Hp (haptoglobin) - Rat Genome Database

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Gene: Hp (haptoglobin) Rattus norvegicus
Analyze
Symbol: Hp
Name: haptoglobin
RGD ID: 2825
Description: Enables hemoglobin binding activity and identical protein binding activity. Involved in several processes, including response to X-ray; response to growth hormone; and response to vitamin. Located in blood microparticle. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); hepatocellular adenoma; kidney failure (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to human HP (haptoglobin) and HPR (haptoglobin-related protein); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ba1-647; liver regeneration-related protein LRRG173; zonulin
RGD Orthologs
Human
Mouse
Squirrel
Pig
Alliance Genes
More Info more info ...
Candidate Gene For: Eau8
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,539,626 - 37,544,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,539,627 - 37,544,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,352,875 - 44,357,420 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01945,006,203 - 45,010,748 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01947,315,910 - 47,320,455 (-)NCBIRnor_WKY
Rnor_6.01942,096,255 - 42,100,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,097,995 - 42,100,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,921,384 - 52,925,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,443,016 - 39,447,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,447,897 - 39,452,447 (-)NCBI
Celera1936,944,700 - 36,949,250 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
AIDS-Associated Nephropathy  (ISO)
allergic disease  (ISO)
alpha thalassemia  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
Anhaptoglobinemia  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (IEP,ISO)
autoimmune disease  (ISO)
autosomal dominant dyskeratosis congenita 6  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (IEP)
Breast Neoplasms  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
Cerebral Hemorrhage  (ISO)
Chemically-Induced Disorders  (ISO)
cholestasis  (IEP)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP)
congestive heart failure  (IEP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (IEP)
Experimental Mammary Neoplasms  (IDA)
Female Genital Neoplasms  (ISO)
Foodborne Diseases  (ISO)
genetic disease  (ISO)
gout  (ISO)
hemochromatosis  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatocellular adenoma  (IEP)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (IEP,ISO)
Hypertensive Nephropathy  (IEP)
Hypoxia  (IEP)
Inflammation  (IEP)
inflammatory bowel disease  (ISO)
Intestinal Reperfusion Injury  (IEP)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
leukemia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP)
lung cancer  (IEP)
malaria  (ISO)
Metabolic Syndrome  (IDA,ISO)
middle cerebral artery infarction  (IEP)
myocardial infarction  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
obesity  (IDA,IEP,ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Pasteurellaceae Infections  (ISO)
pasteurellosis  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
pulmonary embolism  (IEP,ISO)
pulmonary hypertension  (ISO)
retinal detachment  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
Sickle Cell Trait  (ISO)
Starvation  (IEP)
Stroke  (ISO)
trypanosomiasis  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (IDA,IEP,ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (ISO)
Venous Thrombosis  (ISO)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-lariciresinol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
andrographolide  (ISO)
azathioprine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethyl sulfoxide  (EXP)
doramapimod  (ISO)
doxorubicin  (EXP)
flutamide  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methimazole  (ISO)
metronidazole  (EXP)
minocycline  (EXP)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
profenofos  (EXP)
progesterone  (ISO)
quartz  (EXP)
quercetin  (ISO)
sarin  (EXP)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
warfarin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Methemoglobinemia and ascorbate deficiency in hemoglobin E beta thalassemia: metabolic and clinical implications. Allen A, etal., Blood. 2012 Oct 11;120(15):2939-44. doi: 10.1182/blood-2012-06-435875. Epub 2012 Aug 10.
2. Proteomic study of plasma from moderate hypercholesterolemic patients. Alonso-Orgaz S, etal., J Proteome Res. 2006 Sep;5(9):2301-8.
3. Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators. Anderson SP, etal., Mol Carcinog. 1999 Dec;26(4):226-38.
4. Serum concentrations of immunoglobulins and acute phase proteins in Nigerian women with preeclampsia. Arinola G, etal., Reprod Biol. 2006 Nov;6(3):265-74.
5. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. Arumugam TV, etal., J Surg Res. 2002 Apr;103(2):260-7.
