Anapc11 (anaphase promoting complex subunit 11)

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Gene: Anapc11 (anaphase promoting complex subunit 11) Rattus norvegicus

Analyze

Symbol:

Anapc11

Name:

anaphase promoting complex subunit 11

RGD ID:

1561880

Description:

Is predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to localize to anaphase-promoting complex; nucleolus; and nucleoplasm. Orthologous to human ANAPC11 (anaphase promoting complex subunit 11); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

anaphase promoting complex subunit 11 homolog; anaphase promoting complex subunit 11 homolog (yeast); anaphase-promoting complex subunit 11; LOC498030; RGD1561880; similar to anaphase promoting complex subunit 11 homolog

RGD Orthologs

Human

Mouse

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANAPC11 (anaphase promoting complex subunit 11)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Anapc11 (anaphase promoting complex subunit 11)	HGNC	Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Pan paniscus (bonobo/pygmy chimpanzee):	ANAPC11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANAPC11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Anapc11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANAPC11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	ANAPC11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Anapc11 (anaphase promoting complex subunit 11)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ANAPC11 (anaphase promoting complex subunit 11)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Anapc11 (anaphase promoting complex subunit 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	anapc11 (APC11 anaphase promoting complex subunit 11 homolog (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	APC11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	apc-11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	lmgA	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	105,875,209 - 105,886,307 (+)	NCBI
Rnor_6.0 Ensembl	10	109,774,878 - 109,785,877 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	109,774,779 - 109,785,877 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	109,367,837 - 109,378,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	109,988,502 - 109,999,500 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	10	104,418,716 - 104,429,712 (+)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

acrolein (ISO)

alpha-pinene (ISO)

Aroclor 1254 (ISO)

benzo[b]fluoranthene (ISO)

benzophenone (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cadmium dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDT (EXP)

dibutyl phthalate (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

fenofibrate (ISO)

flutamide (EXP)

folic acid (ISO)

hydralazine (ISO)

ozone (ISO)

paracetamol (ISO)

rac-lactic acid (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anaphase-promoting complex-dependent catabolic process (IEA)

cell division (IEA)

positive regulation of mitotic metaphase/anaphase transition (IBA)

protein K11-linked ubiquitination (ISO)

protein ubiquitination (IBA,ISO)

ubiquitin-dependent protein catabolic process (IBA)

Cellular Component

anaphase-promoting complex (IBA,ISO)

cullin-RING ubiquitin ligase complex (IBA)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA)

Molecular Function

cullin family protein binding (IBA,ISO)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

ubiquitin-protein transferase activity (ISO)

ubiquitin-ubiquitin ligase activity (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Pipeline to import KEGG annotations from KEGG into RGD
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10230407	PMID:11739784	PMID:16364912	PMID:18485873	PMID:21926987

Genomics

Comparative Map Data

Anapc11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	105,875,209 - 105,886,307 (+)	NCBI
Rnor_6.0 Ensembl	10	109,774,878 - 109,785,877 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	109,774,779 - 109,785,877 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	109,367,837 - 109,378,930 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	109,988,502 - 109,999,500 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	10	104,418,716 - 104,429,712 (+)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

ANAPC11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	81,890,790 - 81,900,991 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	81,890,790 - 81,900,533 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	79,848,666 - 79,858,409 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,442,895 - 77,451,655 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	17	77,442,894 - 77,451,655	NCBI
Celera	17	76,422,607 - 76,462,372 (+)	NCBI
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,220,929 - 75,260,043 (+)	NCBI		HuRef
CHM1_1	17	79,934,870 - 79,944,613 (+)	NCBI		CHM1_1

Anapc11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,489,247 - 120,499,024 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	120,489,247 - 120,499,024 (+)	Ensembl
GRCm38	11	120,598,421 - 120,608,198 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,598,421 - 120,608,198 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,459,735 - 120,469,512 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	120,414,527 - 120,424,288 (+)	NCBI			mm8
Celera	11	132,333,712 - 132,343,490 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI

ANAPC11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	82,002,135 - 82,007,921 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,002,135 - 82,007,921 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	76,297,262 - 76,305,826 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ANAPC11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	393,900 - 398,925 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	393,891 - 399,910 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	996,046 - 1,001,100 (-)	NCBI
ROS_Cfam_1.0	9	987,263 - 992,302 (-)	NCBI
UMICH_Zoey_3.1	9	1,012,411 - 1,017,465 (-)	NCBI
UNSW_CanFamBas_1.0	9	1,139,005 - 1,144,056 (-)	NCBI
UU_Cfam_GSD_1.0	9	1,217,671 - 1,222,711 (-)	NCBI

Anapc11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	1,004,449 - 1,009,673 (-)	NCBI
SpeTri2.0	NW_004936594	5,402,290 - 5,407,510 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANAPC11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	1,095,091 - 1,099,233 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ANAPC11
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,765,660 - 73,773,687 (+)	NCBI

Anapc11
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624801	10,738,356 - 10,742,334 (+)	NCBI

Position Markers

RH128381

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	10	109,783,101 - 109,783,291	NCBI	Rnor6.0
Rnor_5.0	10	109,376,154 - 109,376,344	UniSTS	Rnor5.0
RGSC_v3.4	10	109,996,724 - 109,996,914	UniSTS	RGSC3.4
Celera	10	104,426,936 - 104,427,126	UniSTS
RH 3.4 Map	1	846.8	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14827894	110992275	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	23861015	112626471	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	53621375	112626471	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	53621375	112626471	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	55678976	112626471	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	65590122	110590122	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	65992275	110992275	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	65992275	110992275	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	67880046	112626471	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	67988218	110992091	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	69385595	112626471	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	69385595	112626471	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	70166960	112626471	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	70800069	112626471	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	71692298	112626471	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	73008136	112626471	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	73008136	112626471	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	73008136	112626471	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	73467158	112626471	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	75544754	112626471	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	75544754	112626471	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	78970279	112626471	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	79927661	112626471	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	80239190	112626471	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	85079943	112626471	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	86566908	112626471	Rat
631538	Oia5	Oil induced arthritis QTL 5			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	90041957	112626471	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	90296897	112626471	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	91689348	112626471	Rat
1579915	Bp280	Blood pressure QTL 280		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	93662786	112626471	Rat
12880395	Cm109	Cardiac mass QTL 109		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	93662786	112626471	Rat
12880396	Am13	Aortic mass QTL 13		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	93662786	112626471	Rat
12880398	Kidm67	Kidney mass QTL 67		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	93662786	112626471	Rat
12880384	Cm107	Cardiac mass QTL 107		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)		93662786	112626471	Rat
12880385	Cm108	Cardiac mass QTL 108		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)		93662786	112626471	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	93886117	110992275	Rat
724530	Bp149	Blood pressure QTL 149		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	93886117	112626471	Rat
1558652	Bw57	Body weight QTL 57	4.2	0.0008	body mass (VT:0001259)	body weight (CMO:0000012)	10	94170766	112626471	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	96520816	110992275	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	98079221	112626471	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	98079221	112626471	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	100155035	110992275	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	cortical volumetric bone mineral density (CMO:0001730)	10	100155035	110992275	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	37
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000054954
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	40	34	17	34	1	3	74	29	41	11	1
Low		9	17	7	2	7	7	8		6			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001126082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000054954 ⟹ ENSRNOP00000051837

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	109,774,878 - 109,785,877 (+)	Ensembl

RefSeq Acc Id:

NM_001126082 ⟹ NP_001119554

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,875,308 - 105,886,307 (+)	NCBI
Rnor_6.0	10	109,774,878 - 109,785,877 (+)	NCBI
Rnor_5.0	10	109,367,837 - 109,378,930 (+)	NCBI
RGSC_v3.4	10	109,988,502 - 109,999,500 (+)	RGD
Celera	10	104,418,716 - 104,429,712 (+)	RGD

