Gene: Hp (haptoglobin) Rattus norvegicus
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Symbol:
Hp
Name:
haptoglobin
Description:
Exhibits hemoglobin binding activity and protein homodimerization activity. Involved in several processes, including aging; response to growth hormone; and response to vitamin. Localizes to the Golgi apparatus; blood microparticle; and endoplasmic reticulum. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); hepatocellular adenoma; kidney failure (multiple); and nonalcoholic fatty liver disease. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to several human genes including HPR (haptoglobin-related protein); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Ba1-647; liver regeneration-related protein LRRG173; zonulin
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HP (haptoglobin) HGNC
Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Hp (haptoglobin) HGNC
Panther, PhylomeDB, OrthoDB, Ensembl
Canis lupus familiaris (dog):
LOC479668 (haptoglobin-like) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101976500 (haptoglobin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HP (haptoglobin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
HPR (haptoglobin-related protein) HGNC
Ensembl, OMA, OrthoDB, Panther, PhylomeDB
Alliance orthologs 3
Mus musculus (house mouse):
Hp (haptoglobin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
HP (haptoglobin)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
HPR (haptoglobin-related protein)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
hp (haptoglobin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 19 42,096,255 - 42,100,805 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 19 52,921,384 - 52,925,934 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 39,443,016 - 39,447,566 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 19 39,447,897 - 39,452,447 (-) NCBI Celera 19 36,944,700 - 36,949,250 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
acute kidney failure IEP 11041863 RGD AIDS-Associated Nephropathy ISO RGD:737269 11041816 protein:increased expression:urine RGD alpha thalassemia ISO RGD:737269 11041792 RGD Anaphylaxis ISO RGD:737269 11041789 RGD arteriosclerosis susceptibility ISO RGD:737269 1626352 associated with Hypertension;DNA:polymorphism RGD arteriosclerosis ISO RGD:10728 1626340 RGD asthma ISO RGD:737269 5509920 RGD asthma ISO RGD:737269 5144151 RGD atherosclerosis treatment IEP 11041860 RGD beta thalassemia ISO RGD:737269 11041795 RGD Brain Injuries IEP 11041806 mRNA:increased expression:liver RGD cardiovascular system disease ISO RGD:737269 1626350 associated with Arthritis, Rheumatoid RGD Carotid Artery Injuries IEP 11041814 RGD Cerebral Hemorrhage ISO RGD:10728 11041810 RGD Cerebral Hemorrhage treatment ISO RGD:737269 11041810 RGD cholestasis IEP 1626374 mRNA:increased expression:liver RGD chronic kidney disease IEP 11041800 protein:increased expression:serum RGD chronic obstructive pulmonary disease ISO RGD:737269 5144151 RGD colitis treatment IEP 11041866 RGD congestive heart failure treatment IEP 11041812 RGD coronary artery disease ISO RGD:737269 1626363 protein:increased expression:serum RGD Coronary Disease severity ISO RGD:737269 1626344 RGD diabetes mellitus ISO RGD:737269 1626347 RGD Diabetes Mellitus, Experimental IEP 1626381 protein:increased expression:serum RGD dilated cardiomyopathy ISO RGD:737269 1626345 protein:increased expression RGD Experimental Arthritis IEP 1626375 mRNA, protein:increased expression:tendon, ankle RGD Experimental Arthritis IEP 1626370 protein:increased expression:serum RGD Experimental Liver Cirrhosis IEP 1626367 protein:increased expression:serum RGD Experimental Liver Cirrhosis IEP 9491781 protein:decreased expression:serum RGD gout ISO RGD:737269 1626362 RGD hemolytic anemia ISO RGD:737269 11041791 associated with Malaria RGD hemolytic-uremic syndrome ISO RGD:737269 1626361 RGD hepatocellular adenoma IEP 1626391 RGD Hypercholesterolemia ISO RGD:737269 1626342 protein:increased expression:plasma RGD hyperglycemia ISO RGD:737269 1626355 associated with Diabetes;protein:increased glycation:plasma RGD hyperinsulinism ISO RGD:737269 1626335 protein:increased expression:serum RGD hypertension susceptibility ISO RGD:737269 1626351 DNA:polymorphism RGD hypertension IEP 7241867 RGD hypertension onset ISO RGD:737269 1626352 DNA:polymorphism RGD Hypertensive Nephropathy treatment IEP 11041817 RGD Hypoxia IEP 1626356 protein:decreased expression:plasma RGD Inflammation IEP 1626376 protein:increased expression:serum RGD inflammatory bowel disease ISO RGD:10728 