Tubb4b (tubulin, beta 4B class IVB)

Gene: Tubb4b (tubulin, beta 4B class IVB) Mus musculus

Analyze

Symbol:

Tubb4b

Name:

tubulin, beta 4B class IVB

RGD ID:

1557719

MGI Page

MGI

Description:

Predicted to enable GTP binding activity and double-stranded RNA binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in myelin sheath. Is expressed in brain ependyma; epithelial layer of oviduct; germ cell of testis; nasal epithelium; and respiratory system epithelium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness. Orthologous to human TUBB4B (tubulin beta 4B class IVb).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

4930542G03Rik; MGC101937; MGC28623; MGC6713; novel tubulin protein; RP23-132N23.7; Tubb2c; Tubb2c1; tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta 2c1; tubulin, beta, 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TUBB4B (tubulin beta 4B class IVb)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Tubb4b (tubulin, beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TUBB4B (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tubb4b (tubulin beta 4B class IVb)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TUBB6 (tubulin beta 6 class V)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	TUBB3 (tubulin beta 3 class III)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	TUBB2A (tubulin beta 2A class IIa)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	TUBB4A (tubulin beta 4A class IVa)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	TUBB2B (tubulin beta 2B class IIb)	HGNC	OrthoDB, OrthoMCL
Homo sapiens (human):	TUBB8 (tubulin beta 8 class VIII)	HGNC	OrthoMCL, Panther
Homo sapiens (human):	TUBB8B (tubulin beta 8B)	HGNC	OrthoMCL, Panther
Homo sapiens (human):	TUBB1 (tubulin beta 1 class VI)	HGNC	OrthoMCL
Homo sapiens (human):	TUBB (tubulin beta class I)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Tubb4b (tubulin, beta 4B class IVb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	TUBB4B (tubulin beta 4B class IVb)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tubb2b (tubulin, beta 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Danio rerio (zebrafish):	zgc:55461	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tubb4b (tubulin, beta 4B class IVb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mec-7	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	betaTub56D	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tbb-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tubb4b	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Related Pseudogenes:

Tubb2a-ps1 Tubb4b-ps1 Tubb4b-ps2

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,112,170 - 25,114,714 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,112,172 - 25,114,714 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,222,158 - 25,224,702 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,222,160 - 25,224,702 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,077,678 - 25,080,222 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,044,171 - 25,046,650 (-)	NCBI		MGSCv36	mm8
Celera	2	24,949,941 - 24,952,486 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.08	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

Chemical and Drug Induced Liver Injury (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leber congenital amaurosis with early-onset deafness (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(-)-demecolcine (ISO)

(1->4)-beta-D-glucan (EXP)

(S)-colchicine (ISO)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-acetamidofluorene (EXP,ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (EXP)

3-methylcholanthrene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (EXP)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

azathioprine (ISO)

beauvericin (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

bromobenzene (ISO)

buspirone (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (EXP,ISO)

chloropicrin (ISO)

cisplatin (ISO)

clozapine (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

diallyl trisulfide (ISO)

diazinon (ISO)

dibenzo[a,l]pyrene (ISO)

diclofenac (ISO)

dioxygen (ISO)

dopamine (ISO)

doxorubicin (ISO)

enniatin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

ethanol (EXP)

fenoldopam (ISO)

fenvalerate (ISO)

finasteride (ISO)

flutamide (ISO)

furan (EXP)

gentamycin (ISO)

haloperidol (ISO)

indometacin (ISO)

isoflavones (ISO)

ivermectin (ISO)

lead(II) chloride (ISO)

leflunomide (ISO)

levofloxacin (ISO)

Licochalcone B (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

microcystin-LR (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-ethyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (EXP,ISO)

oxaliplatin (ISO)

ozone (EXP)

palbociclib (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (EXP)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

phenethyl isothiocyanate (ISO)

phenobarbital (EXP,ISO)

piperonyl butoxide (ISO)

pirinixic acid (EXP,ISO)

propiconazole (EXP)

resorcinol (ISO)

resveratrol (EXP)

rotenone (EXP,ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (EXP,ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thioacetamide (ISO)

topotecan (ISO)

trichloroethene (ISO)

trimellitic anhydride (EXP)

triphenyl phosphate (ISO)

trovafloxacin (EXP,ISO)

tungsten (EXP)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

vincristine (ISO)

vitamin E (ISO)

zearalenone (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule cytoskeleton organization (IBA)

microtubule-based process (NAS)

mitotic cell cycle (IBA)

