Rrm1 (ribonucleotide reductase catalytic subunit M1)

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Gene: Rrm1 (ribonucleotide reductase catalytic subunit M1) Rattus norvegicus

Analyze

Symbol:

Rrm1

Name:

ribonucleotide reductase catalytic subunit M1

RGD ID:

1592569

Description:

Predicted to enable several functions, including ATP binding activity; disordered domain specific binding activity; and identical protein binding activity. Involved in several processes, including male gonad development; pyrimidine nucleobase metabolic process; and response to ionizing radiation. Located in cell projection; neuronal cell body; and nuclear envelope. Biomarker of visual epilepsy. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC685579; MGC94742; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase M1; similar to ribonucleotide reductase M1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RRM1 (ribonucleotide reductase catalytic subunit M1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rrm1 (ribonucleotide reductase M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rrm1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RRM1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RRM1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rrm1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RRM1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RRM1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rrm1 (ribonucleotide reductase catalytic subunit M1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Rrm1 (ribonucleotide reductase M1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RRM1 (ribonucleotide reductase catalytic subunit M1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rrm1 (ribonucleotide reductase M1 polypeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RNR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RnrL	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rnr-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RNR3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rrm1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Rrm1-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Note: NCBI's current annotation of the functional gene (chromosome 1) and a pseudogene (chromosome 14) are not consistent on all assemblies. The functional gene on the Celera assembly is currently annotated with the GeneID of the pseudogene on chromosome 14. [17 Jun 2014]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	156,823,960 - 156,848,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,823,960 - 156,848,261 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,801,707 - 164,826,040 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,981,799 - 172,006,127 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,859,508 - 164,883,799 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	167,538,387 - 167,562,688 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	167,538,263 - 167,562,688 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,726,994 - 173,751,295 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,930,994 - 159,937,860 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	154,890,871 - 154,915,173 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenocortical carcinoma (ISO)

Animal Disease Models (ISO)

delta beta-thalassemia (ISO)

Disease Progression (ISO)

Experimental Liver Neoplasms (IEP)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

neural tube defect (ISO)

visual epilepsy (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-carotene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

corticosterone (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-tocopherol (ISO)

gefitinib (ISO)

gemcitabine (ISO)

graphite (ISO)

hydrogen peroxide (ISO)

indometacin (EXP)

ivermectin (ISO)

lead(0) (ISO)

lidocaine (EXP)

menadione (ISO)

methimazole (EXP)

methylseleninic acid (ISO)

Mitotane (ISO)

N-nitrosodiethylamine (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

progesterone (ISO)

quercetin (ISO)

quinoline (ISO)

raloxifene (ISO)

resveratrol (ISO)

SB 431542 (ISO)

senecionine (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP,ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tocopherol (ISO)

toluene 2,4-diisocyanate (ISO)

topotecan (EXP)

tributylstannane (EXP)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2'-deoxyribonucleotide biosynthetic process (ISO)

cell proliferation in forebrain (IEP)

deoxyribonucleotide biosynthetic process (IBA,ISO)

DNA repair (ISO)

male gonad development (IEP)

mitochondrial DNA replication (ISO)

positive regulation of G0 to G1 transition (ISO)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

positive regulation of G2/M transition of mitotic cell cycle (ISO)

protein heterotetramerization (ISO)

pyrimidine nucleobase metabolic process (IEP)

response to ionizing radiation (IEP)

retina development in camera-type eye (IEP)

ribonucleoside diphosphate metabolic process (ISO)

Cellular Component

cell projection (IDA)

cytosol (ISO)

mitochondrion (IEA)

neuronal cell body (IDA)

nuclear envelope (IDA)

ribonucleoside-diphosphate reductase complex (IBA,ISO)

Molecular Function

ATP binding (IBA)

disordered domain specific binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

purine nucleotide binding (ISO)

ribonucleoside-diphosphate reductase activity (ISO)