6. Epistasis between the haptoglobin common variant and alpha+thalassemia influences risk of severe malaria in Kenyan children. Atkinson SH, etal., Blood. 2014 Mar 27;123(13):2008-16. doi: 10.1182/blood-2013-10-533489. Epub 2014 Jan 29.
7. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. Atkinson SH, etal., PLoS Med. 2006 May;3(5):e172. Epub 2006 May 2.
8. Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients. Austin GE, etal., Clin Chem. 1987 Dec;33(12):2220-4.
9. Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload. Barbosa LC, etal., Blood Cells Mol Dis. 2014 Feb-Mar;52(2-3):95-107.
10. Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete Beenken O, etal., Z Gesamte Inn Med. 1981 May 1;36(9):294-8.
11. A proteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states. Bertile F, etal., Proteomics. 2009 Jan;9(1):148-58. doi: 10.1002/pmic.200701001.
12. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Beyea JA, etal., Dev Dyn. 2005 Oct;234(2):404-12.
13. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Bogdanski P, etal., Pol Merkur Lekarski. 2006 Jul;21(121):12-4.
14. p53-like protein binding affinity to the hormone responsive element of the haptoglobin gene in fetal rat livers. Bogojevic D, etal., Cell Biol Int 2002;26(3):217-24.
15. Hepatic heme and drug metabolism in rats with chronic mountain sickness. Bonkovsky HL, etal., Am J Physiol. 1986 Oct;251(4 Pt 1):G467-74.
16. Potential biomarkers for diagnosis of sarcoidosis using proteomics in serum. Bons JA, etal., Respir Med. 2007 Aug;101(8):1687-95. Epub 2007 Apr 18.
17. Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies. Brandslund I, etal., Scand J Clin Lab Invest. 1982 Oct;42(6):521-7.
18. Proteomic analysis of rat plasma following transient focal cerebral ischemia. Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46.
19. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. Chiellini C, etal., J Cell Physiol. 2002 Feb;190(2):251-8.
20. Serum haptoglobin: a novel marker of adiposity in humans. Chiellini C, etal., J Clin Endocrinol Metab. 2004 Jun;89(6):2678-83.
21. Serum haptoglobin concentrations in "pure" iron-deficiency anemia. Dash S and Das KC, Clin Chem. 1978 May;24(5):839-40.
22. Haptoglobin serum levels are independently associated with insulinemia in overweight and obese women. De Pergola G, etal., J Endocrinol Invest. 2007 May;30(5):399-403.
23. Evidence that brief stress may induce the acute phase response in rats. Deak T, etal., Am J Physiol. 1997 Dec;273(6 Pt 2):R1998-2004.
24. Refractory hypertension is associated with the haptoglobin 2-2 phenotype. Delanghe JR, etal., J Cardiovasc Risk. 1995 Apr;2(2):131-6.
25. Haptoglobin polymorphism and complications in established essential arterial hypertension. Delanghe JR, etal., J Hypertens. 1993 Aug;11(8):861-7.
26. Haptoglobin polymorphism in patients with preeclampsia. Depypere HT, etal., Clin Chem Lab Med. 2006;44(8):924-8.
27. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. Ding F, etal., Int J Biol Markers. 2019 Sep;34(3):221-231. doi: 10.1177/1724600819841619. Epub 2019 May 1.
28. C/EBP alpha and C/EBP beta regulate haptoglobin gene expression during rat liver development and the acute-phase response. Dinic S, etal., Mol Biol Rep. 2005 Sep;32(3):141-7.
29. Zeitschrift für Ernährungswissenschaft Eberle J, etal., Z Ernahrungswiss. 1996 Dec;35(4):332-40.
30. Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke: a population-based study. Engstrom G, etal., Diabetes. 2003 Feb;52(2):442-7.
31. Fatality of acute coronary events in relation to hypertension and low-grade inflammation: a population-based cohort study. Engstrom G, etal., J Hum Hypertens. 2006 Aug;20(8):581-6. Epub 2006 May 4.
32. Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke. Engstrom G, etal., Stroke. 2002 Dec;33(12):2744-9.
33. Proteomic analysis of post-hemorrhagic shock mesenteric lymph. Fang JF, etal., Shock. 2010 Sep;34(3):291-8.
34. Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat. Fernandez V, etal., Hepatology. 2007 Jan;45(1):170-7.
35. Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation. Flisinski M, etal., Ren Fail. 2008;30(4):443-51. doi: 10.1080/08860220801985694.
36. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. Forte A, etal., J Cell Mol Med. 2008 Oct;12(5B):1956-73. doi: 10.1111/j.1582-4934.2008.00212.x.
37. Haptoglobin groups in acute myocardial infarction. Frohlander N and Johnson O, Hum Hered. 1989;39(6):345-50.
38. Liver preconditioning induced by iron in a rat model of ischemia/reperfusion. Galleano M, etal., Life Sci. 2011 Aug 15;89(7-8):221-8. doi: 10.1016/j.lfs.2011.06.005. Epub 2011 Jun 15.
39. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
40. Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. Gelosa P, etal., J Hypertens. 2013 Nov;31(11):2259-69. doi: 10.1097/HJH.0b013e3283642f3e.
41. Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. Gianazza E, etal., Biochem J. 2003 Aug 15;374(Pt 1):239-46.
42. Markers of experimental acute inflammation in the Wistar Han rat with particular reference to haptoglobin and C-reactive protein. Giffen PS, etal., Arch Toxicol. 2003 Jul;77(7):392-402. Epub 2003 Mar 22.
43. [Haptoglobin phenotype distribution in patients at high risk of developing myocardial infarct]. Gogishvili AV, etal., Kardiologiia. 1985 Feb;25(2):55-8.
44. Nucleotide sequence of rat haptoglobin cDNA. Characterization of the alpha beta-subunit junction region of prohaptoglobin. Goldstein LA and Heath EC, J Biol Chem 1984 Jul 25;259(14):9212-7.
45. High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats. Gonzalez-Marrero I, etal., Int J Hypertens. 2013;2013:164653. doi: 10.1155/2013/164653. Epub 2013 Jan 21.
46. Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-treatment. Hakansson A, etal., PLoS One. 2012;7(3):e33510. doi: 10.1371/journal.pone.0033510. Epub 2012 Mar 23.
47. Biosynthesis and processing of rat haptoglobin. Hanley JM, etal., J Biol Chem. 1983 Jun 25;258(12):7858-69.
48. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Hanson MS, etal., Br J Haematol. 2011 Aug;154(4):502-11. doi: 10.1111/j.1365-2141.2011.08738.x. Epub 2011 May 20.
49. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Hassanali Z, etal., Diabetes Obes Metab. 2010 Feb;12(2):139-47. doi: 10.1111/j.1463-1326.2009.01130.x. Epub 2009 Nov 16.
50. Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. Heawchaiyaphum C, etal., J Proteomics. 2018 Feb 20;173:52-61. doi: 10.1016/j.jprot.2017.11.022. Epub 2017 Dec 1.
51. Acute-phase reactants and a supplemental diagnostic aid for Kawasaki disease. Huang MY, etal., Pediatr Cardiol. 2010 Nov;31(8):1209-13. Epub 2010 Oct 19.
52. Ascorbic acid deficiency changes hepatic gene expression of acute phase proteins in scurvy-prone ODS rats. Ikeda S, etal., J Nutr. 1998 May;128(5):832-8.
53. Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area. Imrie H, etal., Am J Trop Med Hyg. 2006 Jun;74(6):965-71.
54. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Irwin DC, etal., Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2.
55. Acute-phase protein expression in DMSO-intoxicated rats. Ivanovic Matic S, etal., Toxicol Lett. 2004 Mar 1;147(2):153-9.
56. Primary pulmonary hypertension. Its association with microangiopathic hemolytic anemia and thrombocytopenia. Jubelirer SJ Arch Intern Med. 1991 Jun;151(6):1221-3.
57. Early inflammatory cytokine and acute phase protein response under the stress of thermal injury in rats. Kataranovski M, etal., Physiol Res. 1999;48(6):473-82.
58. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Keith JC Jr, etal., Arthritis Res Ther. 2005;7(3):R427-38. Epub 2005 Feb 21.
59. Increase in serum haptoglobin and apolipoprotein M in patients with obstructive sleep apnoea. Kim J, etal., J Sleep Res. 2009 Sep;18(3):313-20. doi: 10.1111/j.1365-2869.2008.00725.x. Epub 2009 Jun 30.
60. Kinetic aspects of hemoglobin.haptoglobin-receptor interaction in rat liver plasma membranes, isolated liver cells, and liver cells in primary culture. Kino K, etal., J Biol Chem. 1982 May 10;257(9):4828-33.
61. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Kiraly MA, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E671-82. Epub 2009 Dec 8.
62. Reduction in plasma haptoglobin in humans with acute pulmonary embolism causing tricuspid regurgitation. Kline JA, etal., J Thromb Haemost. 2009 Sep;7(9):1597-9. Epub 2009 Jun 29.
63. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
64. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Kruger AJ, etal., Exp Biol Med (Maywood). 2010 Nov;235(11):1328-37. doi: 10.1258/ebm.2010.010150.
65. Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Larsson AE, etal., Inflamm Bowel Dis. 2006 Jun;12(6):478-85.
66. Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats. Lee MY, etal., J Cereb Blood Flow Metab 2002 Oct;22(10):1176-80.
67. Relationship between group-specific component protein and the development of asthma. Lee SH, etal., Am J Respir Crit Care Med. 2011 Sep 1;184(5):528-36.
68. Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Levy AP, etal., Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40. Epub 2006 Oct 26.
69. Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene. Li M, etal., J Biomed Biotechnol. 2009;2009:397910. doi: 10.1155/2009/397910. Epub 2009 Sep 24.
70. Comparative proteome analysis of serum from acute pulmonary embolism rat model for biomarker discovery. Li SQ, etal., J Proteome Res. 2007 Jan;6(1):150-9.
71. Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. Liu SL, etal., J Biomed Sci. 2011 Aug 1;18:52. doi: 10.1186/1423-0127-18-52.
72. Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene. Marinkovic S and Baumann H, Mol Cell Biol 1990 Apr;10(4):1573-83.
73. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
74. In vivo and in vitro effects of magnesium deficiency on hepatic haptoglobin mRNA levels. Nakagawa M, etal., Magnes Res. 2001 Mar;14(1-2):19-25.
75. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
76. Endotoxin-like effects in acute phase response to Trypanosoma brucei brucei infection are not due to gastrointestinal leakage. Ngure RM, etal., Parasitol Int. 2009 Dec;58(4):325-9. doi: 10.1016/j.parint.2009.06.008. Epub 2009 Jun 28.
77. Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. Nielsen SS, etal., Comp Hepatol. 2006 Sep 12;5:3.
78. Effects of heparin administration on Trypanosoma brucei gambiense infection in rats. Nishimura K, etal., J Parasitol. 2005 Feb;91(1):219-22.
79. Dietary conjugated linoleic acid preserves pancreatic function and reduces inflammatory markers in obese, insulin-resistant rats. Noto A, etal., Metabolism. 2007 Jan;56(1):142-51.
80. Haptoglobin is a Sertoli cell product in the rat seminiferous epithelium: its purification and regulation. O'Bryan MK, etal., J Androl. 1997 Nov-Dec;18(6):637-45.
81. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
82. Pathology, Tissue Metalloproteinase Transcription and Haptoglobin Responses in Mice after Experimental Challenge with Different Isolates of Pasteurella multocida Obtained from Cases of Porcine Pneumonia. Pors SE, etal., J Comp Pathol. 2011 Aug-Oct;145(2-3):251-60. Epub 2011 Mar 8.
83. Proteomic profiling of N-linked glycoproteins identifies ConA-binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma. Qi YJ, etal., Proteomics. 2014 Feb;14(2-3):186-95. doi: 10.1002/pmic.201300226.
84. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
85. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
86. Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Roeb E, etal., Scand J Gastroenterol. 2003 Aug;38(8):878-85.
87. Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome. Russell JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G507-16. doi: 10.1152/ajpgi.00173.2010. Epub 2010 May 27.
88. Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy. Sampietro T, etal., Am J Cardiol. 2005 Dec 15;96(12):1718-20. Epub 2005 Nov 2.
89. Changes of acute-phase proteins in streptozotocin-induced diabetic rats. Saso L, etal., Physiol Res. 2000;49(4):403-9.
90. Adrenalectomy and dexamethasone treatment alter the patterns of basal and acute phase response-induced expression of acute phase protein genes in rat liver. Sevaljevic L, etal., J Steroid Biochem Mol Biol. 1998 Sep;66(5-6):347-53.
91. Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies. Shimada E, etal., Transfusion. 2002 Jun;42(6):766-73.
92. Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall. Shirpoor A, etal., Int Immunopharmacol. 2013 Aug;16(4):498-504. doi: 10.1016/j.intimp.2013.04.024. Epub 2013 May 9.
93. Differential expression of plasma proteins in cyclosporine A-induced rat acute nephrotoxicity. Shu Z, etal., Biosci Biotechnol Biochem. 2009 Mar 23;73(3):592-8. Epub 2009 Mar 7.
94. Proteomic changes induced by effective chemopreventive ratios of n-3:n-6 fatty acids and tamoxifen against MNU-induced mammary cancer in the rat. Skibinski CG, etal., Cancer Prev Res (Phila). 2013 Sep;6(9):979-88. doi: 10.1158/1940-6207.CAPR-13-0152. Epub 2013 Jul 23.
95. The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. Smeets MB, etal., Int J Exp Pathol. 2003 Apr;84(2):69-74.
96. Serum glycoproteins in coronary artery disease. Snyder S, etal., Circulation. 1977 Sep;56(3):359-62.
97. Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases. Soler-Garcia AA, etal., Clin J Am Soc Nephrol. 2009 Apr;4(4):763-71. doi: 10.2215/CJN.0200608. Epub 2009 Mar 11.
98. Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein E mediated cholesterol trafficking in neuroblastoma cell lines. Spagnuolo MS, etal., Front Cell Neurosci. 2014 Aug 5;8:212. doi: 10.3389/fncel.2014.00212. eCollection 2014.
99. Variability of haptoglobin and alpha 2-macroglobulin in Albino Oxford and Dark Augustin inbred strains of rats before and after trauma. Strnad M, etal., Vojnosanit Pregl. 2000 Jul-Aug;57(4):381-6.
100. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
101. Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy. Trutic N, etal., Comp Biochem Physiol C Toxicol Pharmacol. 2002 Nov;133(3):461-70.
102. Comparative proteomic studies of plasma from children with pneumococcal pneumonia. Tsai MH, etal., Scand J Infect Dis. 2009;41(6-7):416-24.
103. Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease. Verrills NM, etal., Am J Respir Crit Care Med. 2011 Jun 15;183(12):1633-43. Epub 2011 Mar 18.
104. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Visser JT, etal., Diabetologia. 2010 Dec;53(12):2621-8. doi: 10.1007/s00125-010-1903-9. Epub 2010 Sep 19.
105. Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis. A retrospective cohort study from disease onset. Wallberg-Jonsson S, etal., J Rheumatol. 1999 Dec;26(12):2562-71.
106. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
107. Haptoglobin in lung defence. Yang F, etal., Redox Rep. 2001;6(6):372-4.
108. Serum proteomic analysis of extracorporeal shock wave therapy-enhanced diabetic wound healing in a streptozotocin-induced diabetes model. Yang MY, etal., Plast Reconstr Surg. 2014 Jan;133(1):59-68. doi: 10.1097/01.prs.0000439050.08733.cf.
109. Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver. Yang S, etal., J Neurosci Res. 2013 Feb;91(2):230-9. doi: 10.1002/jnr.23159. Epub 2012 Nov 22.
110. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
111. Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease. Yuditskaya S, etal., Blood. 2009 Jan 29;113(5):1122-8. Epub 2008 Nov 20.
112. Rapid clearance of circulating haptoglobin from plasma during acute pulmonary embolism in rats results in HMOX1 up-regulation in peripheral blood leukocytes. Zagorski J, etal., J Thromb Haemost. 2010 Feb;8(2):389-96. Epub 2009 Nov 23.
113. Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension. Zhang J, etal., Respir Med. 2009 Dec;103(12):1801-6. Epub 2009 Aug 22.
114. Neuroprotective role of haptoglobin after intracerebral hemorrhage. Zhao X, etal., J Neurosci. 2009 Dec 16;29(50):15819-27. doi: 10.1523/JNEUROSCI.3776-09.2009.
115. Shenfu Injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Zheng SD, etal., Chin J Integr Med. 2015 Jan;21(1):22-8. doi: 10.1007/s11655-013-1440-8. Epub 2013 Mar 15.
Additional References at PubMed
PMID:11865981   PMID:12477932   PMID:15489334   PMID:16502470   PMID:17616219   PMID:17910034   PMID:19056867   PMID:19433579   PMID:19521970   PMID:19545490   PMID:19740759   PMID:20155810  
PMID:21805676   PMID:22254015   PMID:22516433   PMID:22664934   PMID:23012479   PMID:23117660   PMID:23376485   PMID:23533145   PMID:24006456   PMID:25645918  


Genomics

Comparative Map Data
Hp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21937,539,626 - 37,544,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,539,627 - 37,544,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,352,875 - 44,357,420 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01945,006,203 - 45,010,748 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01947,315,910 - 47,320,455 (-)NCBIRnor_WKY
Rnor_6.01942,096,255 - 42,100,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,097,995 - 42,100,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,921,384 - 52,925,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,443,016 - 39,447,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,447,897 - 39,452,447 (-)NCBI
Celera1936,944,700 - 36,949,250 (-)NCBICelera
Cytogenetic Map19q12NCBI
HP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,054,505 - 72,061,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1672,054,505 - 72,061,055 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,088,404 - 72,094,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,646,009 - 70,652,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,646,008 - 70,652,458NCBI
Celera1656,402,627 - 56,409,074 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,855,340 - 57,861,787 (+)NCBIHuRef
CHM1_11673,501,856 - 73,508,303 (+)NCBICHM1_1
T2T-CHM13v2.01677,872,534 - 77,877,369 (+)NCBIT2T-CHM13v2.0
Hp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,301,760 - 110,305,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,301,760 - 110,305,804 (-)EnsemblGRCm39 Ensembl
GRCm388109,575,128 - 109,579,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,575,128 - 109,579,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,099,028 - 112,103,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,464,257 - 112,468,192 (-)NCBIMGSCv36mm8
Celera8113,800,405 - 113,804,474 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.11NCBI
LOC101976500
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,743,357 - 37,748,060 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647521,841,054 - 21,845,821 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1614,980,382 - 14,985,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,643,378 - 14,648,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI

Variants

.