5147444 RGD Intestinal Reperfusion Injury treatment IEP 11041790 RGD iron deficiency anemia ISO RGD:737269 11041798 protein:decreased expression:serum RGD Kawasaki disease ISO RGD:737269 5147383 RGD liver cirrhosis ISO RGD:737269 9491781 associated with Hepatitis C, Chronic;protein:decreased expression:serum RGD Liver Reperfusion Injury IEP 1626366 RGD Liver Reperfusion Injury treatment IEP 11041815 RGD lung cancer IEP 11041857 RGD Mammary Neoplasms, Experimental treatment IDA 11041861 RGD Metabolic Syndrome treatment IDA 11041859 RGD Metabolic Syndrome ISO RGD:737269 1626341 protein:increased expression RGD middle cerebral artery infarction IEP 7175514 RGD myocardial infarction ISO RGD:737269 1626354 RGD myocardial infarction susceptibility ISO RGD:737269 1626360 RGD nonalcoholic fatty liver disease IEP 9491781 protein:increased expression:serum RGD nonalcoholic fatty liver disease ISO RGD:737269 9491781 protein:decreased expression:serum RGD obesity ISO RGD:737269 1626346 protein:increased expression:serum RGD obesity treatment IDA 9685197 RGD obesity IEP 1626339 protein:increased expression:serum RGD obesity ISO RGD:10728 1626349 mRNA:increased expression:white fat RGD obstructive sleep apnea ISO RGD:737269 5147384 RGD pasteurellosis ISO RGD:10728 5144216 RGD Plasmodium falciparum malaria severity ISO RGD:737269 11041793 DNA:missense mutation:cds:p.K54E (human) RGD Pneumococcal Pneumonia ISO RGD:737269 5147385 RGD pre-eclampsia severity ISO RGD:737269 1626343 DNA:polymorphism RGD pre-eclampsia ISO RGD:737269 1626337 protein:increased expression RGD pulmonary embolism ISO RGD:737269 5147425 RGD pulmonary embolism IEP 1626365 mRNA, protein:increased expression:lung, liver, serum RGD pulmonary embolism IEP 5688769 protein:decreased expression:blood microparticle RGD pulmonary embolism IEP 5147419 RGD pulmonary hypertension ISO RGD:737269 5147440 RGD pulmonary hypertension treatment ISO RGD:737269 11041794 RGD pulmonary hypertension ISO RGD:737269 1626353 protein:decreased expression:serum RGD pulmonary hypertension ISO RGD:737269 5147420 RGD sarcoidosis ISO RGD:737269 5147442 RGD Shock, Hemorrhagic IEP 5147418 RGD Sickle Cell Trait ISO RGD:737269 5147440 RGD Sickle Cell Trait ISO RGD:737269 5147416 RGD Starvation IEP 11041864 RGD Stroke ISO RGD:737269 1626348 protein:increased expression:plasma RGD Stroke ISO RGD:737269 11041787 associated with Anemia, Sickle Cell RGD trypanosomiasis ISO RGD:10728 11041867 protein:increased expression:plasma RGD type 1 diabetes mellitus IEP 11041804 protein:increased expression:serum RGD type 1 diabetes mellitus treatment IDA 11041868 RGD type 2 diabetes mellitus treatment IEP 6483015 RGD Venous Thrombosis ISO RGD:737269 1626365 associated with Pulmonary Embolism;protein:increased expression:serum RGD Wounds and Injuries IEP 1626378 protein:increased expression:serum RGD Wounds and Injuries treatment IEP 11041807 associated with Diabetes Mellitus, Experimental RGD
Imported Annotations - ClinVar
Anhaptoglobinemia ISO RGD:737269 8554872 ClinVar Annotator: match by term: Anhaptoglobinemia ClinVar PMID:25741868 PMID:9463309 Anhaptoglobinemia ISO RGD:737269 8554872 ClinVar Annotator: match by OMIM:614081 ClinVar PMID:14616769 PMID:14999562 Anhaptoglobinemia ISO RGD:737269 8554872 ClinVar Annotator: match by OMIM:614081 ClinVar PMID:10644822 more ... Anhaptoglobinemia ISO RGD:737269 8554872 ClinVar Annotator: match by OMIM:614081 ClinVar PMID:14616769
Imported Annotations - CTD
acute kidney failure ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 allergic hypersensitivity disease ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 anemia ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16637741 arthritis ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 atherosclerosis ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Autoimmune Diseases ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Breast Neoplasms ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 cardiovascular system disease ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19769483 Diabetes Complications ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19769483 diabetic angiopathy ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Drug-Related Side Effects and Adverse Reactions ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28885000 Dyslipidemias ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Female Genital Neoplasms ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Foodborne Diseases ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21075095 hemochromatosis ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Hemolysis ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25247420 hepatitis B ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Hepatitis B, Chronic ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Hepatitis C, Chronic ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 human immunodeficiency virus infectious disease ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 hypertension ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 Hypertension, Pregnancy-Induced ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 leukemia ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 malaria ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8730300 PMID:16597321 myocardial infarction ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 more ... Pasteurellaceae Infections ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16755360 retinal detachment ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 schizophrenia ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18583979 sickle cell anemia ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 tuberculosis ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16597321 type 1 diabetes mellitus ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16506275 type 2 diabetes mellitus ISO RGD:737269 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16506275 Imported Annotations - OMIM
Anhaptoglobinemia ISO RGD:737269 7240710 OMIM
(+)-alpha-tocopherol affects activity ISO RGD:737269 6480464 alpha-Tocopherol affects the activity of HP protein polymorphism CTD PMID:19769483 (+)-alpha-tocopherol multiple interactions ISO RGD:10728 6480464 Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] CTD PMID:19769483 (+)-lariciresinol decreases expression ISO RGD:737269 6480464 lariciresinol results in decreased expression of HP protein CTD PMID:27417256 (-)-lariciresinol decreases expression ISO RGD:737269 6480464 lariciresinol results in decreased expression of HP protein CTD PMID:27417256 1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of HP protein CTD PMID:14565772 1,1-dichloroethene increases expression ISO RGD:10728 6480464 vinylidene chloride results in increased expression of HP mRNA CTD PMID:26682919 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of HP mRNA CTD PMID:16940010 17beta-estradiol multiple interactions ISO RGD:737269 6480464 [Estradiol co-treated with Progesterone] results in increased expression of HP mRNA CTD PMID:20660070 17beta-estradiol increases expression ISO RGD:10728 6480464 Estradiol results in increased expression of HP mRNA CTD PMID:19484750 PMID:19693291 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10728 6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]; more ... CTD PMID:16054899 PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10728 6480464 Tetrachlorodibenzodioxin affects the expression of HP mRNA CTD PMID:18343893 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10728 6480464 Tetrachlorodibenzodioxin results in decreased expression of HP mRNA; more ... CTD PMID:16054899 more ... 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of HP protein CTD PMID:15822908 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10728 6480464 Tetrachlorodibenzodioxin results in increased expression of HP mRNA CTD PMID:16114106 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO RGD:10728 6480464 2,3,7,8-tetrachlorodibenzofuran affects the expression of HP mRNA CTD PMID:18343893 3',5'-cyclic AMP multiple interactions ISO RGD:10728 6480464 Cyclic AMP inhibits the reaction [IL1B protein results in increased expression of HP mRNA] CTD PMID:22117073 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of HP protein CTD PMID:26072098 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10728 6480464 [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA; more ... CTD PMID:16054899 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA; more ... CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA CTD PMID:28628672 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HP mRNA CTD PMID:24780913 aflatoxin B1 decreases expression ISO RGD:737269 6480464 Aflatoxin B1 results in decreased expression of HP mRNA CTD PMID:21641981 PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:737269 6480464 Aflatoxin B1 results in decreased methylation of HP gene CTD PMID:27153756 alclofenac decreases expression ISO RGD:737269 6480464 alclofenac results in decreased expression of HP protein CTD PMID:241598 aldehydo-D-glucose affects secretion ISO RGD:737269 6480464 Glucose deficiency affects the secretion of HP protein CTD PMID:24802182 