Gls2 (glutaminase 2) - Rat Genome Database

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Gene: Gls2 (glutaminase 2) Rattus norvegicus
Analyze
Symbol: Gls2
Name: glutaminase 2
RGD ID: 620359
Description: Predicted to enable glutaminase activity. Predicted to be involved in L-glutamine catabolic process and glutamate biosynthetic process. Predicted to act upstream of or within reactive oxygen species metabolic process and regulation of apoptotic process. Predicted to be located in mitochondrion. Orthologous to human GLS2 (glutaminase 2); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ga; GLS; glutaminase 2 (liver, mitochondrial); glutaminase liver isoform, mitochondrial; glutaminase variant 2; glutaminase variant 3; glutaminase variant 4; glutaminase variant 5; glutaminase variant 6; glutaminase variant 8; L-glutaminase; L-glutamine amidohydrolase; liver mitochondrial glutaminase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,201,757 - 1,218,014 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,201,838 - 1,218,013 (+)EnsemblGRCr8
mRatBN7.27617,252 - 633,424 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7617,288 - 633,426 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,375,756 - 3,391,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,251,772 - 5,267,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,553,463 - 5,569,719 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,605,679 - 2,621,853 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)Ensemblrn6Rnor6.0
Rnor_5.072,584,594 - 2,600,729 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,484,397 - 1,495,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7495,890 - 511,971 (+)NCBICelera
RGSC_v3.171,484,396 - 1,495,283 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diiodine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
imipramine  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter. Chung-Bok MI, etal., Biochem J 1997 May 15;324 ( Pt 1):193-200.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Molecular cloning of a cDNA for rat hepatic glutaminase. Sequence similarity to kidney-type glutaminase. Smith EM and Watford M, J Biol Chem 1990 Jun 25;265(18):10631-6.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18614015   PMID:20351271   PMID:22679499   PMID:24270810   PMID:25065305   PMID:25297978   PMID:26316108   PMID:29476059   PMID:34111670  


Genomics

Comparative Map Data
Gls2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,201,757 - 1,218,014 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,201,838 - 1,218,013 (+)EnsemblGRCr8
mRatBN7.27617,252 - 633,424 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7617,288 - 633,426 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,375,756 - 3,391,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,251,772 - 5,267,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,553,463 - 5,569,719 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,605,679 - 2,621,853 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)Ensemblrn6Rnor6.0
Rnor_5.072,584,594 - 2,600,729 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,484,397 - 1,495,283 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7495,890 - 511,971 (+)NCBICelera
RGSC_v3.171,484,396 - 1,495,283 (+)NCBI
Cytogenetic Map7q11NCBI
GLS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,470,952 - 56,488,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,470,944 - 56,488,414 (-)Ensemblhg38GRCh38
GRCh371256,864,736 - 56,881,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,151,003 - 55,168,448 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1256,518,105 - 56,535,542 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,903,771 - 53,921,163 (-)NCBIHuRef
CHM1_11256,832,389 - 56,849,813 (-)NCBICHM1_1
T2T-CHM13v2.01256,438,665 - 56,455,831 (-)NCBIT2T-CHM13v2.0
Gls2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,030,504 - 128,045,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,030,326 - 128,045,873 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,194,635 - 128,210,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,194,457 - 128,210,004 (+)Ensemblmm10GRCm38
MGSCv3710127,631,691 - 127,647,060 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,597,639 - 127,612,883 (+)NCBIMGSCv36mm8
Celera10130,589,515 - 130,604,841 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.44NCBI
Gls2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,050,674 - 4,065,322 (-)Ensembl
ChiLan1.0NW_0049554584,055,088 - 4,065,307 (-)NCBIChiLan1.0ChiLan1.0
GLS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,842,942 - 37,861,603 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,839,707 - 37,858,368 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,426,264 - 32,443,690 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,678,814 - 32,696,694 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,678,814 - 32,696,694 (+)EnsemblpanPan2panpan1.1