Sequence:

show sequence

GGTGCGAGGGCGAGGAGGGGGCGGGGCCTGCTTGCGCCTCCCCCGGAGGCCGGAAGACCCTCAG
CGTCGCCTGGGTGCCACGCAGTGAGCGCTCCCCTTCTCCGGAGTCCCCTCAGGTGCGATTCCAA
TGGGTCCGGGCGGGTCCGTGGGTCCGATTTGGGTTTTGTTTGTTCGAAGGCTGTCTCCTAAGGA
GCTGGCGTCTGCAATCCAGCTGTAACTTCGAGGATTAGTGACTGTCACTCTTCCAATTCCTTTT
AAAAGCGAGGCCCTGGTCACAGACTCTGCTGTCATGAAGGTGAAAATTAAGTGTTGGAATGGTG
TGGCCACTTGGCTCTGGGTAGCCAATGATGAGAACTGCGGCATCTGCAGGATGGCGTTCAATGG
CTGCTGTCCAGACTGTAAGGTGCCTGGTGACGACTGTCCCCTGGTGTGGGGACAGTGCTCTCAC
TGCTTCCATATGCACTGCATCCTCAAGTGGCTGAACGCACAGCAGGTGCAGCAGCACTGCCCCA
TGTGTCGACAGGAGTGGAAGTTCAAAGAGTGAAGCCTGCCATGCCCACTCCCTTCTCCCAGCGC
TGTGCCAGGCTCAGCCCCACCTTTCCCTTCCCCAGATAGGGCATCCCGAGTCCCCTCCACACAG
CTCAGGGGTGCCCAGGGACCCCATTCTGTGCTGGGGACAAGGATGCTTTCTGTTTGGCTGAGAC
GAGGTGGAAACGAGGACTGGAGCTTTGCTGGGTGTTTTGTTTTTCCCATCACATTGACACTTTT
ATTAAATAAGTAAAACTCATTAAAGTTCTGAGCCGCTGGAGGCCTCTGCTTGCCTGTTTTCCCT
GACATATTGATGCAGCTGCAGCATGTTTTGCTGTGAACACACTCATAAATAAACAGTTTGGTAA
AGTATCAGCCAAGACCTTCATCATAATCTGAGTCACAGCTCCGACAGGAAGAGTGGAAGAGACT
CGGGCAGGGCCAAGCTGGGCAAAGACTTTAGGGTGTGTTTGTGTCAAGGGCCTAGCAGCCAGCA
CATAGCCCACCAGCTGCCCTAGTCTTCTGGGAGTCCCAGGATCTCTTCCCATCCTACCCCTAGC
TGAGCAAAGCTGGATGCTGCTCCTCCAGAGCCACTGTGGTTAGAGGAAGAGGTAGCTAAGCAGG
CACCAGCCATGCCCAGATGACCTTGGAAGACTACTTCAGCAAGCTCTTGAGTCTCTTGCCTCTT
CTTCAGGCTGAAAGCAGAGCTGGTGTAGGAGGATGTGGGTCCTCTGGTGTCTTAGGGAAGGACA
GCCATTTGGAAACTCCTTTATTCCCATGGCGGTTGTGGGGTGGGGGGGATTATCAGCCATTGGG
AAAACAGTAGCCCAGCCCTAGTGTGTTAAGCTCCTGGGTAGAGACCAATTTTGGCTGGTATCCG
GGAGTCGTGGCCAGCTCCGCGCCTTGTCTTCACTGACCATTCCCAGTAACACCTTCACATTCCC
TATGCGCTCTACAGCCTGGGGAGTAGACCACCATGGCTGGTTCCACCCATCTGTGTCATCATCA
TGTTTGTTGGCTACAAGACTCCCTGCCACCTCTGTGTGGTGTCCTTGGGGTACCTGAAGCAGAC
CCGTGCTGCTGGGAAACAACTTCATGTCACTCGGCTATCTATGGCATGCTGGTCTGGAGCTGGC
