Ang (angiogenin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ang (angiogenin) Rattus norvegicus
Analyze
Symbol: Ang
Name: angiogenin
RGD ID: 1594539
Description: Predicted to enable several functions, including heparin binding activity; protein homodimerization activity; and tRNA-specific ribonuclease activity. Involved in liver development. Predicted to be located in several cellular components, including growth cone; neuronal cell body; and nucleolus. Predicted to be part of angiogenin-PRI complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ang1; angiogenin ribonuclease 1; angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5; ribonuclease 4
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,786,233 - 26,796,883 (+)NCBIGRCr8
mRatBN7.21524,312,711 - 24,323,361 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1527,093,931 - 27,094,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,053,067 - 28,053,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,302,490 - 26,302,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,022,926 - 28,028,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01531,854,833 - 31,859,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,083,089 - 27,083,526 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,640,646 - 24,641,083 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diallyl disulfide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxycycline  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
Licochalcone B  (ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP,ISO)
trametinib  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)

References

References - curated
# Reference Title Reference Citation
1. A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Abdel-Rahman AM, etal., Chest. 2006 Feb;129(2):266-71.
2. Serum levels of angiogenin (ANG) in invasive cervical cancer and in cervical intraepithelial neoplasia (CIN). Bodner-Adler B, etal., Anticancer Res. 2001 Jan-Feb;21(1B):809-12.
3. Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. Campo L, etal., J Pathol. 2005 Apr;205(5):585-91.
4. Angiogenin, interleukins, and growth-factor levels in serum of patients with ovarian cancer: correlation with angiogenesis. Chopra V, etal., Cancer J Sci Am. 1996 Sep-Oct;2(5):279-85.
5. Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer. Chopra V, etal., J Cancer Res Clin Oncol. 1997;123(3):167-72.
6. Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population. Corrado L, etal., J Neurol Sci. 2007 Jul 15;258(1-2):123-7. Epub 2007 Apr 25.
7. Comparison of cytokeratin 20 RNA and angiogenin in voided urine samples as diagnostic tools for bladder carcinoma. Eissa S, etal., Clin Biochem. 2004 Sep;37(9):803-10.
8. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Greenway MJ, etal., Nat Genet. 2006 Apr;38(4):411-3. Epub 2006 Feb 26.
9. Total Flavonoids in Caragana (TFC) Promotes Angiogenesis and Enhances Cerebral Perfusion in a Rat Model of Ischemic Stroke. He Q, etal., Front Neurosci. 2018 Sep 12;12:635. doi: 10.3389/fnins.2018.00635. eCollection 2018.
10. The kinetic change of the serum angiogenin level in patients with acute cerebral infarction. Huang L, etal., Eur Neurol. 2007;58(4):224-7. Epub 2007 Sep 7.
11. Dominant expression of angiogenin in NeuN positive cells in the focal ischemic rat brain. Huang L, etal., J Neurol Sci. 2009 Oct 15;285(1-2):220-3. Epub 2009 Aug 8.
12. Increased expression of angiogenin in nasal polyps. Hwang KS, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):e23-6.
13. Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription. Ibaragi S, etal., Clin Cancer Res. 2009 Mar 15;15(6):1981-8. Epub 2009 Mar 10.
14. Decreased serum angiogenin level in Alzheimer's disease. Kim YN and Kim do H, Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):116-20. Epub 2012 Mar 15.
15. Airway angiogenesis in patients with rhinitis and controlled asthma. Kristan SS, etal., Clin Exp Allergy. 2009 Mar;39(3):354-60. Epub 2009 Jan 22.
16. Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease. Kristan SS, etal., Scand J Immunol. 2012 Jan;75(1):109-14. doi: 10.1111/j.1365-3083.2011.02623.x.
17. Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice. Kurki EM, etal., Nutr Metab (Lond). 2012 Jun 29;9(1):64.
18. Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts. Liote F, etal., Clin Exp Immunol. 2003 Apr;132(1):163-8.
19. Therapeutic potential of angiogenin modified mesenchymal stem cells: angiogenin improves mesenchymal stem cells survival under hypoxia and enhances vasculogenesis in myocardial infarction. Liu XH, etal., Microvasc Res. 2008 May;76(1):23-30. Epub 2008 Mar 18.
20. Determination of angiogenic factors in serum by protein array in patients with renal cell carcinoma. Lukesova S, etal., Folia Biol (Praha). 2008;54(4):134-40.
21. Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence. Miyake H, etal., Cancer. 1999 Jul 15;86(2):316-24.
22. Angiogenin expression and prognosis in primary breast carcinoma. Montero S, etal., Clin Cancer Res. 1998 Sep;4(9):2161-8.
23. CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients. Moreau C, etal., Amyotroph Lateral Scler. 2009 Jun;10(3):175-81.
24. Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease. Oikonomou KA, etal., Inflamm Bowel Dis. 2011 Apr;17(4):963-70. doi: 10.1002/ibd.21410.
25. Inhibition of prostate carcinoma establishment and metastatic growth in mice by an antiangiogenin monoclonal antibody. Olson KA, etal., Int J Cancer. 2002 Apr 20;98(6):923-9.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Angiogenic remodeling in pediatric eosinophilic esophagitis is associated with increased levels of VEGFA, angiogenin, IL-8 and activation of the TNF-alpha-NFkappaB pathway. Persad R, etal., J Pediatr Gastroenterol Nutr. 2012 Feb 10.
28. Chimeric anti-angiogenin antibody cAb 26-2F inhibits the formation of human breast cancer xenografts in athymic mice. Piccoli R, etal., Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4579-83.
29. Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy. Reverter JL, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1378-82. Epub 2008 Oct 31.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Comprehensive gene review and curation RGD comprehensive gene curation
34. Peripheral blood monocyte subsets predict antiviral response in chronic hepatitis C. Rodriguez-Munoz Y, etal., Aliment Pharmacol Ther. 2011 Oct;34(8):960-71. doi: 10.1111/j.1365-2036.2011.04807.x. Epub 2011 Aug 17.
35. Angiogenin and gestational trophoblastic tumors, a promising prognostic marker. Shaarawy M, etal., Clin Chem Lab Med. 2003 Mar;41(3):306-10.
36. Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness. Shimoyama S, etal., Cancer Res. 1996 Jun 15;56(12):2703-6.
37. Serum concentrations of insulin-like growth factor-1, soluble tumor necrosis factor receptor-1 and angiogenin in endometriosis patients. Steff AM, etal., Am J Reprod Immunol. 2004 Feb;51(2):166-73.
38. A neuroprotective role for angiogenin in models of Parkinson's disease. Steidinger TU, etal., J Neurochem. 2011 Feb;116(3):334-41. doi: 10.1111/j.1471-4159.2010.07112.x. Epub 2010 Dec 22.
39. Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder. Suzumori N, etal., Fertil Steril. 2004 Jul;82(1):93-6.
40. Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. van Es MA, etal., Ann Neurol. 2011 Dec;70(6):964-73. doi: 10.1002/ana.22611.
41. Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Weiner HL, etal., Science. 1987 Jul 17;237(4812):280-2.
42. Increased plasma levels of angiogenin and the risk of bladder carcinoma: from initiation ot recurrence. Zhao H, etal., Cancer. 2005 Jul 1;104(1):30-5.
Additional References at PubMed
PMID:2424496   PMID:2457905   PMID:2479414   PMID:2646638   PMID:2730651   PMID:3470787   PMID:3663649   PMID:7679494   PMID:8448182   PMID:9122172   PMID:9245697   PMID:9602056  
PMID:9707554   PMID:10103013   PMID:10649442   PMID:10999833   PMID:11374889   PMID:11782452   PMID:12548285   PMID:15166501   PMID:15676279   PMID:15735021   PMID:15979542   PMID:16461950  
PMID:16490744   PMID:17125737   PMID:17468498   PMID:19379779   PMID:23170778   PMID:23376485   PMID:23378030   PMID:25219815   PMID:25372031   PMID:26581172   PMID:34781187  


