Mat1a (methionine adenosyltransferase 1A)

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Gene: Mat1a (methionine adenosyltransferase 1A) Rattus norvegicus

Analyze

Symbol:

Mat1a

Name:

methionine adenosyltransferase 1A

RGD ID:

3050

Description:

Enables several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Located in nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A); PARTICIPATES IN methionine cycle/metabolic pathway; cysteine and methionine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AdoMet; adoMet synthase 1; adoMet synthetase 1; MAT 1; MAT-I/III; methionine adenosyltransferase 1; methionine adenosyltransferase I, alpha; methionine adenosyltransferase I/III; MGC108563; S - adenosylmethionine synthetase; S-adenosylmethionine synthase isoform type-1; S-adenosylmethionine synthetase isoform type-1; SADE; SAS

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAT1A (methionine adenosyltransferase 1A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, Treefam
Mus musculus (house mouse):	Mat1a (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mat1a (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAT1A (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAT1A (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mat1a (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MAT1A (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAT1A (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mat1a (methionine adenosyltransferase 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MAT2A (methionine adenosyltransferase 2A)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Mat1a (methionine adenosyltransferase 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MAT1A (methionine adenosyltransferase 1A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mat1a (methionine adenosyltransferase I, alpha)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sams-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAM2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sam-S	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sams-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sams-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAM1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sams-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mat1a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	16,983,084 - 17,001,284 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	16,983,022 - 17,001,274 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,047,431 - 17,066,101 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,174,001 - 18,192,511 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,100,335 - 17,119,005 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,690,649 - 18,709,135 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,690,246 - 18,709,133 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	18,560,492 - 18,578,747 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	17,548,582 - 17,563,989 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	17,548,582 - 17,562,884 (+)	NCBI
Celera	16	17,208,280 - 17,226,582 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amino acid metabolic disorder (ISO)

brain disease (ISO)

Chemical and Drug Induced Liver Injury (ISO)

demyelinating disease (ISO)

fatty liver disease (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypermethioninemia (ISO)

Hyperplasia (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

2-nitrofluorene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-methylcholanthrene (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

buspirone (EXP)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

carmustine (ISO)

cerium trichloride (ISO)

chlorpyrifos (ISO)

choline (ISO)

chrysene (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

coumarin (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dichloroacetic acid (ISO)

dimethyl sulfoxide (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

inulin (ISO)

methapyrilene (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP)

piperonyl butoxide (EXP)

potassium dichromate (ISO)

propanal (ISO)

propiconazole (ISO)

quercetin (ISO)

S-adenosyl-L-methioninate (ISO)

S-adenosyl-L-methionine (ISO)

sevoflurane (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

tamoxifen (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

tetraphene (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

troglitazone (EXP)

urethane (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methionine catabolic process (ISO,ISS)

one-carbon metabolic process (IEA)

protein homotetramerization (ISO)

protein-containing complex assembly (IDA)

S-adenosylmethionine biosynthetic process (IBA,IDA,IEA,ISO)

Cellular Component

cytosol (IBA)

methionine adenosyltransferase complex (ISO)

nuclear matrix (IDA)

Molecular Function

ADP binding (IDA)

amino acid binding (IDA)

ATP binding (IDA,IEA)

identical protein binding (IPI,ISO)

magnesium ion binding (IDA)

metal ion binding (IEA)

methionine adenosyltransferase activity (IBA,IDA,IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

