Ugt2b17 (UDP glucuronosyltransferase family 2 member B17)

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Gene: Ugt2b17 (UDP glucuronosyltransferase family 2 member B17) Rattus norvegicus

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Symbol:

Ugt2b17

Name:

UDP glucuronosyltransferase family 2 member B17

RGD ID:

708541

Description:

Exhibits glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular response to hormone stimulus; and cellular response to testosterone stimulus. Localizes to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B17 (UDP glucuronosyltransferase family 2 member B17); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthaleneacetic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

2B1; liver UDP-glucuronosyltransferase, phenobarbital-inducible form; UDP glucuronosyltransferase 2 family, polypeptide B1; UDP glucuronosyltransferase 2 family, polypeptide B17; UDP-glucuronosyltransferase 2B1; UDP-glucuronosyltransferase 2B4; UDPGT 2B1; UDPGTr-2; Udpgtr2; Ugt2b1

RGD Orthologs

Human

Mouse

Dog

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UGT2B17 (UDP glucuronosyltransferase family 2 member B17)	HGNC	Ensembl, HomoloGene, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ugt2b1 (UDP glucuronosyltransferase 2 family, polypeptide B1)	HGNC	Treefam, OrthoMCL, HomoloGene, Panther, OrthoDB, Ensembl
Canis lupus familiaris (dog):	LOC480777 (UDP-glucuronosyltransferase 2A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UGT2B10 (UDP glucuronosyltransferase family 2 member B10)	HGNC	Panther
Homo sapiens (human):	UGT2B15 (UDP glucuronosyltransferase family 2 member B15)	HGNC	Panther
Homo sapiens (human):	UGT2B4 (UDP glucuronosyltransferase family 2 member B4)	HGNC	Panther
Homo sapiens (human):	UGT2B11 (UDP glucuronosyltransferase family 2 member B11)	HGNC	Panther
Homo sapiens (human):	UGT2B28 (UDP glucuronosyltransferase family 2 member B28)	HGNC	Panther
Homo sapiens (human):	UGT2B7 (UDP glucuronosyltransferase family 2 member B7)	HGNC	Panther
Homo sapiens (human):	UGT2A3 (UDP glucuronosyltransferase family 2 member A3)	HGNC	Panther
Alliance orthologs ³
Homo sapiens (human):	UGT2B10 (UDP glucuronosyltransferase family 2 member B10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Homo sapiens (human):	UGT2B15 (UDP glucuronosyltransferase family 2 member B15)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|TreeFam)
Homo sapiens (human):	UGT2B4 (UDP glucuronosyltransferase family 2 member B4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Homo sapiens (human):	UGT2B11 (UDP glucuronosyltransferase family 2 member B11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Homo sapiens (human):	UGT2B28 (UDP glucuronosyltransferase family 2 member B28)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Homo sapiens (human):	UGT2B17 (UDP glucuronosyltransferase family 2 member B17)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|TreeFam)
Homo sapiens (human):	UGT2B7 (UDP glucuronosyltransferase family 2 member B7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Mus musculus (house mouse):	Ugt2b1 (UDP glucuronosyltransferase 2 family, polypeptide B1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	ugt2a6 (UDP glucuronosyltransferase 2 family, polypeptide A6)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	ugt2a5 (UDP glucuronosyltransferase 2 family, polypeptide A5)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10168	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F10D2.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-3	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-37	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10170	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-44	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10178	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-13	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-15	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-16	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-23	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-24	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-26	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-27	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-28	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-29	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-30	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-32	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-66	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-46	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-47	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-48	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-49	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG15661	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG16732	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-19	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-35	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-41	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-42	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-6	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-62	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG17322	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG17323	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG17324	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG30438	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-58	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG31002	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ATG26	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt37c1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt35b	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Dc	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86De	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Dg	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Dj	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG4302	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG6475	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Dot	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Dh	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Di	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	H23N18.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG5724	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG5999	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt37a1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt37b1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt36Bb	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG3797	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-61	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-25	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt35a	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt36Ba	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt36Bc	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-33	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt58Fa	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-55	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-56	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Da	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-34	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-36	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-38	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-39	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-40	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Ugt86Dd	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-31	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-51	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ugt-52	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	21,024,035 - 21,035,784 (+)	NCBI
Rnor_6.0 Ensembl	14	22,724,070 - 22,825,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	14	22,724,399 - 22,736,148 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	14	22,625,222 - 22,636,971 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	22,639,182 - 22,650,931 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	22,639,181 - 22,650,931 (+)	NCBI
Celera	14	20,517,697 - 20,529,446 (+)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Experimental Diabetes Mellitus (IEP)

