Tigar (TP53 induced glycolysis regulatory phosphatase)

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Gene: Tigar (TP53 induced glycolysis regulatory phosphatase) Rattus norvegicus

Analyze

Symbol:

Tigar

Name:

TP53 induced glycolysis regulatory phosphatase

RGD ID:

1560038

Description:

Predicted to have bisphosphoglycerate 2-phosphatase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including negative regulation of cell death; negative regulation of cellular metabolic process; and regulation of generation of precursor metabolites and energy. Predicted to localize to cytosol; mitochondrial outer membrane; and nucleus. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

fructose-2,6-bisphosphatase TIGAR; hypothetical protein LOC502894; LOC502894; TP53-induced glycolysis and apoptosis regulator; uncharacterized protein LOC502894

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	159,927,138 - 159,946,094 (-)	NCBI
Rnor_6.0 Ensembl	4	159,635,153 - 159,654,063 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	159,635,145 - 159,654,108 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	231,948,786 - 231,966,869 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	163,481,393 - 163,502,412 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	4	148,642,195 - 148,661,115 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-colchicine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

adefovir pivoxil (ISO)

adenine (ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

captan (ISO)

carbamazepine (ISO)

chloroacetaldehyde (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clodronic acid (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dimethylarsinous acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

folpet (ISO)

formaldehyde (ISO)

hydrogen peroxide (ISO)

ifosfamide (ISO)

kainic acid (EXP)

methotrexate (ISO)

methoxyacetic acid (ISO)

methyl methanesulfonate (ISO)

NADP zwitterion (EXP)

NADP(+) (EXP)

nickel atom (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

potassium bromate (ISO)

progesterone (ISO)

promegestone (ISO)

propanal (ISO)

quercetin (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

tamoxifen (ISO)

Triptolide (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to cobalt ion (ISO)

cellular response to DNA damage stimulus (ISO)

cellular response to hypoxia (ISO)

dephosphorylation (IEA)

fructose 1,6-bisphosphate metabolic process (IBA,ISO)

fructose 2,6-bisphosphate metabolic process (IBA,ISO)

intestinal epithelial cell development (ISO)

negative regulation of glucose catabolic process to lactate via pyruvate (ISO)

negative regulation of glycolytic process (IBA,ISO)

negative regulation of mitophagy (ISO)

negative regulation of neuron death (ISO)

negative regulation of programmed cell death (IBA,ISO)

negative regulation of reactive oxygen species metabolic process (ISO)

positive regulation of cardiac muscle cell apoptotic process (ISO)

positive regulation of DNA repair (IBA,ISO)

positive regulation of hexokinase activity (ISO)

regulation of pentose-phosphate shunt (IBA,ISO)

regulation of response to DNA damage checkpoint signaling (ISO)

response to gamma radiation (ISO)

response to ischemia (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

mitochondrial outer membrane (ISO)

mitochondrion (ISO)

nucleus (ISO)

Molecular Function

bisphosphoglycerate 2-phosphatase activity (IBA,ISO)

fructose-2,6-bisphosphate 2-phosphatase activity (IBA,ISO)

protein binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for gene-chemical interactions
3.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16839880	PMID:19015259	PMID:20935145	PMID:22044588	PMID:23185017	PMID:23726973	PMID:24872551	PMID:25928429	PMID:31160088	PMID:31317559

Genomics

Comparative Map Data

Tigar
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	159,927,138 - 159,946,094 (-)	NCBI
Rnor_6.0 Ensembl	4	159,635,153 - 159,654,063 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	159,635,145 - 159,654,108 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	231,948,786 - 231,966,869 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	163,481,393 - 163,502,412 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	4	148,642,195 - 148,661,115 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

TIGAR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	4,307,763 - 4,360,028 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	4,321,213 - 4,360,028 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	4,430,379 - 4,469,194 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	4,300,620 - 4,339,455 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	4,300,631 - 4,332,599	NCBI
Celera	12	6,052,425 - 6,091,264 (+)	NCBI
Cytogenetic Map	12	p13.32	NCBI
HuRef	12	4,287,018 - 4,325,825 (+)	NCBI		HuRef
CHM1_1	12	4,429,992 - 4,468,805 (+)	NCBI		CHM1_1

