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Gene: Nkx6-2 (NK6 homeobox 2) Rattus norvegicus
Symbol: Nkx6-2
Name: NK6 homeobox 2
RGD ID: 1307280
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including neurogenesis; regulation of cell fate commitment; and regulation of myelination. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spastic ataxia 8. Orthologous to human NKX6-2 (NK6 homeobox 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein Nkx-6.2; LOC309095; NK6 transcription factor related, locus 2; NK6 transcription factor related, locus 2 (Drosophila)
Homo sapiens (human) : NKX6-2 (NK6 homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : Nkx6-2 (NK6 homeobox 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx6-2 (NK6 homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX6-2 (NK6 homeobox 2)
Canis lupus familiaris (dog) : NKX6-2 (NK6 homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx6-2 (NK6 homeobox 2)
Sus scrofa (pig) : NKX6-2 (NK6 homeobox 2)
Chlorocebus sabaeus (African green monkey) : NKX6-2 (NK6 homeobox 2)
Heterocephalus glaber (naked mole-rat) : Nkx6-2 (NK6 homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01211,922,389 - 211,923,929 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,922,389 - 211,923,929 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,843,804 - 218,847,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41199,397,361 - 199,398,901 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11199,547,331 - 199,548,851 (-)NCBI
Celera1192,060,331 - 192,061,871 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nkx6-2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307280
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.