Graft vs Host Disease (ISO)

Lung Neoplasms (ISO)

osteoporosis (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP)

1-naphthaleneacetic acid (EXP)

1-naphthol (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-Ethylhexanoic acid (EXP)

2-Ethylphenol (EXP)

2-naphthol (EXP)

2-nitrofluorene (EXP)

3-Ethylphenol (EXP)

3-phenylpropionic acid (EXP)

3H-1,2-dithiole-3-thione (EXP)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

4-ethylphenol (EXP)

4-hydroxyphenyl retinamide (ISO)

4-methylumbelliferone (EXP,ISO)

4-tert-butylphenol (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

alpha-hexachlorocyclohexane (EXP)

amentoflavone (ISO)

amiodarone (EXP)

amitriptyline (EXP)

ammonium chloride (EXP)

androstane-3,17-diol (ISO)

androsterone (ISO)

aristolochic acid (EXP)

Aroclor 1254 (EXP,ISO)

atrazine (EXP)

benzene (EXP)

benzo[a]pyrene (ISO)

benzyl alcohol (EXP)

bezafibrate (EXP)

bicalutamide (ISO)

biphenyl-4-ol (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

butylated hydroxyanisole (ISO)

calcitriol (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

chloramphenicol (EXP)

chlorohydrocarbon (EXP)

ciprofibrate (EXP)

cisplatin (EXP)

clofibrate (EXP,ISO)

clofibric acid (EXP)

clomipramine (EXP)

cortisol (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

cyproconazole (EXP)

daidzein (ISO)

DDE (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

diclofenac (ISO)

diethylstilbestrol (EXP)

doxorubicin (EXP)

elemental selenium (EXP)

endosulfan (EXP,ISO)

epoxiconazole (EXP)

equol (ISO)

ethyl methanesulfonate (ISO)

eugenol (ISO)

felbamate (EXP)

fipronil (EXP,ISO)

fluconazole (EXP)

flumequine (ISO)

flurbiprofen (EXP)

flutamide (EXP)

formaldehyde (ISO)

fumonisin B1 (ISO)

gabapentin (EXP)

genistein (ISO)

glafenine (EXP)

glutathione (EXP)

hexachlorobenzene (EXP)

hydratropic acid (EXP)

ibuprofen (EXP)

imipramine (EXP)

indole-3-methanol (EXP)

iron atom (EXP)

iron(0) (EXP)

ketoconazole (EXP)

ketoprofen (EXP)

L-ascorbic acid (EXP)

lansoprazole (EXP)

Lasiocarpine (EXP)

lipopolysaccharide (ISO)

lithocholic acid (EXP)

lorcaserin (ISO)

MeIQx (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (EXP)

Mitotane (EXP)

N-nitrosodiethylamine (EXP,ISO)

N-Vinyl-2-pyrrolidone (EXP)

naproxen (EXP)

nefazodone (EXP)

nelfinavir (EXP)

nimesulide (EXP)

Nonylphenol (EXP)

O-methyleugenol (ISO)

oltipraz (ISO)

omeprazole (EXP)

orphenadrine (EXP)

p-cresol (EXP)

p-toluidine (EXP)

pantoprazole (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenformin (EXP)

phenobarbital (EXP,ISO)

phenytoin (EXP)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

pirprofen (EXP)

poly(I:C) (EXP)

pravastatin (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

prochloraz (EXP)

propiconazole (EXP,ISO)

quercetin 3-O-beta-D-galactopyranoside (ISO)

quinolines (EXP)

rabeprazole (EXP)

rotenone (EXP)

selenium atom (EXP)

senecionine (ISO)

tamoxifen (EXP)

taurine (EXP)

tert-butyl ethyl ether (EXP)

