Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Apoa1 (apolipoprotein A1) Rattus norvegicus
Analyze
Symbol: Apoa1
Name: apolipoprotein A1
Description: Exhibits amyloid-beta binding activity; lipase inhibitor activity; and lipid transporter activity. Involved in several processes, including animal organ regeneration; lipid transport; and peripheral nervous system axon regeneration. Localizes to several cellular components, including the discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including hypertension; major depressive disorder; nephrotic syndrome; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; INTERACTS WITH (+)-alpha-tocopherol; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-AI; apoA-I; apolipoprotein A-1; apolipoprotein A-I; preproapolipoprotein A-I
Orthologs:
Homo sapiens (human) : APOA1 (apolipoprotein A1)  HGNC  Alliance
Mus musculus (house mouse) : Apoa1 (apolipoprotein A-I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoa1 (apolipoprotein A1)
Pan paniscus (bonobo/pygmy chimpanzee) : APOA1 (apolipoprotein A1)
Canis lupus familiaris (dog) : APOA1 (apolipoprotein A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoa1 (apolipoprotein A1)
Sus scrofa (pig) : APOA1 (apolipoprotein A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0850,525,091 - 50,526,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0849,151,163 - 49,152,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera846,109,311 - 46,111,065 (+)NCBICelera
Cytogenetic Map8q22NCBI
RH 3.4 Map8472.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Apoa1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2130
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.