Tigar
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	127,062,079 - 127,086,564 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	127,062,079 - 127,086,520 (-)	Ensembl
GRCm38	6	127,085,116 - 127,109,552 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	127,085,116 - 127,109,557 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	127,035,134 - 127,059,570 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	127,052,982 - 127,075,160 (-)	NCBI			mm8
MGSCv36	6	127,984,031 - 128,005,972 (-)	NCBI			mm8
Celera	6	128,766,834 - 128,786,116 (-)	NCBI		Celera
Cytogenetic Map	6	F3	NCBI

Tigar
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	2,129,678 - 2,154,380 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	2,129,719 - 2,153,873 (+)	NCBI	ChiLan1.0	ChiLan1.0

TIGAR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	4,353,272 - 4,386,758 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	4,353,272 - 4,385,380 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	4,429,945 - 4,462,142 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

TIGAR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	27	40,523,314 - 40,549,332 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	27	40,521,751 - 40,549,304 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Tigar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936606	4,518,525 - 4,540,109 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIGAR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	66,044,686 - 66,067,377 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	66,044,679 - 66,067,571 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	68,266,609 - 68,289,947 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TIGAR
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	4,354,911 - 4,381,762 (+)	NCBI
ChlSab1.1 Ensembl	11	4,355,053 - 4,381,273 (+)	Ensembl

Tigar
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624860	1,416,419 - 1,455,953 (+)	NCBI

Position Markers

D4Mit25

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	159,648,325 - 159,648,465	NCBI	Rnor6.0
Rnor_5.0	4	231,953,550 - 231,953,690	UniSTS	Rnor5.0
RGSC_v3.4	4	163,495,152 - 163,495,293	RGD	RGSC3.4
RGSC_v3.4	4	163,495,153 - 163,495,293	UniSTS	RGSC3.4
RGSC_v3.1	4	163,740,089 - 163,740,229	RGD
Celera	4	148,655,370 - 148,655,510	UniSTS
RH 3.4 Map	4	1003.6	UniSTS
RH 3.4 Map	4	1003.6	RGD
Cytogenetic Map	4	q42	UniSTS

D4Got310

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	159,648,729 - 159,648,916	NCBI	Rnor6.0
Rnor_5.0	4	231,953,099 - 231,953,286	UniSTS	Rnor5.0
RGSC_v3.4	4	163,495,557 - 163,496,365	UniSTS	RGSC3.4
RGSC_v3.4	4	163,495,557 - 163,495,744	UniSTS	RGSC3.4
Celera	4	148,655,774 - 148,655,961	UniSTS
Cytogenetic Map	4	q42	UniSTS

RH128614

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	159,635,296 - 159,635,496	NCBI	Rnor6.0
Rnor_5.0	4	231,966,518 - 231,966,718	UniSTS	Rnor5.0
RGSC_v3.4	4	163,481,539 - 163,481,739	UniSTS	RGSC3.4
Celera	4	148,642,341 - 148,642,541	UniSTS
RH 3.4 Map	4	1009.1	UniSTS
Cytogenetic Map	4	q42	UniSTS

BF386144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	4	159,636,639 - 159,636,805	NCBI	Rnor6.0
Rnor_6.0	6	91,332,590 - 91,332,756	NCBI	Rnor6.0
Rnor_5.0	6	100,794,516 - 100,794,682	UniSTS	Rnor5.0
Rnor_5.0	4	231,965,209 - 231,965,375	UniSTS	Rnor5.0
RGSC_v3.4	6	91,001,278 - 91,001,444	UniSTS	RGSC3.4
RGSC_v3.4	4	163,482,882 - 163,483,048	UniSTS	RGSC3.4
Celera	4	148,643,684 - 148,643,850	UniSTS
Celera	6	86,015,520 - 86,015,686	UniSTS
RH 3.4 Map	6	549.8	UniSTS
Cytogenetic Map	4	q42	UniSTS
Cytogenetic Map	6	q24	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	7850904	182171018	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	105971071	168047091	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	123111827	168111827	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131532269	168047091	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	145547014	184226339	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155386197	184226339	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	145547014	184226339	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	145547014	184226339	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	123587009	168587009	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	136351734	174694858	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155386197	184226339	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	145547014	184226339	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	145547014	184226339	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131532269	168047091	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	145373934	176509907	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123478354	168478354	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	124442168	169442168	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157423126	184226339	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	128602727	173602727	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	136351734	180689124	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	156855449	184226339	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86438317	168047091	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	131864442	176864442	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	84475257	178931073	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	cortical volumetric bone mineral density (CMO:0001730)	4	137171018	182171018	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	136351734	174694858	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	132455408	168047091	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	131834282	176834282	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (VE) (CMO:0000132)	4	134917642	179917642	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	23850384	169318094	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94893247	168046938	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	117926139	162926139	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	125884464	168047091	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	146497452	184226339	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	146942075	168998263	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	108876717	169215811	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146086918	168047091	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	136908430	182878540	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		17	8	2		2	6	9	74		19	3	6
Low	3	26	49	39	19	39	2	2		35	22	8	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC093610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000091662 ⟹ ENSRNOP00000074722

