Hal (histidine ammonia lyase) - Rat Genome Database

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Gene: Hal (histidine ammonia lyase) Rattus norvegicus
Analyze
Symbol: Hal
Name: histidine ammonia lyase
RGD ID: 68363
Description: Enables histidine ammonia-lyase activity. Predicted to be involved in L-histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Orthologous to human HAL (histidine ammonia-lyase); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histidase; histidine ammonia-lyase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,894,495 - 29,924,744 (+)NCBIGRCr8
mRatBN7.2728,007,449 - 28,037,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,006,972 - 28,037,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx729,997,815 - 30,028,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,160,030 - 32,190,285 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,934,946 - 31,965,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,326,087 - 34,356,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,326,087 - 34,356,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,391,142 - 34,421,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,520,913 - 30,551,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,541,183 - 30,571,416 (+)NCBI
Celera725,107,998 - 25,136,986 (+)NCBICelera
RH 3.4 Map7191.8RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (EXP)
corn oil  (EXP)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fenofibrate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
fonofos  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
gliotoxin  (EXP)
graphite  (EXP)
hexadecanoic acid  (ISO)
imipramine  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methoxsalen  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
sanguinarine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Isolation of a rat histidase cDNA sequence and expression in Escherichia coli--evidence of extrahepatic/epidermal distribution. Sano H, etal., Eur J Biochem 1997 Nov 15;250(1):212-21.
13. Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases. Taylor RG, etal., J Biol Chem 1990 Oct 25;265(30):18192-9.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Soy protein, casein, and zein regulate histidase gene expression by modulating serum glucagon. Tovar AR, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E1016-22.
Additional References at PubMed
PMID:7961661   PMID:8486363   PMID:12477932   PMID:15741241   PMID:15806399  


Genomics

Comparative Map Data
Hal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,894,495 - 29,924,744 (+)NCBIGRCr8
mRatBN7.2728,007,449 - 28,037,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,006,972 - 28,037,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx729,997,815 - 30,028,068 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,160,030 - 32,190,285 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,934,946 - 31,965,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,326,087 - 34,356,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,326,087 - 34,356,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,391,142 - 34,421,405 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,520,913 - 30,551,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,541,183 - 30,571,416 (+)NCBI
Celera725,107,998 - 25,136,986 (+)NCBICelera
RH 3.4 Map7191.8RGD
Cytogenetic Map7q13NCBI
HAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,972,662 - 95,996,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,972,662 - 95,996,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371296,366,440 - 96,390,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,891,273 - 94,914,202 (-)NCBINCBI36Build 36hg18NCBI36
Build 341294,869,609 - 94,892,539NCBI
Celera1296,033,432 - 96,056,362 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,428,306 - 93,452,016 (-)NCBIHuRef
CHM1_11296,331,432 - 96,355,134 (-)NCBICHM1_1
T2T-CHM13v2.01295,946,669 - 95,970,341 (-)NCBIT2T-CHM13v2.0
Hal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,324,630 - 93,352,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,324,630 - 93,355,166 (+)EnsemblGRCm39 Ensembl
GRCm381093,488,768 - 93,516,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,488,768 - 93,519,304 (+)EnsemblGRCm38mm10GRCm38
MGSCv371092,951,513 - 92,979,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361093,707,053 - 93,735,128 (+)NCBIMGSCv36mm8
MGSCv361092,918,567 - 92,946,542 (+)NCBIMGSCv36mm8
Celera1095,474,543 - 95,502,727 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.49NCBI
Hal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,316,326 - 32,341,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540532,317,345 - 32,341,409 (-)NCBIChiLan1.0ChiLan1.0
HAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210104,043,373 - 104,067,070 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112104,039,763 - 104,063,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,561,401 - 93,585,215 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,950,020 - 96,973,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,950,020 - 96,973,662 (-)Ensemblpanpan1.1panPan2
HAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,767,314 - 35,791,086 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,759,672 - 35,791,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,153,957 - 36,177,503 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,432,429 - 36,455,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,433,070 - 36,455,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,705,313 - 35,728,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,799,841 - 35,823,389 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,063,032 - 36,086,577 (-)NCBIUU_Cfam_GSD_1.0
Hal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,156,940 - 24,178,046 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,058,698 - 12,078,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650712,058,583 - 12,078,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,522,542 - 87,547,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,522,483 - 87,547,489 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,725,402 - 91,751,694 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,343,715 - 91,367,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037153,758,865 - 153,784,917 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,318,511 - 11,343,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475011,318,572 - 11,344,326 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hal
181 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000006971
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat

Markers in Region
RH142423  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8729,908,988 - 29,909,256 (+)Marker Load Pipeline
mRatBN7.2728,021,944 - 28,022,212 (+)MAPPERmRatBN7.2
Rnor_6.0734,340,581 - 34,340,848NCBIRnor6.0
Rnor_5.0734,405,636 - 34,405,903UniSTSRnor5.0
RGSC_v3.4730,535,407 - 30,535,674UniSTSRGSC3.4
Celera725,122,491 - 25,122,758UniSTS
RH 3.4 Map7191.8UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 5 4 51 80 81 59 14 59 6 112 31 36 16 47 22

Sequence


Ensembl Acc Id: ENSRNOT00000006971   ⟹   ENSRNOP00000006971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,006,972 - 28,037,701 (+)Ensembl
Rnor_6.0 Ensembl734,326,087 - 34,356,413 (+)Ensembl
RefSeq Acc Id: NM_017159   ⟹   NP_058855
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8729,894,495 - 29,924,744 (+)NCBI
mRatBN7.2728,007,449 - 28,037,701 (+)NCBI
Rnor_6.0734,326,087 - 34,356,413 (+)NCBI
Rnor_5.0734,391,142 - 34,421,405 (+)NCBI
RGSC_v3.4730,520,913 - 30,551,145 (+)RGD
Celera725,107,998 - 25,136,986 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058855 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63491 (Get FASTA)   NCBI Sequence Viewer  
  AAH89809 (Get FASTA)   NCBI Sequence Viewer  
  BAA24432 (Get FASTA)   NCBI Sequence Viewer  
  BAA24433 (Get FASTA)   NCBI Sequence Viewer  
  EDM16911 (Get FASTA)   NCBI Sequence Viewer  
  EDM16912 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006971.4
GenBank Protein P21213 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058855   ⟸   NM_017159
- UniProtKB: Q5EBB8 (UniProtKB/Swiss-Prot),   P21213 (UniProtKB/Swiss-Prot),   A6IFY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006971   ⟸   ENSRNOT00000006971
Protein Domains
Par3/HAL N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21213-F1-model_v2 AlphaFold P21213 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695146
Promoter ID:EPDNEW_R5671
Type:multiple initiation site
Name:Hal_1
Description:histidine ammonia lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0734,326,031 - 34,326,091EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68363 AgrOrtholog
BioCyc Gene G2FUF-34389 BioCyc
BioCyc Pathway HISHP-PWY [L-histidine degradation VI] BioCyc
  PWY-5030 [L-histidine degradation III] BioCyc
BioCyc Pathway Image HISHP-PWY BioCyc
  PWY-5030 BioCyc
Ensembl Genes ENSRNOG00000004502 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006971.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (N-terminal domain) UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325816 IMAGE-MGC_LOAD
InterPro Aromatic_Lyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HutH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Par3/HAL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phe/His_NH3-lyase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108720 IMAGE-MGC_LOAD
NCBI Gene 29301 ENTREZGENE
PANTHER HISTIDINE AMMONIA-LYASE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Lyase_aromatic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Par3_HAL_N_term UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hal PhenoGen
PROSITE PAL_HISTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004502 RatGTEx
Superfamily-SCOP L-aspartase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC233953
UniProt A6IFY6 ENTREZGENE, UniProtKB/TrEMBL
  A6IFY7_RAT UniProtKB/TrEMBL
  HUTH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB8 ENTREZGENE
UniProt Secondary Q5EBB8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hal  histidine ammonia lyase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol 632935
gene_expression expressed in liver, skin, renal cortex tubular epithelium, fundic mucosal glands of stomach, gastric intramuscular (Auerbach's) plexus, and adrenal cortex 632935
gene_expression expressed in liver and skin 628345
gene_function catalyzes the oxidative deamination of histidine to form urocanic acid 628345
gene_process catabolizes and thereby eliminates excess histidine in liver 628345
gene_regulation enzyme activity is increased by casein, soy or zein diets and is correlated with serum concentrations of glucagon 628345
gene_regulation mRNA in the liver is regulated by the dietary protein content 628345