Tesaglitazar (EXP)

testosterone (EXP,ISO)

Testosterone propionate (EXP)

tetrachloromethane (EXP,ISO)

triadimefon (EXP)

trichloroethene (ISO)

trifluralin (EXP)

triphenyl phosphate (EXP)

trovafloxacin (EXP)

uranium atom (EXP)

ursodeoxycholic acid (EXP,ISO)

valdecoxib (EXP)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vorinostat (ISO)

warfarin (ISO)

zaragozic acid A (EXP,ISO)

zidovudine (EXP)

zinc acetate (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biphenyl catabolic process (IDA)

cellular glucuronidation (IDA,ISO)

cellular response to ethanol (IEP)

cellular response to glucocorticoid stimulus (IEP)

cellular response to growth hormone stimulus (IEP)

cellular response to testosterone stimulus (IEP)

drug metabolic process (TAS)

estrogen metabolic process (IDA,ISO)

response to lipopolysaccharide (IEP)

Cellular Component

endoplasmic reticulum membrane (IEA)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (IBA,IDA)

Molecular Function

glucuronosyltransferase activity (IDA,IMP,ISO)

retinoic acid binding (ISO)

UDP-glycosyltransferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ascorbate and aldarate metabolic pathway (IEA)

O-linked glycan biosynthetic pathway (IEA)

pentose and glucuronate interconversion pathway (IEA)

phase I biotransformation pathway via cytochrome P450 (IEA)

porphyrin and chlorophyll metabolic pathway (IEA)

retinol metabolic pathway (IEA)

starch and sucrose metabolic pathway (IEA)

steroid hormone biosynthetic pathway (IEA)

References

References - curated


1.	Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2.	Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
3.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
5.	Ishii Y, etal., Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76.
6.	Itäaho K, etal., Drug Metab Dispos. 2008 Nov;36(11):2307-15. doi: 10.1124/dmd.108.022731. Epub 2008 Aug 21.
7.	Li Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):172-4.
8.	Li YQ, etal., Pharm Res. 1999 Feb;16(2):191-7.
9.	Mackenzie PI J Biol Chem 1986 May 5;261(13):6119-25.
10.	MGD data from the GO Consortium
11.	Pipeline to import KEGG annotations from KEGG into RGD
12.	RGD automated data pipeline
13.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2113533	PMID:20308471	PMID:22579593

Genomics

Comparative Map Data

Ugt2b17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	21,024,035 - 21,035,784 (+)	NCBI
Rnor_6.0 Ensembl	14	22,724,070 - 22,825,444 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	14	22,724,399 - 22,736,148 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	14	22,625,222 - 22,636,971 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	22,639,182 - 22,650,931 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	22,639,181 - 22,650,931 (+)	NCBI
Celera	14	20,517,697 - 20,529,446 (+)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

UGT2B17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	68,537,184 - 68,568,527 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	68,537,173 - 68,576,322 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	69,402,902 - 69,434,245 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	4	69,402,891 - 69,442,040 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	69,085,497 - 69,116,840 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	69,231,670 - 69,263,011	NCBI
Celera	4	49,985,485 - 50,019,693 (-)	NCBI
Cytogenetic Map	4	q13.2	NCBI
CHM1_1	4	69,439,588 - 69,470,934 (-)	NCBI		CHM1_1

Ugt2b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	87,064,498 - 87,074,362 (-)	NCBI	GRCm39		mm39
GRCm38	5	86,916,639 - 86,926,503 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,916,638 - 86,926,530 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	87,345,664 - 87,355,528 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	87,991,200 - 88,001,064 (-)	NCBI			mm8
Celera	5	84,136,470 - 84,146,336 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI

LOC480777
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	13	59,138,348 - 59,222,802 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	13	58,911,301 - 58,932,594 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Position Markers