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	4	159,635,153 - 159,654,063 (-)	Ensembl

RefSeq Acc Id:

NM_001025064 ⟹ NP_001020235

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	159,927,141 - 159,946,058 (-)	NCBI
Rnor_6.0	4	159,635,150 - 159,654,063 (-)	NCBI
Rnor_5.0	4	231,948,786 - 231,966,869 (+)	NCBI
RGSC_v3.4	4	163,481,393 - 163,502,412 (-)	RGD
Celera	4	148,642,195 - 148,661,115 (-)	RGD

Sequence:

show sequence

CGGAAGTAGTGCAGGCAAAGTGGACCTGCAGTCAGTCGCAGCAAGGTGCTGCAGAGTCGGGTTG
TGGCTCACGTGCCTTGGACCAAGATGCCGCGCTTCGCCTTGACCATCATCCGCCAGGCAAGGAG
TAGACGCGCCCCTTTCCGAGACTGGGTTTAGGCAAGCAGCCGCCACTGGTCAGTTTCTGAGCAA
CGTGCACTTTACCCACGCCTTCTCCAGTGATCTCACGAGGACTAAGCAGACCATACATGGCATT
CTGGAGAAAAGCAGATTTTGCAAAGACATAGCAGTGAAGTATGACTCCAGACTTCGGGAAAGGA
TGTACGGGGTTGCAGAAGGCAAGCCGCTAAGTGAGCTTCGGGCCATGGCCAAAGCCGCTGGAGA
AGAGTGTCCCATGTTCACCCCGCCTGGAGGAGAGACAGTAGAGCAGGTAAAAATGCGTGGAAAG
GATTTCTTTGATTTCATTTGTCAGTTGATTCTGGGCAAGGCAGGCCAGAGAGAAAACTTCCTCC
CCGGAGCGCCAGACAACTGTTTGGAAAGCTCTTTGGCGGAGGTTTTCCCCGTGGGAAAACACGG
CAGCTTGGGGACAGACCCCAAGCATGGTGCCCTGGGTTTAACCGCCAGCATCTTGGTCGTGAGC
CACGGGGCTTACATGAGAAGCCTCTTTGGTTATTTCCTGAGTGACCTCAGATGCTCACTGCCAG
CCACAATAGACAAATTCGAACTTTCCTCCATCACTCCCAACACTGGCATCAGTGTCTTCATCAT
CGACTGTGAGGAAGCACGCAAGCCAACCGTCCAGTGTGTTTGTATGAACCTCCAGGAGCATCTA
AACAAAGGGGTTGAAAAGCACTGAGTCCAAAGCCCCCAACCGTGGGGCTCCGAATGGAGGGCCT
TGGCCTCTTGTGTTTTCATCCTCTGCCCCTGCTGTTTAGAAGCAGGTGAGACTTGTGCCATAAA
GCCCCACTGGGGTCCTGACTGTATCCGCTGTTAGTGGGAATCCACTCAGAGTCAGCCTGGTTTT
TCTGAGACACCATTTTCTACCATGATTTTGTCACCCTGTGCTGTTATGTCTGTGAACTATTAAC
TTATGAGGACACTCAGCATTGCACACGGGGGATGAAGCCTTTTCTCCACATTCTCCTTTCATTG
GCCTCTTCGATGTCTAGATGGTGTTGGCTGTTGAAGATCATTTAATGTTTTTCCACTCACTCAC
CAAGTGCTTGCAAGAAAGAATGGTTTAAATAATTCTCCCGCATTTGCAGTGACTGTGTCAGAGT
