Wwox (WW domain-containing oxidoreductase) - Rat Genome Database

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Gene: Wwox (WW domain-containing oxidoreductase) Rattus norvegicus
Analyze
Symbol: Wwox
Name: WW domain-containing oxidoreductase
RGD ID: 1309927
Description: Predicted to enable enzyme binding activity and identical protein binding activity. Predicted to contribute to transcription coactivator activity. Predicted to be involved in cellular response to transforming growth factor beta stimulus; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including Golgi apparatus; mitochondrion; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to colocalize with microvillus and plasma membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase); INTERACTS WITH (+)-schisandrin B; acrylamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC292041
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Wwoxlde  
Genetic Models: WIC-Wwoxlde/Fta
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21942,432,141 - 43,360,278 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1942,432,152 - 43,359,391 (+)Ensembl
Rnor_6.01946,761,353 - 47,695,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01957,582,172 - 58,503,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41944,516,391 - 44,829,849 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11944,521,372 - 44,611,040 (+)NCBI
Celera1941,740,658 - 42,034,912 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (ISO)
2-nitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
O-methyleugenol  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
quercitrin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

References

Additional References at PubMed
PMID:11058590   PMID:14651853   PMID:15064722   PMID:18371080   PMID:18487609   PMID:19366691   PMID:19465938   PMID:19918364   PMID:21873635   PMID:25416187   PMID:31340538   PMID:33565365  


Genomics

Comparative Map Data
Wwox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21942,432,141 - 43,360,278 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1942,432,152 - 43,359,391 (+)Ensembl
Rnor_6.01946,761,353 - 47,695,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01957,582,172 - 58,503,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41944,516,391 - 44,829,849 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11944,521,372 - 44,611,040 (+)NCBI
Celera1941,740,658 - 42,034,912 (+)NCBICelera
Cytogenetic Map19q12NCBI
WWOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1678,099,400 - 79,212,667 (+)EnsemblGRCh38hg38GRCh38
GRCh381678,099,654 - 79,212,667 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371678,133,551 - 79,246,564 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361676,691,052 - 77,804,065 (+)NCBINCBI36hg18NCBI36
Build 341676,691,051 - 76,691,596NCBI
Celera1662,433,225 - 63,546,286 (+)NCBI
Cytogenetic Map16q23.1-q23.2NCBI
HuRef1663,889,774 - 65,003,146 (+)NCBIHuRef
CHM1_11679,544,693 - 80,658,050 (+)NCBICHM1_1
Wwox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398115,166,377 - 116,079,451 (+)NCBIGRCm39mm39
GRCm39 Ensembl8115,166,395 - 116,079,447 (+)Ensembl
GRCm388114,439,635 - 115,352,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8114,439,655 - 115,352,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv378116,963,552 - 117,876,612 (+)NCBIGRCm37mm9NCBIm37
MGSCv368117,325,673 - 118,238,685 (+)NCBImm8
Celera8118,649,907 - 119,566,431 (+)NCBICelera
Cytogenetic Map8E1NCBI
Wwox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555221,265,404 - 2,184,562 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555221,265,732 - 2,185,372 (+)NCBIChiLan1.0ChiLan1.0
WWOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11678,124,887 - 79,232,509 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1678,125,302 - 79,231,546 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01658,689,609 - 59,800,333 (+)NCBIMhudiblu_PPA_v0panPan3
WWOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1572,298,254 - 73,243,667 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl572,299,157 - 73,261,406 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha572,245,508 - 73,191,719 (-)NCBI
ROS_Cfam_1.0572,604,717 - 73,550,987 (-)NCBI
ROS_Cfam_1.0 Ensembl572,605,629 - 73,567,870 (-)Ensembl
UMICH_Zoey_3.1572,544,957 - 73,491,126 (-)NCBI
UNSW_CanFamBas_1.0572,380,513 - 73,326,290 (-)NCBI
UU_Cfam_GSD_1.0572,857,621 - 73,810,182 (-)NCBI
Wwox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934932,379,557 - 33,246,838 (-)NCBI
SpeTri2.0NW_00493647526,342,245 - 27,209,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl68,911,139 - 9,871,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.168,910,209 - 9,871,048 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.269,684,508 - 9,774,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WWOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1563,580,049 - 64,698,212 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl563,580,741 - 63,916,157 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604712,176,137 - 12,459,672 (-)NCBIVero_WHO_p1.0
Wwox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247467,983,863 - 8,924,312 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D19Mit7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,983,518 - 42,983,632 (+)MAPPERmRatBN7.2
Rnor_6.01947,318,201 - 47,318,314NCBIRnor6.0
Rnor_5.01958,132,164 - 58,132,277UniSTSRnor5.0
RGSC_v3.41945,090,803 - 45,090,916UniSTSRGSC3.4
RGSC_v3.41945,090,802 - 45,090,916RGDRGSC3.4
RGSC_v3.11945,095,501 - 45,095,902RGD
Celera1942,291,103 - 42,291,216UniSTS
RH 3.4 Map19581.1UniSTS
RH 3.4 Map19581.1RGD
RH 2.0 Map19607.0RGD
SHRSP x BN Map1934.6298RGD
FHH x ACI Map1935.68RGD
Cytogenetic Map19q12UniSTS
D19Rat66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,899,669 - 42,899,812 (+)MAPPERmRatBN7.2
Rnor_6.01947,231,083 - 47,231,225NCBIRnor6.0
Rnor_5.01958,046,185 - 58,046,327UniSTSRnor5.0
RGSC_v3.41945,001,545 - 45,001,687RGDRGSC3.4
RGSC_v3.41945,001,546 - 45,001,688UniSTSRGSC3.4
RGSC_v3.11945,006,426 - 45,006,568RGD
Celera1942,206,578 - 42,206,720UniSTS
RH 3.4 Map19575.2UniSTS
RH 3.4 Map19575.2RGD
RH 2.0 Map19617.3RGD
SHRSP x BN Map1936.9799RGD
Cytogenetic Map19q12UniSTS
D19Got41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,482,277 - 42,482,688 (+)MAPPERmRatBN7.2
mRatBN7.21942,482,491 - 42,482,688 (+)MAPPERmRatBN7.2
Rnor_6.01946,812,501 - 46,812,909NCBIRnor6.0
Rnor_6.01946,812,715 - 46,812,909NCBIRnor6.0
Rnor_5.01957,632,162 - 57,632,356UniSTSRnor5.0
Rnor_5.01957,631,948 - 57,632,356UniSTSRnor5.0
RGSC_v3.41944,566,511 - 44,566,705UniSTSRGSC3.4
RGSC_v3.41944,566,510 - 44,566,705RGDRGSC3.4
RGSC_v3.41944,566,297 - 44,566,705UniSTSRGSC3.4
RGSC_v3.11944,571,392 - 44,571,586RGD
Celera1941,790,706 - 41,791,019UniSTS
Celera1941,790,920 - 41,791,019UniSTS
RH 3.4 Map19566.0UniSTS
RH 3.4 Map19566.0RGD
RH 2.0 Map19575.4RGD
Cytogenetic Map19q12UniSTS
D19Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,596,759 - 42,596,944 (+)MAPPERmRatBN7.2
Rnor_6.01946,927,922 - 46,928,106NCBIRnor6.0
Rnor_5.01957,746,512 - 57,746,696UniSTSRnor5.0
RGSC_v3.41944,681,934 - 44,682,117RGDRGSC3.4
RGSC_v3.41944,681,935 - 44,682,119UniSTSRGSC3.4
RGSC_v3.11944,686,815 - 44,686,998RGD
Celera1941,905,166 - 41,905,350UniSTS
RH 3.4 Map19565.5RGD
RH 3.4 Map19565.5UniSTS
RH 2.0 Map19589.9RGD
Cytogenetic Map19q12UniSTS