AA945116

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	14	307.7	UniSTS
Cytogenetic Map	14	p21	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	27597761	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	27597761	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	34403399	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	41333960	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	41333960	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	42766285	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	4833233	23004027	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	4833233	26466248	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	4833233	33040042	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	9756435	72854397	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	10539977	55539977	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	10539977	55539977	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	10729268	61873323	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	12680424	30155192	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	12680424	106641756	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	12680613	32593926	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	16336988	33163485	Rat
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	19159919	38289187	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	19161893	43957503	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	19191541	43957628	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	20189386	65189386	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	20266223	43957628	Rat
10755459	Coatc15	Coat color QTL 15		0.01681	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	14	21457565	66457565	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		23	23		23
Low	1		14	12		12	2	2	4		12	3	2
Below cutoff		8	16	2	18	2	6	6	7	17	6	7	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH002270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M13506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_173295 ⟹ NP_775417

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	21,024,035 - 21,035,784 (+)	NCBI
Rnor_6.0	14	22,724,399 - 22,736,148 (+)	NCBI
Rnor_5.0	14	22,625,222 - 22,636,971 (+)	NCBI
RGSC_v3.4	14	22,639,182 - 22,650,931 (+)	RGD
Celera	14	20,517,697 - 20,529,446 (+)	RGD

Sequence:

show sequence

AAAAAAAGCATTCCATTTCTGCAAGATGTCTATGAAACAGACTTCAGTGTTTCTGTTGATACAG
CTCATATGCTACTTTAGACCTGGAGCCTGTGGAAAAGTGCTAGTGTGGCCCACAGAATACAGCC
ACTGGATTAATATAAAGATAATTCTGAATGAACTTGCCCAGAGAGGTCATGAAGTCACGGTTCT
TGTATCTTCGGCTTCCATTCTCATTGAGCCTACCAAGGAATCTTCTATTAATTTTGAGATTTAC
TCTGTACCTTTGAGTAAAAGTGATCTTGAATATAGTTTTGCAAAATGGATAGATGAATGGACAC
GTGATTTTGAAACACTCTCGATTTGGACATATTATTCAAAAATGCAAAAAGTCTTCAATGAATA
TTCTGATGTCGTTGAAAATTTATGCAAAGCACTCATTTGGAACAAGAGTCTTATGAAAAAACTC
CAAGGATCTCAATTTGATGTCATTCTCGCAGATGCTGTGGGTCCCTGTGGTGAGCTGCTAGCAG
AACTGCTTAAGACACCTTTAGTGTACAGTCTCCGCTTCTGTCCTGGATACAGATGTGAAAAGTT
CAGTGGGGGACTTCCACTGCCTCCTTCCTATGTGCCTGTTGTTCTTTCAGAATTAAGTGACCGC
ATGACATTTGTGGAAAGAGTGAAGAATATGTTGCAGATGCTGTATTTTGACTTTTGGTTTCAAC
CATTTAAAGAGAAGTCCTGGAGTCAGTTTTACAGTGATGTTCTAGGTAGACCCACAACATTAAC
TGAGATGATGGGGAAGGCAGATATATGGCTCATTCGAACCTTCTGGGACTTGGAATTTCCACAC
CCATTCTTACCTAATTTTGACTTTGTTGGAGGACTACATTGCAAACCAGCCAAACCACTGCCTA
GGGAAATGGAAGAATTTGTTCAGAGCTCTGGAGAACATGGTGTAGTGGTGTTTTCTCTGGGATC
AATGGTTAAAAACCTGACTGAAGAAAAAGCCAATGTAGTTGCTTCTGCTCTTGCCCAAATTCCA
CAGAAGGTTGTATGGAGATTTGATGGTAAGAAACCAGATACCTTAGGATCTAACACTCGGCTGT
ACAAGTGGATCCCCCAGAATGACCTTCTTGGTCATCCAAAAACCAAAGCTTTTGTAGCTCATGG
TGGAACAAATGGCATCTATGAGGCAATCTACCATGGCATTCCTATTGTTGGTATTCCCTTGTTT
GCAGATCAACCGGATAACATTAATCACATGGTAGCCAAAGGAGCTGCTGTTAGAGTTGACTTCA
GCATACTGTCAACTACAGGCCTTCTCACTGCCTTGAAGATTGTCATGAATGACCCTTCCTATAA
GGAGAATGCCATGAGATTATCCAGAATCCACCATGATCAGCCAGTGAAGCCCCTGGACCGAGCC
GTCTTCTGGATCGAGTATGTCATGCGTCACAAAGGAGCCAAGCACCTCCGCTCAACTCTGCATG
ACCTTAGCTGGTTCCAGTACCACTCTCTGGATGTCATTGGGTTCCTATTGCTCTGTGTGGTAGG
TGTGGTATTCATCATCACAAAATTCTGCCTCTTTTGTTGCCGTAAGACTGCTAACATGGGAAAG
AAGAAGAAAGAGTAGCATCATAAAGGCTGAAGCAGAGCCCTGAGAGATGAGCCTCTGCCAGCTG
CTTCCAGAGGAACCTGTTGTCATGCCAGTGCCTTCCCTCTAAAAGAAGACAGCGTTGGGACCTC
ATTGAACATGGCTCCAATGAATTCACTATGTTCTGAAGACATGCAAGATTTCATGCCAAATATA
TATTCAGTGCTAAAAAAACAAAATCCTGTGTTCAGTTTAGAATGTTTTGATGTAGCTGAGAAGC
TTTGCCCAACAACAATAACTGAAGCTACTGTAGTTCATAAAGTTCACATGGCTTTATAGCCTTT
GCAAAACATATCTATAAATCAATTAGTTTTTGAAAATACCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_775417	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42310	(Get FASTA)	NCBI Sequence Viewer
	AAA42313	(Get FASTA)	NCBI Sequence Viewer
	EDL89826	(Get FASTA)	NCBI Sequence Viewer
	P09875	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_775417 ⟸ NM_173295
- Peptide Label:	precursor
- UniProtKB:	P09875 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSMKQTSVFLLIQLICYFRPGACGKVLVWPTEYSHWINIKIILNELAQRGHEVTVLVSSASILI EPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVENLC KALIWNKSLMKKLQGSQFDVILADAVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLPP SYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGKADI WLIRTFWDLEFPHPFLPNFDFVGGLHCKPAKPLPREMEEFVQSSGEHGVVVFSLGSMVKNLTEE KANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNGIYEA IYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMRLSR IHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGVVFIITKF CLFCCRKTANMGKKKKE hide sequence