CCACAGTGTTCAGACTGAAGCTTCTTACTGTCATCCGTGTGTAAAGGGAAATGGCTGAATGCTC
TAGCGTCCTCTGGAGAAACTGGCTCTTGGGAATTATTATTATCATTGTTATTGTTATTATTGCC
TCAAATACAGCTGAGGGACTGAAGGGACTAGGAGTACTTCCAGTTACCCTGAGAACCCCAGTTC
AGATCCCTTTACCCATATTGGGCAGCTCACAGCTTCCTGGAACTCCAGCATCAGGGAGGCAGTG
CCCGCTCTGGGCCTCTGCAGACACTTGCACACATGCACACAAATAAAAGTAGTAAAAGCAGCCT
GGGGGAAGGAAGGAACACACTGCCTGATCAGACACATTACGATCCTCTGAGAAGAAGGCAAACA
CAGCTTTCCAGCAAAAGCGGTGGGGGTGGGGAATGCTCAAGTTACCCTCGCTTTGTATCCAAGC
TGCCTGTGAAGACTGGTTGACCCATCCAAAGAAGAGGTGCTGAAAACTGGTACGCAGAAGGCTC
AGAGGAGTGACCTTCCTCCAGGTGGCGCTGTCGGAAAGGGATTTTGATTGCTGCTCAAGAGTCC
TCAATTAGGAAACTGGACTGCTAAAAATGCCAGGCCCACACTACAGCCTCAGGAAAATGTAACA
CTGGGCCCAGATATAGAGGAGTTTGACCAGGAAGAGCTGGTAGGATTGAGAGCTTACTGAACAG
TAGGTGACAAACTTAAGAAACCTAGAAATACAGTTCACCTGCAAAGGGAGGTGTAGGTCAAGGC
TCACCACAGTTGACTTGCCTGCTGTAAAGTGCTACTAGGTCCTTCTGTCTAGACACTTTGTGGG
GGCGCTGCCAACACTTTGGGTACTGGTGGCCCCACACTAGGGATTTACTTGAGGTTCCAAATGC
ACGTGTACCTTGAACAAAGACATCACTGACATGAGTCCAAAGTGTGACCATGTTCTGAGAAACC
AAAGGACATGATTATAAAGGCCGTAGAAAAGTCTCCCTATGGGTGACAGTGAACTTCAGTTCAA
AAGTCATGTCGGCATTTGGGGTGAGTGTTGGGTTGTGTGAATCTGAGAGGAAAGTTATAAAAAC
CTGAGGAGTTTGGAGGTGTCGCTCAGTGGGCCCTGGCTTCCATCACAAGTGGAGAAAAATCAGA
ACAGAAACCTGCTTTTTTAAGAGAAATCCAGTGTTAGGTCACTCCCTCCGTGTAGAGCACCACT
GGAAGTCCTGGTGCGGAGCTGCTGTGAGACAGAGCAGAGCTCATAAGCAGAGTGGGTGAGCAGC
AGTATTGTTCTACTGCCTTTCAAATGCACATAAATACCCAGCTCTGTAGTCTTCCTTTTACCCG
TACTGTTTGAGGGTATTTATTTGGGAATGTATGGCTCTACTTAATTGTAACCAGTATTCTACCG
AATGAATAAAGATCTTTGGTTTATAAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

XM_006237501 ⟹ XP_006237563

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	159,927,138 - 159,946,094 (-)	NCBI
Rnor_6.0	4	159,635,145 - 159,654,108 (-)	NCBI
Rnor_5.0	4	231,948,786 - 231,966,869 (+)	NCBI