Variants in Hp
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:169
Count of miRNA genes:93
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000020197, ENSRNOT00000050989
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
D19Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01952,922,785 - 52,922,895NCBIRnor5.0
Rnor_5.01952,922,786 - 52,922,896NCBIRnor5.0
RGSC_v3.41939,446,055 - 39,446,164RGDRGSC3.4
RGSC_v3.41939,446,054 - 39,446,163UniSTSRGSC3.4
RGSC_v3.11939,450,936 - 39,451,045RGD
Celera1936,947,738 - 36,947,847UniSTS
RH 2.0 Map19457.6RGD
Cytogenetic Map19q12UniSTS
D19Arb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,544,401 - 37,544,765 (-)MAPPERmRatBN7.2
Rnor_6.01942,095,668 - 42,096,031NCBIRnor6.0
Rnor_5.01952,920,797 - 52,921,160UniSTSRnor5.0
RGSC_v3.41939,447,789 - 39,448,152RGDRGSC3.4
RGSC_v3.41939,447,790 - 39,448,152UniSTSRGSC3.4
RGSC_v3.11939,452,670 - 39,453,033RGD
Celera1936,949,474 - 36,949,837UniSTS
FHH x ACI Map1930.2099UniSTS
FHH x ACI Map1930.2099RGD
Cytogenetic Map19q12UniSTS
D19Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,540,644 - 37,540,803 (-)MAPPERmRatBN7.2
Rnor_6.01942,099,630 - 42,099,786NCBIRnor6.0
Rnor_5.01952,924,759 - 52,924,915UniSTSRnor5.0
RGSC_v3.41939,444,034 - 39,444,191RGDRGSC3.4
RGSC_v3.41939,444,035 - 39,444,191UniSTSRGSC3.4
RGSC_v3.11939,448,915 - 39,449,072RGD
Celera1936,945,719 - 36,945,875UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25 25 25
Medium 1 15 10 11 10 2 2 1 1 23 11 2
Low 3 42 17 6 8 6 6 9 73 34 18 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF476963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020197   ⟹   ENSRNOP00000020196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,539,627 - 37,542,488 (-)Ensembl
Rnor_6.0 Ensembl1942,097,995 - 42,100,804 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104067   ⟹   ENSRNOP00000089249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,539,766 - 37,544,237 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115765   ⟹   ENSRNOP00000079870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,539,627 - 37,544,523 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118054   ⟹   ENSRNOP00000085960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1937,539,627 - 37,544,232 (-)Ensembl
RefSeq Acc Id: NM_012582   ⟹   NP_036714
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21937,539,626 - 37,544,178 (-)NCBI
Rnor_6.01942,096,255 - 42,100,805 (+)NCBI
Rnor_5.01952,921,384 - 52,925,934 (+)NCBI
RGSC_v3.41939,443,016 - 39,447,566 (-)RGD
Celera1936,944,700 - 36,949,250 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036714   ⟸   NM_012582
- Peptide Label: precursor
- UniProtKB: Q7TP23 (UniProtKB/Swiss-Prot),   P06866 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020196   ⟸   ENSRNOT00000020197
RefSeq Acc Id: ENSRNOP00000079870   ⟸   ENSRNOT00000115765
RefSeq Acc Id: ENSRNOP00000089249   ⟸   ENSRNOT00000104067
RefSeq Acc Id: ENSRNOP00000085960   ⟸   ENSRNOT00000118054
Protein Domains
Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06866-F1-model_v2 AlphaFold P06866 1-347 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701135
Promoter ID:EPDNEW_R11659
Type:initiation region
Name:Hp_1
Description:haptoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01942,097,982 - 42,098,042EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2825 AgrOrtholog
BioCyc Gene G2FUF-5730 BioCyc
Ensembl Genes ENSRNOG00000014964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020196.5 UniProtKB/TrEMBL
  ENSRNOP00000079870.1 UniProtKB/TrEMBL
  ENSRNOP00000085960 ENTREZGENE
  ENSRNOP00000085960.1 UniProtKB/Swiss-Prot
  ENSRNOP00000089249.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020197.7 UniProtKB/TrEMBL
  ENSRNOT00000104067.1 UniProtKB/TrEMBL
  ENSRNOT00000115765.1 UniProtKB/TrEMBL
  ENSRNOT00000118054 ENTREZGENE
  ENSRNOT00000118054.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7321960 IMAGE-MGC_LOAD
InterPro Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24464 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108751 IMAGE-MGC_LOAD
NCBI Gene 24464 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24255:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hp PhenoGen
PIRSF Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC210914
UniProt A0A0H2UHM3_RAT UniProtKB/TrEMBL
  A0A8I5ZPF0_RAT UniProtKB/TrEMBL
  A0A8I6A9F4_RAT UniProtKB/TrEMBL
  HPT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TP23 ENTREZGENE
UniProt Secondary Q5EBB4 UniProtKB/Swiss-Prot
  Q7TP23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hp  Haptoglobin      Symbol and Name status set to approved 70586 APPROVED