ACCAACTATCAGGAGTGAAGAAGGCCACTTCCTGGTGTAACTCAGCCTAAGGATCGCGGAGCGC
TGCAGAGGGAGCTGAGATTTGTGGATTTGGAGCTGCTTGGGCGGGCAGGTGTGGTCTGTCCTTG
CTTGGTGGCTATGAAAGACTGAGGGGCAGGGTGCTAGGGTCAGCTTGTTTCTTCTTTTTTTTTT
GGTTCTTTTTTTCGGAGCTGGGGACCGAACCCAGGGCCTTGCGCTTCCTAGGTAAGTGCTCTAC
CACTGAGCTAAATCCCCAGCCCCCAGCTTGTTTCTTCTATCTCCAGTCTGCCCACCCCCTTGGG
GTGTCCTCCGTGCCTTTTCTAGGAACCTAGGAGTCTAGGAAGCACTCCTGACATCCTTATGCTC
CCAGGTTCCTCCGTTCCCCTCAGAGTCCCTCATGGCCACACACGTCACTCATTCTGGGTTCCTT
AGCACCCAGATTCCTTATGATGTGCTCATGTTGTCAGCAGCTCCTGGTCCCAGGGTCAACTCCA
CCTGCTTCCTCCAAAAAAGTCACCTGATAGACCAGCTATAGCTTGTGCTCACCCTGAGCCGCTT
TCCCAGACAGGAACAGAAGGCCTTGTAGGAAGCTTACACCATTGGCCTCAGGAGGCTTTCTCCA
TGCCGTCTTTCTAATCTACCTGTGCCTGCCCTGTGTTGCCAGAGACTGTGGTATCCCTGTTCTG
CTCCCACCCCCATCCTCACACATGTCTCTTACATGTTACCCTCTTATGTCCAGTATTTAACGAT
TGTTTGCTAAGTGGTTTCCTAGGCCACAACCCTGTGGGCAGGGCAGTACCTTGCTCCTGGGGTC
TGGAGTTGCTTGCCCAGGTTTTTCTGAAGGTTGGGGCCTTAGCTTGATACTTCTCAGAAAGGAC
AAGCCAAGTAGCAGAATCTCCAGTCAAGAGTATGAGACAAAATAACCCCAACCTAGCCCTTAGG
AAGATGAGGTAGGAGTTATTTTCTCCAAGTTCCAGGCCAATCTGGGTTATAGAGTAAGACCCTA
TTGGTGAGCCTGGGGCAGGACTAAAGAATAAGCAAGGTGGTCCCTGTGGCGGCTAGATTTATGT
GACAAAGTAGAGGCATCTGAGAGGAGGGAGGGATCCTCAGTTGAAAAAAAATGCCTTCATAAGA
TAAGGCTTTAGGCAGGCCTATAGGACATTTTCTTCTTTCCTCTTCATAATTTTCTTGCATTTTA
TATGTGGATGTTTTGCCTGCGAGCATCATCTGTGCACTACATGCATCCCCCAATTCCTATAGAG
GCCAGAAGAAGGCATCTGATCCCCTGGAACTAGAGTTCAGACAGTTGGGAGCCGCCTGCCTGTG
GTGCTGGGAATCCAACTTGGGTCCTCTGGAAGAGCAGTCAGTGCTTTTAACTGCTGAGCCATCT
CTTGGAAAAAATCAGTTAGTGATTGATGAGGGAGGGCCCAGCCAATTGTGAGTGGTGCCATCCC
TGGGCAAGCTGACCAAGCCATGAGGAGTAAGTAGCACTCCTCTGTGACCCCTGCATCAGCTTCT
GTCTCCATGTTCTGCTTCAGTTCCTGACTTGGCTTTCTACAGCAGACTGTGACTCAGGAAATGT
AAACCAAATGAATCCTTTTCTCCTC

