Gjb1 (gap junction protein, beta 1) - Rat Genome Database

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Gene: Gjb1 (gap junction protein, beta 1) Rattus norvegicus
Analyze
Symbol: Gjb1
Name: gap junction protein, beta 1
RGD ID: 61926
Description: Enables gap junction channel activity. Involved in epididymis development and purine ribonucleotide transport. Located in gap junction and lateral plasma membrane. Part of protein-containing complex. Biomarker of autoimmune thyroiditis and extrahepatic cholestasis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 1. Orthologous to human GJB1 (gap junction protein beta 1); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin 32; connexin g; connexin-32; Cx32; Cxng; GAP junction 28 kDa liver protein; gap junction beta-1 protein; gap junction membrane channel protein beta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,501,848 - 66,509,783 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)Ensembl
Rnor_6.0X71,272,030 - 71,279,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,272,042 - 71,279,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,448,873 - 89,456,812 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,522,360 - 89,530,242 (+)NCBI
CeleraX66,857,755 - 66,865,686 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
atazanavir sulfate  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorendic acid  (EXP)
chloroform  (EXP)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fluoranthene  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
fucoxanthin  (ISO)
gliotoxin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
linoleic acid  (ISO)
LY294002  (EXP)
malonaldehyde  (ISO)
mercury dichloride  (EXP,ISO)
methapyrilene  (ISO)
methylarsonic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-(2-hydroxyethyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
oleamide  (ISO)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorononanoic acid  (ISO)
phenanthrene  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
propanal  (ISO)
pyrene  (EXP)
quercetin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
trimethylarsine oxide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Connexin32 can restore hearing in connexin26 deficient mice. Degen J, etal., Eur J Cell Biol. 2011 Oct;90(10):817-24. doi: 10.1016/j.ejcb.2011.05.001. Epub 2011 Aug 2.
2. Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Dufresne J, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C33-43.
3. Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat. Fallon MB, etal., Am J Physiol. 1995 May;268(5 Pt 1):C1186-94.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP. Goldberg GS, etal., J Biol Chem 2002 Sep 27;277(39):36725-30.
7. Reduced cell-cell communication in experimentally induced autoimmune thyroid disease. Green LM, etal., Endocrinology. 1996 Jul;137(7):2823-32.
8. Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. Maza J, etal., J Biol Chem. 2005 Jun 3;280(22):21115-21. Epub 2005 Apr 7.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Structure of a gap junction gene: rat connexin-32. Miller T, etal., Biosci Rep 1988 Oct;8(5):455-64.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. Molecular cloning of cDNA for rat liver gap junction protein. Paul DL J Cell Biol 1986 Jul;103(1):123-34.
15. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Rash JE, etal., Cell Commun Adhes 2001;8(4-6):315-20.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Differential changes in expression of gap junction proteins connexin 26 and 32 during hepatocarcinogenesis in rats. Sakamoto H, etal., Jpn J Cancer Res. 1992 Nov;83(11):1210-5.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1667015   PMID:2987225   PMID:3017758   PMID:3034905   PMID:7593302   PMID:12829745   PMID:12850269   PMID:14637306   PMID:15239104   PMID:15489334   PMID:16679308   PMID:16731531  
PMID:17546509   PMID:18809458   PMID:19297523   PMID:19960225   PMID:20089884   PMID:20578039   PMID:22718765   PMID:22871113   PMID:23023213   PMID:23149765   PMID:24812055   PMID:25254904  
PMID:25530438   PMID:25969535   PMID:26268619   PMID:26494227   PMID:26655499   PMID:27246301   PMID:29116012   PMID:29790387   PMID:30268116   PMID:33171391   PMID:34678594  


