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Gene: Gclm (glutamate cysteine ligase, modifier subunit) Rattus norvegicus
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Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
Description: Exhibits glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding activity; and protein heterodimerization activity. Involved in several processes, including aging; cellular response to growth factor stimulus; and response to gonadotropin. Localizes to the glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase) regulatory; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase modifier subunit
Orthologs:
Homo sapiens (human) : GCLM (glutamate-cysteine ligase modifier subunit)  HGNC  Alliance
Mus musculus (house mouse) : Gclm (glutamate-cysteine ligase, modifier subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclm (glutamate-cysteine ligase modifier subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLM (glutamate-cysteine ligase modifier subunit)
Canis lupus familiaris (dog) : GCLM (glutamate-cysteine ligase modifier subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclm (glutamate-cysteine ligase modifier subunit)
Sus scrofa (pig) : GCLM (glutamate-cysteine ligase modifier subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gclm
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619871
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.