hide sequence

RefSeq Acc Id:

XM_006247906 ⟹ XP_006247968

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	105,875,209 - 105,883,827 (+)	NCBI
Rnor_6.0	10	109,774,779 - 109,783,488 (+)	NCBI
Rnor_5.0	10	109,367,837 - 109,378,930 (+)	NCBI

Sequence:

show sequence

TGGCGCTCCTTCTGAGGAGCCAGACGCGGCACGGTCGTTTTTATACCTTCCCGCGCGGAGGCAA
CGGAAGGGCGGGGCGCCTCGTGATTAGGTGGTGAAGGTGCGAGGGCGAGGAGGGGGCGGGGCCT
GCTTGCGCCTCCCCCGGAGGCCGGAAGACCCTCAGCGTCGCCTGGGTGCCACGCAGTGAGCGCT
CCCCTTCTCCGGAGTCCCCTCAGGTCACAGACTCTGCTGTCATGAAGGTGAAAATTAAGTGTTG
GAATGGTGTGGCCACTTGGCTCTGGGTAGCCAATGATGAGAACTGCGGCATCTGCAGGATGGCG
TTCAATGGCTGCTGTCCAGACTGTAAGGTGCCTGGTGACGACTGTCCCCTGGTGTGGGGACAGT
GCTCTCACTGCTTCCATATGCACTGCATCCTCAAGTGGCTGAACGCACAGCAGGTGCAGCAGCA
CTGCCCCATGTGTCGACAGGAGTGGAAGTTCAAAGAGTGAAGCCTGCCATGCCCACTCCCTTCT
CCCAGCGCTGTGCCAGGCTCAGCCCCACCTTTCCCTTCCCCAGATAGGGCATCCCGAGTCCCCT
CCACACAGCTCAGGGGTGCCCAGGGACCCCATTCTGTGCTGGGGACAAGGATGCTTTCTGTTTG
GCTGAGACGAGGTGGAAACGAGGACTGGAGCTTTGCTGGGTGTTTTGTTTTTCCCATCACATTG
ACACTTTTATTAAATAAGTAAAACTCATTAAAGTTCTGAGCCGCTGGAGGCCTCTGCTTGCCTG
TTTTCCCTGACATATTGATGCAGCTGCAGCATGTTTTGCTGTGAACACACTCATAAATAAACAG
TTTGGTAAAGTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001119554	(Get FASTA)	NCBI Sequence Viewer
	XP_006247968	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM06864	(Get FASTA)	NCBI Sequence Viewer
	EDM06865	(Get FASTA)	NCBI Sequence Viewer
	EDM06866	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001119554 ⟸ NM_001126082
- UniProtKB:	D3ZXH8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWL NAQQVQQHCPMCRQEWKFKE hide sequence

RefSeq Acc Id:	XP_006247968 ⟸ XM_006247906
- Peptide Label:	isoform X1
- UniProtKB:	D3ZXH8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWL NAQQVQQHCPMCRQEWKFKE hide sequence

RefSeq Acc Id:

ENSRNOP00000051837 ⟸ ENSRNOT00000054954

Protein Domains

RING-type

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697967

Promoter ID:

EPDNEW_R8491

Type:

initiation region

Name:

Anapc11_1

Description:

anaphase promoting complex subunit 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	109,774,943 - 109,775,003	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561880	AgrOrtholog
Ensembl Genes	ENSRNOG00000036686	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000051837	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000054954	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
InterPro	Apc11	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:498030	UniProtKB/TrEMBL
NCBI Gene	498030	ENTREZGENE
Pfam	zf-Apc11	UniProtKB/TrEMBL
PhenoGen	Anapc11	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
UniProt	D3ZXH8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-11-05	Anapc11	anaphase promoting complex subunit 11	Anapc11	anaphase promoting complex subunit 11 homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Anapc11	anaphase promoting complex subunit 11 homolog (yeast)	RGD1561880_predicted	similar to anaphase promoting complex subunit 11 homolog (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561880_predicted	similar to anaphase promoting complex subunit 11 homolog (predicted)	LOC498030	similar to anaphase promoting complex subunit 11 homolog	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498030	similar to anaphase promoting complex subunit 11 homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)