Areg (amphiregulin) - Rat Genome Database

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Gene: Areg (amphiregulin) Rattus norvegicus
Symbol: Areg
Name: amphiregulin
RGD ID: 2149
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to cAMP. Located in extracellular space. Used to study high grade glioma. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
Previously known as: AR; schwannoma-derived growth factor; SDGF
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21416,972,185 - 16,981,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,971,509 - 16,980,539 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01418,290,441 - 18,299,471 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01416,982,558 - 16,991,588 (-)NCBIRnor_WKY
Rnor_6.01418,521,921 - 18,531,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,431,477 - 18,440,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,466,313 - 18,475,571 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,466,313 - 18,475,571 (-)NCBI
Celera1416,350,045 - 16,359,315 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrobenzanthrone  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (EXP,ISO)
bazedoxifene  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzofurans  (ISO)
bifenthrin  (EXP)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cholesterol  (ISO)
choline  (ISO)
Chorionic gonadotropin  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
estrone  (ISO)
etoposide  (ISO)
exemestane  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
Heliotrine  (ISO)
herbicide  (EXP)
hexane  (EXP)
hexestrol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lasofoxifene  (ISO)
lipopolysaccharide  (ISO)
loxtidine  (ISO)
manganese(II) chloride  (EXP)
marimastat  (ISO)
menadione  (ISO)
mestranol  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
naphthalene  (EXP,ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
progesterone  (EXP,ISO)
promegestone  (ISO)
propanal  (ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP,ISO)
protoporphyrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rolipram  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
SU6656  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (ISO)
undecane  (EXP)
valproic acid  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
cytoplasm  (ISO)
extracellular space  (IBA,IDA,ISO)
nucleus  (ISO)
plasma membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
2. Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 93 cases. Bostwick DG, etal., Prostate. 2004 Feb 1;58(2):164-8.
3. Amphiregulin causes functional downregulation of adherens junctions in psoriasis. Chung E, etal., J Invest Dermatol. 2005 Jun;124(6):1134-40.
4. Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. D'Antonio A, etal., Int J Oncol. 2002 Nov;21(5):941-8.
5. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
6. Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression. el-Marjou A, etal., Carcinogenesis. 2000 Dec;21(12):2211-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
9. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. Kimura H and Schubert D, J Cell Biol. 1992 Feb;116(3):777-83.
10. Structure, expression and function of a schwannoma-derived growth factor. Kimura H, etal., Nature 1990 Nov 15;348(6298):257-60.
11. Expression of amphiregulin and epidermal growth factor receptor in human breast cancer: analysis of autocriny and stromal-epithelial interactions. Ma L, etal., J Pathol. 2001 Aug;194(4):413-9.
12. Zhonghua zhong liu za zhi [Chinese journal of oncology] Ma L, etal., Zhonghua Zhong Liu Za Zhi. 2005 Sep;27(9):521-3.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas. Mishima K, etal., Int J Cancer. 1996 May 3;66(3):352-7.
15. Oxidative stress increases gene expression of heparin-binding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells. Miyazaki Y, etal., Biochem Biophys Res Commun. 1996 Sep 13;226(2):542-6.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Preneoplastic mammary tumor markers: Cripto and Amphiregulin are overexpressed in hyperplastic stages of tumor progression in transgenic mice. Niemeyer CC, etal., Int J Cancer. 1999 May 17;81(4):588-91.
18. Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and CRIPTO in human normal and malignant breast tissues. Panico L, etal., Int J Cancer. 1996 Jan 3;65(1):51-6.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway. Qin L and Partridge NC, J Cell Biochem. 2005 Oct 15;96(3):632-40.
22. Amphiregulin is a novel growth factor involved in normal bone development and in the cellular response to parathyroid hormone stimulation. Qin L, etal., J Biol Chem. 2005 Feb 4;280(5):3974-81. Epub 2004 Oct 27.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
26. A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients. Thogersen VB, etal., Cancer Res. 2001 Aug 15;61(16):6227-33.