D19Got40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,436,199 - 42,436,413 (+)MAPPERmRatBN7.2
Rnor_6.01946,765,429 - 46,765,642NCBIRnor6.0
Rnor_5.01957,586,216 - 57,586,429UniSTSRnor5.0
RGSC_v3.41944,520,350 - 44,520,564RGDRGSC3.4
RGSC_v3.41944,520,351 - 44,520,564UniSTSRGSC3.4
RGSC_v3.11944,525,231 - 44,525,445RGD
Celera1941,744,618 - 41,744,831UniSTS
RH 3.4 Map19562.2RGD
RH 3.4 Map19562.2UniSTS
RH 2.0 Map19590.2RGD
Cytogenetic Map19q12UniSTS
D19Got45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,617,586 - 42,617,871 (+)MAPPERmRatBN7.2
Rnor_6.01946,948,749 - 46,949,033NCBIRnor6.0
Rnor_5.01957,767,125 - 57,767,409UniSTSRnor5.0
RGSC_v3.41944,703,632 - 44,703,917RGDRGSC3.4
RGSC_v3.41944,703,633 - 44,703,917UniSTSRGSC3.4
RGSC_v3.11944,708,514 - 44,708,798RGD
Celera1941,926,096 - 41,926,380UniSTS
RH 3.4 Map19571.7RGD
RH 3.4 Map19571.7UniSTS
RH 2.0 Map19597.5RGD
Cytogenetic Map19q12UniSTS
D19Got47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,632,153 - 42,632,285 (+)MAPPERmRatBN7.2
Rnor_6.01946,963,387 - 46,963,520NCBIRnor6.0
Rnor_5.01957,780,964 - 57,781,097UniSTSRnor5.0
RGSC_v3.41944,717,891 - 44,718,022RGDRGSC3.4
RGSC_v3.41944,717,892 - 44,718,023UniSTSRGSC3.4
RGSC_v3.11944,722,772 - 44,722,903RGD
Celera1941,940,439 - 41,940,570UniSTS
RH 3.4 Map19574.7RGD
RH 3.4 Map19574.7UniSTS
RH 2.0 Map19602.9RGD
Cytogenetic Map19q12UniSTS
D19Got37  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,765 - 43,356,080 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,741 - 47,691,055NCBIRnor6.0
Rnor_5.01958,498,502 - 58,498,816UniSTSRnor5.0
RGSC_v3.41945,487,437 - 45,487,752RGDRGSC3.4
RGSC_v3.41945,487,438 - 45,487,752UniSTSRGSC3.4
RGSC_v3.11945,492,319 - 45,492,633RGD
Celera1942,661,321 - 42,661,635UniSTS
RH 3.4 Map19584.6UniSTS
RH 3.4 Map19584.6RGD
RH 2.0 Map19607.4RGD
Cytogenetic Map19q12UniSTS
D19Got39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,848,111 - 42,848,407 (+)MAPPERmRatBN7.2
Rnor_6.01947,179,548 - 47,179,841NCBIRnor6.0
Rnor_5.01957,994,650 - 57,994,943UniSTSRnor5.0
RGSC_v3.41944,950,644 - 44,950,938RGDRGSC3.4
RGSC_v3.41944,950,645 - 44,950,938UniSTSRGSC3.4
RGSC_v3.11944,955,526 - 44,955,819RGD
Celera1942,155,028 - 42,155,321UniSTS
RH 3.4 Map19576.0RGD
RH 3.4 Map19576.0UniSTS
RH 2.0 Map19609.0RGD
Cytogenetic Map19q12UniSTS
D19Got60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,825 - 43,356,068 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,801 - 47,691,043NCBIRnor6.0
Rnor_5.01958,498,562 - 58,498,804UniSTSRnor5.0
RGSC_v3.41945,487,497 - 45,487,740RGDRGSC3.4
RGSC_v3.41945,487,498 - 45,487,740UniSTSRGSC3.4
RGSC_v3.11945,492,379 - 45,492,621RGD
Celera1942,661,381 - 42,661,623UniSTS
RH 3.4 Map19576.1RGD
RH 3.4 Map19576.1UniSTS
RH 2.0 Map19617.0RGD
Cytogenetic Map19q12UniSTS
D19Got59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,278,835 - 43,279,001 (+)MAPPERmRatBN7.2
Rnor_6.01947,614,262 - 47,614,427NCBIRnor6.0
Rnor_5.01958,423,036 - 58,423,201UniSTSRnor5.0
RGSC_v3.41945,401,305 - 45,401,568RGDRGSC3.4
RGSC_v3.41945,401,306 - 45,401,471UniSTSRGSC3.4
RGSC_v3.11945,406,187 - 45,406,352RGD
Celera1942,585,291 - 42,585,456UniSTS
RH 3.4 Map19585.5UniSTS
RH 3.4 Map19585.5RGD
Cytogenetic Map19q12UniSTS
AW530821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,509,009 - 42,509,169 (+)MAPPERmRatBN7.2
Rnor_6.01946,840,249 - 46,840,408NCBIRnor6.0
Rnor_5.01957,658,839 - 57,658,998UniSTSRnor5.0
RGSC_v3.41944,594,143 - 44,594,302UniSTSRGSC3.4
Celera1941,817,406 - 41,817,565UniSTS
RH 3.4 Map19565.5UniSTS
Cytogenetic Map19q12UniSTS
BQ195504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,647,971 - 42,648,175 (+)MAPPERmRatBN7.2
Rnor_6.01946,978,951 - 46,979,154NCBIRnor6.0
Rnor_5.01957,798,005 - 57,798,208UniSTSRnor5.0
