Gjb1 (gap junction protein, beta 1) - Rat Genome Database

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Gene: Gjb1 (gap junction protein, beta 1) Rattus norvegicus
Analyze
Symbol: Gjb1
Name: gap junction protein, beta 1
RGD ID: 61926
Description: Enables gap junction channel activity. Involved in epididymis development and purine ribonucleotide transport. Located in gap junction and lateral plasma membrane. Part of protein-containing complex. Biomarker of autoimmune thyroiditis and extrahepatic cholestasis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 1. Orthologous to human GJB1 (gap junction protein beta 1); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin 32; connexin g; connexin-32; Cx32; Cxng; GAP junction 28 kDa liver protein; gap junction beta-1 protein; gap junction membrane channel protein beta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,541,845 - 70,549,776 (+)NCBIGRCr8
mRatBN7.2X66,501,848 - 66,509,783 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,985,201 - 67,993,132 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,485,591 - 71,493,522 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,046,498 - 69,054,429 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,272,030 - 71,279,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,272,042 - 71,279,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,448,873 - 89,456,812 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,522,360 - 89,530,242 (+)NCBI
CeleraX66,857,755 - 66,865,686 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
atazanavir sulfate  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorendic acid  (EXP)
chloroform  (EXP)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
diquat  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fluoranthene  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fucoxanthin  (ISO)
gliotoxin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
linoleic acid  (ISO)
LY294002  (EXP)
malonaldehyde  (ISO)
mercury dichloride  (EXP,ISO)
methapyrilene  (ISO)
methylarsonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-(2-hydroxyethyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
oleamide  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
propanal  (ISO)
pyrene  (EXP)
quercetin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimethylarsine oxide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Connexin32 can restore hearing in connexin26 deficient mice. Degen J, etal., Eur J Cell Biol. 2011 Oct;90(10):817-24. doi: 10.1016/j.ejcb.2011.05.001. Epub 2011 Aug 2.
2. Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Dufresne J, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C33-43.
3. Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat. Fallon MB, etal., Am J Physiol. 1995 May;268(5 Pt 1):C1186-94.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP. Goldberg GS, etal., J Biol Chem 2002 Sep 27;277(39):36725-30.
7. Reduced cell-cell communication in experimentally induced autoimmune thyroid disease. Green LM, etal., Endocrinology. 1996 Jul;137(7):2823-32.
8. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. Maza J, etal., J Biol Chem. 2005 Jun 3;280(22):21115-21. Epub 2005 Apr 7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Structure of a gap junction gene: rat connexin-32. Miller T, etal., Biosci Rep 1988 Oct;8(5):455-64.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. Molecular cloning of cDNA for rat liver gap junction protein. Paul DL J Cell Biol 1986 Jul;103(1):123-34.
15. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Rash JE, etal., Cell Commun Adhes 2001;8(4-6):315-20.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Differential changes in expression of gap junction proteins connexin 26 and 32 during hepatocarcinogenesis in rats. Sakamoto H, etal., Jpn J Cancer Res. 1992 Nov;83(11):1210-5.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1667015   PMID:2987225   PMID:3017758   PMID:3034905   PMID:7593302   PMID:12829745   PMID:12850269   PMID:14637306   PMID:15239104   PMID:15489334   PMID:16679308   PMID:16731531  
PMID:17546509   PMID:18809458   PMID:19297523   PMID:19960225   PMID:20089884   PMID:20578039   PMID:22718765   PMID:22871113   PMID:23023213   PMID:23149765   PMID:24812055   PMID:25254904  
PMID:25530438   PMID:25969535   PMID:26268619   PMID:26494227   PMID:26655499   PMID:27246301   PMID:29116012   PMID:29790387   PMID:30268116   PMID:33171391   PMID:34678594   PMID:38347637  


