Hp (haptoglobin) - Rat Genome Database

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Gene: Hp (haptoglobin) Mus musculus
Analyze
Symbol: Hp
Name: haptoglobin
RGD ID: 10728
MGI Page MGI
Description: Predicted to enable hemoglobin binding activity; identical protein binding activity; and serine-type endopeptidase activity. Acts upstream of or within Notch signaling pathway and response to bacterium. Located in extracellular space. Is expressed in several structures, including adrenal gland; immune system; liver; lung; and white fat. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; artery disease (multiple); gout; hyperglycemia; and obesity. Orthologous to human HP (haptoglobin) and HPR (haptoglobin-related protein).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HP-; HP-1; pre; preHP2; zo; zonulin
RGD Orthologs
Human
Rat
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,301,760 - 110,305,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,301,760 - 110,305,804 (-)EnsemblGRCm39 Ensembl
GRCm388109,575,128 - 109,579,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,575,128 - 109,579,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,099,028 - 112,103,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,464,257 - 112,468,192 (-)NCBIMGSCv36mm8
Celera8113,800,405 - 113,804,474 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS-Associated Nephropathy  (ISO)
allergic disease  (ISO)
alpha thalassemia  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
Anhaptoglobinemia  (ISO)
arteriosclerosis  (IAGP,ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
autosomal dominant dyskeratosis congenita 6  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (IMP,ISO)
Chemically-Induced Disorders  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Female Genital Neoplasms  (ISO)
Foodborne Diseases  (ISO)
genetic disease  (ISO)
gout  (ISO)
hemochromatosis  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (IEP)
Intestinal Reperfusion Injury  (ISO)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
leukemia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Pasteurellaceae Infections  (ISO)
pasteurellosis  (IEP)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
retinal detachment  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
Sickle Cell Trait  (ISO)
Starvation  (ISO)
Stroke  (ISO)
trypanosomiasis  (IEP)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Venous Thrombosis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-lariciresinol  (ISO)
(-)-lariciresinol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
1,1-dichloroethene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
alclofenac  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
andrographolide  (EXP)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP,ISO)
carnosic acid  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethyl sulfoxide  (ISO)
doramapimod  (EXP)
doxorubicin  (ISO)
flutamide  (ISO)
fructose  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-ascorbic acid  (EXP,ISO)
lactulose  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methimazole  (ISO)
metronidazole  (ISO)
microcystin-LR  (EXP)
minocycline  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodimethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
profenofos  (ISO)
progesterone  (EXP,ISO)
quartz  (ISO)
quercetin  (ISO)
sarin  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Methemoglobinemia and ascorbate deficiency in hemoglobin E beta thalassemia: metabolic and clinical implications. Allen A, etal., Blood. 2012 Oct 11;120(15):2939-44. doi: 10.1182/blood-2012-06-435875. Epub 2012 Aug 10.
2. Proteomic study of plasma from moderate hypercholesterolemic patients. Alonso-Orgaz S, etal., J Proteome Res. 2006 Sep;5(9):2301-8.
3. Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators. Anderson SP, etal., Mol Carcinog. 1999 Dec;26(4):226-38.
4. Serum concentrations of immunoglobulins and acute phase proteins in Nigerian women with preeclampsia. Arinola G, etal., Reprod Biol. 2006 Nov;6(3):265-74.
5. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. Arumugam TV, etal., J Surg Res. 2002 Apr;103(2):260-7.
6. Epistasis between the haptoglobin common variant and alpha+thalassemia influences risk of severe malaria in Kenyan children. Atkinson SH, etal., Blood. 2014 Mar 27;123(13):2008-16. doi: 10.1182/blood-2013-10-533489. Epub 2014 Jan 29.
7. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. Atkinson SH, etal., PLoS Med. 2006 May;3(5):e172. Epub 2006 May 2.
8. Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients. Austin GE, etal., Clin Chem. 1987 Dec;33(12):2220-4.
9. Haptoglobin and myeloperoxidase (- G463A) gene polymorphisms in Brazilian sickle cell patients with and without secondary iron overload. Barbosa LC, etal., Blood Cells Mol Dis. 2014 Feb-Mar;52(2-3):95-107.
10. Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete Beenken O, etal., Z Gesamte Inn Med. 1981 May 1;36(9):294-8.
11. A proteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states. Bertile F, etal., Proteomics. 2009 Jan;9(1):148-58. doi: 10.1002/pmic.200701001.
12. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Bogdanski P, etal., Pol Merkur Lekarski. 2006 Jul;21(121):12-4.
13. Hepatic heme and drug metabolism in rats with chronic mountain sickness. Bonkovsky HL, etal., Am J Physiol. 1986 Oct;251(4 Pt 1):G467-74.
14. Potential biomarkers for diagnosis of sarcoidosis using proteomics in serum. Bons JA, etal., Respir Med. 2007 Aug;101(8):1687-95. Epub 2007 Apr 18.
15. Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies. Brandslund I, etal., Scand J Clin Lab Invest. 1982 Oct;42(6):521-7.
16. Proteomic analysis of rat plasma following transient focal cerebral ischemia. Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46.
17. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. Chiellini C, etal., J Cell Physiol. 2002 Feb;190(2):251-8.
18. Serum haptoglobin: a novel marker of adiposity in humans. Chiellini C, etal., J Clin Endocrinol Metab. 2004 Jun;89(6):2678-83.
19. Serum haptoglobin concentrations in "pure" iron-deficiency anemia. Dash S and Das KC, Clin Chem. 1978 May;24(5):839-40.
20. Haptoglobin serum levels are independently associated with insulinemia in overweight and obese women. De Pergola G, etal., J Endocrinol Invest. 2007 May;30(5):399-403.
21. Evidence that brief stress may induce the acute phase response in rats. Deak T, etal., Am J Physiol. 1997 Dec;273(6 Pt 2):R1998-2004.
22. Refractory hypertension is associated with the haptoglobin 2-2 phenotype. Delanghe JR, etal., J Cardiovasc Risk. 1995 Apr;2(2):131-6.
23. Haptoglobin polymorphism and complications in established essential arterial hypertension. Delanghe JR, etal., J Hypertens. 1993 Aug;11(8):861-7.
24. Haptoglobin polymorphism in patients with preeclampsia. Depypere HT, etal., Clin Chem Lab Med. 2006;44(8):924-8.
25. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. Ding F, etal., Int J Biol Markers. 2019 Sep;34(3):221-231. doi: 10.1177/1724600819841619. Epub 2019 May 1.
26. Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke: a population-based study. Engstrom G, etal., Diabetes. 2003 Feb;52(2):442-7.
27. Fatality of acute coronary events in relation to hypertension and low-grade inflammation: a population-based cohort study. Engstrom G, etal., J Hum Hypertens. 2006 Aug;20(8):581-6. Epub 2006 May 4.
28. Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke. Engstrom G, etal., Stroke. 2002 Dec;33(12):2744-9.
29. Proteomic analysis of post-hemorrhagic shock mesenteric lymph. Fang JF, etal., Shock. 2010 Sep;34(3):291-8.
30. Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat. Fernandez V, etal., Hepatology. 2007 Jan;45(1):170-7.
31. Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation. Flisinski M, etal., Ren Fail. 2008;30(4):443-51. doi: 10.1080/08860220801985694.
32. Expression profiles in surgically-induced carotid stenosis: a combined transcriptomic and proteomic investigation. Forte A, etal., J Cell Mol Med. 2008 Oct;12(5B):1956-73. doi: 10.1111/j.1582-4934.2008.00212.x.
33. Haptoglobin groups in acute myocardial infarction. Frohlander N and Johnson O, Hum Hered. 1989;39(6):345-50.
34. Liver preconditioning induced by iron in a rat model of ischemia/reperfusion. Galleano M, etal., Life Sci. 2011 Aug 15;89(7-8):221-8. doi: 10.1016/j.lfs.2011.06.005. Epub 2011 Jun 15.
35. Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. Gelosa P, etal., J Hypertens. 2013 Nov;31(11):2259-69. doi: 10.1097/HJH.0b013e3283642f3e.
36. Markers of experimental acute inflammation in the Wistar Han rat with particular reference to haptoglobin and C-reactive protein. Giffen PS, etal., Arch Toxicol. 2003 Jul;77(7):392-402. Epub 2003 Mar 22.