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

glutathione metabolic pathway (IEA)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (IEA,ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

pyrimidine metabolic pathway (IEA)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients.	Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
2.	Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.	Daino K, etal., Int J Cancer. 2009 Aug 1;125(3):612-20.
3.	Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats.	Dragan YP, etal., Mol Carcinog. 2004 Jul;40(3):150-9.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Insulin-like growth factor I in the developing and mature rat testis: immunohistochemical aspects.	Hansson HA, etal., Biol Reprod. 1989 Jun;40(6):1321-8.
6.	Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina.	Hansson HA, etal., Exp Eye Res. 1989 Mar;48(3):411-20.
7.	The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo.	Manjeshwar S, etal., Mol Carcinog. 1999 Mar;24(3):188-96.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein.	Sikorska M, etal., Biochem Cell Biol. 1990 May;68(5):880-8.
14.	Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats.	Youdale T, etal., Can J Biochem Cell Biol. 1984 Sep;62(9):914-9.
15.	Visualization of proliferating cells in the adult mammalian brain with the aid of ribonucleotide reductase.	Zhu H, etal., Brain Res. 2003 Jul 11;977(2):180-9.
16.	Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU.	Zhu H, etal., Brain Res. 2005 Mar 2;1036(1-2):7-17.

Additional References at PubMed

PMID:8130196	PMID:12477932	PMID:15632090	PMID:16861739	PMID:17726094	PMID:19176520	PMID:21336276	PMID:21925507	PMID:23376485	PMID:25416956

Genomics

Comparative Map Data

Rrm1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	156,823,960 - 156,848,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,823,960 - 156,848,261 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,801,707 - 164,826,040 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,981,799 - 172,006,127 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,859,508 - 164,883,799 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	167,538,387 - 167,562,688 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	167,538,263 - 167,562,688 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,726,994 - 173,751,295 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,930,994 - 159,937,860 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	154,890,871 - 154,915,173 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

RRM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	4,094,685 - 4,138,932 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	4,094,707 - 4,138,932 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	4,115,915 - 4,160,162 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	4,072,500 - 4,116,682 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	4,072,586 - 4,116,681	NCBI
Celera	11	4,120,880 - 4,164,701 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	3,849,345 - 3,893,165 (+)	NCBI		HuRef
CHM1_1	11	4,115,391 - 4,159,561 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	4,159,950 - 4,204,024 (+)	NCBI		T2T-CHM13v2.0

Rrm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	102,090,902 - 102,118,978 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	102,090,902 - 102,118,978 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	102,441,695 - 102,469,771 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	102,441,695 - 102,469,771 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	109,590,209 - 109,618,285 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	102,315,688 - 102,342,747 (+)	NCBI		MGSCv36	mm8
Celera	7	102,809,638 - 102,837,567 (+)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	54.72	NCBI

Rrm1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,850,530 - 19,905,266 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	19,850,523 - 19,904,879 (+)	NCBI	ChiLan1.0	ChiLan1.0

RRM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	11	5,588,407 - 5,632,547 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	3,956,528 - 3,999,205 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	4,068,119 - 4,110,474 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	4,068,119 - 4,110,474 (+)	Ensembl	panpan1.1		panPan2

RRM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	26,595,838 - 26,631,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	26,595,914 - 26,631,135 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	26,365,162 - 26,400,602 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,805,233 - 26,840,936 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,805,323 - 26,840,930 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	26,595,614 - 26,630,876 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,811,885 - 26,847,337 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,714,390 - 26,749,830 (+)	NCBI		UU_Cfam_GSD_1.0

Rrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,215,865 - 59,249,179 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	815,399 - 848,793 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936498	815,401 - 848,749 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,025,073 - 6,065,143 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,026,151 - 6,065,211 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	6,818,979 - 6,880,069 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RRM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	62,606,112 - 62,649,979 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	62,604,486 - 62,650,200 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	63,252,138 - 63,296,602 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rrm1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	5,523,665 - 5,568,994 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	5,523,648 - 5,568,997 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rrm1
47 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	290
Count of miRNA genes:	188
Interacting mature miRNAs:	208
Transcripts:	ENSRNOT00000074058
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
634315	Niddm45	Non-insulin dependent diabetes mellitus QTL 45	7.16		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	144267916	172949660	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
1582204	Livw1	Liver weight QTL 1	3.6	0.0003	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	1	155422851	172949803	Rat
4889419	Cstrr2	Cold stress response QTL 2		0.05	urine catecholamine amount (VT:0010502)	absolute change in urine norepinephrine level (CMO:0001634)	1	155866514	158592016	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	156677124	176484451	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat

Markers in Region

BI279462

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	156,847,740 - 156,847,913 (+)	MAPPER	mRatBN7.2
mRatBN7.2	14	72,179,804 - 72,179,977 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	76,911,798 - 76,911,970	NCBI	Rnor6.0
Rnor_6.0	1	167,562,167 - 167,562,339	NCBI	Rnor6.0
Rnor_5.0	14	76,896,190 - 76,896,362	UniSTS	Rnor5.0
Rnor_5.0	1	173,750,774 - 173,750,946	UniSTS	Rnor5.0
RGSC_v3.4	14	77,411,056 - 77,411,228	UniSTS	RGSC3.4
Celera	14	71,132,095 - 71,132,267	UniSTS
Celera	1	154,914,652 - 154,914,824	UniSTS
RH 3.4 Map	1	1275.7	UniSTS
Cytogenetic Map	1	q32	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	47	31	19	31	8	11	74	35	41	11	8
Low			10	10		10
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000074058 ⟹ ENSRNOP00000064166

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,823,960 - 156,848,261 (+)	Ensembl
Rnor_6.0 Ensembl	1	167,538,263 - 167,562,688 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093070 ⟹ ENSRNOP00000075981

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,824,317 - 156,825,141 (+)	Ensembl
Rnor_6.0 Ensembl	1	167,538,744 - 167,539,568 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093112 ⟹ ENSRNOP00000076052

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	167,539,036 - 167,546,917 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113303 ⟹ ENSRNOP00000076633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	156,823,960 - 156,848,261 (+)	Ensembl

RefSeq Acc Id:

NM_001013236 ⟹ NP_001013254

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	156,823,960 - 156,848,262 (+)	NCBI
Rnor_6.0	1	167,538,387 - 167,562,688 (+)	NCBI
Rnor_5.0	1	173,726,994 - 173,751,295 (+)	NCBI
Celera	1	154,890,871 - 154,915,173 (+)	RGD

Sequence:

show sequence

CGGGTGGCGGGAGCGGGAAGGAGTTCGTAATTTGGTTCGTCCCTTCTGGAGGAGAAAGTGCTGT
CTGTCCGGCAGTTTCAACCTCTCGGTCTGAGCGGCCCCTAAGGAGTCCAACCCTTCACATCTGA
CAGTCGTCTCTATCCTATCTTCGCCTCGGAGCTGCTAACTGGTCTCGAACCCCTCAGCACTTCA
GCTTCTAGCGGCGATGCATGTGATCAAGCGAGATGGCCGCCAAGAGCGAGTTATGTTTGACAAA
ATTACATCCCGAATCCAGAAACTCTGTTATGGACTCAATATGGACTTTGTGGATCCTGCTCAGA
TCACCATGAAAGTAATCCAAGGCCTATACAGTGGGGTCACCACAGTGGAACTGGACACCCTGGC
TGCTGAGACAGCTGCCACCTTGACTACGAAGCACCCTGACTATGCCATCCTGGCAGCAAGGATC
GCTGTCTCTAACTTGCACAAGGAAACAAAGAAAGTGTTCAGTGACGTGATGGAGGATCTCTACA
ACTACATAAATCCACACAACGGCAGACATTCTCCCATGGTGGCCAGCTCAACACTCGAGATTGT
TATGGCCCATAAGGATCGCCTGAATTCTGCCATTATCTATGACCGGGATTTCTCTTACAACTAC
TTTGGTTTTAAGACACTGGAACGGTCATATTTGTTGAAGATCAATGGAAAAGTGGCTGAAAGAC
CACAGCACATGTTGATGAGGGTATCTGTGGGGATTCACAAAGAAGATATTGATGCTGCAATTGA
AACATACAATCTACTTTCTGAGAAGTGGTTTACTCACGCCTCTCCGACTCTCTTCAATGCTGGG
ACCAACCGCCCACAGTTGTCCAGCTGTTTCCTCTTGAGTATGAAAGATGACAGCATTGAGGGGA
TTTATGATACTCTGAAGCAGTGTGCCTTGATTTCTAAGTCTGCTGGAGGAATTGGTGTTGCCGT
GAGTTGTATTCGGGCCACTGGCAGCTACATTGCTGGGACTAATGGCAATTCTAATGGCCTTGTG
CCAATGCTGAGAGTCTATAACAACACAGCTCGTTATGTGGATCAAGGTGGAAACAAGCGCCCAG
GGGCATTTGCTATTTACCTGGAGCCTTGGCACCTGGACATCTTTGAGTTTCTTGACTTGAAGAA
GAACACAGGCAAGGAAGAACAGCGCGCGCGGGATCTCTTCTTTGCACTGTGGATCCCAGATCTC
TTCATGAAGCGAGTGGAGACCAACCAGGACTGGTCACTGATGTGTCCCAATGAGTGTCCTGGTC
TGGACGAGGTCTGGGGAGAGGAGTTTGAGAAGTTATATGAAAGTTACGAGAAGCAGGGCCGTGT
CCGAAAAGTTGTGAAGGCTCAGCAGCTTTGGTACGCCATCATTGAGTCTCAGACGGAGACGGGC
ACCCCATACATGCTCTACAAAGACTCCTGTAACCGGAAGAGCAACCAGCAGAACCTGGGAACCA
TCAAGTGCAGCAACCTGTGCACAGAGATAGTAGAGTACACCAGTAAAGATGAGGTTGCGGTTTG
TAACTTGGCTTCTCTGGCTCTGAACATGTATGTCACACCAGAACACACGTATGACTTTGAGAAA
CTGGCAGAAGTCACTAAAGTCATTGTCCGAAATCTGAATAAAATAATTGATATAAACTACTATC
CTATTCCAGAGGCACACTTATCAAATAAACGCCATCGGCCCATTGGAATTGGGGTACAAGGTCT
AGCAGATGCTTTCATCCTGATGAGGTATCCCTTTGAGAGCCCAGAAGCCCAGCTACTAAATAAG
CAAATCTTTGAAACCATCTATTATGGAGCCCTGGAAGCCAGCTGTGACCTAGCCAAGGAGTATG
GCCCCTACGAAACGTATGAGGGATCTCCAGTCAGCAAGGGTATTCTTCAGTATGATATGTGGAA
TGTTACTCCTACAGACCTGTGGGACTGGAAGCTTCTCAAGGAGAAGATTGCAAAGTACGGTATA
AGAAACAGTTTACTTATTGCCCCAATGCCTACTGCTTCAACTGCTCAGATTCTGGGGAATAATG
AGTCCATTGAGCCTTACACCAGTAACATCTACACTCGCAGAGTCTTGTCAGGAGAATTTCAGAT
TGTGAATCCTCACTTACTGAAAGATCTTACTGAGCGGGGCTTGTGGAATGAAGAGATGAAAAAT
CAGATTATTGCCTGCAATGGCTCCATTCAGAGCATACCAGAAATTCCTGAGGACCTGAAGCAGC
TCTATAAGACCGTGTGGGAAATCTCTCAGAAGACTGTTCTCAAGATGGCAGCCGAGAGAGGTGC
TTTCATCGATCAAAGCCAGTCTTTAAACATCCATATCGCTGAGCCCAACTATGGCAAACTCACT
AGTATGCACTTCTACGGTTGGAAGCAGGGTTTAAAGACTGGGATGTATTATTTAAGGACAAGAC
CTGCCGCTAATCCAATCCAGTTCACTCTGAACAAGGAAAAGCTGAAAGATAAGGAAAAGGCACT
GAAGGAGGAAGAAGAGAAGGAGAGGAACACAGCAGCCATGGTGTGCTCTTTGGAGAACAGAGAG
GAGTGTCTGATGTGTGGATCCTGAGACAAGGCCTAGAAGAGCCAGCGTCTTTCCGCCATAGCAG
ACCATGTGACATAGATAGGCATAGTGGGTTTGCTTGATTAAGGGAAAGCTTTGCCGGACATTTC
TGCCAGGAGAAGAATCCTTGATTTGCAGTACTGTTTCTCTATAGTGTAAAGGTCATTTTAAACA
AAACAAAAAACCAAAGCCAGCTTTGATATTAGGAATCAAAGTACAGGTTTTGGGAATGCAGAAG
AGCCTTCCTGGAAATAGTGATGTTGTTTAGGAAGTCTCTTCTCCCTCCAGCTTTCCCTGTCTGA
CTGTCTCAGTTTGGGCAAAGAGCTTTAGTTCGCTTTGACCGATGGCCTAGAAGTAAAATCAAGC
AATAAGTCACCAGCTGGAGATCTAGACAAACTTCCATAGTTGTTTTGAAATAAAAATTTCTAAG
TGAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013254	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85906	(Get FASTA)	NCBI Sequence Viewer
	EDM18189	(Get FASTA)	NCBI Sequence Viewer
	EDM18190	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013254 ⟸ NM_001013236

