TIGAR (TP53 induced glycolysis regulatory phosphatase) - Rat Genome Database

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Gene: TIGAR (TP53 induced glycolysis regulatory phosphatase) Canis lupus familiaris
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Symbol: TIGAR
Name: TP53 induced glycolysis regulatory phosphatase
RGD ID: 12168136
Description: ENCODES a protein that exhibits bisphosphoglycerate 2-phosphatase activity (inferred); catalytic activity (inferred); fructose-2,6-bisphosphate 2-phosphatase activity (inferred); INVOLVED IN cardiac muscle cell apoptotic process (ortholog); fructose 2,6-bisphosphate metabolic process (ortholog); glucose catabolic process to lactate via pyruvate (ortholog); ASSOCIATED WITH Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); Nerve Degeneration (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrial outer membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C27H12orf5; fructose-2,6-bisphosphatase TIGAR
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,521,751 - 40,549,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,523,314 - 40,549,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,132,902 - 6,160,282 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,877,557 - 40,905,336 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,877,558 - 40,905,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,815,806 - 40,843,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,791,244 - 40,818,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,543,778 - 5,570,944 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
TIGAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,521,751 - 40,549,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,523,314 - 40,549,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,132,902 - 6,160,282 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,877,557 - 40,905,336 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,877,558 - 40,905,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,815,806 - 40,843,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,791,244 - 40,818,291 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,543,778 - 5,570,944 (+)NCBIUU_Cfam_GSD_1.0
TIGAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,321,213 - 4,360,028 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl124,307,763 - 4,360,028 (+)EnsemblGRCh38hg38GRCh38
GRCh37124,430,379 - 4,469,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,300,620 - 4,339,455 (+)NCBINCBI36Build 36hg18NCBI36
Build 34124,300,631 - 4,332,599NCBI
Celera126,052,425 - 6,091,264 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,287,018 - 4,325,825 (+)NCBIHuRef
CHM1_1124,429,992 - 4,468,805 (+)NCBICHM1_1
T2T-CHM13v2.0124,327,996 - 4,366,805 (+)NCBIT2T-CHM13v2.0
Tigar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396127,062,079 - 127,086,564 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6127,062,079 - 127,086,520 (-)EnsemblGRCm39 Ensembl
GRCm386127,085,116 - 127,109,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6127,085,116 - 127,109,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv376127,035,134 - 127,059,570 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366127,052,982 - 127,075,160 (-)NCBIMGSCv36mm8
MGSCv366127,984,031 - 128,005,972 (-)NCBIMGSCv36mm8
Celera6128,766,834 - 128,786,116 (-)NCBICelera
Cytogenetic Map6F3NCBI
Tigar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24159,927,138 - 159,946,094 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,927,139 - 159,946,029 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4166,156,946 - 166,175,860 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04161,939,848 - 161,958,766 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04160,573,896 - 160,592,815 (-)NCBIRnor_WKY
Rnor_6.04159,635,145 - 159,654,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,635,153 - 159,654,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04231,948,786 - 231,966,869 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,481,393 - 163,502,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4148,642,195 - 148,661,115 (-)NCBICelera
Cytogenetic Map4q42NCBI
Tigar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,129,678 - 2,154,380 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,129,719 - 2,153,873 (+)NCBIChiLan1.0ChiLan1.0
TIGAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1124,353,272 - 4,386,758 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,353,272 - 4,385,380 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0124,429,945 - 4,462,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Tigar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,632,126 - 104,665,630 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366064,518,525 - 4,540,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIGAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl566,044,686 - 66,067,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1566,044,679 - 66,067,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2568,266,609 - 68,289,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIGAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,354,911 - 4,381,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,355,053 - 4,381,273 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,861,799 - 3,888,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tigar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,417,131 - 1,457,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248601,416,419 - 1,455,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 8 3 6 12 2
Low 5 14 6 6 6 3 8 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000045644   ⟹   ENSCAFP00000036710
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2740,523,314 - 40,549,332 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054424   ⟹   ENSCAFP00845042770
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2740,877,558 - 40,890,674 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845054431   ⟹   ENSCAFP00845042777
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2740,877,559 - 40,905,335 (-)Ensembl
RefSeq Acc Id: XM_038439270   ⟹   XP_038295198
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02740,877,557 - 40,905,336 (-)NCBI
RefSeq Acc Id: XM_038513939   ⟹   XP_038369867
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12740,815,806 - 40,843,030 (-)NCBI
RefSeq Acc Id: XM_038513940   ⟹   XP_038369868
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12740,815,806 - 40,828,833 (-)NCBI
RefSeq Acc Id: XM_038576514   ⟹   XP_038432442
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0275,543,778 - 5,570,944 (+)NCBI
RefSeq Acc Id: XM_038641777   ⟹   XP_038497705
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02740,791,244 - 40,818,291 (-)NCBI
RefSeq Acc Id: XM_543863   ⟹   XP_543863
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12740,521,751 - 40,549,304 (-)NCBI
Dog10K_Boxer_Tasha276,132,902 - 6,160,282 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_543863   ⟸   XM_543863
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TN64 (UniProtKB/TrEMBL),   J9NU72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000036710   ⟸   ENSCAFT00000045644
RefSeq Acc Id: XP_038369867   ⟸   XM_038513939
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038369868   ⟸   XM_038513940
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038497705   ⟸   XM_038641777
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038295198   ⟸   XM_038439270
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TN64 (UniProtKB/TrEMBL),   J9NU72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038432442   ⟸   XM_038576514
- Peptide Label: isoform X5
RefSeq Acc Id: ENSCAFP00845042770   ⟸   ENSCAFT00845054424
RefSeq Acc Id: ENSCAFP00845042777   ⟸   ENSCAFT00845054431

Promoters
RGD ID:13688223
Promoter ID:EPDNEW_C6291
Type:initiation region
Name:TIGAR_1
Description:TP53 induced glycolysis regulatory phosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12740,549,272 - 40,549,332EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029387 Ensembl
  ENSCAFG00030025534 UniProtKB/TrEMBL
  ENSCAFG00040023811 UniProtKB/TrEMBL
  ENSCAFG00040023840 UniProtKB/TrEMBL
  ENSCAFG00845030667 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030041222.1 UniProtKB/TrEMBL
  ENSCAFP00030041231.1 UniProtKB/TrEMBL
  ENSCAFP00040038702 UniProtKB/TrEMBL
  ENSCAFP00040038753 UniProtKB/TrEMBL
  ENSCAFP00845042770.1 UniProtKB/TrEMBL
  ENSCAFP00845042777 ENTREZGENE
  ENSCAFP00845042777.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030047152.1 UniProtKB/TrEMBL
  ENSCAFT00030047162.1 UniProtKB/TrEMBL
  ENSCAFT00040044330 UniProtKB/TrEMBL
  ENSCAFT00040044384 UniProtKB/TrEMBL
  ENSCAFT00845054424.1 UniProtKB/TrEMBL
  ENSCAFT00845054431 ENTREZGENE
  ENSCAFT00845054431.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1240 UniProtKB/TrEMBL
InterPro His_Pase_superF_clade-1 UniProtKB/TrEMBL
  His_PPase_superfam UniProtKB/TrEMBL
  PG/BPGM_mutase_AS UniProtKB/TrEMBL
NCBI Gene TIGAR ENTREZGENE
Pfam His_Phos_1 UniProtKB/TrEMBL
PROSITE PG_MUTASE UniProtKB/TrEMBL
SMART PGAM UniProtKB/TrEMBL
Superfamily-SCOP SSF53254 UniProtKB/TrEMBL
UniProt A0A8C0PHS6_CANLF UniProtKB/TrEMBL
  A0A8C0PKH3_CANLF UniProtKB/TrEMBL
  A0A8C0TN64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q4T8_CANLF UniProtKB/TrEMBL
  A0A8I3QB57_CANLF UniProtKB/TrEMBL
  J9NU72 ENTREZGENE
VGNC ID VGNC:47368 ENTREZGENE