RGSC_v3.41944,733,588 - 44,733,791UniSTSRGSC3.4
Celera1941,955,752 - 41,955,955UniSTS
RH 3.4 Map19576.0UniSTS
Cytogenetic Map19q12UniSTS
AU049580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,484,856 - 42,485,148 (+)MAPPERmRatBN7.2
Rnor_6.01946,815,078 - 46,815,369NCBIRnor6.0
Rnor_5.01957,634,525 - 57,634,816UniSTSRnor5.0
RGSC_v3.41944,568,874 - 44,569,165UniSTSRGSC3.4
Celera1941,793,188 - 41,793,479UniSTS
Cytogenetic Map19q12UniSTS
RH132785  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,359,990 - 43,360,170 (+)MAPPERmRatBN7.2
Rnor_6.01947,694,964 - 47,695,143NCBIRnor6.0
Rnor_5.01958,502,725 - 58,502,904UniSTSRnor5.0
RGSC_v3.41945,491,663 - 45,491,842UniSTSRGSC3.4
Celera1942,665,546 - 42,665,725UniSTS
RH 3.4 Map19585.0UniSTS
Cytogenetic Map19q12UniSTS
RH142718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,297,447 - 43,297,556 (+)MAPPERmRatBN7.2
Rnor_6.01947,632,475 - 47,632,583NCBIRnor6.0
Rnor_5.01958,440,758 - 58,440,866UniSTSRnor5.0
RGSC_v3.41945,428,460 - 45,428,568UniSTSRGSC3.4
Celera1942,603,540 - 42,603,648UniSTS
RH 3.4 Map19575.8UniSTS
Cytogenetic Map19q12UniSTS
BE101992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,356,992 - 43,357,180 (+)MAPPERmRatBN7.2
Rnor_6.01947,691,968 - 47,692,155NCBIRnor6.0
Rnor_5.01958,499,729 - 58,499,916UniSTSRnor5.0
RGSC_v3.41945,488,665 - 45,488,852UniSTSRGSC3.4
Celera1942,662,548 - 42,662,735UniSTS
RH 3.4 Map19575.8UniSTS
Cytogenetic Map19q12UniSTS
BE120591  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,590,454 - 42,590,626 (+)MAPPERmRatBN7.2
Rnor_6.01946,921,617 - 46,921,788NCBIRnor6.0
Rnor_5.01957,740,207 - 57,740,378UniSTSRnor5.0
RGSC_v3.41944,675,630 - 44,675,801UniSTSRGSC3.4
Celera1941,898,863 - 41,899,034UniSTS
RH 3.4 Map19565.5UniSTS
Cytogenetic Map19q12UniSTS
RH135382  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,029,290 - 43,029,487 (+)MAPPERmRatBN7.2
Rnor_6.01947,364,015 - 47,364,211NCBIRnor6.0
Rnor_5.01958,177,978 - 58,178,174UniSTSRnor5.0
RGSC_v3.41945,137,778 - 45,137,974UniSTSRGSC3.4
Celera1942,336,874 - 42,337,070UniSTS
RH 3.4 Map19576.5UniSTS
Cytogenetic Map19q12UniSTS
RH141830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,935,630 - 42,935,813 (+)MAPPERmRatBN7.2
Rnor_6.01947,266,047 - 47,266,229NCBIRnor6.0
Rnor_5.01958,081,149 - 58,081,331UniSTSRnor5.0
RGSC_v3.41945,038,090 - 45,038,272UniSTSRGSC3.4
Celera1942,242,538 - 42,242,720UniSTS
RH 3.4 Map19574.3UniSTS
Cytogenetic Map19q12UniSTS
AI548764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,727,096 - 42,727,289 (+)MAPPERmRatBN7.2
Rnor_6.01947,057,967 - 47,058,159NCBIRnor6.0
Rnor_5.01957,874,462 - 57,874,654UniSTSRnor5.0
RGSC_v3.41944,829,468 - 44,829,660UniSTSRGSC3.4
Celera1942,034,531 - 42,034,723UniSTS
RH 3.4 Map19579.9UniSTS
Cytogenetic Map19q12UniSTS
BE119764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,355,103 - 43,355,312 (+)MAPPERmRatBN7.2
Rnor_6.01947,690,079 - 47,690,287NCBIRnor6.0
Rnor_5.01958,497,840 - 58,498,048UniSTSRnor5.0
RGSC_v3.41945,486,776 - 45,486,984UniSTSRGSC3.4
Celera1942,660,659 - 42,660,867UniSTS
RH 3.4 Map19575.9UniSTS
Cytogenetic Map19q12UniSTS
BG373585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21942,446,599 - 42,446,714 (+)MAPPERmRatBN7.2
Rnor_6.01946,775,829 - 46,775,943NCBIRnor6.0
Rnor_5.01957,596,616 - 57,596,730UniSTSRnor5.0
RGSC_v3.41944,530,751 - 44,530,865UniSTSRGSC3.4
Celera1941,755,018 - 41,755,132UniSTS
RH 3.4 Map19565.0UniSTS
Cytogenetic Map19q12UniSTS
BE101986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21943,177,806 - 43,177,969 (+)MAPPERmRatBN7.2
Rnor_6.01947,515,159 - 47,515,321NCBIRnor6.0
Rnor_5.01958,324,609 - 58,324,771UniSTSRnor5.0
RGSC_v3.41945,299,310 - 45,299,472UniSTSRGSC3.4
Celera1942,485,702 - 42,485,864UniSTS