Sequence:

show sequence

TAAGCCGCCTCGACCAACAGCTACAGAGCCGGTCCGCAGGGCAGACGGAAGTAGTGCAGGCAAA
GTGGACCTGCAGTCAGTCGCAGCAAGGTGCTGCAGAGTCGGGTTGTGGCTCACGTGCCTTGGAC
CAAGATGCCGCGCTTCGCCTTGACCATCATCCGCCATGGCGAAACAAGACTTAACAAGGAGAAA
ATCATTCAAGGGCAAGGAGTAGACGCGCCCCTTTCCGAGACTGGGTTTAGGCAAGCAGCCGCCA
CTGGTCAGTTTCTGAGCAACGTGCACTTTACCCACGCCTTCTCCAGTGATCTCACGAGGACTAA
GCAGACCATACATGGCATTCTGGAGAAAAGCAGATTTTGCAAAGACATAGCAGTGAAGTATGAC
TCCAGACTTCGGGAAAGGATGTACGGGGTTGCAGAAGGCAAGCCGCTAAGTGAGCTTCGGGCCA
TGGCCAAAGCCGCTGGAGAAGAGTGTCCCATGTTCACCCCGCCTGGAGGAGAGACAGTAGAGCA
GGTAAAAATGCGTGGAAAGGATTTCTTTGATTTCATTTGTCAGTTGATTCTGGGCAAGGCAGGC
CAGAGAGAAAACTTCCTCCCCGGAGCGCCAGACAACTGTTTGGAAAGCTCTTTGGCGGAGGTTT
TCCCCGTGGGAAAACACGGCAGCTTGGGGACAGACCCCAAGCATGGTGCCCTGGGTTTAACCGC
CAGCATCTTGGTCGTGAGCCACGGGGCTTACATGAGAAGCCTCTTTGGTTATTTCCTGAGTGAC
CTCAGATGCTCACTGCCAGCCACAATAGACAAATTCGAACTTTCCTCCATCACTCCCAACACTG
GCATCAGTGTCTTCATCATCGACTGTGAGGAAGCACGCAAGCCAACCGTCCAGTGTGTTTGTAT
GAACCTCCAGGAGCATCTAAACAAAGGGGTTGAAAAGCACTGAGTCCAAAGCCCCCAACCGTGG
GGCTCCGAATGGAGGGCCTTGGCCTCTTGTGTTTTCATCCTCTGCCCCTGCTGTTTAGAAGCAG
GTGAGACTTGTGCCATAAAGCCCCACTGGGGTCCTGACTGTATCCGCTGTTAGTGGGAATCCAC
TCAGAGTCAGCCTGGTTTTTCTGAGACACCATTTTCTACCATGATTTTGTCACCCTGTGCTGTT
ATGTCTGTGAACTATTAACTTATGAGGACACTCAGCATTGCACACGGGGGATGAAGCCTTTTCT
CCACATTCTCCTTTCATTGGCCTCTTCGATGTCTAGATGGTGTTGGCTGTTGAAGATCATTTAA
TGTTTTTCCACTCACTCACCAAGTGCTTGCAAGAAAGAATGGTTTAAATAATTCTCCCGCATTT
GCAGTGATTGTGTCAGAGTCCACAGTGTTCAGACTGAAGCTTCTTACTGTCATCCGTGTGTAAA
GGGAAATGGCTGAATGCTCTAGCGTCCTCTGGAGAAACTGGCTCTTGGGAATTATTATTATCAT
TGTTATTGTTATTATTGCCTCAAATACAGCTGAGGGACTGAAGGGACTAGGAGTACTTCCAGTT
ACCCTGAGAACCCCAGTTCAGATCCCTTTACCCATATTGGGCAGCTCACAGCTTCCTGGAACTC
CAGCATCAGGGAGGCAGTGCCCGCTCTGGGCCTCTGCAGACACTTGCACACATGCACACAAATA
AAAGTAGTAAAAGCAGCCTGGGGGAAGGAAGGAACACACTGCCTGATCAGACACATTACGATCC
TCTGAGAAGAAGGCAAACACAGCTTTCCAGCAAAAGCGGTGGGGGTGGGGAATGCTCAAGTTAC
CCTCGCTTTGTATCCAAGCTGCCTGTGAAGACTGGTTGACCCATCCAAAGAAGAGGTGCTGAAA
ACTGGTACGCAGAAGGCTCAGAGGAGTGACCTTCCTCCAGGTGGCGCTGTCGGAAAGGGATTTT
GATTGCTGCTCAAGAGTCCTCAATTAGGAAACTGGACTGCTAAAAATGCCAGGCCCACACTACA
GCCTCAGGAAAATGTAACACTGGGCCCAGATATAGAGGAGTTTGACCAGGAAGAGCTGGTAGGA
TTGAGAGCTTACTGAACAGTAGGTGACAAACTTAAGAAACCTAGAAATACAGTTCACCTGCAAA
GGGAGGTGTAGGTCAAGGCTCACCACAGTTGACTTGCCTGCTGTAAAGTGCTACTAGGTCCTTC
TGTCTAGACACTTTGTGGGGGCGCTGCCAACACTTTGGGTACTGGTGGCCCCACACTAGGGATT
TACTTGAGGTTCCAAATGCACGTGTACCTTGAACAAAGACATCACTGACATGAGTCCAAAGTGT
GACCATGTTCTGAGAAACCAAAGGACATGATTATAAAGGCCGTAGAAAAGTCTCCCTATGGGTG
ACAGTGAACTTCAGTTCAAAAGTCATGTCGGCATTTGGGGTGAGTGTTGGGTTGTGTGAATCTG
AGAGGAAAGTTATAAAAACCTGAGGAGTTTGGAGGTGTCGCTCAGTGGGCCCTGGCTTCCATCA
CAAGTGGAGAAAAATCAGAACAGAAACCTGCTTTTTTAAGAGAAATCCAGTGTTAGGTCACTCC
CTCCGTGTAGAGCACCACTGGAAGTCCTGGTGCGGAGCTGCTGTGAGACAGAGCAGAGCTCATA
AGCAGAGTGGGTGAGCAGCAGTATTGTTCTACTGCCTTTCAAATGCACATAAATACCCAGCTCT
GTAGTCTTCCTTTTACCCGTACTGTTTGAGGGTATTTATTTGGGAATGTATGGCTCTACTTAAT
TGTAACCAGTATTCTACCGAATGAATAAAGATCTTTGGTTTATAGAGGG