Additional References at PubMed
PMID:8588926   PMID:8702723   PMID:10331984   PMID:12743035   PMID:15291759   PMID:17369357   PMID:19229996   PMID:21258428   PMID:22184114   PMID:24816162   PMID:30773606   PMID:35996142  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21416,972,185 - 16,981,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,971,509 - 16,980,539 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01418,290,441 - 18,299,471 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01416,982,558 - 16,991,588 (-)NCBIRnor_WKY
Rnor_6.01418,521,921 - 18,531,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,431,477 - 18,440,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,466,313 - 18,475,571 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,466,313 - 18,475,571 (-)NCBI
Celera1416,350,045 - 16,359,315 (-)NCBICelera
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38474,445,136 - 74,455,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl474,445,136 - 74,455,005 (+)EnsemblGRCh38hg38GRCh38
GRCh37475,310,853 - 75,320,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,529,717 - 75,539,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,675,887 - 75,685,760NCBI
Celera472,671,109 - 72,680,980 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,121,847 - 71,131,718 (+)NCBIHuRef
CHM1_1475,346,752 - 75,356,715 (+)NCBICHM1_1
T2T-CHM13v2.0477,788,795 - 77,798,664 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39591,287,458 - 91,296,291 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,287,458 - 91,296,291 (+)EnsemblGRCm39 Ensembl
GRCm38591,139,599 - 91,148,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,139,599 - 91,148,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,568,641 - 91,577,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,214,815 - 92,223,632 (+)NCBIMGSCv36mm8
Celera589,277,608 - 89,286,422 (+)NCBICelera
Cytogenetic Map5E2NCBI
cM Map544.78NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955474680,204 - 689,088 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474680,212 - 689,021 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1455,570,299 - 55,580,142 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,570,299 - 55,580,142 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0449,737,191 - 49,747,013 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11362,925,761 - 62,936,753 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,926,301 - 62,936,738 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,614,442 - 62,625,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,756,606 - 63,767,617 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,757,757 - 63,767,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,371,389 - 63,382,383 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,853,171 - 62,864,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,996,005 - 64,007,006 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440528512,822,538 - 12,834,155 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,274,565 - 1,283,746 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365981,276,599 - 1,283,612 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl870,417,923 - 70,428,102 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,417,935 - 70,428,106 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,568,826 - 74,579,003 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1722,979,574 - 22,990,179 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,980,249 - 22,990,162 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,272,704 - 1,282,711 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247301,290,655 - 1,299,410 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,290,692 - 1,299,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Areg
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:131
Interacting mature miRNAs:144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1
Low 3 6 2 2 8 2 2 32 13 11
Below cutoff 28 24 19 8 19 2 3 33 2 20 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003703   ⟹   ENSRNOP00000003703
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,972,187 - 16,981,535 (-)Ensembl
Rnor_6.0 Ensembl1418,521,930 - 18,531,179 (-)Ensembl
RefSeq Acc Id: NM_017123   ⟹   NP_058819
Rat AssemblyChrPosition (strand)Source
mRatBN7.21416,972,185 - 16,981,443 (-)NCBI
Rnor_6.01418,521,921 - 18,531,179 (-)NCBI
Rnor_5.01418,431,477 - 18,440,735 (-)NCBI
RGSC_v3.41418,466,313 - 18,475,571 (-)RGD
Celera1416,350,045 - 16,359,315 (-)RGD
Protein Sequences
Protein RefSeqs NP_058819 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA38967 (Get FASTA)   NCBI Sequence Viewer  
  EDL88581 (Get FASTA)   NCBI Sequence Viewer  
  P24338 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058819   ⟸   NM_017123
- Peptide Label: preproprotein
- UniProtKB: P24338 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003703   ⟸   ENSRNOT00000003703
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24338-F1-model_v2 AlphaFold P24338 1-243 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699222
Promoter ID:EPDNEW_R9746
Type:single initiation site
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,531,208 - 18,531,268EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2149 AgrOrtholog
BioCyc Gene G2FUF-16216 BioCyc
Ensembl Genes ENSRNOG00000002754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003703 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003703 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  EGF_rcpt_ligand UniProtKB/Swiss-Prot
KEGG Report rno:29183 UniProtKB/Swiss-Prot
PANTHER PTHR10740 UniProtKB/Swiss-Prot
PhenoGen Areg PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Areg  amphiregulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function has mitogenic activity 69755
gene_process may act as a growth factor during nervous system development 69755
gene_product member of the epidermal growth factor family 69755