Apoa2 (apolipoprotein A2) - Rat Genome Database

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Gene: Apoa2 (apolipoprotein A2) Rattus norvegicus
Analyze
Symbol: Apoa2
Name: apolipoprotein A2
RGD ID: 2131
Description: Enables cholesterol transfer activity. Involved in several processes, including animal organ regeneration; response to estrogen; and response to glucocorticoid. Predicted to be located in extracellular space. Predicted to be part of chylomicron; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of hyperthyroidism. Orthologous to human APOA2 (apolipoprotein A2); PARTICIPATES IN lipoprotein metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1-nitropropane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Apo-AII; ApoA-II; APOAII; apolipoprotein A-II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   F344.ACI-Lmx1aqc/Kyo  
QTLs:   GLUCO223_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-ephedrine  (ISO)
1,1-dichloroethene  (ISO)
1-nitropropane  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
atenolol  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcium silicate  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlorohydrocarbon  (EXP)
clofibric acid  (EXP)
Clofop  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
dextran sulfate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
hydrazine  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nifedipine  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentetic acid  (ISO)
perflubutane  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Allayee H, etal., Circ Res 2003 Jun 13;92(11):1262-7. Epub 2003 May 8.
2. The compositional abnormalities of lipoproteins in diabetic renal failure. Attman PO, etal., Nephrol Dial Transplant. 1998 Nov;13(11):2833-41.
3. Apolipoprotein A-II is inversely associated with risk of future coronary artery disease. Birjmohun RS, etal., Circulation. 2007 Oct 30;116(18):2029-35. Epub 2007 Oct 8.
4. Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistance. Castellani LW, etal., Diabetes. 2001 Mar;50(3):643-51.
5. Quantification of apolipoprotein AI-containing lipoprotein particles in non-insulin-dependent diabetes mellitus. Contiero E, etal., Diabetes Res Clin Pract. 1998 Mar;39(3):201-9.
6. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Association between apolipoprotein A2 MspI polymorphism and hypertriglyceridemia in Koreans. Hong SH, etal., Hum Biol. 1998 Feb;70(1):41-6.
10. Structure and evolution of the apolipoprotein multigene family. Luo CC, etal., J Mol Biol 1986 Feb 5;187(3):325-40.
11. Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs. Mahlberg FH and Rothblat GH, J Biol Chem. 1992 Mar 5;267(7):4541-50.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Amino acid sequence of rat apolipoprotein A-II deduced from the nucleotide sequence of cloned cDNA. Nagashima M, etal., J Lipid Res 1986 Jul;27(7):706-12.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Predominance of large low density lipoprotein particles and lower fractional esterification rate of cholesterol in high density lipoprotein in children with insulin-dependent diabetes mellitus. Ohta T, etal., Eur J Pediatr. 1998 Apr;157(4):276-81.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Impaired anti-inflammatory function of apolipoprotein A-II concentrations predicts metabolic syndrome and diabetes at 4 years follow-up in elderly Turks. Onat A, etal., Clin Chem Lab Med. 2009 Oct 12.
18. Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. Panduro A, etal., Biochemistry. 1990 Sep 11;29(36):8430-5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. Silver DL, etal., J Biol Chem. 1999 Feb 12;274(7):4140-6.
25. Differences in HDL-cholesterol:apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients. Soedamah-Muthu SS, etal., Diabetologia. 2000 Nov;43(11):1353-9.
26. Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats. Staels B, etal., Arterioscler Thromb. 1991 May-Jun;11(3):760-9.
27. Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat. Staels B, etal., Arterioscler Thromb. 1992 Mar;12(3):286-94.
28. Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine. Staels B, etal., J Lipid Res. 1989 Aug;30(8):1137-45.
29. Differential regulation of hepatic apolipoprotein A-I and A-II gene expression by thyroid hormone in rat liver. Strobl W, etal., Atherosclerosis. 1992 Dec;97(2-3):161-70.
30. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
31. Effect of acute inflammation on rat apolipoprotein mRNA levels. Tu GF, etal., Inflammation. 1987 Jun;11(2):241-51.
32. Diagnostic and prognostic significance of mRNA expressions of apolipoprotein A and C family genes in hepatitis B virus-related hepatocellular carcinoma. Wang X, etal., J Cell Biochem. 2019 Oct;120(10):18246-18265. doi: 10.1002/jcb.29131. Epub 2019 Jun 18.
Additional References at PubMed
PMID:210174   PMID:218942   PMID:1596514   PMID:1606170   PMID:3104518   PMID:6403543   PMID:7837794   PMID:7918467   PMID:8106353   PMID:8245722   PMID:8422330   PMID:8636092  
PMID:8640403   PMID:8647961   PMID:8962133   PMID:9150245   PMID:9186920   PMID:9651324   PMID:10357838   PMID:10764676   PMID:11027668   PMID:11162594   PMID:11591715   PMID:12458630  
PMID:12576517   PMID:14729860   PMID:14967812   PMID:14988251   PMID:16682745   PMID:17264082   PMID:17652309   PMID:19056867   PMID:19199708   PMID:20495215   PMID:22516433   PMID:23376485  
PMID:23533145   PMID:27477018  


Genomics

Comparative Map Data
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,222,292 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
T2T-CHM13v2.01160,359,748 - 160,361,078 (-)NCBIT2T-CHM13v2.0
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)EnsemblGRCm39 Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBIMGSCv36mm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903520,650 - 521,910 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,806,549 - 1,808,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794164,370 - 166,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoa2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000004662
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Related Rat Strains
The following Strains have been annotated to Apoa2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 29 29 29
Medium 12 12 12 1 3 1
Low 2 8 15 18 8 9 7 17 24 10 8
Below cutoff 1 10 1 1 30 11 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X03468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000004662   ⟹   ENSRNOP00000004662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)Ensembl
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)Ensembl
RefSeq Acc Id: NM_013112   ⟹   NP_037244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,644,718 - 83,646,355 (+)NCBI
Rnor_6.01389,597,165 - 89,598,802 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
RGSC_v3.41387,114,734 - 87,116,372 (+)RGD
Celera1383,275,901 - 83,277,538 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250238   ⟹   XP_006250300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,644,460 - 83,646,358 (+)NCBI
Rnor_6.01389,596,875 - 89,598,805 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006250239   ⟹   XP_006250301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21383,644,464 - 83,646,358 (+)NCBI
Rnor_6.01389,596,872 - 89,598,805 (+)NCBI
Rnor_5.01394,223,741 - 94,225,670 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037244   ⟸   NM_013112
- Peptide Label: preproprotein
- UniProtKB: P04638 (UniProtKB/Swiss-Prot),   A6JFV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250301   ⟸   XM_006250239
- Peptide Label: isoform X1
- UniProtKB: P04638 (UniProtKB/Swiss-Prot),   A6JFV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250300   ⟸   XM_006250238
- Peptide Label: isoform X1
- UniProtKB: P04638 (UniProtKB/Swiss-Prot),   A6JFV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004662   ⟸   ENSRNOT00000004662

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04638-F1-model_v2 AlphaFold P04638 1-102 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2131 AgrOrtholog
BioCyc Gene G2FUF-17383 BioCyc
Ensembl Genes ENSRNOG00000003500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004662 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004662 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApoA-II_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25649 UniProtKB/Swiss-Prot
NCBI Gene 25649 ENTREZGENE
PANTHER APOLIPOPROTEIN A-II UniProtKB/Swiss-Prot
  APOLIPOPROTEIN A-II UniProtKB/TrEMBL
  APOLIPOPROTEIN A-II UniProtKB/TrEMBL
  PTHR11027 UniProtKB/Swiss-Prot
Pfam ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apoa2 PhenoGen
Superfamily-SCOP Apolipoprotein A-II UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JFV5 ENTREZGENE, UniProtKB/TrEMBL
  A6JFV6_RAT UniProtKB/TrEMBL
  APOA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoa2  apolipoprotein A2  Apoa2  apolipoprotein A-II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Apoa2  apolipoprotein A-II    Apolipoprotein A-II  Name updated 629478 APPROVED
2002-06-10 Apoa2  Apolipoprotein A-II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a lipid binding domain 634654
gene_function may bind lipids 634654
gene_homology has high homology with human Apoa2 over the lipid binding domain although the overall homology is only about 50% 634654
gene_product member of the apolipoprotein gene family 634655