RH 3.4 Map19584.6UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat


Genetic Models
This gene Wwox is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:23
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000058779
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001106188   ⟹   NP_001099658
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,240 - 42,727,478 (+)NCBI
Rnor_6.01946,761,469 - 47,058,348 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
RGSC_v3.41944,516,391 - 44,829,849 (+)RGD
Celera1941,740,658 - 42,034,912 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255666   ⟹   XP_006255728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 43,360,278 (+)NCBI
Rnor_6.01946,761,360 - 47,695,247 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255670   ⟹   XP_006255732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 42,944,187 (+)NCBI
Rnor_6.01946,761,366 - 47,270,854 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255671   ⟹   XP_006255733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 43,029,600 (+)NCBI
Rnor_6.01946,761,367 - 47,364,324 (+)NCBI
Rnor_5.01957,582,172 - 58,503,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772491   ⟹   XP_008770713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 42,730,421 (+)NCBI
Rnor_6.01946,761,353 - 47,060,805 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097634   ⟹   XP_038953562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 42,815,259 (+)NCBI
RefSeq Acc Id: XM_039097635   ⟹   XP_038953563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,141 - 43,360,278 (+)NCBI
RefSeq Acc Id: XM_039097636   ⟹   XP_038953564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 42,568,928 (+)NCBI
RefSeq Acc Id: XM_039097637   ⟹   XP_038953565
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21942,432,243 - 42,502,625 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099658   ⟸   NM_001106188
- Sequence:
RefSeq Acc Id: XP_006255728   ⟸   XM_006255666
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006255733   ⟸   XM_006255671
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006255732   ⟸   XM_006255670
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008770713   ⟸   XM_008772491
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_038953563   ⟸   XM_039097635
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038953562   ⟸   XM_039097634
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038953564   ⟸   XM_039097636
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038953565   ⟸   XM_039097637
- Peptide Label: isoform X8
Protein Domains
WW

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309927 AgrOrtholog
Ensembl Genes ENSRNOG00000012030 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000055573 UniProtKB/TrEMBL
  ENSRNOP00000078346 ENTREZGENE
  ENSRNOP00000082048 ENTREZGENE
  ENSRNOP00000082697 ENTREZGENE
  ENSRNOP00000091460 ENTREZGENE
Ensembl Transcript ENSRNOT00000058779 UniProtKB/TrEMBL
  ENSRNOT00000106285 ENTREZGENE
  ENSRNOT00000110208 ENTREZGENE
  ENSRNOT00000111033 ENTREZGENE
  ENSRNOT00000115464 ENTREZGENE
InterPro NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene 292041 ENTREZGENE
Pfam PF00397 UniProtKB/TrEMBL
PhenoGen Wwox PhenoGen
PROSITE WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF51045 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt D3ZG54_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Wwox  WW domain-containing oxidoreductase   Wwox_predicted  WW domain-containing oxidoreductase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Wwox_predicted  WW domain-containing oxidoreductase (predicted)      Symbol and Name status set to approved 70820 APPROVED