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Gene: Sfrp1 (secreted frizzled-related protein 1) Rattus norvegicus
Symbol: Sfrp1
Name: secreted frizzled-related protein 1
RGD ID: 621074
Description: Predicted to have several functions, including Wnt-protein binding activity; frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of osteoclast differentiation; and osteoblast differentiation. Predicted to localize to several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human SFRP1 (secreted frizzled related protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 3-aminobenzamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: sFRP-1
Homo sapiens (human) : SFRP1 (secreted frizzled related protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Sfrp1 (secreted frizzled-related protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sfrp1 (secreted frizzled related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SFRP1 (secreted frizzled related protein 1)
Canis lupus familiaris (dog) : SFRP1 (secreted frizzled related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sfrp1 (secreted frizzled related protein 1)
Sus scrofa (pig) : SFRP1 (secreted frizzled related protein 1)
Chlorocebus sabaeus (African green monkey) : SFRP1 (secreted frizzled related protein 1)
Heterocephalus glaber (naked mole-rat) : Sfrp1 (secreted frizzled related protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01673,372,007 - 73,410,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,372,007 - 73,410,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,006,739 - 73,045,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,030,458 - 73,067,304 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,031,966 - 73,066,892 (-)NCBI
Celera1666,467,691 - 66,505,810 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sfrp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621074
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.