prot),   A6HVF9 (UniProtKB/TrEMBL),   Q2VC85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018343   ⟸   ENSRNOT00000018343
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48508-F1-model_v2 AlphaFold P48508 1-274 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691722
Promoter ID:EPDNEW_R2247
Type:initiation region
Description:glutamate cysteine ligase, modifier subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,827,478 - 225,827,538EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619871 AgrOrtholog
BioCyc Gene G2FUF-51379 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
Ensembl Genes ENSRNOG00000013409 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055026913 UniProtKB/Swiss-Prot
  ENSRNOG00060002796 UniProtKB/Swiss-Prot
  ENSRNOG00065023096 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018343 ENTREZGENE
  ENSRNOT00000018343.5 UniProtKB/Swiss-Prot
  ENSRNOT00055046467 UniProtKB/Swiss-Prot
  ENSRNOT00060004493 UniProtKB/Swiss-Prot
  ENSRNOT00065039464 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gclm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29739 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13295 UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gclm PhenoGen
RatGTEx ENSRNOG00000013409 RatGTEx
  ENSRNOG00055026913 RatGTEx
  ENSRNOG00060002796 RatGTEx
  ENSRNOG00065023096 RatGTEx
Superfamily-SCOP NAD(P)-linked oxidoreductase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC229541
  Q71S94_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Gclm  glutamate cysteine ligase, modifier subunit      Symbol and Name updated 629477 APPROVED
2003-03-14 Gclm  glutamate cysteine ligase, modifier subunit  Glclr  Glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory  Data merged from RGD:2701 628472 PROVISIONAL
2002-08-07 Gclm        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Glclr  Glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 274 amino acids; 30.5 kDa 632726