Tubb4b (tubulin, beta 4B class IVb)

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Gene: Tubb4b (tubulin, beta 4B class IVb) Rattus norvegicus

Analyze

Symbol:

Tubb4b

Name:

tubulin, beta 4B class IVb

RGD ID:

735101

Description:

Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in intercellular bridge and mitotic spindle. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb); INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC73008; Tubb2; Tubb2c; tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta, 2; tubulin, beta2-like; Unknown (protein for MGC:73008)

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TUBB4B (tubulin beta 4B class IVb)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tubb4b (tubulin, beta 4B class IVB)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TUBB8 (tubulin beta 8 class VIII)	HGNC	EggNOG, Panther
Homo sapiens (human):	TUBB2A (tubulin beta 2A class IIa)	HGNC	OrthoDB
Homo sapiens (human):	TUBB4A (tubulin beta 4A class IVa)	HGNC	OrthoDB
Homo sapiens (human):	TUBB2B (tubulin beta 2B class IIb)	HGNC	OrthoDB
Homo sapiens (human):	TUBB8B (tubulin beta 8B)	HGNC	Panther
Alliance orthologs ³
Mus musculus (house mouse):	Tubb4b (tubulin, beta 4B class IVB)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	TUBB4B (tubulin beta 4B class IVb)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tubb2b (tubulin, beta 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	zgc:55461	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tubb4b (tubulin, beta 4B class IVb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mec-7	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	betaTub56D	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tbb-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	8,037,844 - 8,040,294 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,037,799 - 8,040,296 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,142,521 - 11,144,977 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,728,750 - 19,731,206 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	17,918,593 - 17,921,049 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	2,441,585 - 2,444,369 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,441,733 - 2,444,281 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,422,868 - 2,425,649 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,387,050 - 3,389,500 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,387,049 - 3,389,500 (-)	NCBI
Celera	3	2,864,558 - 2,867,008 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

Chemical and Drug Induced Liver Injury (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

Kleefstra syndrome 1 (ISO)

Leber congenital amaurosis with early-onset deafness (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(S)-colchicine (EXP)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-acetamidofluorene (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-methylcholanthrene (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

azathioprine (ISO)

beauvericin (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bleomycin A2 (EXP)

bromobenzene (EXP)

buspirone (EXP)

cadmium dichloride (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cisplatin (ISO)

clozapine (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

diazinon (EXP)

dibenzo[a,l]pyrene (ISO)

diclofenac (ISO)

dioxygen (ISO)

dopamine (EXP)

doxorubicin (ISO)

enniatin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fenoldopam (EXP)

fenvalerate (EXP)

finasteride (EXP)

flutamide (EXP)

furan (ISO)

gentamycin (EXP)

haloperidol (ISO)

isoflavones (EXP)

ivermectin (ISO)

lead(II) chloride (ISO)

leflunomide (ISO)

levofloxacin (EXP)

Licochalcone B (ISO)

methamphetamine (EXP)

methapyrilene (EXP)

microcystin (EXP)

N-(6-acetamidohexyl)acetamide (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP,ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP)

permethrin (ISO)

phenethyl isothiocyanate (ISO)

phenobarbital (EXP,ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

propiconazole (ISO)

resorcinol (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (EXP,ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

trovafloxacin (EXP,ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vincaleukoblastine (EXP)

vincristine (EXP,ISO)

vitamin E (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoskeleton organization (IEA)

microtubule cytoskeleton organization (IBA)

microtubule-based process (IEA)

mitotic cell cycle (IBA)

Cellular Component

cytoplasm (IBA,IEA)

intercellular bridge (ISO)

microtubule (IBA,IEA,ISO)

microtubule cytoskeleton (ISO)

mitotic spindle (ISO)

Molecular Function

double-stranded RNA binding (ISO)

GTP binding (IBA,IEA)

GTPase activity (IEA)

metal ion binding (IEA)

protein binding (IPI,ISO)

structural constituent of cytoskeleton (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells.	Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Information Derived from GenBank Report	RGD, Sept. 2003
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11487543	PMID:15489334	PMID:17634366	PMID:19666135	PMID:20131911	PMID:20458337	PMID:21266579	PMID:21525035	PMID:21630459	PMID:22120110	PMID:22871113	PMID:23106098
PMID:23376485	PMID:23533145	PMID:23979707	PMID:24625528	PMID:24769233	PMID:25002582	PMID:25763846	PMID:25931508	PMID:26316108	PMID:29476059	PMID:31904090