Genomics

Comparative Map Data
Gjb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,541,845 - 70,549,776 (+)NCBIGRCr8
mRatBN7.2X66,501,848 - 66,509,783 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,985,201 - 67,993,132 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,485,591 - 71,493,522 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,046,498 - 69,054,429 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,272,030 - 71,279,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,272,042 - 71,279,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,448,873 - 89,456,812 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,522,360 - 89,530,242 (+)NCBI
CeleraX66,857,755 - 66,865,686 (+)NCBICelera
Cytogenetic MapXq22NCBI
GJB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,215,239 - 71,225,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,212,811 - 71,225,516 (+)EnsemblGRCh38hg38GRCh38
GRCh37X70,435,089 - 70,445,366 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,351,787 - 70,361,777 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X70,226,096 - 70,228,065NCBI
CeleraX70,788,947 - 70,798,946 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,252,835 - 64,262,404 (+)NCBIHuRef
CHM1_1X70,328,093 - 70,338,111 (+)NCBICHM1_1
T2T-CHM13v2.0X69,649,327 - 69,659,597 (+)NCBIT2T-CHM13v2.0
Gjb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,419,982 - 100,429,235 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,419,984 - 100,429,235 (+)EnsemblGRCm39 Ensembl
GRCm38X101,376,376 - 101,385,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,376,378 - 101,385,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,572,676 - 98,580,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,580,056 - 97,588,344 (+)NCBIMGSCv36mm8
CeleraX88,294,129 - 88,302,410 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.06NCBI
Gjb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,785,996 - 10,787,910 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,779,415 - 10,787,910 (+)NCBIChiLan1.0ChiLan1.0
GJB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,899,720 - 70,901,737 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,903,323 - 70,905,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,490,579 - 60,492,606 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,538,213 - 70,548,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,547,110 - 70,547,961 (+)Ensemblpanpan1.1panPan2
GJB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,565,995 - 55,575,332 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,573,808 - 55,574,659 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,392,855 - 46,402,183 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,534,870 - 56,544,201 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,542,150 - 56,544,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,502,814 - 54,512,141 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,834,274 - 55,843,612 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,761,402 - 55,770,733 (+)NCBIUU_Cfam_GSD_1.0
Gjb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,627,492 - 46,635,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762389,669 - 395,898 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762389,655 - 398,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,242,045 - 57,249,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,241,990 - 57,249,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,844,639 - 64,852,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,013,991 - 61,019,222 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,017,716 - 61,018,567 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,883,820 - 2,885,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,517,324 - 1,519,265 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,511,347 - 1,519,265 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gjb1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:135
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000004979
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 21 99 91 90 59 19 59 6 182 61 79 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000076034   ⟹   ENSRNOP00000068485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,501,860 - 66,508,609 (+)Ensembl
Rnor_6.0 EnsemblX71,272,042 - 71,278,791 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076816   ⟹   ENSRNOP00000068248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,272,045 - 71,279,977 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095443   ⟹   ENSRNOP00000083358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)Ensembl
RefSeq Acc Id: NM_017251   ⟹   NP_058947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,541,845 - 70,549,776 (+)NCBI
mRatBN7.2X66,501,848 - 66,509,779 (+)NCBI
Rnor_6.0X71,272,030 - 71,279,969 (+)NCBI
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBI
RGSC_v3.4X89,448,873 - 89,456,812 (+)RGD
CeleraX66,857,755 - 66,865,686 (+)RGD
Sequence:
RefSeq Acc Id: XM_008773255   ⟹   XP_008771477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,542,370 - 70,549,776 (+)NCBI
mRatBN7.2X66,502,799 - 66,509,783 (+)NCBI
Rnor_6.0X71,273,845 - 71,279,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601945   ⟹   XP_017457434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,541,865 - 70,549,776 (+)NCBI
mRatBN7.2X66,501,902 - 66,509,783 (+)NCBI
Rnor_6.0X71,278,037 - 71,279,973 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058947   ⟸   NM_017251
- UniProtKB: P08033 (UniProtKB/Swiss-Prot),   A0A654IET2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771477   ⟸   XM_008773255
- Peptide Label: isoform X1
- UniProtKB: P08033 (UniProtKB/Swiss-Prot),   A0A654IET2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457434   ⟸   XM_017601945
- Peptide Label: isoform X1
- UniProtKB: P08033 (UniProtKB/Swiss-Prot),   A0A654IET2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068248   ⟸   ENSRNOT00000076816
Ensembl Acc Id: ENSRNOP00000068485   ⟸   ENSRNOT00000076034
Ensembl Acc Id: ENSRNOP00000083358   ⟸   ENSRNOT00000095443
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08033-F1-model_v2 AlphaFold P08033 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701876
Promoter ID:EPDNEW_R12400
Type:initiation region
Name:Gjb1_1
Description:gap junction protein, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,272,051 - 71,272,111EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61926 AgrOrtholog
BioCyc Gene G2FUF-2101 BioCyc
Ensembl Genes ENSRNOG00000003746 Ensembl
  ENSRNOG00000063213 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055029347 UniProtKB/Swiss-Prot
  ENSRNOG00060024199 UniProtKB/Swiss-Prot
  ENSRNOG00065017332 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076034.2 UniProtKB/TrEMBL
  ENSRNOT00000095443.1 UniProtKB/Swiss-Prot
  ENSRNOT00055050862 UniProtKB/Swiss-Prot
  ENSRNOT00060041884 UniProtKB/Swiss-Prot
  ENSRNOT00065028895 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127952 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29584 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93534 IMAGE-MGC_LOAD
NCBI Gene 29584 ENTREZGENE
PANTHER GAP JUNCTION BETA-1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gjb1 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003746 RatGTEx
  ENSRNOG00000063213 RatGTEx
  ENSRNOG00055029347 RatGTEx
  ENSRNOG00060024199 RatGTEx
  ENSRNOG00065017332 RatGTEx
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219925
UniProt A0A096MKE6_RAT UniProtKB/TrEMBL
  A0A654IET2 ENTREZGENE, UniProtKB/TrEMBL
  CXB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Gjb1  gap junction protein, beta 1  Gjb1  gap junction membrane channel protein beta 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gjb1  gap junction membrane channel protein beta 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adult epididymis; present between apical cells and principal cells, between narrow cells and principal cells and between clear and principal cells 628541
gene_physical_interaction interacts with other subunits as homomers and heteromers to form gap junction 628541
gene_process may play a role in epididymal development 628541
gene_regulation expression is low throughout the epididymis in young animals and begins to increase in the second and third weeks postnatally 628541