APOA2 (apolipoprotein A2) - Rat Genome Database

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Gene: APOA2 (apolipoprotein A2) Pan paniscus
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Symbol: APOA2
Name: apolipoprotein A2
RGD ID: 11760653
Description: ENCODES a protein that exhibits apolipoprotein receptor binding (ortholog); cholesterol binding (ortholog); cholesterol transfer activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to lipoprotein particle stimulus (ortholog); cholesterol efflux (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH APOLIPOPROTEIN A-II DEFICIENCY (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN chylomicron (ortholog); extracellular space (ortholog); very-low-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Apo-AII; ApoA-II; apolipoprotein A-II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to lipoprotein particle stimulus  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (ISO)
cholesterol transport  (IEA,ISO)
diacylglycerol catabolic process  (ISO)
high-density lipoprotein particle assembly  (ISO)
high-density lipoprotein particle clearance  (ISO)
high-density lipoprotein particle remodeling  (ISO)
lipid transport  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
low-density lipoprotein particle remodeling  (ISO)
negative regulation of cholesterol import  (ISO)
negative regulation of cholesterol transport  (ISO)
negative regulation of cholesterol transporter activity  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of lipase activity  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of very-low-density lipoprotein particle remodeling  (ISO)
peptidyl-methionine modification  (ISO)
phosphatidylcholine biosynthetic process  (ISO)
phospholipid catabolic process  (ISO)
phospholipid efflux  (ISO)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of lipid catabolic process  (ISO)
positive regulation of phagocytosis  (ISS)
protein oxidation  (ISO)
protein stabilization  (ISS)
regulation of intestinal cholesterol absorption  (ISO)
regulation of protein stability  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to xenobiotic stimulus  (ISO)
reverse cholesterol transport  (ISO)
triglyceride-rich lipoprotein particle remodeling  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21298813   PMID:22301074   PMID:22722832   PMID:30032202  


Genomics

Comparative Map Data
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,222,290 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
T2T-CHM13v2.01160,359,748 - 160,361,078 (-)NCBIT2T-CHM13v2.0
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)EnsemblGRCm39 Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBIMGSCv36mm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,176,767 - 86,178,819 (+)NCBIGRCr8
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903520,650 - 521,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,806,549 - 1,808,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794164,370 - 166,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000050602   ⟹   ENSPPAP00000027759
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050605   ⟹   ENSPPAP00000027762
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1140,546,704 - 140,547,865 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050607   ⟹   ENSPPAP00000027764
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1140,546,790 - 140,547,690 (-)Ensembl
RefSeq Acc Id: XM_055112387   ⟹   XP_054968362
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBI
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBI
RefSeq Acc Id: XM_063604309   ⟹   XP_063460379
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054968362 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460379 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000027759.1
  ENSPPAP00000027762.1
  ENSPPAP00000027764.1
GenBank Protein P0DM95 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSPPAP00000027764   ⟸   ENSPPAT00000050607
Ensembl Acc Id: ENSPPAP00000027762   ⟸   ENSPPAT00000050605
Ensembl Acc Id: ENSPPAP00000027759   ⟸   ENSPPAT00000050602
RefSeq Acc Id: XP_054968362   ⟸   XM_055112387
- Peptide Label: isoform X2
- UniProtKB: P0DM95 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063460379   ⟸   XM_063604309
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050602.1 UniProtKB/Swiss-Prot
  ENSPPAT00000050605.1 UniProtKB/TrEMBL
  ENSPPAT00000050607.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApoA-II_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene APOA2 ENTREZGENE
PANTHER APOLIPOPROTEIN A-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82936 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R9BDP4_PANPA UniProtKB/TrEMBL
  A0A2R9BHK7_PANPA UniProtKB/TrEMBL
  APOA2_PANPA UniProtKB/Swiss-Prot, ENTREZGENE