Gene: Tubb4b (tubulin, beta 4B class IVb) Rattus norvegicus
Analyze
Symbol:
Tubb4b
Name:
tubulin, beta 4B class IVb
Description:
Predicted to have GTP binding activity and double-stranded RNA binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to the cytoplasm and microtubule. Orthologous to human TUBB4B (tubulin beta 4B class IVb); INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1-naphthyl isothiocyanate.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
MGC73008; Tubb2; Tubb2c; tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta, 2; tubulin, beta2-like; Unknown (protein for MGC:73008)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TUBB4B (tubulin beta 4B class IVb) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Tubb4b (tubulin, beta 4B class IVB) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tubb4b (tubulin beta 4B class IVb) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TUBB4B (tubulin beta 4B class IVb) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TUBB4B (tubulin beta 4B class IVb) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tubb4b (tubulin beta 4B class IVb) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TUBB4B (tubulin beta 4B class IVb) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TUBB2A (tubulin beta 2A class IIa) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
TUBB4A (tubulin beta 4A class IVa) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
TUBB2B (tubulin beta 2B class IIb) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
TUBB6 (tubulin beta 6 class V) HGNC
OrthoMCL
Homo sapiens (human):
TUBB1 (tubulin beta 1 class VI) HGNC
OrthoMCL
Homo sapiens (human):
TUBB (tubulin beta class I) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Tubb4b (tubulin, beta 4B class IVB)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, TreeFam)
Homo sapiens (human):
TUBB4B (tubulin beta 4B class IVb)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
zgc:55461
Alliance
DIOPT (InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Danio rerio (zebrafish):
tubb4b (tubulin, beta 4B class IVb)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Saccharomyces cerevisiae (baker's yeast):
TUB2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
betaTub56D
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB)
Caenorhabditis elegans (roundworm):
tbb-4
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 2,441,585 - 2,444,369 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 2,441,733 - 2,444,281 (-) Ensembl Rnor_5.0 3 2,422,868 - 2,425,649 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 3,387,050 - 3,389,500 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 3 3,387,049 - 3,389,500 (-) NCBI Celera 3 2,864,558 - 2,867,008 (-) NCBI Celera Cytogenetic Map 3 p13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Chemical and Drug Induced Liver Injury ISO RGD:1601774 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25231249
Imported Annotations - OMIM
LEBER CONGENITAL AMAUROSIS WITH EARLY-ONSET DEAFNESS ISO RGD:1601774 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TUBB4B mRNA] CTD PMID:31150632 (-)-demecolcine decreases expression ISO RGD:1601774 6480464 Demecolcine results in decreased expression of TUBB4B mRNA CTD PMID:23649840 (S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of TUBB4B mRNA CTD PMID:30723492 17alpha-ethynylestradiol increases expression ISO RGD:1557719 6480464 Ethinyl Estradiol results in increased expression of TUBB4B mRNA CTD PMID:19400957 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of TUBB4B mRNA CTD PMID:19400957 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of TUBB4B mRNA CTD PMID:17351261 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1601774 6480464 Tetrachlorodibenzodioxin results in increased expression of TUBB4B mRNA CTD PMID:21807756 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1557719 6480464 Tetrachlorodibenzodioxin affects the expression of TUBB4B mRNA CTD PMID:18343893 more ... 2,3,7,8-Tetrachlorodibenzofuran affects expression ISO RGD:1557719 6480464 2 more ... CTD PMID:18343893 , PMID:20702594 2-acetamidofluorene increases expression EXP 6480464 2-Acetylaminofluorene results in increased expression of TUBB4B mRNA CTD PMID:22584684 2-acetamidofluorene increases expression ISO RGD:1557719 6480464 2-Acetylaminofluorene results in increased expression of TUBB4B mRNA CTD PMID:21607683 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1557719 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of TUBB2C mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine affects methylation ISO RGD:1557719 6480464 N-Methyl-3, 4-methylenedioxyamphetamine affects the methylation of TUBB2C promoter CTD PMID:26251327 3-methylcholanthrene increases expression ISO RGD:1557719 6480464 Methylcholanthrene results in increased expression of TUBB4B mRNA CTD PMID:20713471 4-hydroxyphenyl retinamide decreases expression ISO RGD:1557719 6480464 Fenretinide results in decreased expression of TUBB4B mRNA CTD PMID:28973697 5-fluorouracil affects response to substance ISO RGD:1601774 6480464 TUBB4B protein affects the susceptibility to Fluorouracil CTD PMID:15548681 7,12-dimethyltetraphene multiple interactions EXP 6480464 [9 more ... CTD PMID:22248470 aflatoxin B1 increases expression ISO RGD:1557719 6480464 Aflatoxin B1 results in increased expression of TUBB4B mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:1601774 6480464 Aflatoxin B1 results in decreased methylation of TUBB4B polyA tail CTD PMID:30157460 arsane decreases expression ISO RGD:1601774 6480464 Arsenic results in decreased expression of TUBB4B protein CTD PMID:19818359 arsenic atom decreases expression ISO RGD:1601774 6480464 Arsenic results in decreased expression of TUBB4B protein CTD PMID:19818359 azathioprine decreases expression ISO RGD:1601774 6480464 Azathioprine results in decreased expression of TUBB4B mRNA CTD PMID:22623647 benzo[a]pyrene increases expression ISO RGD:1557719 6480464 Benzo(a)pyrene results in increased expression of TUBB4B mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:1601774 6480464 Benzo(a)pyrene results in increased expression of TUBB4B mRNA CTD PMID:20498004 , PMID:31255691 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1601774 6480464 7 more ... CTD PMID:20382639 benzo[b]fluoranthene increases expression ISO RGD:1557719 6480464 benzo(b)fluoranthene results in increased expression of TUBB4B mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of TUBB4B mRNA CTD PMID:20920545 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of TUBB4B protein CTD PMID:22649256 bisphenol A affects expression ISO RGD:1601774 6480464 bisphenol A affects the expression of TUBB4B mRNA CTD PMID:30903817 bisphenol A decreases expression ISO RGD:1601774 6480464 bisphenol A results in decreased expression of TUBB4B mRNA CTD PMID:29275510 bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of TUBB4B protein CTD PMID:25933445 bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of TUBB4B mRNA CTD PMID:12628495 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of TUBB4B mRNA CTD PMID:24136188 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of TUBB4B promoter CTD PMID:22457795 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of TUBB4B mRNA CTD PMID:25993096 carbamazepine affects expression ISO RGD:1601774 6480464 Carbamazepine affects the expression of TUBB4B mRNA CTD PMID:24752500 carbon nanotube decreases expression ISO RGD:1557719 6480464 Nanotubes, Carbon analog results in decreased expression of TUBB4B mRNA CTD PMID:25620056 carbon nanotube decreases expression ISO RGD:1601774 6480464 Nanotubes, Carbon results in decreased expression of TUBB4B mRNA CTD PMID:28673683 chloropicrin affects expression ISO RGD:1601774 6480464 chloropicrin affects the expression of TUBB4B mRNA CTD PMID:26352163 chloropicrin increases expression ISO RGD:1601774 6480464 chloropicrin results in increased expression of TUBB2C mRNA CTD PMID:28476498 cisplatin decreases expression ISO RGD:1601774 6480464 Cisplatin results in decreased expression of TUBB4B mRNA CTD PMID:27594783 copper(II) sulfate decreases expression ISO RGD:1601774 6480464 Copper Sulfate results in decreased expression of TUBB4B mRNA CTD PMID:19549813 coumestrol increases expression ISO RGD:1601774 6480464 Coumestrol results in increased expression of TUBB4B mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1601774 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TUBB4B mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:1601774 6480464 Cyclosporine results in decreased expression of TUBB4B mRNA CTD PMID:25562108 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of TUBB4B mRNA CTD PMID:23914054 diazinon increases expression EXP 6480464 Diazinon results in increased expression of TUBB4B mRNA CTD PMID:29108742 dibenzo[a,l]pyrene increases expression ISO RGD:1601774 6480464 dibenzo(a, l)pyrene results in increased expression of TUBB4B mRNA CTD PMID:31255691 diclofenac affects expression ISO RGD:1601774 6480464 Diclofenac affects the expression of TUBB4B mRNA CTD PMID:24752500 dioxygen decreases expression ISO RGD:1601774 6480464 Oxygen deficiency results in decreased expression of TUBB4B mRNA CTD PMID:26516004 dopamine increases expression EXP 6480464 Dopamine results in increased expression of TUBB4B mRNA CTD PMID:21983523 doxorubicin increases expression ISO RGD:1601774 6480464 Doxorubicin results in increased expression of TUBB4B mRNA CTD PMID:29803840 Enterolactone multiple interactions ISO RGD:1601774 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TUBB4B mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:1601774 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TUBB4B protein CTD PMID:23301498 ethanol affects expression ISO RGD:1557719 6480464 Ethanol affects the expression of TUBB4B mRNA CTD PMID:30319688 fenoldopam increases expression EXP 6480464 Fenoldopam results in increased expression of TUBB4B mRNA CTD PMID:21983523 finasteride increases expression EXP 6480464 Finasteride results in increased expression of TUBB4B mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of TUBB4B mRNA CTD PMID:24136188 furan increases expression ISO RGD:1557719 6480464 furan results in increased expression of TUBB4B mRNA CTD PMID:24183702 isoflavones multiple interactions EXP 6480464 [9 more ... CTD PMID:22248470 lead(II) chloride increases expression ISO RGD:1601774 6480464 lead chloride results in increased expression of TUBB4B protein CTD PMID:24419708 leflunomide decreases expression ISO RGD:1601774 6480464 leflunomide results in decreased expression of TUBB4B mRNA CTD PMID:28988120 levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of TUBB4B mRNA CTD PMID:24136188 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of TUBB4B protein CTD PMID:19826936 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of TUBB4B mRNA CTD PMID:30467583 microcystin decreases expression EXP 6480464 Microcystins results in decreased expression of TUBB4B protein CTD PMID:22430071 N-(6-acetamidohexyl)acetamide increases expression ISO RGD:1601774 6480464 hexamethylene bisacetamide results in increased expression of TUBB4B protein CTD PMID:17569113 N-ethyl-N-nitrosourea increases expression ISO RGD:1557719 6480464 Ethylnitrosourea results in increased expression of TUBB4B mRNA CTD PMID:19100860 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of TUBB4B mRNA CTD PMID:19638242 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TUBB2C mRNA CTD PMID:28943392 N-nitrosodiethylamine increases expression ISO RGD:1557719 6480464 Diethylnitrosamine results in increased expression of TUBB4B mRNA CTD PMID:19100860 more ... oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TUBB4B mRNA CTD PMID:25729387 palbociclib decreases expression ISO RGD:1601774 6480464 palbociclib results in decreased expression of TUBB4B mRNA CTD PMID:22869556 paracetamol increases expression ISO RGD:1601774 6480464 Acetaminophen results in increased expression of TUBB4B mRNA CTD PMID:22230336 , PMID:29067470 paracetamol affects expression ISO RGD:1557719 6480464 Acetaminophen affects the expression of TUBB4B mRNA CTD PMID:17562736 pentachlorophenol increases expression ISO RGD:1557719 6480464 Pentachlorophenol results in increased expression of TUBB4B mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of TUBB4B mRNA CTD PMID:19162173 permethrin increases expression ISO RGD:1557719 6480464 Permethrin results in increased expression of TUBB2C mRNA CTD PMID:30629241 phenethyl isothiocyanate affects binding ISO RGD:1601774 6480464 TUBB4B protein binds to phenethyl isothiocyanate CTD PMID:21838287 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of TUBB4B mRNA CTD PMID:19162173 phenobarbital affects expression ISO RGD:1557719 6480464 Phenobarbital affects the expression of TUBB4B mRNA CTD PMID:23091169 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of TUBB4B mRNA CTD PMID:22484513 pirinixic acid increases expression ISO RGD:1557719 6480464 pirinixic acid results in increased expression of TUBB4B mRNA CTD PMID:18301758 , PMID:20813756 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of TUBB4B mRNA CTD PMID:19162173 , PMID:22484513 propiconazole increases expression ISO RGD:1557719 6480464 propiconazole results in increased expression of TUBB4B mRNA CTD PMID:21278054 resorcinol increases expression ISO RGD:1601774 6480464 resorcinol results in increased expression of TUBB4B mRNA CTD PMID:22623647 resveratrol increases expression ISO RGD:1557719 6480464 resveratrol results in increased expression of TUBB4B protein CTD PMID:25505154 rotenone affects expression ISO RGD:1557719 6480464 Rotenone affects the expression of TUBB4B mRNA CTD PMID:21893155 rotenone decreases expression ISO RGD:1601774 6480464 Rotenone results in decreased expression of TUBB4B mRNA CTD PMID:29955902 rotenone affects expression EXP 6480464 Rotenone affects the expression of TUBB4B mRNA CTD PMID:28374803 rotenone multiple interactions ISO RGD:1557719 6480464 TRP53 affects the reaction [Rotenone affects the expression of TUBB4B mRNA] CTD PMID:21893155 silicon dioxide increases expression ISO RGD:1601774 6480464 Silicon Dioxide analog results in increased expression of TUBB2C mRNA, Silicon Dioxide results in increased expression of TUBB2C mRNA CTD PMID:25351596 , PMID:25895662 silicon dioxide affects secretion ISO RGD:1601774 6480464 Silicon Dioxide analog affects the secretion of TUBB4B protein CTD PMID:25895662 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of TUBB4B mRNA CTD PMID:19072884 sodium arsenite increases expression ISO RGD:1557719 6480464 sodium arsenite results in increased expression of TUBB4B protein CTD PMID:29044176 sodium arsenite increases expression ISO RGD:1601774 6480464 sodium arsenite results in increased expression of TUBB4B mRNA CTD PMID:28595984 sodium fluoride increases expression ISO RGD:1557719 6480464 Sodium Fluoride results in increased expression of TUBB4B protein CTD PMID:27548804 , PMID:28918527 sulforaphane affects binding ISO RGD:1601774 6480464 TUBB4B protein binds to sulforafan CTD PMID:21838287 tamoxifen affects expression ISO RGD:1557719 6480464 Tamoxifen affects the expression of TUBB4B mRNA CTD PMID:20937368 tamoxifen increases expression ISO RGD:1557719 6480464 Tamoxifen results in increased expression of TUBB4B mRNA CTD PMID:19400957 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of TUBB4B mRNA CTD PMID:19400957 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TUBB4B mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of TUBB4B mRNA CTD PMID:31150632 thapsigargin decreases expression ISO RGD:1601774 6480464 Thapsigargin results in decreased expression of TUBB4B mRNA CTD PMID:22378314 thimerosal decreases expression ISO RGD:1601774 6480464 Thimerosal results in decreased expression of TUBB4B mRNA CTD PMID:27188386 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TUBB2C mRNA CTD PMID:28943392 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of TUBB4B mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TUBB4B mRNA CTD PMID:25729387 trimellitic anhydride increases expression ISO RGD:1557719 6480464 trimellitic anhydride results in increased expression of TUBB4B mRNA CTD PMID:19042947 trovafloxacin multiple interactions ISO RGD:1557719 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TUBB4B mRNA CTD PMID:18930950 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of TUBB4B mRNA CTD PMID:24136188 tungsten increases expression ISO RGD:1557719 6480464 Tungsten results in increased expression of TUBB4B mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:1601774 6480464 Tunicamycin results in decreased expression of TUBB4B mRNA CTD PMID:22378314 , PMID:29453283 urethane increases expression ISO RGD:1601774 6480464 Urethane results in increased expression of TUBB4B mRNA CTD PMID:28818685 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of TUBB4B mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:1601774 6480464 Valproic Acid affects the expression of TUBB4B mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1601774 6480464 Valproic Acid results in increased expression of TUBB4B mRNA CTD PMID:28001369 valproic acid decreases expression ISO RGD:1601774 6480464 Valproic Acid results in decreased expression of TUBB4B mRNA CTD PMID:29154799 vincaleukoblastine decreases expression EXP 6480464 Vinblastine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 vincristine decreases expression ISO RGD:1601774 6480464 Vincristine results in decreased expression of TUBB4B mRNA CTD PMID:23649840 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 vitamin E increases expression ISO RGD:1601774 6480464 Vitamin E results in increased expression of TUBB4B mRNA CTD PMID:19244175 zoledronic acid decreases expression ISO RGD:1601774 6480464 zoledronic acid results in decreased expression of TUBB4B mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