Genomics

Comparative Map Data

Tubb4b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	8,037,844 - 8,040,294 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,037,799 - 8,040,296 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,142,521 - 11,144,977 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,728,750 - 19,731,206 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	17,918,593 - 17,921,049 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	2,441,585 - 2,444,369 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,441,733 - 2,444,281 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,422,868 - 2,425,649 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,387,050 - 3,389,500 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,387,049 - 3,389,500 (-)	NCBI
Celera	3	2,864,558 - 2,867,008 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

TUBB4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,241,287 - 137,243,707 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	137,241,287 - 137,243,707 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	140,135,739 - 140,138,159 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,255,532 - 139,257,980 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	110,651,151 - 110,653,744 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,595,024 - 109,597,472 (+)	NCBI		HuRef
CHM1_1	9	140,284,445 - 140,286,893 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,478,956 - 149,481,376 (+)	NCBI		T2T-CHM13v2.0

Tubb4b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,112,170 - 25,114,714 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,112,172 - 25,114,714 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,222,158 - 25,224,702 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,222,160 - 25,224,702 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,077,678 - 25,080,222 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,044,171 - 25,046,650 (-)	NCBI		MGSCv36	mm8
Celera	2	24,949,941 - 24,952,486 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI

Tubb4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,235,629 - 5,239,370 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,237,050 - 5,239,370 (+)	NCBI	ChiLan1.0	ChiLan1.0

TUBB4B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	137,269,849 - 137,271,758 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,268,942 - 137,271,758 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	108,300,868 - 108,303,321 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TUBB4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,432,114 - 48,434,626 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,427,766 - 48,571,640 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,618,435 - 47,620,948 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,293,272 - 49,295,782 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,289,395 - 49,295,750 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,069,677 - 48,072,187 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,368,505 - 48,371,015 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,415,650 - 48,418,163 (-)	NCBI		UU_Cfam_GSD_1.0

Tubb4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,623,429 - 202,625,856 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	749,202 - 751,739 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936669	749,203 - 751,622 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TUBB4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	314,135,349 - 314,137,803 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TUBB4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	945,643 - 948,087 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	945,459 - 948,065 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,357,929 - 4,360,605 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tubb4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	712,987 - 717,951 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	715,013 - 717,462 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tubb4b
10 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	95
Count of miRNA genes:	82
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000013863
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											7
Medium	3	43	57	41	19	41	8	11	74	35	34	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC060597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000013863 ⟹ ENSRNOP00000013863

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,037,799 - 8,040,296 (-)	Ensembl
Rnor_6.0 Ensembl	3	2,441,733 - 2,444,281 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102939 ⟹ ENSRNOP00000078046

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,037,988 - 8,040,296 (-)	Ensembl

RefSeq Acc Id:

NM_199094 ⟹ NP_954525

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	8,037,844 - 8,040,294 (-)	NCBI
Rnor_6.0	3	2,441,589 - 2,444,348 (-)	NCBI
Rnor_5.0	3	2,422,868 - 2,425,649 (-)	NCBI
RGSC_v3.4	3	3,387,050 - 3,389,500 (-)	RGD
Celera	3	2,864,558 - 2,867,008 (-)	RGD

Sequence:

show sequence

AGCACTCTGTGCGCCTGCTCCTCCCTAAGTGTTCCTCTTCTACAGCCGCTCCGCAGTCGCCGCC
GCCATGAGGGAGATCGTGCACCTGCAGGCTGGGCAGTGCGGCAACCAGATTGGCGCCAAGTTCT
GGGAGGTAATCAGCGACGAGCATGGCATTGATCCCACTGGCACGTACCACGGAGATAGCGACCT
CCAGCTGGAGCGCATCAACGTGTACTACAACGAGGCCACCGGTGGCAAGTATGTGCCCCGCGCT
GTGCTCGTGGACTTGGAGCCCGGCACCATGGACTCGGTGCGCTCAGGGCCCTTCGGGCAGATCT
TCAGACCTGATAACTTCGTTTTTGGTCAGAGTGGGGCTGGGAACAACTGGGCCAAGGGGCACTA
CACAGAAGGTGCAGAGCTGGTTGACTCGGTGTTGGACGTTGTGAGGAAGGAAGCTGAGAGCTGT
GACTGCCTGCAAGGCTTCCAGCTGACCCACTCCCTGGGTGGGGGGACTGGGTCTGGGATGGGTA
CCCTCCTTATCAGCAAGATCCGGGAGGAGTACCCAGACAGAATCATGAACACCTTCAGTGTGGT
CCCTTCCCCCAAGGTGTCGGACACAGTGGTTGAGCCCTACAATGCCACCCTTTCAGTCCACCAG
CTTGTTGAAAACACAGATGAGACCTATTGTATTGATAATGAAGCACTCTATGACATCTGCTTCA
GAACCCTAAAGCTGACCACACCCACTTATGGTGACCTGAACCATCTAGTGTCCGCCACCATGAG
TGGGGTAACCGCTTGCCTACGATTCCCTGGCCAGCTAAATGCTGACCTGCGGAAACTGGCTGTA
AATATGGTGCCCTTCCCTCGCCTGCACTTCTTCATGCCTGGCTTTGCCCCCTTGACCAGCCGGG
GAAGCCAGCAGTACCGAGCCCTGACAGTTCCTGAGCTCACCCAGCAGATGTTTGATGCTAAGAA
CATGATGGCTGCCTGTGATCCCCGCCATGGGCGCTACTTGACAGTGGCTGCCGTGTTCAGGGGC
CGCATGTCTATGAAGGAGGTGGACGAACAGATGCTTAATGTCCAAAACAAGAACAGCAGCTACT
TTGTTGAGTGGATCCCCAACAACGTGAAAACAGCTGTCTGTGACATTCCACCTCGGGGCCTAAA
AATGTCCGCCACCTTCATTGGCAACAGCACGGCTATTCAGGAGCTGTTCAAACGCATCTCAGAG
CAGTTCACAGCCATGTTCCGACGCAAGGCCTTCCTACACTGGTACACGGGCGAGGGCATGGATG
AGATGGAGTTCACTGAGGCTGAGAGCAACATGAATGACCTGGTGTCCGAGTACCAGCAGTACCA
GGATGCTACAGCTGAGGAGGAAGGAGAGTTTGAGGAGGAGGCTGAGGAGGAGGTGGCTTAGAGC
TGTCTTAGTCACTACAGCATGGGAGCAGTGTGAACTCTTTATTCATTCACAGCTTGTCTGCTAG
CCATGTCCACTGTGCATTTGCTGTCCTGTGTCCTGACATCACTTGTACAGATACCACCATTAAA
GCAATTCATAGTGACAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_954525	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60597	(Get FASTA)	NCBI Sequence Viewer
	EDL93630	(Get FASTA)	NCBI Sequence Viewer
	Q6P9T8	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_954525 ⟸ NM_199094

- Sequence:

show sequence

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAV
LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCD
CLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQL
VENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTACLRFPGQLNADLRKLAVN
MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGR
MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQ
FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA

hide sequence

RefSeq Acc Id:

ENSRNOP00000013863 ⟸ ENSRNOT00000013863

RefSeq Acc Id:

ENSRNOP00000078046 ⟸ ENSRNOT00000102939

Protein Domains

Tubulin Tubulin_C

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P9T8-F1-model_v2	AlphaFold	Q6P9T8	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691861

Promoter ID:

EPDNEW_R2386

Type:

multiple initiation site

Name:

Tubb4b_1

Description:

tubulin, beta 4B class IVb

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	2,444,348 - 2,444,408	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735101	AgrOrtholog
BioCyc Gene	G2FUF-50476	BioCyc
Ensembl Genes	ENSRNOG00000010170	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013863	ENTREZGENE
	ENSRNOP00000013863.5	UniProtKB/TrEMBL
	ENSRNOP00000078046.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013863	ENTREZGENE
	ENSRNOT00000013863.6	UniProtKB/TrEMBL
	ENSRNOT00000102939.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6889737	IMAGE-MGC_LOAD
InterPro	Beta-tubulin_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Beta_tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_GTPase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:296554	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:73008	IMAGE-MGC_LOAD
NCBI Gene	296554	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tubb4b	PhenoGen
PRINTS	BETATUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN_B_AUTOREG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52490	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55307	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5Y8E3_RAT	UniProtKB/TrEMBL
	G3V7C6_RAT	UniProtKB/TrEMBL
	Q6P9T8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-10-19	Tubb4b	tubulin, beta 4B class IVb	Tubb2c	tubulin, beta 2C	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-12	Tubb2c	tubulin, beta 2C	Tubb4b	tubulin, beta 4B class IVb	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-10	Tubb4b	tubulin, beta 4B class IVb	Tubb2c	tubulin, beta 2c	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tubb2c	tubulin, beta 2c	Tubb2	tubulin, beta, 2	Symbol and Name updated	1299863	APPROVED
2005-07-08	Tubb2	tubulin, beta, 2	MGC73008	Unknown (protein for MGC:73008)	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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