Rnase4 (ribonuclease A family member 4) - Rat Genome Database
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Gene: Rnase4 (ribonuclease A family member 4) Rattus norvegicus
Analyze
Symbol: Rnase4
Name: ribonuclease A family member 4
RGD ID: 61823
Description: Predicted to have ribonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis and cellular response to starvation. Predicted to localize to extracellular space. Orthologous to human RNASE4 (ribonuclease A family member 4); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Rab1; ribonuclease 4; ribonuclease A b1; ribonuclease, RNase A family 4; RL3; RNase 4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01528,018,040 - 28,035,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,018,040 - 28,035,389 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,028,521 - 28,035,389 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,850,396 - 31,866,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,073,756 - 27,090,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11527,089,455 - 27,106,139 (+)NCBI
Celera1524,631,848 - 24,647,995 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
avobenzone  (ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
furan  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
hydroquinone  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Additional References at PubMed
PMID:3467790   PMID:15489334   PMID:23260145   PMID:23376485   PMID:24006456   PMID:24337645  


Genomics

Comparative Map Data
Rnase4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01528,018,040 - 28,035,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,018,040 - 28,035,389 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,028,521 - 28,035,389 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,850,396 - 31,866,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,073,756 - 27,090,441 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11527,089,455 - 27,106,139 (+)NCBI
Celera1524,631,848 - 24,647,995 (+)NCBICelera
Cytogenetic Map15p14NCBI
RNASE4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1420,684,560 - 20,701,216 (+)EnsemblGRCh38hg38GRCh38
GRCh381420,684,560 - 20,701,216 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371421,152,259 - 21,168,761 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,222,212 - 20,238,598 (+)NCBINCBI36hg18NCBI36
Build 341420,226,771 - 20,238,597NCBI
Celera141,013,244 - 1,029,632 (+)NCBI
Cytogenetic Map14q11.2NCBI
HuRef141,273,295 - 1,289,678 (+)NCBIHuRef
CHM1_11421,154,392 - 21,170,777 (+)NCBICHM1_1
Rnase4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,328,534 - 51,343,608 (+)NCBIGRCm39mm39
GRCm381451,091,077 - 51,106,151 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,091,077 - 51,106,151 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,710,752 - 51,725,826 (+)NCBIGRCm37mm9NCBIm37
MGSCv361442,955,672 - 42,970,033 (+)NCBImm8
MGSCv361450,013,147 - 50,028,091 (+)NCBImm8
Celera1447,385,172 - 47,400,997 (+)NCBICelera
Cytogenetic Map14C1NCBI
RNASE4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11419,605,890 - 19,621,987 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,620,758 - 19,621,201 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0141,548,729 - 1,564,819 (+)NCBIMhudiblu_PPA_v0panPan3
RNASE4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1517,981,647 - 18,004,631 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11517,981,661 - 17,998,644 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
RNASE4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,243,687 - 78,262,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,244,284 - 78,244,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNASE4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,216,021 - 21,233,306 (+)NCBI
ChlSab1.1 Ensembl2921,216,477 - 21,232,699 (+)Ensembl

Position Markers
RH127443  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01528,035,009 - 28,035,192NCBIRnor6.0
Rnor_5.01531,866,023 - 31,866,206UniSTSRnor5.0
RGSC_v3.41527,090,059 - 27,090,242UniSTSRGSC3.4
Celera1524,647,613 - 24,647,796UniSTS
Cytogenetic Map15p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151582824233657761Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152102134241082727Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152377896946825072Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:67
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000041495
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 46 46 46 2
Low 6 23 52 34 26 34 9 12 29 25 38 19 9
Below cutoff 52 13 2 9 2 7 10 68 41 33 3 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01082896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01082897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC114343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HG328957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000041495   ⟹   ENSRNOP00000043003
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,018,040 - 28,035,389 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089631   ⟹   ENSRNOP00000073131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,028,521 - 28,035,389 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090272   ⟹   ENSRNOP00000069341
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,023,018 - 28,034,590 (+)Ensembl
RefSeq Acc Id: NM_020082   ⟹   NP_064467
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,018,040 - 28,035,391 (+)NCBI
Rnor_5.01531,850,396 - 31,866,409 (+)NCBI
RGSC_v3.41527,073,756 - 27,090,441 (+)RGD
Celera1524,631,848 - 24,647,995 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251906   ⟹   XP_006251968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,022,982 - 28,035,395 (+)NCBI
Rnor_5.01531,850,396 - 31,866,409 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251907   ⟹   XP_006251969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,032,611 - 28,035,395 (+)NCBI
Rnor_5.01531,850,396 - 31,866,409 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064467   ⟸   NM_020082
- Peptide Label: precursor
- UniProtKB: O55004 (UniProtKB/Swiss-Prot),   W0UVG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251968   ⟸   XM_006251906
- Peptide Label: isoform X1
- UniProtKB: O55004 (UniProtKB/Swiss-Prot),   W0UVG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251969   ⟸   XM_006251907
- Peptide Label: isoform X1
- UniProtKB: O55004 (UniProtKB/Swiss-Prot),   W0UVG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073131   ⟸   ENSRNOT00000089631
RefSeq Acc Id: ENSRNOP00000069341   ⟸   ENSRNOT00000090272
RefSeq Acc Id: ENSRNOP00000043003   ⟸   ENSRNOT00000041495
Protein Domains
RNAse_Pc

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699629
Promoter ID:EPDNEW_R10151
Type:initiation region
Name:Rnase4_1
Description:ribonuclease A family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10152  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,017,985 - 28,018,045EPDNEW
RGD ID:13699642
Promoter ID:EPDNEW_R10152
Type:multiple initiation site
Name:Rnase4_2
Description:ribonuclease A family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10151  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,022,993 - 28,023,053EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61823 AgrOrtholog
Ensembl Genes ENSRNOG00000025625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000051860 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043003 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069341 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073131 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041495 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089631 UniProtKB/TrEMBL
  ENSRNOT00000090272 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10580 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103267 IMAGE-MGC_LOAD
  IMAGE:7372999 IMAGE-MGC_LOAD
InterPro ATPase_V1-cplx_f_g_su UniProtKB/TrEMBL
  ATPase_V1-cplx_fsu_euk UniProtKB/TrEMBL
  ATPase_V1_fsu_sf UniProtKB/TrEMBL
  RNaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56759 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187485 IMAGE-MGC_LOAD
  MGC:91709 IMAGE-MGC_LOAD
NCBI Gene 56759 ENTREZGENE
PANTHER PTHR11437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-synt_F UniProtKB/TrEMBL
  RnaseA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnase4 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF159468 UniProtKB/TrEMBL
  SSF54076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233653
TIGRFAMs V_ATP_synt_F UniProtKB/TrEMBL
UniGene Rn.1742 ENTREZGENE
UniProt B2GUW7_RAT UniProtKB/TrEMBL
  O55004 ENTREZGENE, UniProtKB/Swiss-Prot
  W0UVG1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rnase4  ribonuclease A family member 4  Rnase4  ribonuclease, RNase A family 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rnase4  ribonuclease, RNase A family 4       Name updated 70584 APPROVED
2001-07-23 Rnase4  ibonuclease, RNase A family 4      Name withdrawn 67952 WITHDRAWN
2001-07-23 Rnase4  ribonuclease, RNase A family 4      Name withdrawn 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 61732