GLS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110722,105 - 737,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10722,202 - 737,753 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10785,318 - 800,983 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010731,085 - 746,763 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10731,091 - 746,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110708,149 - 723,814 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010951,254 - 966,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,074,979 - 1,090,642 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gls2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,028,150 - 58,044,275 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646823,682 - 842,199 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936646825,957 - 842,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,806,406 - 21,820,001 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1521,806,405 - 21,820,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,529,902 - 23,543,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,430,345 - 52,448,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,427,919 - 52,448,463 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037193,533,565 - 193,552,090 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gls2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,545,142 - 11,561,942 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480211,545,196 - 11,559,851 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Gls2
146 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:48
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000018737
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH130821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27633,186 - 633,377 (+)MAPPERmRatBN7.2
Rnor_6.072,621,616 - 2,621,806NCBIRnor6.0
Rnor_5.072,600,492 - 2,600,682UniSTSRnor5.0
RGSC_v3.471,495,050 - 1,495,240UniSTSRGSC3.4
Celera7511,734 - 511,924UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 80 59 6 344 180 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L76175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000018737   ⟹   ENSRNOP00000018737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,864 - 1,218,011 (+)Ensembl
mRatBN7.2 Ensembl7617,288 - 633,423 (+)Ensembl
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095875   ⟹   ENSRNOP00000087957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,848 - 1,218,013 (+)Ensembl
mRatBN7.2 Ensembl7617,478 - 633,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099901   ⟹   ENSRNOP00000091564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,857 - 1,218,012 (+)Ensembl
mRatBN7.2 Ensembl7622,140 - 633,426 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104921   ⟹   ENSRNOP00000076539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,863 - 1,218,012 (+)Ensembl
mRatBN7.2 Ensembl7617,478 - 633,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105072   ⟹   ENSRNOP00000092457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,864 - 1,218,011 (+)Ensembl
mRatBN7.2 Ensembl7617,288 - 633,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108866   ⟹   ENSRNOP00000081355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,838 - 1,218,013 (+)Ensembl
mRatBN7.2 Ensembl7617,288 - 633,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108990   ⟹   ENSRNOP00000097147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,202,321 - 1,217,747 (+)Ensembl
mRatBN7.2 Ensembl7617,730 - 633,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110409   ⟹   ENSRNOP00000097543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,202,069 - 1,217,747 (+)Ensembl
mRatBN7.2 Ensembl7617,478 - 633,157 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113202   ⟹   ENSRNOP00000097539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,201,838 - 1,218,013 (+)Ensembl
mRatBN7.2 Ensembl7617,288 - 633,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115333   ⟹   ENSRNOP00000087936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,202,069 - 1,217,747 (+)Ensembl
mRatBN7.2 Ensembl7617,478 - 633,157 (+)Ensembl
RefSeq Acc Id: NM_001270786   ⟹   NP_001257715
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,201,879 - 1,218,014 (+)NCBI
mRatBN7.27617,288 - 633,424 (+)NCBI
Rnor_6.072,605,719 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Celera7495,890 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270787   ⟹   NP_001257716
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,201,879 - 1,218,014 (+)NCBI
mRatBN7.27617,288 - 633,424 (+)NCBI
Rnor_6.072,605,719 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Celera7495,890 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138904   ⟹   NP_620259
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,207,124 - 1,218,014 (+)NCBI
mRatBN7.27622,534 - 633,424 (+)NCBI
Rnor_6.072,610,963 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
RGSC_v3.471,484,397 - 1,495,283 (+)RGD
Celera7501,081 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240728   ⟹   XP_006240790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,201,757 - 1,218,014 (+)NCBI
mRatBN7.27617,484 - 633,157 (+)NCBI
Rnor_6.072,605,679 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240730   ⟹   XP_006240792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,202,173 - 1,218,014 (+)NCBI
mRatBN7.27617,559 - 633,424 (+)NCBI
Rnor_6.072,605,991 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594652   ⟹   XP_017450141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,201,757 - 1,218,014 (+)NCBI
mRatBN7.27617,252 - 633,424 (+)NCBI
Rnor_6.072,605,679 - 2,621,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594653   ⟹   XP_017450142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,202,159 - 1,218,014 (+)NCBI
mRatBN7.27617,568 - 633,424 (+)NCBI
Rnor_6.072,606,053 - 2,621,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078386   ⟹   XP_038934314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,202,159 - 1,218,014 (+)NCBI
mRatBN7.27617,568 - 633,424 (+)NCBI