37. [Haptoglobin phenotype distribution in patients at high risk of developing myocardial infarct]. Gogishvili AV, etal., Kardiologiia. 1985 Feb;25(2):55-8.
38. High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats. Gonzalez-Marrero I, etal., Int J Hypertens. 2013;2013:164653. doi: 10.1155/2013/164653. Epub 2013 Jan 21.
39. Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-treatment. Hakansson A, etal., PLoS One. 2012;7(3):e33510. doi: 10.1371/journal.pone.0033510. Epub 2012 Mar 23.
40. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Hanson MS, etal., Br J Haematol. 2011 Aug;154(4):502-11. doi: 10.1111/j.1365-2141.2011.08738.x. Epub 2011 May 20.
41. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Hassanali Z, etal., Diabetes Obes Metab. 2010 Feb;12(2):139-47. doi: 10.1111/j.1463-1326.2009.01130.x. Epub 2009 Nov 16.
42. Peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. Heawchaiyaphum C, etal., J Proteomics. 2018 Feb 20;173:52-61. doi: 10.1016/j.jprot.2017.11.022. Epub 2017 Dec 1.
43. Acute-phase reactants and a supplemental diagnostic aid for Kawasaki disease. Huang MY, etal., Pediatr Cardiol. 2010 Nov;31(8):1209-13. Epub 2010 Oct 19.
44. Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area. Imrie H, etal., Am J Trop Med Hyg. 2006 Jun;74(6):965-71.
45. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Irwin DC, etal., Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2.
46. Primary pulmonary hypertension. Its association with microangiopathic hemolytic anemia and thrombocytopenia. Jubelirer SJ Arch Intern Med. 1991 Jun;151(6):1221-3.
47. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Keith JC Jr, etal., Arthritis Res Ther. 2005;7(3):R427-38. Epub 2005 Feb 21.
48. Increase in serum haptoglobin and apolipoprotein M in patients with obstructive sleep apnoea. Kim J, etal., J Sleep Res. 2009 Sep;18(3):313-20. doi: 10.1111/j.1365-2869.2008.00725.x. Epub 2009 Jun 30.
49. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Kiraly MA, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E671-82. Epub 2009 Dec 8.
50. Reduction in plasma haptoglobin in humans with acute pulmonary embolism causing tricuspid regurgitation. Kline JA, etal., J Thromb Haemost. 2009 Sep;7(9):1597-9. Epub 2009 Jun 29.
51. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
52. Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. Kruger AJ, etal., Exp Biol Med (Maywood). 2010 Nov;235(11):1328-37. doi: 10.1258/ebm.2010.010150.
53. Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity. Larsson AE, etal., Inflamm Bowel Dis. 2006 Jun;12(6):478-85.
54. Relationship between group-specific component protein and the development of asthma. Lee SH, etal., Am J Respir Crit Care Med. 2011 Sep 1;184(5):528-36.
55. Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Levy AP, etal., Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40. Epub 2006 Oct 26.
56. Proteomic analysis of serum in lung cancer induced by 3-methylcholanthrene. Li M, etal., J Biomed Biotechnol. 2009;2009:397910. doi: 10.1155/2009/397910. Epub 2009 Sep 24.
57. Comparative proteome analysis of serum from acute pulmonary embolism rat model for biomarker discovery. Li SQ, etal., J Proteome Res. 2007 Jan;6(1):150-9.
58. Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. Liu SL, etal., J Biomed Sci. 2011 Aug 1;18:52. doi: 10.1186/1423-0127-18-52.
59. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
60. MGDs mouse GO annotations MGD data from the GO Consortium
61. MGD IEA MGD IEA
62. Endotoxin-like effects in acute phase response to Trypanosoma brucei brucei infection are not due to gastrointestinal leakage. Ngure RM, etal., Parasitol Int. 2009 Dec;58(4):325-9. doi: 10.1016/j.parint.2009.06.008. Epub 2009 Jun 28.
63. Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. Nielsen SS, etal., Comp Hepatol. 2006 Sep 12;5:3.
