HP (haptoglobin) - Rat Genome Database

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Gene: HP (haptoglobin) Sus scrofa
Analyze
Symbol: HP
Name: haptoglobin
RGD ID: 14147955
Description: ENCODES a protein that exhibits hemoglobin binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); liver development (ortholog); negative regulation of hydrogen peroxide catabolic process (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); AIDS-Associated Nephropathy (ortholog); allergic disease (ortholog); FOUND IN blood microparticle (ortholog); extracellular space (ortholog); haptoglobin-hemoglobin complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: haptoglobin alpha 1S; zonulin
RGD Orthologs
Human
Mouse
Rat
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1614,980,382 - 14,985,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,643,378 - 14,648,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
AIDS-Associated Nephropathy  (ISO)
allergic disease  (ISO)
alpha thalassemia  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
Anhaptoglobinemia  (ISO)
arteriosclerosis  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
autosomal dominant dyskeratosis congenita 6  (ISO)
beta thalassemia  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
Cerebral Hemorrhage  (ISO)
Chemically-Induced Disorders  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetes Complications  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Female Genital Neoplasms  (ISO)
Foodborne Diseases  (ISO)
genetic disease  (ISO)
gout  (ISO)
hemochromatosis  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
iron deficiency anemia  (ISO)
Kawasaki disease  (ISO)
leukemia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Pasteurellaceae Infections  (ISO)
pasteurellosis  (ISO)
Plasmodium falciparum malaria  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
retinal detachment  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
severe acute respiratory syndrome  (ISO)
sickle cell anemia  (ISO)
Sickle Cell Trait  (ISO)
Starvation  (ISO)
Stroke  (ISO)
trypanosomiasis  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
Venous Thrombosis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:12139523   PMID:14681463   PMID:15210076   PMID:16438801   PMID:17145712   PMID:17629575   PMID:18777092   PMID:18931071   PMID:22301074   PMID:22922649   PMID:30032202   PMID:34103548  


Genomics

Comparative Map Data
HP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1614,980,382 - 14,985,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,643,378 - 14,648,241 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
HP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,054,505 - 72,061,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,054,505 - 72,061,055 (+)EnsemblGRCh38hg38GRCh38
GRCh371672,088,404 - 72,094,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,646,009 - 70,652,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 341670,646,008 - 70,652,458NCBI
Celera1656,402,627 - 56,409,074 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,855,340 - 57,861,787 (+)NCBIHuRef
CHM1_11673,501,856 - 73,508,303 (+)NCBICHM1_1
T2T-CHM13v2.01677,872,534 - 77,877,369 (+)NCBIT2T-CHM13v2.0
Hp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,301,760 - 110,305,804 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,301,760 - 110,305,804 (-)EnsemblGRCm39 Ensembl
GRCm388109,575,128 - 109,579,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,575,128 - 109,579,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv378112,099,028 - 112,103,072 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368112,464,257 - 112,468,192 (-)NCBIMGSCv36mm8
Celera8113,800,405 - 113,804,474 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.11NCBI
Hp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,449,151 - 54,453,701 (-)NCBIGRCr8
mRatBN7.21937,539,626 - 37,544,178 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,539,627 - 37,544,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1944,352,875 - 44,357,420 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,006,203 - 45,010,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,315,910 - 47,320,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01942,096,255 - 42,100,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,097,995 - 42,100,804 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01952,921,384 - 52,925,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41939,443,016 - 39,447,566 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11939,447,897 - 39,452,447 (-)NCBI
Celera1936,944,700 - 36,949,250 (-)NCBICelera
Cytogenetic Map19q12NCBI
LOC101976500
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,743,357 - 37,748,060 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647521,841,054 - 21,845,821 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in HP
143 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 3 3 5 2 22 2 2 3
Below cutoff 1 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005664359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF492467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ004687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU914723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU263974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU723190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01119187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_214000   ⟹   NP_999165
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,980,382 - 14,985,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005664359   ⟹   XP_005664416
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1614,980,506 - 14,985,234 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999165   ⟸   NM_214000
- Peptide Label: precursor
- UniProtKB: Q8SPS7 (UniProtKB/Swiss-Prot),   B3GQZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005664416   ⟸   XM_005664359
- Peptide Label: isoform X1
- UniProtKB: A0A8D0LMR0 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Peptidase S1   Sushi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002749 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005022282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025039574 UniProtKB/TrEMBL
  ENSSSCG00030069422 UniProtKB/TrEMBL
  ENSSSCG00035055040 UniProtKB/TrEMBL
  ENSSSCG00040043677 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00045021880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050013969 UniProtKB/TrEMBL
  ENSSSCG00055021547 UniProtKB/TrEMBL
  ENSSSCG00065032557 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070001777 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003046 ENTREZGENE
  ENSSSCT00000003046.4 UniProtKB/TrEMBL
  ENSSSCT00000104823.1 UniProtKB/TrEMBL
  ENSSSCT00005035691.1 UniProtKB/Swiss-Prot
  ENSSSCT00005035749.1 UniProtKB/TrEMBL
  ENSSSCT00005035765.1 UniProtKB/TrEMBL
  ENSSSCT00005035812.1 UniProtKB/TrEMBL
  ENSSSCT00025053880.1 UniProtKB/TrEMBL
  ENSSSCT00030097244.1 UniProtKB/TrEMBL
  ENSSSCT00035073420.1 UniProtKB/TrEMBL
  ENSSSCT00040059197.1 UniProtKB/Swiss-Prot
  ENSSSCT00040059608.1 UniProtKB/TrEMBL
  ENSSSCT00040059747.1 UniProtKB/TrEMBL
  ENSSSCT00040059824.1 UniProtKB/TrEMBL
  ENSSSCT00040060024.1 UniProtKB/TrEMBL
  ENSSSCT00045037657.1 UniProtKB/Swiss-Prot
  ENSSSCT00045037735.1 UniProtKB/TrEMBL
  ENSSSCT00045037770.1 UniProtKB/TrEMBL
  ENSSSCT00045037821.1 UniProtKB/TrEMBL
  ENSSSCT00045037868.1 UniProtKB/TrEMBL
  ENSSSCT00050018880.1 UniProtKB/TrEMBL
  ENSSSCT00055042676.1 UniProtKB/TrEMBL
  ENSSSCT00065044215.1 UniProtKB/Swiss-Prot
  ENSSSCT00065044232.1 UniProtKB/TrEMBL
  ENSSSCT00065044240.1 UniProtKB/TrEMBL
  ENSSSCT00065044249.1 UniProtKB/TrEMBL
  ENSSSCT00065044265.1 UniProtKB/TrEMBL
  ENSSSCT00070003326.1 UniProtKB/Swiss-Prot
  ENSSSCT00070003340.1 UniProtKB/TrEMBL
  ENSSSCT00070003347.1 UniProtKB/TrEMBL
  ENSSSCT00070003353.1 UniProtKB/TrEMBL
  ENSSSCT00070003367.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397061 UniProtKB/Swiss-Prot
NCBI Gene HP ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24255:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Haptoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SK09_PIG UniProtKB/TrEMBL
  A0A4X1SL78_PIG UniProtKB/TrEMBL
  A0A4X1SL89_PIG UniProtKB/TrEMBL
  A0A8D0LMR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1I145_PIG UniProtKB/TrEMBL
  A0A8D2C4X4_PIG UniProtKB/TrEMBL
  A0A8D2C5F0_PIG UniProtKB/TrEMBL
  B3GQZ2 ENTREZGENE, UniProtKB/TrEMBL
  HPT_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A2C9F356 UniProtKB/TrEMBL
  A0A8W4F968 UniProtKB/TrEMBL