Genomics

Comparative Map Data
Gjb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,501,848 - 66,509,783 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)Ensembl
Rnor_6.0X71,272,030 - 71,279,973 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,272,042 - 71,279,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,448,873 - 89,456,812 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,522,360 - 89,530,242 (+)NCBI
CeleraX66,857,755 - 66,865,686 (+)NCBICelera
Cytogenetic MapXq22NCBI
GJB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,215,239 - 71,225,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX71,212,811 - 71,225,516 (+)EnsemblGRCh38hg38GRCh38
GRCh37X70,435,089 - 70,445,366 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,351,787 - 70,361,777 (+)NCBINCBI36hg18NCBI36
Build 34X70,226,096 - 70,228,065NCBI
CeleraX70,788,947 - 70,798,946 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,252,835 - 64,262,404 (+)NCBIHuRef
CHM1_1X70,328,093 - 70,338,111 (+)NCBICHM1_1
T2T-CHM13v2.0X69,649,327 - 69,659,597 (+)NCBI
Gjb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,419,982 - 100,429,235 (+)NCBIGRCm39mm39
GRCm39 EnsemblX100,419,984 - 100,429,235 (+)Ensembl
GRCm38X101,376,376 - 101,385,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,376,378 - 101,385,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,572,676 - 98,580,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X97,580,056 - 97,588,344 (+)NCBImm8
CeleraX88,294,129 - 88,302,410 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.06NCBI
Gjb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,785,996 - 10,787,910 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,779,415 - 10,787,910 (+)NCBIChiLan1.0ChiLan1.0
GJB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X70,538,213 - 70,548,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,547,110 - 70,547,961 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X60,490,579 - 60,492,606 (+)NCBIMhudiblu_PPA_v0panPan3
GJB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,565,995 - 55,575,332 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,573,808 - 55,574,659 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,392,855 - 46,402,183 (+)NCBI
ROS_Cfam_1.0X56,534,870 - 56,544,201 (+)NCBI
ROS_Cfam_1.0 EnsemblX56,542,150 - 56,544,198 (+)Ensembl
UMICH_Zoey_3.1X54,502,814 - 54,512,141 (+)NCBI
UNSW_CanFamBas_1.0X55,834,274 - 55,843,612 (+)NCBI
UU_Cfam_GSD_1.0X55,761,402 - 55,770,733 (+)NCBI
Gjb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,627,492 - 46,635,864 (-)NCBI
SpeTri2.0NW_004936762389,655 - 398,035 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,242,045 - 57,249,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,241,990 - 57,249,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,844,639 - 64,852,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,013,991 - 61,019,222 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,017,716 - 61,018,567 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660652,883,820 - 2,885,847 (+)NCBIVero_WHO_p1.0
Gjb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,517,324 - 1,519,265 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249031,511,347 - 1,519,265 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:135
Interacting mature miRNAs:151
Transcripts:ENSRNOT00000004979
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 3 40 40 40 21 29 2 3
Low 2 5 7 6 7 21 6 37 8 6
Below cutoff 13 11 10 2 3 18 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076034   ⟹   ENSRNOP00000068485
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,501,860 - 66,508,609 (+)Ensembl
Rnor_6.0 EnsemblX71,272,042 - 71,278,791 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076816   ⟹   ENSRNOP00000068248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,272,045 - 71,279,977 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095443   ⟹   ENSRNOP00000083358
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,501,820 - 66,509,925 (+)Ensembl
RefSeq Acc Id: NM_017251   ⟹   NP_058947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,501,848 - 66,509,779 (+)NCBI
Rnor_6.0X71,272,030 - 71,279,969 (+)NCBI
Rnor_5.0X72,123,958 - 72,131,901 (+)NCBI
RGSC_v3.4X89,448,873 - 89,456,812 (+)RGD
CeleraX66,857,755 - 66,865,686 (+)RGD
Sequence:
RefSeq Acc Id: XM_008773255   ⟹   XP_008771477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,502,799 - 66,509,783 (+)NCBI
Rnor_6.0X71,273,845 - 71,279,973 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601945   ⟹   XP_017457434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,501,902 - 66,509,783 (+)NCBI
Rnor_6.0X71,278,037 - 71,279,973 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058947   ⟸   NM_017251
- UniProtKB: P08033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771477   ⟸   XM_008773255
- Peptide Label: isoform X1
- UniProtKB: P08033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457434   ⟸   XM_017601945
- Peptide Label: isoform X1
- UniProtKB: P08033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068248   ⟸   ENSRNOT00000076816
RefSeq Acc Id: ENSRNOP00000068485   ⟸   ENSRNOT00000076034
RefSeq Acc Id: ENSRNOP00000083358   ⟸   ENSRNOT00000095443
Protein Domains
CNX   Connexin_CCC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08033-F1-model_v2 AlphaFold P08033 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701876
Promoter ID:EPDNEW_R12400
Type:initiation region
Name:Gjb1_1
Description:gap junction protein, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,272,051 - 71,272,111EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61926 AgrOrtholog
BioCyc Gene G2FUF-2101 BioCyc
Ensembl Genes ENSRNOG00000003746 Ensembl
  ENSRNOG00000063213 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068485.1 UniProtKB/TrEMBL
  ENSRNOP00000083358 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000076034.2 UniProtKB/TrEMBL
  ENSRNOT00000095443 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127952 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29584 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93534 IMAGE-MGC_LOAD
NCBI Gene 29584 ENTREZGENE
PANTHER PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gjb1 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219925
UniProt A0A096MKE6_RAT UniProtKB/TrEMBL
  A0A654IET2_RAT UniProtKB/TrEMBL
  CXB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Gjb1  gap junction protein, beta 1  Gjb1  gap junction membrane channel protein beta 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gjb1  gap junction membrane channel protein beta 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adult epididymis; present between apical cells and principal cells, between narrow cells and principal cells and between clear and principal cells 628541
gene_physical_interaction interacts with other subunits as homomers and heteromers to form gap junction 628541
gene_process may play a role in epididymal development 628541
gene_regulation expression is low throughout the epididymis in young animals and begins to increase in the second and third weeks postnatally 628541