Mir214 (microRNA 214) - Rat Genome Database

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Gene: Mir214 (microRNA 214) Rattus norvegicus
Analyze
Symbol: Mir214
Name: microRNA 214
RGD ID: 2325548
Description: Predicted to enable mRNA 3'-UTR binding activity; mRNA base-pairing translational repressor activity; and sequence-specific DNA binding activity. Involved in positive regulation of regulatory T cell differentiation. Predicted to be located in nucleus and perinuclear region of cytoplasm. Used to study hypertension and renal hypertension. Orthologous to human MIR214 (microRNA 214); INTERACTS WITH 2-acetamidofluorene; aflatoxin B1; amphetamine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-214
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,121,645 - 77,121,752 (+)NCBIGRCr8
mRatBN7.21374,588,374 - 74,588,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,588,372 - 74,588,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,157,633 - 77,157,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,465,002 - 78,465,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,724,856 - 75,724,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,130,905 - 80,131,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01385,024,815 - 85,024,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis. He Y, etal., Biosci Rep. 2018 Nov 7;38(6). pii: BSR20180895. doi: 10.1042/BSR20180895. Print 2018 Dec 21.
3. MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. Liu Y, etal., J Am Soc Nephrol. 2018 Oct;29(10):2518-2528. doi: 10.1681/ASN.2018020117. Epub 2018 Jul 26.
4. Elevated circulating microRNA-210 levels in patients with hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: a potential new biomarker. Zhang Q, etal., Biomarkers. 2013 Feb;18(1):23-9. doi: 10.3109/1354750X.2012.728624. Epub 2012 Oct 10.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:20403161   PMID:21276775   PMID:21704009   PMID:22426211   PMID:23727574   PMID:23904244   PMID:25755099   PMID:26025394   PMID:26158200   PMID:26646371  
PMID:26692091   PMID:27357906   PMID:27959394   PMID:28298073   PMID:28701356   PMID:29226348   PMID:30504847   PMID:30720150   PMID:30964156   PMID:31373336   PMID:31453981   PMID:31790686  
PMID:31959866   PMID:32003595   PMID:32093712   PMID:32410577   PMID:33040786   PMID:34087284   PMID:34296787   PMID:34530740   PMID:34744059   PMID:35451808   PMID:35988281   PMID:37032493  
PMID:37087800   PMID:38371458   PMID:38631219   PMID:39094924  


Genomics

Comparative Map Data
Mir214
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,121,645 - 77,121,752 (+)NCBIGRCr8
mRatBN7.21374,588,374 - 74,588,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,588,372 - 74,588,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,157,633 - 77,157,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,465,002 - 78,465,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,724,856 - 75,724,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,130,905 - 80,131,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01385,024,815 - 85,024,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map13q22NCBI
MIR214
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,138,798 - 172,138,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,138,798 - 172,138,907 (-)EnsemblGRCh38hg38GRCh38
GRCh371172,107,938 - 172,108,047 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,374,560 - 170,374,669 (-)NCBINCBI36Build 36hg18NCBI36
Celera1145,217,369 - 145,217,478 (-)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,331,930 - 143,332,039 (-)NCBIHuRef
CHM1_11173,530,115 - 173,530,224 (-)NCBICHM1_1
T2T-CHM13v2.01171,495,517 - 171,495,626 (-)NCBIT2T-CHM13v2.0
Mir214
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,050,937 - 162,051,046 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,050,937 - 162,051,046 (+)EnsemblGRCm39 Ensembl
GRCm381162,223,368 - 162,223,477 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,223,368 - 162,223,477 (+)EnsemblGRCm38mm10GRCm38
MGSCv371164,153,499 - 164,153,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1164,673,727 - 164,673,836 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.07NCBI
MIR214
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,818,559 - 26,818,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,818,559 - 26,818,670 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha726,349,187 - 26,349,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,569,331 - 26,569,440 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1726,480,256 - 26,480,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,551,084 - 26,551,193 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,701,038 - 26,701,147 (+)NCBIUU_Cfam_GSD_1.0
MIR214
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9114,527,990 - 114,528,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19114,527,992 - 114,528,101 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,099,461 - 126,099,570 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir214
1 total Variants
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Scn3arno-miR-214-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Arl2rno-miR-214-3pMirtarbaseexternal_infoReporter assayFunctional MTI20007690

Predicted Targets
Summary Value
Count of predictions:15937
Count of gene targets:8427
Count of transcripts:9091
Interacting mature miRNAs:rno-miR-214-3p, rno-miR-214-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat


Related Rat Strains
The following Strains have been annotated to Mir214
SS.BN-(D13Rat151-D13Rat197)-Tg(CAG-Mir214)A/Mcwi     SS.BN-(D13Rat151-D13Rat197)-Tg(CAG-Mir214)B/Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1374,588,372 - 74,588,481 (+)Ensembl
RefSeq Acc Id: NR_031927
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,121,645 - 77,121,752 (+)NCBI
mRatBN7.21374,588,374 - 74,588,481 (+)NCBI
Rnor_6.01380,130,905 - 80,131,014 (+)NCBI
Rnor_5.01385,024,815 - 85,024,924 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-17662 BioCyc
Ensembl Genes ENSRNOG00000035513 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053636 ENTREZGENE
miRBase MI0000954 ENTREZGENE
NCBI Gene 100314055 ENTREZGENE
PhenoGen Mir214 PhenoGen
RatGTEx ENSRNOG00000035513 RatGTEx
RNAcentral URS00002524E1 RNACentral
  URS000075B4CD RNACentral
  URS000075E0F4 RNACentral
  URS00021EDA27 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir214  microRNA 214  Mir214  microRNA mir-214  Name updated 61478 APPROVED
2010-06-02 Mir214  microRNA mir-214      Symbol and Name status set to provisional 70820 PROVISIONAL