64. Dietary conjugated linoleic acid preserves pancreatic function and reduces inflammatory markers in obese, insulin-resistant rats. Noto A, etal., Metabolism. 2007 Jan;56(1):142-51.
65. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
66. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
67. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Pathak BG, etal., Genomics 1996 Apr 1;33(1):124-7.
68. Pathology, Tissue Metalloproteinase Transcription and Haptoglobin Responses in Mice after Experimental Challenge with Different Isolates of Pasteurella multocida Obtained from Cases of Porcine Pneumonia. Pors SE, etal., J Comp Pathol. 2011 Aug-Oct;145(2-3):251-60. Epub 2011 Mar 8.
69. Proteomic profiling of N-linked glycoproteins identifies ConA-binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma. Qi YJ, etal., Proteomics. 2014 Feb;14(2-3):186-95. doi: 10.1002/pmic.201300226.
70. Mouse MP Annotation Import Pipeline RGD automated import pipeline
71. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
72. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
73. Effect of glutathione depletion and hydrophilic bile acids on hepatic acute phase reaction in rats with extrahepatic cholestasis. Roeb E, etal., Scand J Gastroenterol. 2003 Aug;38(8):878-85.
74. Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome. Russell JC, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G507-16. doi: 10.1152/ajpgi.00173.2010. Epub 2010 May 27.
75. Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy. Sampietro T, etal., Am J Cardiol. 2005 Dec 15;96(12):1718-20. Epub 2005 Nov 2.
76. Changes of acute-phase proteins in streptozotocin-induced diabetic rats. Saso L, etal., Physiol Res. 2000;49(4):403-9.
77. Rat gene mapping using PCR-analyzed microsatellites. Serikawa T, etal., Genetics 1992 Jul;131(3):701-21.
78. Anaphylactic transfusion reactions in haptoglobin-deficient patients with IgE and IgG haptoglobin antibodies. Shimada E, etal., Transfusion. 2002 Jun;42(6):766-73.
79. Vasoprotective effect of vitamin E: rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall. Shirpoor A, etal., Int Immunopharmacol. 2013 Aug;16(4):498-504. doi: 10.1016/j.intimp.2013.04.024. Epub 2013 May 9.
80. Differential expression of plasma proteins in cyclosporine A-induced rat acute nephrotoxicity. Shu Z, etal., Biosci Biotechnol Biochem. 2009 Mar 23;73(3):592-8. Epub 2009 Mar 7.
81. Proteomic changes induced by effective chemopreventive ratios of n-3:n-6 fatty acids and tamoxifen against MNU-induced mammary cancer in the rat. Skibinski CG, etal., Cancer Prev Res (Phila). 2013 Sep;6(9):979-88. doi: 10.1158/1940-6207.CAPR-13-0152. Epub 2013 Jul 23.
82. The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. Smeets MB, etal., Int J Exp Pathol. 2003 Apr;84(2):69-74.
83. Serum glycoproteins in coronary artery disease. Snyder S, etal., Circulation. 1977 Sep;56(3):359-62.
84. Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases. Soler-Garcia AA, etal., Clin J Am Soc Nephrol. 2009 Apr;4(4):763-71. doi: 10.2215/CJN.0200608. Epub 2009 Mar 11.
85. Variability of haptoglobin and alpha 2-macroglobulin in Albino Oxford and Dark Augustin inbred strains of rats before and after trauma. Strnad M, etal., Vojnosanit Pregl. 2000 Jul-Aug;57(4):381-6.
86. Comparative proteomic studies of plasma from children with pneumococcal pneumonia. Tsai MH, etal., Scand J Infect Dis. 2009;41(6-7):416-24.
87. Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease. Verrills NM, etal., Am J Respir Crit Care Med. 2011 Jun 15;183(12):1633-43. Epub 2011 Mar 18.
88. Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat. Visser JT, etal., Diabetologia. 2010 Dec;53(12):2621-8. doi: 10.1007/s00125-010-1903-9. Epub 2010 Sep 19.
89. Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis. A retrospective cohort study from disease onset. Wallberg-Jonsson S, etal., J Rheumatol. 1999 Dec;26(12):2562-71.
90. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
91. Serum proteomic analysis of extracorporeal shock wave therapy-enhanced diabetic wound healing in a streptozotocin-induced diabetes model. Yang MY, etal., Plast Reconstr Surg. 2014 Jan;133(1):59-68. doi: 10.1097/01.prs.0000439050.08733.cf.
92. Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver. Yang S, etal., J Neurosci Res. 2013 Feb;91(2):230-9. doi: 10.1002/jnr.23159. Epub 2012 Nov 22.
93. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
94. Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease. Yuditskaya S, etal., Blood. 2009 Jan 29;113(5):1122-8. Epub 2008 Nov 20.
95. Rapid clearance of circulating haptoglobin from plasma during acute pulmonary embolism in rats results in HMOX1 up-regulation in peripheral blood leukocytes. Zagorski J, etal., J Thromb Haemost. 2010 Feb;8(2):389-96. Epub 2009 Nov 23.
96. Potential diagnostic biomarkers in serum of idiopathic pulmonary arterial hypertension. Zhang J, etal., Respir Med. 2009 Dec;103(12):1801-6. Epub 2009 Aug 22.
97. Neuroprotective role of haptoglobin after intracerebral hemorrhage. Zhao X, etal., J Neurosci. 2009 Dec 16;29(50):15819-27. doi: 10.1523/JNEUROSCI.3776-09.2009.
98. Shenfu Injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Zheng SD, etal., Chin J Integr Med. 2015 Jan;21(1):22-8. doi: 10.1007/s11655-013-1440-8. Epub 2013 Mar 15.
Additional References at PubMed
PMID:1302014   PMID:1535334   PMID:1542575   PMID:1886768   PMID:1968046   PMID:2571576   PMID:3866909   PMID:6059653   PMID:7564277   PMID:7774933   PMID:7789972   PMID:8164679  
PMID:8228167   PMID:8288218   PMID:8288241   PMID:8294478   PMID:8453636   PMID:8662221   PMID:8786117   PMID:9069116   PMID:9300815   PMID:9611252   PMID:9731043   PMID:10349636  
PMID:10982846   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11865977   PMID:11865978   PMID:11865980   PMID:11865981   PMID:12039846   PMID:12393471   PMID:12477932   PMID:12562322  
PMID:12652657   PMID:14697247   PMID:15131800   PMID:15613548   PMID:15667571   PMID:15793279   PMID:15852445   PMID:16141072   PMID:16141073   PMID:16742000   PMID:16944957   PMID:17082477  
PMID:17644369   PMID:17919498   PMID:17962599   PMID:18436583   PMID:18599520   PMID:19176700   PMID:19433579   PMID:19490627   PMID:19775690   PMID:19795414   PMID:19952271   PMID:21267068  
PMID:21677750   PMID:21708824   PMID:21873550   PMID:21873635   PMID:22749805   PMID:23012479   PMID:23096414   PMID:23117660   PMID:23274064   PMID:23548836   PMID:23564505   PMID:23937658  
PMID:24006456   PMID:24959824   PMID:25582460   PMID:25618031   PMID:25801896   PMID:27294203   PMID:27480124   PMID:28286877   PMID:28378742   PMID:28423466   PMID:28440464   PMID:28464519  
PMID:30194503   PMID:30482269   PMID:30771488   PMID:30790555   PMID:31076532   PMID:31573976   PMID:32101700   PMID:32325033   PMID:34789790  


Genomics

Comparative Map Data
Hp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,301,760 - 110,305,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,301,760 - 110,305,804 (-)EnsemblGRCm39 Ensembl
GRCm388109,575,128 - 109,579,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,575,128 - 109,579,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,099,028 - 112,103,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,464,257 - 112,468,192 (-)NCBIMGSCv36mm8
Celera8113,800,405 - 113,804,474 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.11NCBI
HP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,054,505 - 72,061,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,054,505 - 72,061,055 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,088,404 - 72,094,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,646,009 - 70,652,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,646,008 - 70,652,458NCBI
Celera1656,402,627 - 56,409,074 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,855,340 - 57,861,787 (+)NCBIHuRef
CHM1_11673,501,856 - 73,508,303 (+)NCBICHM1_1
T2T-CHM13v2.01677,872,534 - 77,877,369 (+)NCBIT2T-CHM13v2.0
Hp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,449,151 - 54,453,701 (-)NCBIGRCr8
mRatBN7.21937,539,626 - 37,544,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,539,627 - 37,544,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,352,875 - 44,357,420 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,006,203 - 45,010,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,315,910 - 47,320,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,096,255 - 42,100,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,097,995 - 42,100,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,921,384 - 52,925,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,443,016 - 39,447,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,447,897 - 39,452,447 (-)NCBI
Celera1936,944,700 - 36,949,250 (-)NCBICelera
Cytogenetic Map19q12NCBI
LOC101976500
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,743,357 - 37,748,060 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647521,841,054 - 21,845,821 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1614,980,382 - 14,985,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,643,378 - 14,648,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI

Variants

.