Cellular Component

axonemal microtubule (ISO)

cytoplasm (IBA)

cytoskeleton (IEA)

intercellular bridge (ISO)

microtubule (IBA,ISO)

microtubule cytoskeleton (ISO)

mitotic spindle (ISO)

myelin sheath (HDA)

tubulin complex (NAS)

Molecular Function

double-stranded RNA binding (ISO)

GTP binding (IBA,NAS)

GTPase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

structural constituent of cytoskeleton (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal branching involved in lung morphogenesis (IAGP)

abnormal oviduct epithelium motile cilium morphology (IAGP)

abnormal respiratory motile cilium morphology (IAGP)

hydrocephaly (IAGP)

postnatal growth retardation (IAGP)

postnatal lethality, incomplete penetrance (IAGP)

preweaning lethality, incomplete penetrance (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3782288	PMID:7671812	PMID:8889548	PMID:10330459	PMID:10349636	PMID:10423398	PMID:10479457	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11724907	PMID:12477932
PMID:12520002	PMID:14610273	PMID:14625387	PMID:15189821	PMID:15234001	PMID:15489334	PMID:15782199	PMID:15952741	PMID:16141072	PMID:16141073	PMID:16574095	PMID:16602821
PMID:17079460	PMID:17428829	PMID:17634366	PMID:18258849	PMID:18307411	PMID:18374910	PMID:19545277	PMID:19574443	PMID:20016102	PMID:20360068	PMID:20658693	PMID:21266579
PMID:21270055	PMID:21565611	PMID:21589869	PMID:21677750	PMID:21873635	PMID:22675208	PMID:23213461	PMID:23246003	PMID:23284756	PMID:23449471	PMID:23451260	PMID:23562608
PMID:23986237	PMID:24274029	PMID:24457600	PMID:25516972	PMID:25564622	PMID:26336360	PMID:27141870	PMID:27150575	PMID:27341756	PMID:28128212	PMID:28378742	PMID:28634551
PMID:28827394	PMID:29459677	PMID:29518331	PMID:29676259	PMID:30110642	PMID:30333137	PMID:30446499	PMID:30550785	PMID:30562941	PMID:30595499	PMID:30713523	PMID:31028279
PMID:31077711	PMID:32325033	PMID:34474245	PMID:35112129	PMID:35741845	PMID:36114006	PMID:36293380	PMID:36808153	PMID:37439173	PMID:38031972	PMID:38187761

Genomics

Comparative Map Data

Tubb4b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,112,170 - 25,114,714 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,112,172 - 25,114,714 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,222,158 - 25,224,702 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,222,160 - 25,224,702 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,077,678 - 25,080,222 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,044,171 - 25,046,650 (-)	NCBI		MGSCv36	mm8
Celera	2	24,949,941 - 24,952,486 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.08	NCBI

TUBB4B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,241,287 - 137,243,707 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	137,241,287 - 137,243,707 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	140,135,739 - 140,138,159 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,255,532 - 139,257,980 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	110,651,151 - 110,653,744 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,595,024 - 109,597,472 (+)	NCBI		HuRef
CHM1_1	9	140,284,445 - 140,286,893 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,478,956 - 149,481,376 (+)	NCBI		T2T-CHM13v2.0

Tubb4b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,435,999 - 28,438,455 (-)	NCBI		GRCr8
mRatBN7.2	3	8,037,838 - 8,040,294 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,037,799 - 8,040,296 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,142,521 - 11,144,977 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,728,750 - 19,731,206 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,918,593 - 17,921,049 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,441,585 - 2,444,369 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,441,733 - 2,444,281 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,422,868 - 2,425,649 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,387,050 - 3,389,500 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,387,049 - 3,389,500 (-)	NCBI
Celera	3	2,864,558 - 2,867,008 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Tubb4b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,235,629 - 5,239,370 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,237,050 - 5,239,370 (+)	NCBI	ChiLan1.0	ChiLan1.0

