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Gene: S100a8 (S100 calcium binding protein A8) Rattus norvegicus
Symbol: S100a8
Name: S100 calcium binding protein A8
Description: Predicted to have several functions, including arachidonic acid binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including autocrine signaling; response to ethanol; and response to lipopolysaccharide. Localizes to the extracellular space. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A8 (S100 calcium binding protein A8); INTERACTS WITH (S)-colchicine; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calgranulin-A; migration inhibitory factor-related protein 8; MRP-8; Mrp8; p8; protein S100-A8; S100 calcium binding protein A8 (calgranulin A); S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A)
Homo sapiens (human) : S100A8 (S100 calcium binding protein A8)  HGNC  Alliance
Mus musculus (house mouse) : S100a8 (S100 calcium binding protein A8 (calgranulin A))  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : S100A8 (S100 calcium binding protein A8)
Canis lupus familiaris (dog) : S100A8 (S100 calcium binding protein A8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S100a8 (S100 calcium binding protein A8)
Sus scrofa (pig) : S100A8 (S100 calcium binding protein A8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02190,073,239 - 190,074,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02209,507,598 - 209,508,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,961,994 - 182,962,513 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12182,912,099 - 182,912,619 (+)NCBI
Celera2170,099,876 - 170,100,395 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on S100a8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620265
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.