Dapk1 (death associated protein kinase 1) - Rat Genome Database
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Gene: Dapk1 (death associated protein kinase 1) Rattus norvegicus
Analyze
Symbol: Dapk1
Name: death associated protein kinase 1
RGD ID: 1311629
Description: Predicted to have several functions, including ATP binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Predicted to be involved in several processes, including cellular response to interferon-gamma; regulation of cellular protein metabolic process; and regulation of signal transduction. Predicted to localize to actin cytoskeleton; cytoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human DAPK1 (death associated protein kinase 1); PARTICIPATES IN type II interferon signaling pathway; urinary bladder cancer pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: death-associated protein kinase 1; LOC306722
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2173,930,223 - 4,090,991 (-)NCBI
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0174,297,038 - 4,454,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0176,525,247 - 6,683,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,617,607 - 9,779,457 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,617,606 - 9,779,457 (-)NCBI
Celera174,059,212 - 4,219,046 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Brevetoxin B  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chelidonine  (ISO)
chloroprene  (ISO)
cholesterol  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dimethylarsinous acid  (ISO)
disodium selenite  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
glycine betaine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7828849   PMID:10629061   PMID:11485996   PMID:12477932   PMID:12730201   PMID:15010850   PMID:16132846   PMID:18583991   PMID:18995835   PMID:19180116   PMID:19712061   PMID:20053891  
PMID:20141836   PMID:21738225   PMID:22095288   PMID:23071094   PMID:28543175   PMID:30419147   PMID:31549396  


Genomics

Comparative Map Data
Dapk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2173,930,223 - 4,090,991 (-)NCBI
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0174,297,038 - 4,454,941 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0176,525,247 - 6,683,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,617,607 - 9,779,457 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,617,606 - 9,779,457 (-)NCBI
Celera174,059,212 - 4,219,046 (-)NCBICelera
Cytogenetic Map17p14NCBI
DAPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,497,228 - 87,708,634 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,497,228 - 87,708,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,112,143 - 90,323,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,302,576 - 89,513,369 (+)NCBINCBI36hg18NCBI36
Build 34987,342,349 - 87,553,097NCBI
Celera960,684,038 - 60,893,765 (+)NCBI
Cytogenetic Map9q21.33ENTREZGENE
HuRef959,938,084 - 60,147,991 (+)NCBIHuRef
CHM1_1990,259,940 - 90,471,316 (+)NCBICHM1_1
Dapk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,749,506 - 60,911,005 (+)NCBIGRCm39mm39
GRCm39 Ensembl1360,749,761 - 60,911,005 (+)Ensembl
GRCm381360,601,723 - 60,763,191 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,601,947 - 60,763,191 (+)EnsemblGRCm38mm10GRCm38
MGSCv371360,703,308 - 60,864,547 (+)NCBIGRCm37mm9NCBIm37
MGSCv361360,612,049 - 60,772,424 (+)NCBImm8
Celera1361,661,141 - 61,823,107 (+)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.53NCBI
Dapk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543229,197 - 254,379 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543229,925 - 254,327 (-)NCBIChiLan1.0ChiLan1.0
DAPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1986,680,202 - 86,887,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,681,953 - 86,887,958 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0958,628,872 - 58,836,205 (+)NCBIMhudiblu_PPA_v0panPan3
DAPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl172,280,103 - 72,447,822 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1172,278,939 - 72,448,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dapk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366802,842,930 - 3,020,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,724,644 - 27,954,350 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,724,644 - 27,954,708 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,963,591 - 31,970,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,118,948 - 98,330,435 (+)NCBI
ChlSab1.1 Ensembl1298,118,603 - 98,330,471 (+)Ensembl
Dapk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248099,585,426 - 9,794,582 (-)NCBI