TUBB4B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,155,911 - 2,159,194 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,158,244 - 2,160,933 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,300,868 - 108,303,321 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,269,849 - 137,271,758 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,268,942 - 137,271,758 (+)	Ensembl	panpan1.1		panPan2

TUBB4B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,432,114 - 48,434,626 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,427,766 - 48,571,640 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,618,435 - 47,620,948 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,293,272 - 49,295,782 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,289,395 - 49,295,750 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,069,677 - 48,072,187 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,368,505 - 48,371,015 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,415,650 - 48,418,163 (-)	NCBI		UU_Cfam_GSD_1.0

Tubb4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,623,429 - 202,625,856 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	749,202 - 751,739 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	749,203 - 751,622 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TUBB4B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	314,135,349 - 314,137,803 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TUBB4B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	945,643 - 948,087 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	945,459 - 948,065 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,357,929 - 4,360,605 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tubb4b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	712,987 - 717,951 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	715,013 - 717,462 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tubb4b
127 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	198
Count of miRNA genes:	187
Interacting mature miRNAs:	191
Transcripts:	ENSMUST00000043584, ENSMUST00000145607
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4141836	Tgq11_m	triglyceride QTL 11 (mouse)			Not determined			1	25324559	Mouse
4142333	Tgq10_m	triglyceride QTL 10 (mouse)			Not determined			1	25324559	Mouse
1301838	Sluc16_m	susceptibility to lung cancer 16 (mouse)			Not determined		2	1	26529589	Mouse
12904743	Carcdq3_m	cardiac collagen deposition QTL 3 (mouse)					2	3234940	28179150	Mouse
1301769	Orgwq2_m	organ weight QTL 2 (mouse)			Not determined		2	3887126	93421651	Mouse
1301980	Fcsa5_m	femoral cross-sectional area 5 (mouse)			Not determined		2	7679115	41679261	Mouse
1301790	Pcfm1_m	periosteal circumference and femur length 1 (mouse)			Not determined		2	8236296	42236396	Mouse
10043876	Adip22_m	adiposity 22 (mouse)			Not determined		2	8308051	42308240	Mouse
1300624	Insq7_m	insulin QTL 7 (mouse)			Not determined		2	9384446	43384575	Mouse
10755513	Amzn4_m	anatomical modifier of Zfp423 4 (mouse)					2	9384446	43384575	Mouse
12903993	Opfaq1_m	open field activity QTL 1 (mouse)					2	9676691	27022642	Mouse
8552707	Cia23_m	collagen induced arthritis QTL 23 (mouse)			Not determined		2	12129537	66556453	Mouse
1301641	Sbmd2_m	spinal bone mineral density 2 (mouse)			Not determined		2	14214567	48214713	Mouse
1357881	Estoq1_m	embryo survival total QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357454	Kidq1_m	kidney weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357436	Splq1_m	spleen weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
39128209	Lwq14_m	liver weight QTL 14 (mouse)					2	20897778	118894840	Mouse
1558899	Egq1_m	early growth QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1558966	W10q9_m	weight 10 weeks QTL 9 (mouse)			Not determined		2	20897778	118894840	Mouse
1558915	W3q1_m	weight 3 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1558738	W6q1_m	weight 6 weeks QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1357681	Hrtq1_m	heart weight QTL 1 (mouse)			Not determined		2	20897778	118894840	Mouse
1301376	Etohc1_m	ethanol consumption 1 (mouse)			Not determined		2	21129725	55129871	Mouse
4141708	Pbwg1.2_m	postnatal body weight growth 1.2 (mouse)			Not determined			21129725	55129871	Mouse
13463470	Tubisq1_m	tubulointerstitial injury severity, QTL 1 (mouse)					2	23689145	57689269	Mouse
1302174	Dssc2_m	dextran sodium sulfate induced colitis QTL2 (mouse)			Not determined		2	24224632	148700377	Mouse
26884438	Sklq12_m	skull length QTL 12, 16 week (mouse)					2	24590012	54890012	Mouse
8552705	Cia25_m	collagen induced arthritis 25 (mouse)			Not determined		2	24679115	33523172	Mouse
8552706	Cia24_m	collagen induced arthritis QTL 24 (mouse)			Not determined		2	24679115	33523172	Mouse
12792980	Fbmd1_m	femoral bone mineral density 1, females only (mouse)					2	25034492	45034492	Mouse

