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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3decreases expressionEXP 6480464CTDEmodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 proteinPMID:28161596
Abcc3increases expressionEXP 6480464CTDEmodin results in increased expression of ABCC3 mRNAPMID:19549930
Abcc3multiple interactionsEXP 6480464CTD[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC3 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC3 proteinPMID:35753641
Abcc3decreases expressionISOAbcc3 (Mus musculus)6480464CTDEmodin results in decreased expression of ABCC3 mRNAPMID:30517764
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