Position Markers
RH141019  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,298,331 - 4,298,510NCBIRnor6.0
Rnor_5.0176,526,354 - 6,526,533UniSTSRnor5.0
RGSC_v3.4179,618,714 - 9,618,893UniSTSRGSC3.4
Celera174,060,319 - 4,060,498UniSTS
RH 3.4 Map1747.2UniSTS
Cytogenetic Map17p14UniSTS
RH127309  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,297,397 - 4,297,610NCBIRnor6.0
Rnor_5.0176,525,420 - 6,525,633UniSTSRnor5.0
RGSC_v3.4179,617,780 - 9,617,993UniSTSRGSC3.4
Celera174,059,385 - 4,059,598UniSTS
RH 3.4 Map1732.6UniSTS
Cytogenetic Map17p14UniSTS
BE105522  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,407,746 - 4,407,928NCBIRnor6.0
Rnor_5.0176,636,888 - 6,637,070UniSTSRnor5.0
RGSC_v3.4179,731,586 - 9,731,768UniSTSRGSC3.4
Celera174,171,108 - 4,171,290UniSTS
RH 3.4 Map1732.7UniSTS
Cytogenetic Map17p14UniSTS
BE120223  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,452,770 - 4,452,948NCBIRnor6.0
Rnor_5.0176,681,912 - 6,682,090UniSTSRnor5.0
RGSC_v3.4179,777,449 - 9,777,627UniSTSRGSC3.4
Celera174,217,038 - 4,217,216UniSTS
RH 3.4 Map1749.1UniSTS
Cytogenetic Map17p14UniSTS
RH138301  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,427,193 - 4,427,321NCBIRnor6.0
Rnor_5.0176,656,335 - 6,656,463UniSTSRnor5.0
RGSC_v3.4179,751,872 - 9,752,000UniSTSRGSC3.4
Celera174,191,461 - 4,191,589UniSTS
RH 3.4 Map1747.8UniSTS
Cytogenetic Map17p14UniSTS
RH138879  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,371,104 - 4,371,241NCBIRnor6.0
Rnor_5.0176,600,246 - 6,600,383UniSTSRnor5.0
RGSC_v3.4179,695,032 - 9,695,169UniSTSRGSC3.4
Celera174,134,491 - 4,134,628UniSTS
RH 3.4 Map1747.7UniSTS
Cytogenetic Map17p14UniSTS
FH3103  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0174,333,072 - 4,333,583NCBIRnor6.0
Rnor_5.0176,562,214 - 6,562,725UniSTSRnor5.0
RGSC_v3.4179,656,999 - 9,657,510UniSTSRGSC3.4
Celera174,096,463 - 4,096,974UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17333697224030841Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17333697224030841Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17333697237790462Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17333697263676140Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17333697273413148Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17333697273413148Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17333697273413148Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17341403928073589Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:532
Count of miRNA genes:262
Interacting mature miRNAs:336
Transcripts:ENSRNOT00000066950
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 22 20 8 20 70 32 31 11
Low 3 39 35 21 11 21 8 11 4 3 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066950   ⟹   ENSRNOP00000062122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,297,224 - 4,454,778 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080750   ⟹   ENSRNOP00000073577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,297,235 - 4,454,701 (-)Ensembl
RefSeq Acc Id: NM_001107335   ⟹   NP_001100805
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2173,930,223 - 4,090,991 (-)NCBI
Rnor_6.0174,297,224 - 4,454,778 (-)NCBI
Rnor_5.0176,525,247 - 6,683,920 (-)NCBI
RGSC_v3.4179,617,607 - 9,779,457 (-)RGD
Celera174,059,212 - 4,219,046 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253522   ⟹   XP_006253584
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0174,297,038 - 4,454,707 (-)NCBI
Rnor_5.0176,525,247 - 6,683,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253523   ⟹   XP_006253585
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0174,297,038 - 4,454,707 (-)NCBI
Rnor_5.0176,525,247 - 6,683,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771440   ⟹   XP_008769662
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0174,297,038 - 4,454,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771441   ⟹   XP_008769663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2173,930,228 - 4,090,514 (-)NCBI
Rnor_6.0174,297,038 - 4,454,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095611   ⟹   XP_038951539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2173,930,228 - 4,090,514 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100805 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769663 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951539 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69063 (Get FASTA)   NCBI Sequence Viewer  
  EDL93864 (Get FASTA)   NCBI Sequence Viewer  
  EDL93865 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100805   ⟸   NM_001107335
- UniProtKB: F1LNN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253584   ⟸   XM_006253522
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253585   ⟸   XM_006253523
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008769663   ⟸   XM_008771441
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769662   ⟸   XM_008771440
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073577   ⟸   ENSRNOT00000080750
RefSeq Acc Id: ENSRNOP00000062122   ⟸   ENSRNOT00000066950
RefSeq Acc Id: XP_038951539   ⟸   XM_039095611
- Peptide Label: isoform X2
Protein Domains
ANK_REP_REGION   Death   Protein kinase   Roc

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700275
Promoter ID:EPDNEW_R10794
Type:initiation region
Name:Dapk1_1
Description:death associated protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0174,454,714 - 4,454,774EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 6526078 6526079 G A snv BUF/N (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 4298055 4298056 G A snv Buf/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311629 AgrOrtholog
Ensembl Genes ENSRNOG00000018198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062122 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000073577 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066950 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080750 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DAPK1 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  ROC_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:306722 UniProtKB/TrEMBL
NCBI Gene 306722 ENTREZGENE
PANTHER PTHR24342:SF17 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Dapk1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  DEATH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K5V8 ENTREZGENE, UniProtKB/TrEMBL
  B5DFH6_RAT UniProtKB/TrEMBL
  F1LNN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dapk1  death associated protein kinase 1   Dapk1_predicted  death associated protein kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dapk1_predicted  death associated protein kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED