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Gene: Areg (amphiregulin) Rattus norvegicus
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Symbol: Areg
Name: amphiregulin
Description: Exhibits epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to cAMP. Localizes to the extracellular space. Used to study malignant glioma. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human AREG (amphiregulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AR; schwannoma-derived growth factor; SDGF
Orthologs:
Homo sapiens (human) : AREG (amphiregulin)  HGNC  Alliance
Mus musculus (house mouse) : Areg (amphiregulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Areg (amphiregulin)
Pan paniscus (bonobo/pygmy chimpanzee) : AREG (amphiregulin)
Canis lupus familiaris (dog) : AREG (amphiregulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Areg (amphiregulin)
Sus scrofa (pig) : AREG (amphiregulin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01418,521,921 - 18,531,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01418,431,477 - 18,440,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,466,313 - 18,475,571 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11418,466,313 - 18,475,571 (-)NCBI
Celera1416,350,045 - 16,359,315 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Areg
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2149
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.