methionine cycle/metabolic pathway (IDA,IMP,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Analysis of the 5' non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme.	Alvarez L, etal., FEBS Lett 1991 Sep 23;290(1-2):142-6.
2.	Characterization of rat liver-specific methionine adenosyltransferase gene promoter. Role of distal upstream cis-acting elements in the regulation of the transcriptional activity.	Alvarez L, etal., J Biol Chem 1997 Sep 5;272(36):22875-83.
3.	Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene.	Chamberlin ME, etal., Am J Hum Genet. 1997 Mar;60(3):540-6.
4.	Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity.	Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.	Gonzalez B, etal., J Mol Biol. 2000 Jul 7;300(2):363-75.
8.	Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism.	Gonzalez B, etal., J Mol Biol. 2003 Aug 8;331(2):407-16.
9.	Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase.	Horikawa S, etal., Eur J Biochem 1989 Oct 1;184(3):497-501.
10.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
11.	Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats.	Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
12.	S-adenosylmethionine in liver health, injury, and cancer.	Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
13.	Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver.	Lu SC, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Jul;279(1):G178-85.
14.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
15.	Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers and dimers are in equilibrium.	Mingorance J, etal., Int J Biochem Cell Biol 1997 Mar;29(3):485-91.
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
19.	Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution.	Reytor E, etal., FASEB J. 2009 Oct;23(10):3347-60. doi: 10.1096/fj.09-130187. Epub 2009 Jun 4.
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10601859	PMID:10677294	PMID:12477932	PMID:12496263	PMID:15489334	PMID:20102719	PMID:22213190	PMID:22318685	PMID:23425511	PMID:25416956	PMID:27548429	PMID:34948004

Genomics

Comparative Map Data

Mat1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	16,983,084 - 17,001,284 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	16,983,022 - 17,001,274 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,047,431 - 17,066,101 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,174,001 - 18,192,511 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,100,335 - 17,119,005 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,690,649 - 18,709,135 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,690,246 - 18,709,133 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	18,560,492 - 18,578,747 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	17,548,582 - 17,563,989 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	17,548,582 - 17,562,884 (+)	NCBI
Celera	16	17,208,280 - 17,226,582 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

MAT1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	80,271,820 - 80,289,658 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	80,271,820 - 80,289,658 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	82,031,576 - 82,049,414 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	82,021,556 - 82,039,414 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	82,021,556 - 82,039,230	NCBI
Celera	10	76,021,909 - 76,039,786 (-)	NCBI		Celera
Cytogenetic Map	10	q22.3	NCBI
HuRef	10	75,874,785 - 75,892,650 (-)	NCBI		HuRef
CHM1_1	10	82,314,612 - 82,332,492 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	81,140,919 - 81,158,757 (-)	NCBI		T2T-CHM13v2.0

Mat1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	40,826,969 - 40,846,385 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	40,826,992 - 40,846,369 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	41,105,012 - 41,124,428 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	41,105,035 - 41,124,412 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	41,918,670 - 41,937,701 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	40,014,094 - 40,033,125 (+)	NCBI		MGSCv36	mm8
Celera	14	37,265,428 - 37,284,459 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	22.36	NCBI

Mat1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955510	281,331 - 300,985 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955510	283,860 - 300,991 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAT1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	92,248,370 - 92,268,054 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	76,677,815 - 76,697,512 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	80,280,063 - 80,298,302 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	80,280,063 - 80,298,291 (-)	Ensembl	panpan1.1		panPan2

MAT1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	29,450,857 - 29,467,251 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	29,452,601 - 29,466,929 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	29,575,218 - 29,592,037 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	29,753,050 - 29,769,565 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	29,753,057 - 29,769,102 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	29,622,538 - 29,639,457 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	29,825,220 - 29,841,704 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	30,179,220 - 30,195,966 (-)	NCBI		UU_Cfam_GSD_1.0

Mat1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	51,267,381 - 51,283,984 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936716	126,574 - 143,155 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936716	126,628 - 142,986 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAT1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	82,107,390 - 82,127,049 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	82,109,405 - 82,126,487 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	88,716,155 - 88,733,936 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAT1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	51,540,162 - 51,558,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	51,540,162 - 51,558,576 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	11,863,034 - 11,882,962 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mat1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624841	6,843,741 - 6,862,683 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624841	6,843,725 - 6,864,700 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mat1a
171 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	196
Count of miRNA genes:	140
Interacting mature miRNAs:	163
Transcripts:	ENSRNOT00000015190
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat

Markers in Region

RH127581

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	17,000,996 - 17,001,203 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	18,708,848 - 18,709,054	NCBI	Rnor6.0
Rnor_5.0	16	18,578,460 - 18,578,666	UniSTS	Rnor5.0
RGSC_v3.4	16	17,563,702 - 17,563,908	UniSTS	RGSC3.4
Celera	16	17,226,295 - 17,226,501	UniSTS
RH 3.4 Map	16	167.1	UniSTS
Cytogenetic Map	16	p14	UniSTS

MAT1A

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	16,998,802 - 16,999,578 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	18,706,654 - 18,707,429	NCBI	Rnor6.0
Rnor_5.0	16	18,576,266 - 18,577,041	UniSTS	Rnor5.0
RGSC_v3.4	16	17,561,508 - 17,562,283	UniSTS	RGSC3.4
Celera	16	17,224,101 - 17,224,876	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			22	22		22
Medium			12	11		11					2	2
Low	2	23	19	4	16	4	5	5	7	15	23	9	5
Below cutoff	1	20	4	4	3	4	3	4	27	15	9		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X15734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X60822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015190 ⟹ ENSRNOP00000015190

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	16,983,022 - 17,001,274 (+)	Ensembl
Rnor_6.0 Ensembl	16	18,690,649 - 18,709,133 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081484 ⟹ ENSRNOP00000072105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	18,690,246 - 18,709,121 (+)	Ensembl

RefSeq Acc Id:

NM_012860 ⟹ NP_036992

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	16,983,084 - 17,001,284 (+)	NCBI
Rnor_6.0	16	18,690,649 - 18,709,135 (+)	NCBI
Rnor_5.0	16	18,560,492 - 18,578,747 (+)	NCBI
RGSC_v3.4	16	17,548,582 - 17,563,989 (+)	RGD
Celera	16	17,208,280 - 17,226,582 (+)	RGD

Sequence:

show sequence

CTTAGGCAGAAGTCATCTCCTTGTGATTCTGCCCAAGATCTGCCCGTTGGGTTTGTAGGGGGAG
GAAGAAAAAAAAAAAGAGAGAGACAGAGAAAAGAAACTACAGGCAAACTTTCAGCTTTGAAGTT
GTCACCTTGGAGAAGTGAAGTCGAGAAGTGTGACACCATGAATGGACCTGTGGATGGCTTGTGT
GACCATTCTCTAAGTGAAGAGGGAGCCTTCATGTTCACATCTGAATCGGTAGGAGAAGGGCATC
CAGATAAGATCTGTGACCAGATTAGTGATGCAGTGCTGGATGCCCATCTCAAGCAAGACCCCAA
TGCCAAGGTGGCCTGTGAGACAGTGTGCAAGACAGGGATGGTGCTCCTGTGTGGAGAGATCACC
TCAATGGCCATGATTGACTACCAGCGGGTGGTGAGAGACACCATTAAGCACATTGGCTACGATG
ACTCTGCCAAGGGCTTCGACTTCAAGACCTGCAATGTGCTCGTGGCTCTGGAGCAACAGTCCCC
AGACATTGCCCAATGTGTCCATCTAGACAGAAATGAGGAGGACGTTGGTGCAGGAGATCAGGGT
CTGATGTTCGGCTATGCCACTGACGAGACAGAGGAGTGCATGCCGCTCACCATTGTTCTTGCTC
ACAAACTCAACACCCGGATGGCAGATCTGAGGCGCTCTGGTGTCCTTCCCTGGCTGAGACCTGA
TTCTAAGACTCAGGTAACAGTTCAGTACGTGCAGGATAATGGTGCTGTCATCCCTGTTCGCGTC
CACACCATCGTCATCTCTGTGCAACACAACGAAGACATAACACTGGAGGCCATGCGAGAGGCCC
TGAAGGAGCAGGTGATCAAAGCTGTGGTGCCAGCCAAGTACCTGGATGAAGACACCATCTACCA
CCTGCAGCCAAGTGGGCGGTTTGTCATCGGAGGTCCCCAGGGGGATGCAGGTGTCACAGGCCGC
AAGATTATTGTGGACACATACGGAGGCTGGGGTGCCCATGGTGGTGGTGCCTTCTCTGGAAAGG
ACTACACCAAGGTGGACCGCTCAGCAGCTTATGCCGCCCGCTGGGTGGCCAAGTCTCTGGTGAA
GGCTGGGCTCTGCCGGAGAGTCCTTGTTCAGGTGTCCTATGCCATTGGTGTGGCAGAACCTCTG
TCCATTTCCATTTTCACCTACGGAACTTCCAAGAAGACCGAGCGAGAGCTACTAGAGGTTGTGA
ACAAGAACTTTGATCTCCGGCCGGGTGTTATTGTCAGGGACTTGGATCTGAAGAAGCCCATCTA
CCAGAAGACTGCATGCTATGGTCATTTCGGAAGAAGCGAGTTTCCCTGGGAGGTCCCCAAGAAG
CTTGTGTTTTAGAGCTGCCGGGAAGCTTAGCTCTGTCCTATACTCAACCTCCTCAAGATCTCAA
CTCCCTGGTCTCAGAGAGCCCTCCCTGCTTCCCACCCTCATGGCAAAGCCAGCTTCCTCTGATT
TTCCCCCTACCCGGCAATCTGCAAACATCTTATTAGTGGCAAGGCAGGTGGTTTCTGGTGCTAG
GTCATCAGGTCTCCTTGCAAGGATAGTCAGTGTTCCCTCCCTGTCTCTCAGATGACAGCAATGT
TAATTTTGTGTAAAAGTTGCTCCTATCATCCCCTCCCGTAGTCTGAAGCTAACCAGGCCATCTC
TTCCTCCGTCCTGGACATGTGCCCAGACGAATGTTTTGTCCCATATCTCTGGCTTCCCCTTTAC
ATTGGCAGCCAGAGGTCCTGAGCCGGGGCTTCCTCAGGGTCCCTCTGAGACTGGGCATCTGCTC
CCTAGGATATGGTCAGTGTCCCCTGAACATCTGCATTCTGTGAGGGACTGAGCTGTGTGTTCTT
CATCCCAACACAATAAGGTGGTATCGTCATTATCCACAGTGACAGATGGGGAAACTGAGGCTCG
GAGAGTTATGGAGCTCTGACAGGTTCCTATAGCTGCGTGCACCAGAGTCAAGAAACAGATCTTG
ACTCTAGGAATTTTGACTCTAACCCTCACACCTGCATCCCAAACAAGATGTTGACCAGAGTGAT
GACACATGGATTGACAAGAGGTTATGACCTCTTATTTAAGGCCTGGGTTTCAGGAGAATTAGAT
GAACCTAATGGCTCTTGGTGAGCCCTGGACAGTGTTCCCACAAAATCAAGATGGAAACATGTAA
GTGTCTCATTTGTTCTGGAAGAGGGCTTAAGGAAAGCTGAGCATCTTGGTCTATAAAGCTGGAC
TGGGGTCTGTAATTAAGAGGAAGCTTCATGGTCCTAGCGCCCAACACTCAAAGACAGGTGTGTG
AATTCTTTGAGCATGGGATCTAATCATGGACAGCCCCATGTGCTTGCTTCCTCACAGAGGAGAG
GCAGTTCGTTGTTCCAGCACAGACAACCAGCCTCTATAGGGGACCCTTCAAGGCTTTCTTGTGC
CCTGGACCCTCACACTTATGCAGTCTGAATGCTGCTAGGGAAGTGGGTGATCCAGGTGAGGAGC
CAGCGTCCAAGCAGTTGACAAGTTGCCCAAGATCTCACAAGAACTGACTTTTACCAGGTAGCCT
GGGTGTGTCTGTCTAGCAGAGTCCTGAGAACATGTCTCTAGGTGTCCCATCATGATCAGCATCA
CACACCCAGCCTGTCCCTCGTTGGGGCTTCCCCACAGCATACTGCCCTCATAGCTCTCAAACAC
GTGGCTTCAGGAACGGACCTGGCTCATATCGATGGTTCTGGCTTAGGAGAAGGACTGAGCAGCT
TCATCAAGGAGCAGACACCTTGCATCTGCCTTAACTGGACAGAGACCCCAGCTTTCCCCATTCC
ACCAGGGCGAGGAAACAGCAGAGAGAAAAGCCCCAGGAGCCAACAGATCCTGAAGCTGTATGTG
ATGTAGAAGCTTGGGTCTTTCCATGGGGTCAGGGCTGCCTGGGAGCCAAGTTCCTCACAGCAGA
GGGAAGGATGGGTATGCAGAAGGCTGAATTCCTGTAACTTAAGCTTTATCTAAATAAAAATCCA
GAATTGTATACTTGTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036992	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89770	(Get FASTA)	NCBI Sequence Viewer
	CAA33754	(Get FASTA)	NCBI Sequence Viewer
	EDL90871	(Get FASTA)	NCBI Sequence Viewer
	P13444	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036992 ⟸ NM_012860

- UniProtKB:

Q5FVU2 (UniProtKB/Swiss-Prot), P13444 (UniProtKB/Swiss-Prot), F1LZ34 (UniProtKB/TrEMBL), A6K9L6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTG
MVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNE
EDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQD
NGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGP
QGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVS
YAIGVAEPLSISIFTYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRS
EFPWEVPKKLVF

hide sequence

RefSeq Acc Id:

ENSRNOP00000072105 ⟸ ENSRNOT00000081484

RefSeq Acc Id:

ENSRNOP00000015190 ⟸ ENSRNOT00000015190

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P13444-F1-model_v2	AlphaFold	P13444	1-397	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3050	AgrOrtholog
BioCyc Gene	G2FUF-11910	BioCyc
BioCyc Pathway	METHIONINE-DEG1-PWY [L-methionine degradation I (to L-homocysteine)]	BioCyc
	PWY-5041 [S-adenosyl-L-methionine salvage II]	BioCyc
Ensembl Genes	ENSRNOG00000011351	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000015190	ENTREZGENE
	ENSRNOP00000015190.8	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015190	ENTREZGENE
	ENSRNOT00000015190.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7368255	IMAGE-MGC_LOAD
InterPro	ADOMET_SYNTHASE_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synt_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synt_central	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synt_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synthetase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synthetase_sfam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25331	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:108563	IMAGE-MGC_LOAD
NCBI Gene	25331	ENTREZGENE
PANTHER	PTHR11964	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	S-AdoMet_synt_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synt_M	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S-AdoMet_synt_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mat1a	PhenoGen
PIRSF	MAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADOMET_SYNTHASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADOMET_SYNTHASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55973	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC228124
UniProt	A6K9L6	ENTREZGENE, UniProtKB/TrEMBL
	F1LZ34	ENTREZGENE, UniProtKB/TrEMBL
	METK1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5FVU2	ENTREZGENE
UniProt Secondary	Q5FVU2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-10	Mat1a	methionine adenosyltransferase 1A	Mat1a	methionine adenosyltransferase I, alpha	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2001-10-23	Mat1a	methionine adenosyltransferase I, alpha			Name updated to reflect Human and Mouse nomenclature	68913	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	is the major methyl group donor in cell metabolism	729300
gene_protein	397 amino acid residues and has a molecular mass of 43.697 kDa	728958

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)