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HP mRNA CTD PMID:16483693 andrographolide multiple interactions ISO RGD:10728 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 azathioprine multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein CTD PMID:8614026 benzene increases expression ISO RGD:10728 6480464 Benzene results in increased expression of HP mRNA CTD PMID:15120971 PMID:15122651 benzo[a]pyrene decreases expression ISO RGD:737269 6480464 Benzo(a)pyrene results in decreased expression of HP mRNA CTD PMID:19737606 benzo[a]pyrene decreases expression ISO RGD:10728 6480464 Benzo(a)pyrene results in decreased expression of HP mRNA CTD PMID:23735875 beta-naphthoflavone decreases expression ISO RGD:737269 6480464 beta-Naphthoflavone results in decreased expression of HP mRNA CTD PMID:19737606 beta-naphthoflavone multiple interactions ISO RGD:10728 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA CTD PMID:19737545 bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of HP mRNA CTD PMID:16648578 bis(2-ethylhexyl) phthalate increases expression ISO RGD:10728 6480464 Diethylhexyl Phthalate results in increased expression of HP mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10728 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HP mRNA] CTD PMID:19850644 bisphenol A increases expression ISO RGD:737269 6480464 bisphenol A results in increased expression of HP mRNA CTD PMID:17989879 bisphenol A increases expression ISO RGD:10728 6480464 bisphenol A results in increased expression of HP mRNA CTD PMID:30245210 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HP gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HP mRNA CTD PMID:28628672 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HP mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:10728 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA; more ... CTD PMID:27082013 bisphenol F multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HP mRNA CTD PMID:28628672 cadmium atom affects binding ISO RGD:737269 6480464 HP protein binds to Cadmium CTD PMID:23896426 calciol increases expression ISO RGD:10728 6480464 Cholecalciferol results in increased expression of HP mRNA CTD PMID:16508948 calcitriol increases expression ISO RGD:737269 6480464 Calcitriol results in increased expression of HP protein CTD PMID:27107558 cannabidiol increases expression ISO RGD:10728 6480464 Cannabidiol results in increased expression of HP mRNA CTD PMID:21542829 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of HP mRNA CTD PMID:19836432 carbon nanotube increases expression ISO RGD:10728 6480464 Nanotubes, Carbon results in increased expression of HP mRNA CTD PMID:25620056 cisplatin increases secretion EXP 6480464 Cisplatin results in increased secretion of HP protein CTD PMID:28885000 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of HP mRNA CTD PMID:12851107 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of HP mRNA CTD PMID:24386269 copper atom affects binding ISO RGD:737269 6480464 HP protein binds to Copper CTD PMID:23896426 copper(0) affects binding ISO RGD:737269 6480464 HP protein binds to Copper CTD PMID:23896426 copper(2+) affects binding ISO RGD:737269 6480464 HP protein binds to Copper CTD PMID:23896426 copper(II) sulfate decreases expression ISO RGD:737269 6480464 Copper Sulfate results in decreased expression of HP mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:10728 6480464 Asbestos, Crocidolite results in increased expression of HP mRNA CTD PMID:23917077 crocidolite asbestos decreases expression ISO RGD:737269 6480464 Asbestos, Crocidolite results in decreased expression of HP mRNA CTD PMID:24160326 cyclosporin A increases expression ISO RGD:737269 6480464 Cyclosporine results in increased expression of HP mRNA CTD PMID:21632981 cyclosporin A decreases expression ISO RGD:737269 6480464 Cyclosporine results in decreased expression of HP mRNA CTD PMID:27989131 cyclosporin A affects expression ISO RGD:737269 6480464 Cyclosporine affects the expression of HP mRNA CTD PMID:20106945 PMID:25562108 D-glucose affects secretion ISO RGD:737269 6480464 Glucose deficiency affects the secretion of HP protein CTD PMID:24802182 D-penicillamine decreases expression ISO RGD:737269 6480464 Penicillamine results in decreased expression of HP protein CTD PMID:241598 dexamethasone multiple interactions ISO RGD:10728 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA; more ... CTD PMID:16054899 dexamethasone multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA; more ... CTD PMID:28628672 dexamethasone increases expression ISO RGD:737269 6480464 Dexamethasone results in increased expression of HP mRNA CTD PMID:19853017 PMID:25047013 dexamethasone increases expression ISO RGD:10728 6480464 Dexamethasone results in increased expression of HP mRNA CTD PMID:22733784 diclofenac decreases expression ISO RGD:10728 6480464 Diclofenac results in decreased expression of HP mRNA CTD PMID:26934552 diclofenac increases expression ISO RGD:10728 6480464 Diclofenac results in increased expression of HP mRNA CTD PMID:26934552 dicrotophos decreases expression ISO RGD:737269 6480464 dicrotophos results in decreased expression of HP mRNA CTD PMID:28302478 diisopropyl fluorophosphate increases expression EXP 6480464 Isoflurophate results in increased expression of HP protein CTD PMID:30389396 diisopropyl fluorophosphate decreases expression EXP 6480464 Isoflurophate results in decreased expression of HP protein CTD PMID:30389396 dimethyl sulfoxide increases expression EXP 6480464 Dimethyl Sulfoxide results in increased expression of HP mRNA; more ... CTD PMID:14757319 doramapimod decreases expression ISO RGD:10728 6480464 BIRB 796 results in decreased expression of HP mRNA CTD PMID:21328587 doxorubicin increases secretion EXP 6480464 Doxorubicin results in increased secretion of HP protein CTD PMID:28885000 flutamide increases expression EXP 6480464 Flutamide results in increased expression of HP mRNA CTD PMID:19299419 PMID:21525395 furan decreases expression EXP 6480464 furan results in decreased expression of HP mRNA CTD PMID:26194646 genistein increases expression EXP 6480464 Genistein results in increased expression of HP protein CTD PMID:24552547 glucose affects secretion ISO RGD:737269 6480464 Glucose deficiency affects the secretion of HP protein CTD PMID:24802182 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of HP mRNA CTD PMID:15159207 hydrogen peroxide multiple interactions ISO RGD:737269 6480464 [HP gene polymorphism co-treated with GSTM1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide; more ... CTD PMID:20444272 hydrogen peroxide decreases expression ISO RGD:737269 6480464 Hydrogen Peroxide results in decreased expression of HP mRNA CTD PMID:26339600 indometacin multiple interactions ISO RGD:737269 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HP mRNA; more ... CTD PMID:28628672 L-ascorbic acid affects activity ISO RGD:737269 6480464 Ascorbic Acid affects the activity of HP protein polymorphism CTD PMID:19769483 L-ascorbic acid affects response to substance ISO RGD:737269 6480464 HP gene polymorphism affects the susceptibility to Ascorbic Acid deficiency CTD PMID:20926521 L-ascorbic acid multiple interactions ISO RGD:10728 6480464 Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] CTD PMID:19769483 lead(0) increases expression ISO RGD:737269 6480464 Lead results in increased expression of HP protein CTD PMID:22923205 lead(0) affects binding ISO RGD:737269 6480464 HP protein binds to Lead CTD PMID:23896426 lead(2+) increases expression ISO RGD:737269 6480464 Lead results in increased expression of HP protein CTD PMID:22923205 lead(2+) affects binding ISO RGD:737269 6480464 HP protein binds to Lead CTD PMID:23896426 lipopolysaccharide increases expression ISO RGD:10728 6480464 Lipopolysaccharides results in increased expression of HP mRNA CTD PMID:25890327 lipopolysaccharide multiple interactions ISO RGD:10728 6480464 (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of HP mRNA] CTD PMID:25890327 menadione affects expression ISO RGD:737269 6480464 Vitamin K 3 affects the expression of HP mRNA CTD PMID:20044591 methimazole increases expression ISO RGD:737269 6480464 Methimazole results in increased expression of HP mRNA CTD PMID:20144635 morphine decreases expression EXP 6480464 Morphine results in decreased expression of HP protein CTD PMID:23056601 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:10728 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of HP mRNA CTD PMID:20061341 N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of HP protein CTD PMID:17719030 nickel atom affects binding ISO RGD:737269 6480464 HP protein binds to Nickel CTD PMID:23896426 nickel atom increases expression ISO RGD:737269 6480464 Nickel results in increased expression of HP mRNA CTD PMID:24768652 PMID:25583101 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of HP protein CTD PMID:16687475 paracetamol decreases expression ISO RGD:737269 6480464 Acetaminophen results in decreased expression of HP mRNA CTD PMID:26690555 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HP mRNA; more ... CTD PMID:15800402 paracetamol affects expression ISO RGD:10728 6480464 Acetaminophen affects the expression of HP mRNA CTD PMID:17562736 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of HP mRNA CTD PMID:18692542 pirinixic acid multiple interactions ISO RGD:10728 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of HP mRNA CTD PMID:20813756 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HP mRNA CTD PMID:16940010 pirinixic acid decreases expression ISO RGD:10728 6480464 pirinixic acid results in decreased expression of HP mRNA CTD PMID:20813756 potassium bromate multiple interactions ISO RGD:10728 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of HP mRNA; more ... CTD PMID:27082013 potassium bromate affects expression ISO RGD:10728 6480464 potassium bromate affects the expression of HP mRNA CTD PMID:27082013 potassium chromate increases expression ISO RGD:10728 6480464 potassium chromate(VI) results in increased expression of HP protein CTD PMID:23618972 potassium chromate multiple interactions ISO RGD:10728 6480464 potassium chromate(VI) promotes the reaction [IL6 protein results in increased metabolism of HP protein] CTD PMID:23618972 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:10728 6480464 Pregnenolone Carbonitrile results in increased expression of HP mRNA CTD PMID:28903501 profenofos increases expression EXP 6480464 profenofos results in increased expression of HP mRNA CTD PMID:17569032 progesterone affects expression ISO RGD:10728 6480464 Progesterone affects the expression of HP mRNA CTD PMID:17251523 progesterone multiple interactions ISO RGD:737269 6480464 [Estradiol co-treated with Progesterone] results in increased expression of HP mRNA CTD PMID:20660070 quartz increases expression EXP 6480464 Quartz results in increased expression of HP mRNA CTD PMID:19836432 quercetin decreases expression ISO RGD:737269 6480464 Quercetin results in decreased expression of HP mRNA CTD PMID:21632981 sarin decreases expression EXP 6480464 Sarin results in decreased expression of HP protein CTD PMID:26778279 serpentine asbestos decreases expression ISO RGD:737269 6480464 Asbestos, Serpentine results in decreased expression of HP mRNA CTD PMID:24160326 silicon dioxide decreases expression ISO RGD:737269 6480464 Silicon Dioxide analog results in decreased expression of HP mRNA CTD PMID:25895662 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of HP mRNA CTD PMID:22431001 silicon dioxide increases expression ISO RGD:737269 6480464 Silicon Dioxide analog results in increased expression of HP mRNA CTD PMID:23806026 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of HP protein CTD PMID:29459688 sodium fluoride decreases expression ISO RGD:10728 6480464 Sodium Fluoride results in decreased expression of HP protein CTD PMID:28918527 sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of HP protein CTD PMID:29653260 sulforaphane increases expression ISO RGD:737269 6480464 sulforafan results in increased expression of HP mRNA CTD PMID:26833863 T-2 Toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of HP mRNA CTD PMID:26141394 testosterone decreases expression ISO RGD:10728 6480464 Testosterone results in decreased expression of HP mRNA CTD PMID:19693291 testosterone increases expression ISO RGD:10728 6480464 Testosterone results in increased expression of HP mRNA CTD PMID:19693291 tetrachloromethane affects expression ISO RGD:10728 6480464 Carbon Tetrachloride affects the expression of HP mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein CTD PMID:8614026 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of HP mRNA CTD PMID:30012374 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of HP gene CTD PMID:27618143 urethane decreases expression ISO RGD:737269 6480464 Urethane results in decreased expression of HP mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:737269 6480464 Valproic Acid results in decreased methylation of HP gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:737269 6480464 Valproic Acid results in decreased expression of HP mRNA CTD PMID:29154799 vitamin E affects activity ISO RGD:737269 6480464 alpha-Tocopherol affects the activity of HP protein polymorphism CTD PMID:19769483 vitamin E multiple interactions ISO RGD:10728 6480464 Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] CTD PMID:19769483 warfarin increases expression EXP 6480464 Warfarin results in increased expression of HP protein CTD PMID:22342526 zinc atom affects binding ISO RGD:737269 6480464 HP protein binds to Zinc CTD PMID:23896426 zinc(0) affects binding ISO RGD:737269 6480464 HP protein binds to Zinc CTD PMID:23896426
Gene-Chemical Interaction Annotations