Protein Domains

UDPGT

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699257

Promoter ID:

EPDNEW_R9782

Type:

multiple initiation site

Name:

Ugt2b17_2

Description:

UDP glucuronosyltransferase family 2 member B17

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9783

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	22,724,389 - 22,724,449	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
14	22724490	22724491	G	A	snv	COP/CrCrl (MCW & UW), FHH/EurMcwi (MCW), SR/JrHsd (MCW)
14	22724715	22724716	C	T	snv	CDR, COP/CrCrl (MCW & UW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
14	22639273	22639274	G	A	snv	FHH/EurMcwi (MCW), COP/CrCrl (MCW & UW), SR/JrHsd (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708541	AgrOrtholog
Ensembl Genes	ENSRNOG00000001990	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002724	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000069054	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002724	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000089471	UniProtKB/TrEMBL
InterPro	UDP_glucos_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UDP_glycos_trans_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286954	UniProtKB/Swiss-Prot
NCBI Gene	286954	ENTREZGENE
Pfam	UDPGT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	UGT2B4	RGD
PhenoGen	Ugt2b17	PhenoGen
PROSITE	UDPGT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JUD3_RAT	UniProtKB/TrEMBL
	P09875	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-09-09	Ugt2b17	UDP glucuronosyltransferase family 2 member B17	Ugt2b17	UDP glucuronosyltransferase 2 family, polypeptide B17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-02-04	Ugt2b17	UDP glucuronosyltransferase 2 family, polypeptide B17	Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-03-11	Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	Ugt2b17	UDP glucuronosyltransferase 2 family, polypeptide B17	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-08-29	Ugt2b17	UDP glucuronosyltransferase 2 family, polypeptide B17	Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Ugt2b1	UDP glucuronosyltransferase 2 family, polypeptide B1	Udpgtr2	liver UDP-glucuronosyltransferase, phenobarbital-inducible form	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	Udpgtr2				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)