Markers in Region

UniSTS:234342

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	25,222,881 - 25,222,989	UniSTS	GRCm38
GRCm38	5	7,180,018 - 7,180,126	UniSTS	GRCm38
MGSCv37	5	7,180,018 - 7,180,126	UniSTS	GRCm37
MGSCv37	2	25,078,401 - 25,078,509	UniSTS	GRCm37
Celera	5	7,106,978 - 7,107,086	UniSTS
Celera	2	24,950,665 - 24,950,773	UniSTS
Cytogenetic Map	2	A3	UniSTS
Cytogenetic Map	5	A1	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_146116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK002568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK006924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK015901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK076895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK146587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK194925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK195017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK214079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL732309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC022919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CJ309661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000043584 ⟹ ENSMUSP00000042342

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	25,112,172 - 25,114,714 (-)	Ensembl
GRCm38.p6 Ensembl	2	25,222,160 - 25,224,702 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000145607

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	25,113,535 - 25,114,666 (-)	Ensembl
GRCm38.p6 Ensembl	2	25,223,523 - 25,224,654 (-)	Ensembl

RefSeq Acc Id:

NM_146116 ⟹ NP_666228

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	25,112,170 - 25,114,714 (-)	NCBI
GRCm38	2	25,222,158 - 25,224,702 (-)	ENTREZGENE
MGSCv37	2	25,077,678 - 25,080,222 (-)	RGD
Celera	2	24,949,941 - 24,952,486 (-)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

GGCGGGTCATAAGAGGTATATAAATGTTGGCAGAGCGTCGGTTGTAGCACTCTGTGCGCCTGCT
CCTCCCGAAGTGCTCCTCTTCTACAGCTGTTCCGCAGTCGCCGCCGCCATGAGGGAGATCGTGC
ACCTGCAGGCTGGGCAGTGCGGCAACCAGATTGGCGCCAAGTTCTGGGAGGTAATCAGCGACGA
GCATGGCATTGATCCCACTGGCACTTACCACGGAGATAGCGACCTCCAGCTGGAGCGCATCAAC
GTGTACTACAACGAAGCCACCGGTGGCAAGTATGTGCCCCGCGCCGTGCTCGTGGACTTGGAGC
CCGGCACCATGGACTCGGTGCGTTCAGGGCCCTTCGGGCAGATCTTCAGACCTGATAACTTCGT
CTTTGGTCAGAGTGGGGCTGGGAACAACTGGGCCAAGGGGCACTACACAGAAGGTGCAGAGCTG
GTTGACTCGGTGTTGGACGTTGTGAGAAAGGAAGCTGAGAGCTGTGACTGCCTGCAGGGCTTCC
AGCTGACCCACTCCCTGGGTGGGGGGACTGGGTCTGGGATGGGTACCCTCCTTATCAGCAAGAT
CCGGGAGGAGTACCCAGACAGAATCATGAACACCTTCAGTGTGGTACCTTCCCCCAAGGTGTCG
GACACAGTGGTTGAGCCCTACAATGCCACCCTTTCAGTCCACCAGCTGGTTGAAAACACAGATG
AGACCTATTGTATTGATAATGAAGCACTTTATGACATCTGCTTCAGAACCCTAAAGCTGACCAC
ACCCACTTACGGTGACCTGAACCATCTAGTGTCCGCCACCATGAGTGGGGTAACCACTTGCCTG
CGATTCCCTGGCCAGCTAAATGCTGACCTGCGGAAACTGGCTGTAAATATGGTGCCCTTCCCTC
GCCTGCACTTCTTCATGCCTGGCTTTGCCCCCTTGACCAGCCGGGGCAGCCAGCAGTACCGTGC
CCTGACAGTTCCTGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATGGCTGCCTGTGAT
CCAAGACATGGGCGCTACTTGACTGTGGCTGCCGTGTTCAGGGGCCGCATGTCTATGAAGGAGG
TGGACGAACAGATGCTTAATGTCCAAAACAAGAACAGCAGCTACTTTGTTGAGTGGATCCCCAA
CAATGTGAAGACAGCTGTCTGTGACATTCCACCTCGGGGCCTGAAAATGTCGGCCACCTTCATT
GGCAACAGCACCGCTATTCAGGAGCTGTTCAAACGCATCTCAGAGCAGTTCACAGCCATGTTCC
GACGCAAGGCCTTCCTACACTGGTACACGGGTGAAGGCATGGATGAGATGGAGTTCACTGAGGC
TGAGAGCAACATGAACGACCTGGTGTCCGAGTACCAGCAGTACCAGGACGCTACAGCTGAGGAA
GAGGGAGAGTTTGAGGAGGAGGCTGAGGAGGAGGTGGCTTAGAGCTGTCTTAGTCACTAAAGCA
TGGGAGCAGTGTGAACTCTTTATTCATTCACAGCCTGTCTGCTAGCCATGTCCACTGTGCATTT
GCTGTCCTGTGTCCTGACATCACTTGTACAGATACCACCATTAAAGCAATTCATAGTGTGTGGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_666228	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH05547	(Get FASTA)	NCBI Sequence Viewer
	AAH22919	(Get FASTA)	NCBI Sequence Viewer
	AAH83319	(Get FASTA)	NCBI Sequence Viewer
	BAB22193	(Get FASTA)	NCBI Sequence Viewer
	BAB24792	(Get FASTA)	NCBI Sequence Viewer
	BAE27282	(Get FASTA)	NCBI Sequence Viewer
	BAE39195	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000042342
	ENSMUSP00000042342.5
GenBank Protein	P68372	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_666228 ⟸ NM_146116

- UniProtKB:

Q3UJ73 (UniProtKB/Swiss-Prot), Q3TKF0 (UniProtKB/Swiss-Prot), Q99JZ6 (UniProtKB/Swiss-Prot), P68372 (UniProtKB/Swiss-Prot), Q3U9U3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAV
LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCD
CLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQL
VENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN
MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGR
MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQ
FTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA

hide sequence

RefSeq Acc Id:

ENSMUSP00000042342 ⟸ ENSMUST00000043584

Protein Domains

Tubulin/FtsZ 2-layer sandwich Tubulin/FtsZ GTPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P68372-F1-model_v2	AlphaFold	P68372	1-445	view protein structure

Promoters

RGD ID:

6833022

Promoter ID:

MM_KWN:28106

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000027720, OTTMUST00000027721

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	25,080,076 - 25,081,077 (-)	MPROMDB

RGD ID:

6876558

Promoter ID:

EPDNEW_M1730

Type:

multiple initiation site

Name:

Tubb4b_1

Description:

Mus musculus tubulin, beta 4B class IVB , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	25,224,657 - 25,224,717	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1915472	AgrOrtholog
Ensembl Genes	ENSMUSG00000036752	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000043584	ENTREZGENE
	ENSMUST00000043584.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Beta-tubulin_BS	UniProtKB/Swiss-Prot
	Beta_tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_GTPase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:227613	UniProtKB/Swiss-Prot
MGD	MGI:1915472	ENTREZGENE
NCBI Gene	227613	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN BETA-4B CHAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tubb4b	PhenoGen
PRINTS	BETATUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN_B_AUTOREG	UniProtKB/Swiss-Prot
SMART	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52490	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55307	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	P68372	ENTREZGENE
	Q3TKF0	ENTREZGENE
	Q3U9U3	ENTREZGENE
	Q3UJ73	ENTREZGENE
	Q99JZ6	ENTREZGENE
	Q9CVR0_MOUSE	UniProtKB/TrEMBL
	Q9DCR1_MOUSE	UniProtKB/TrEMBL
	TBB4B_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	P05217	UniProtKB/Swiss-Prot
	Q3TKF0	UniProtKB/Swiss-Prot
	Q3UJ73	UniProtKB/Swiss-Prot
	Q99JZ6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-10-18	Tubb4b	tubulin, beta 4B class IVB	Tubb2c	tubulin, beta 2C	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

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