Variants in Hp
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:182
Interacting mature miRNAs:192
Transcripts:ENSMUST00000074898
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
35673316Ari3_mantibody response to influenza 3, day 15, IgM (mouse)8109426632113826632Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
36049782Arc2_mantibody response to CHIKV 2, day 7, IgM (mouse)8109426632113826632Mouse
36049783Arc3_mantibody response to CHIKV 3, day 7, FRNT50 (mouse)8109426632113826632Mouse
36049780Ars12_mantibody response to SARS-CoV 12, 4 days post-rechallenge, IgM (mouse)8109426632113826632Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
36049781Arc1_mantibody response to CHIKV 1, day 7, IgG (mouse)8109426632113826632Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
Hp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388109,575,642 - 109,576,771UniSTSGRCm38
MGSCv378112,099,542 - 112,100,671UniSTSGRCm37
Celera8113,800,919 - 113,802,048UniSTS
Cytogenetic Map8D3UniSTS
cM Map855.0UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000074898   ⟹   ENSMUSP00000074436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,301,760 - 110,305,804 (-)Ensembl
GRCm38.p6 Ensembl8109,575,128 - 109,579,172 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,302,394 - 110,305,289 (-)Ensembl
GRCm38.p6 Ensembl8109,575,762 - 109,578,657 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8110,302,202 - 110,305,642 (-)Ensembl
GRCm38.p6 Ensembl8109,575,570 - 109,579,010 (-)Ensembl
RefSeq Acc Id: NM_001329965   ⟹   NP_001316894
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,301,760 - 110,305,804 (-)NCBI
GRCm388109,575,128 - 109,579,172 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017370   ⟹   NP_059066
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398110,301,760 - 110,305,804 (-)NCBI
GRCm388109,575,128 - 109,579,172 (-)ENTREZGENE
MGSCv378112,099,028 - 112,103,072 (-)RGD
Celera8113,800,405 - 113,804,474 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_059066   ⟸   NM_017370
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q61646 (UniProtKB/Swiss-Prot),   Q3UBS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001316894   ⟸   NM_001329965
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSMUSP00000074436   ⟸   ENSMUST00000074898
Protein Domains
Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61646-F1-model_v2 AlphaFold Q61646 1-347 view protein structure

Promoters
RGD ID:8668233
Promoter ID:EPDNEW_M12148
Type:initiation region
Name:Hp_1
Description:Mus musculus haptoglobin , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388109,579,064 - 109,579,124EPDNEW
RGD ID:6849260
Promoter ID:MM_XEF:7228
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   Liver
Transcripts:NM_001040470,   NM_001082110,   NM_001126102,   NM_001133306,   NM_005143,   NM_012582,   NM_020995,   NM_214000
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368112,101,201 - 112,102,222 (-)MPROMDB
RGD ID:6843300
Promoter ID:MM_KWN:55688
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_4Hour,   Liver
Transcripts:NM_017370
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368112,102,801 - 112,103,372 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96211 AgrOrtholog
Ensembl Genes ENSMUSG00000031722 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000074898 ENTREZGENE
  ENSMUST00000074898.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15439 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96211 ENTREZGENE
NCBI Gene 15439 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24255:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hp PhenoGen
PIRSF Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HPT_MOUSE UniProtKB/Swiss-Prot
  Q3UBS3 ENTREZGENE, UniProtKB/TrEMBL
  Q61646 ENTREZGENE