Genomics

Comparative Map Data
Ang
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,786,233 - 26,796,883 (+)NCBIGRCr8
mRatBN7.21524,312,711 - 24,323,361 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1527,093,931 - 27,094,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,053,067 - 28,053,504 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,302,490 - 26,302,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,022,926 - 28,028,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01531,854,833 - 31,859,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,083,089 - 27,083,526 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,640,646 - 24,641,083 (+)NCBICelera
Cytogenetic Map15p14NCBI
ANG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,684,177 - 20,694,186 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,684,177 - 20,698,971 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,152,336 - 21,162,345 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,222,176 - 20,232,185 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,222,608 - 20,232,183NCBI
Celera141,013,208 - 1,023,217 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,273,259 - 1,283,264 (+)NCBIHuRef
CHM1_11421,154,356 - 21,164,361 (+)NCBICHM1_1
T2T-CHM13v2.01414,881,287 - 14,891,295 (+)NCBIT2T-CHM13v2.0
Ang
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,328,607 - 51,339,462 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,328,607 - 51,339,466 (+)EnsemblGRCm39 Ensembl
GRCm381451,091,077 - 51,102,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,091,150 - 51,102,009 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,710,752 - 51,721,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,018,364 - 50,023,956 (+)NCBIMGSCv36mm8
Celera1447,385,172 - 47,396,946 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.37NCBI
ANG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,184,500 - 22,194,602 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,400,986 - 21,410,662 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,548,693 - 1,558,528 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,605,854 - 19,615,571 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,614,950 - 19,615,393 (+)Ensemblpanpan1.1panPan2
Ang
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,124,921 - 32,130,709 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493688039,372 - 40,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,215,985 - 21,226,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605925,203,862 - 25,214,926 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ang
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:85
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000064029
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY395869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY665826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_001006992   ⟹   NP_001006993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,791,240 - 26,796,883 (+)NCBI
mRatBN7.21524,317,718 - 24,323,361 (+)NCBI
Rnor_6.01528,028,040 - 28,028,477 (+)NCBI
Rnor_5.01531,854,833 - 31,859,801 (+)NCBI
RGSC_v3.41527,083,089 - 27,083,526 (+)RGD
Celera1524,640,646 - 24,641,083 (+)RGD
Sequence:
RefSeq Acc Id: NM_001412006   ⟹   NP_001398935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,786,233 - 26,796,883 (+)NCBI
mRatBN7.21524,312,711 - 24,323,361 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001006993 (Get FASTA)   NCBI Sequence Viewer  
  NP_001398935 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC23487 (Get FASTA)   NCBI Sequence Viewer  
  AAR28758 (Get FASTA)   NCBI Sequence Viewer  
  AAV87193 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001006993   ⟸   NM_001006992
- Peptide Label: precursor
- UniProtKB: Q5GAM6 (UniProtKB/TrEMBL),   W0UV65 (UniProtKB/TrEMBL),   Q5WRG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001398935   ⟸   NM_001412006
- Peptide Label: precursor
- UniProtKB: Q5GAM6 (UniProtKB/TrEMBL),   W0UV65 (UniProtKB/TrEMBL),   Q5WRG2 (UniProtKB/TrEMBL)
Protein Domains
Ribonuclease A-domain


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594539 AgrOrtholog
BioCyc Gene G2FUF-14030 BioCyc
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:305843 UniProtKB/TrEMBL
NCBI Gene 305843 ENTREZGENE
PANTHER ANGIOGENIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Ang PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/TrEMBL
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt Q5GAM6 ENTREZGENE, UniProtKB/TrEMBL
  Q5WRG2 ENTREZGENE, UniProtKB/TrEMBL
  W0UV65 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Ang  angiogenin  Ang  angiogenin, ribonuclease, RNase A family, 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Ang  angiogenin, ribonuclease, RNase A family, 5  Ang1  angiogenin, ribonuclease A family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 Ang1  angiogenin, ribonuclease A family, member 1      Symbol and Name status set to provisional 70820 PROVISIONAL