- UniProtKB:

Q5U2Q5 (UniProtKB/TrEMBL), M0R486 (UniProtKB/TrEMBL), A0A8I5Y915 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETA
ATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHK
DRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNL
LSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIR
ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGK
EEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVV
KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLAS
LALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAF
ILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPT
DLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPH
LLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQ
SQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEE
EKERNTAAMVCSLENREECLMCGS

hide sequence

RefSeq Acc Id:

ENSRNOP00000076052 ⟸ ENSRNOT00000093112

RefSeq Acc Id:

ENSRNOP00000075981 ⟸ ENSRNOT00000093070

RefSeq Acc Id:

ENSRNOP00000064166 ⟸ ENSRNOT00000074058

RefSeq Acc Id:

ENSRNOP00000076633 ⟸ ENSRNOT00000113303

Protein Domains

ATP-cone

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U2Q5-F1-model_v2	AlphaFold	Q5U2Q5	1-792	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1592569	AgrOrtholog
BioCyc Gene	G2FUF-58247	BioCyc
BioCyc Pathway	PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I]	BioCyc
	PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP]	BioCyc
	PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I]	BioCyc
	PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I]	BioCyc
Ensembl Genes	ENSRNOG00000045752	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000064166	ENTREZGENE
	ENSRNOP00000064166.1	UniProtKB/TrEMBL
	ENSRNOP00000075981.1	UniProtKB/TrEMBL
	ENSRNOP00000076633.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000074058	ENTREZGENE
	ENSRNOT00000074058.3	UniProtKB/TrEMBL
	ENSRNOT00000093070.2	UniProtKB/TrEMBL
	ENSRNOT00000113303.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.70.20	UniProtKB/TrEMBL
InterPro	ATP-cone	UniProtKB/TrEMBL
	NrdE_NrdA	UniProtKB/TrEMBL
	Ribncl_Rdtase_lsu_N	UniProtKB/TrEMBL
	Ribncl_red_lg_C	UniProtKB/TrEMBL
	Ribnucl_Rdtase_R1-su_N	UniProtKB/TrEMBL
	Rrm1	UniProtKB/TrEMBL
KEGG Report	rno:685579	UniProtKB/TrEMBL
NCBI Gene	685579	ENTREZGENE
PANTHER	PTHR11573	UniProtKB/TrEMBL
	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT	UniProtKB/TrEMBL
Pfam	ATP-cone	UniProtKB/TrEMBL
	Ribonuc_red_lgC	UniProtKB/TrEMBL
	Ribonuc_red_lgN	UniProtKB/TrEMBL
PhenoGen	Rrm1	PhenoGen
PRINTS	RIBORDTASEM1	UniProtKB/TrEMBL
PROSITE	ATP_CONE	UniProtKB/TrEMBL
	RIBORED_LARGE	UniProtKB/TrEMBL
Superfamily-SCOP	PFL-like glycyl radical enzymes	UniProtKB/TrEMBL
	Ribonucleo_red_N	UniProtKB/TrEMBL
UniProt	A0A1B0GWQ3_RAT	UniProtKB/TrEMBL
	A0A8I5Y915	ENTREZGENE, UniProtKB/TrEMBL
	M0R486	ENTREZGENE, UniProtKB/TrEMBL
	Q5U2Q5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-21	Rrm1	ribonucleotide reductase catalytic subunit M1	Rrm1	ribonucleotide reductase M1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Rrm1	ribonucleotide reductase M1	LOC100361270	ribonucleotide reductase M1	Data Merged	1643240	APPROVED
2010-05-05	LOC100361270	ribonucleotide reductase M1			Symbol and Name status set to provisional	70820	PROVISIONAL
2009-01-26	Rrm1	ribonucleotide reductase M1	LOC685579	similar to ribonucleotide reductase M1	Symbol and Name updated	1299863	APPROVED
2006-11-20	LOC685579	similar to ribonucleotide reductase M1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)