RefSeq Acc Id: XM_039078387   ⟹   XP_038934315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,202,170 - 1,218,014 (+)NCBI
mRatBN7.27617,570 - 633,424 (+)NCBI
RefSeq Acc Id: NP_620259   ⟸   NM_138904
- Peptide Label: isoform 3
- UniProtKB: A6KSA7 (UniProtKB/TrEMBL),   A0A8I6AH34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257716   ⟸   NM_001270787
- Peptide Label: isoform 2
- UniProtKB: A0A0H2UHL2 (UniProtKB/TrEMBL),   A0A8I6AH34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257715   ⟸   NM_001270786
- Peptide Label: isoform 1
- UniProtKB: Q5FVU0 (UniProtKB/Swiss-Prot),   Q3MHS6 (UniProtKB/Swiss-Prot),   Q64606 (UniProtKB/Swiss-Prot),   P28492 (UniProtKB/Swiss-Prot),   A0A0S2EF23 (UniProtKB/TrEMBL),   A0A8I6GM40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240790   ⟸   XM_006240728
- Peptide Label: isoform X1
- UniProtKB: A0A0S2EF05 (UniProtKB/TrEMBL),   A0A8I6GM40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240792   ⟸   XM_006240730
- Peptide Label: isoform X2
- UniProtKB: A6KSA7 (UniProtKB/TrEMBL),   A0A8I6AH34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450141   ⟸   XM_017594652
- Peptide Label: isoform X3
- UniProtKB: A0A0S2EF12 (UniProtKB/TrEMBL),   A0A8I6ACB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450142   ⟸   XM_017594653
- Peptide Label: isoform X4
- UniProtKB: A0A0S2EFM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018737   ⟸   ENSRNOT00000018737
RefSeq Acc Id: XP_038934314   ⟸   XM_039078386
- Peptide Label: isoform X5
- UniProtKB: A6KSA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934315   ⟸   XM_039078387
- Peptide Label: isoform X5
- UniProtKB: A6KSA8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097147   ⟸   ENSRNOT00000108990
Ensembl Acc Id: ENSRNOP00000097539   ⟸   ENSRNOT00000113202
Ensembl Acc Id: ENSRNOP00000097543   ⟸   ENSRNOT00000110409
Ensembl Acc Id: ENSRNOP00000081355   ⟸   ENSRNOT00000108866
Ensembl Acc Id: ENSRNOP00000076539   ⟸   ENSRNOT00000104921
Ensembl Acc Id: ENSRNOP00000087936   ⟸   ENSRNOT00000115333
Ensembl Acc Id: ENSRNOP00000092457   ⟸   ENSRNOT00000105072
Ensembl Acc Id: ENSRNOP00000087957   ⟸   ENSRNOT00000095875
Ensembl Acc Id: ENSRNOP00000091564   ⟸   ENSRNOT00000099901
Protein Domains
Glutaminase EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28492-F1-model_v2 AlphaFold P28492 1-602 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694925
Promoter ID:EPDNEW_R5450
Type:initiation region
Name:Gls2_1
Description:glutaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5451  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,605,688 - 2,605,748EPDNEW
RGD ID:13694926
Promoter ID:EPDNEW_R5451
Type:multiple initiation site
Name:Gls2_2
Description:glutaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5450  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,605,879 - 2,605,939EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620359 AgrOrtholog
BioCyc Gene G2FUF-35390 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  GLUTAMINDEG-PWY [L-glutamine degradation I] BioCyc
  PWY-5921 [glutaminyl-tRNAgln biosynthesis via transamidation] BioCyc
BioCyc Pathway Image CITRULBIO-PWY BioCyc
  GLUTAMINDEG-PWY BioCyc
  PWY-5921 BioCyc
Ensembl Genes ENSRNOG00000031612 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018737 ENTREZGENE
  ENSRNOT00000095875 ENTREZGENE
  ENSRNOT00000099901 ENTREZGENE
  ENSRNOT00000104921 ENTREZGENE
  ENSRNOT00000108990 ENTREZGENE
  ENSRNOT00000110409 ENTREZGENE
Gene3D-CATH 1.10.238.210 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
  3.40.710.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7326030 IMAGE-MGC_LOAD
  IMAGE:7369495 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot
  Glutaminase UniProtKB/Swiss-Prot
  Glutaminase_EF-hand UniProtKB/Swiss-Prot
KEGG Report rno:192268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108591 IMAGE-MGC_LOAD
  MGC:124940 IMAGE-MGC_LOAD
NCBI Gene 192268 ENTREZGENE
PANTHER GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR12544 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  EF-hand_14 UniProtKB/Swiss-Prot
  Glutaminase UniProtKB/Swiss-Prot
PhenoGen Gls2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031612 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF56601 UniProtKB/Swiss-Prot
UniProt A0A0H2UHL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF05 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF12 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF23 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF49_RAT UniProtKB/TrEMBL
  A0A0S2EFM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSS2_RAT UniProtKB/TrEMBL
  A0A8I6ACB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM40 ENTREZGENE, UniProtKB/TrEMBL
  A6KSA7 ENTREZGENE, UniProtKB/TrEMBL
  A6KSA8 ENTREZGENE, UniProtKB/TrEMBL
  GLSL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3MHS6 ENTREZGENE
  Q5FVU0 ENTREZGENE
  Q64606 ENTREZGENE
UniProt Secondary Q3MHS6 UniProtKB/Swiss-Prot
  Q5FVU0 UniProtKB/Swiss-Prot
  Q64606 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Gls2  glutaminase 2  Gls2  glutaminase 2 (liver, mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gls2  glutaminase 2 (liver, mitochondrial)  Ga  liver mitochondrial glutaminase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ga  liver mitochondrial glutaminase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the mitochondrial matrix, possibly in loose association with the inner membrane 728635
gene_regulation expressed only after birth and restricted to a small periportal population of hepatocytes 728635