hide sequence

RefSeq Acc Id:

XM_039108258 ⟹ XP_038964186

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	159,927,138 - 159,946,077 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020235	(Get FASTA)	NCBI Sequence Viewer
	XP_006237563	(Get FASTA)	NCBI Sequence Viewer
	XP_038964186	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH93610	(Get FASTA)	NCBI Sequence Viewer
	EDM01816	(Get FASTA)	NCBI Sequence Viewer
	EDM01817	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001020235 ⟸ NM_001025064
- UniProtKB:	Q566D2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRENFL PGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTASILVVSHGAYMRSLFGYFLSDLRCSLP ATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMNLQEHLNKGVEKH hide sequence

RefSeq Acc Id:

XP_006237563 ⟸ XM_006237501

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPRFALTIIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAATGQFLSNVHFTHAFSSDLTRTKQ
TIHGILEKSRFCKDIAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQV
KMRGKDFFDFICQLILGKAGQRENFLPGAPDNCLESSLAEVFPVGKHGSLGTDPKHGALGLTAS
ILVVSHGAYMRSLFGYFLSDLRCSLPATIDKFELSSITPNTGISVFIIDCEEARKPTVQCVCMN
LQEHLNKGVEKH

hide sequence

RefSeq Acc Id:

ENSRNOP00000074722 ⟸ ENSRNOT00000091662

RefSeq Acc Id:	XP_038964186 ⟸ XM_039108258
- Peptide Label:	isoform X2

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693420

Promoter ID:

EPDNEW_R3945

Type:

initiation region

Name:

Tigar_1

Description:

TP53 induced glycolysis regulatory phosphatase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	159,654,056 - 159,654,116	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560038	AgrOrtholog
Ensembl Genes	ENSRNOG00000051816	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000074722	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000091662	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1240	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7319640	IMAGE-MGC_LOAD
InterPro	His_PPase_superfam	UniProtKB/TrEMBL
KEGG Report	rno:502894	UniProtKB/TrEMBL
MGC_CLONE	MGC:105772	IMAGE-MGC_LOAD
NCBI Gene	502894	ENTREZGENE
PhenoGen	Tigar	PhenoGen
Superfamily-SCOP	SSF53254	UniProtKB/TrEMBL
UniProt	Q566D2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-04-17	Tigar	TP53 induced glycolysis regulatory phosphatase	LOC502894	hypothetical protein LOC502894	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC502894	hypothetical protein LOC502894			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar