APOA2 (apolipoprotein A2) - Rat Genome Database

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Gene: APOA2 (apolipoprotein A2) Sus scrofa
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Symbol: APOA2
Name: apolipoprotein A2
RGD ID: 13894749
Description: ENCODES a protein that exhibits cholesterol transfer activity (ortholog); lipid binding (ortholog); lipid transporter activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); animal organ regeneration (ortholog); cholesterol homeostasis (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH APOLIPOPROTEIN A-II DEFICIENCY (ortholog); coronary artery disease (ortholog); Diabetic Nephropathies (ortholog); FOUND IN extracellular space (ortholog); high-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apolipoprotein A-II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,320 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (ISO)
animal organ regeneration  (ISO)
cholesterol efflux  (IEA)
cholesterol homeostasis  (IBA,IEA,ISO)
cholesterol metabolic process  (IBA,IEA,ISO)
cholesterol transport  (IBA,ISO)
diacylglycerol catabolic process  (IEA)
high-density lipoprotein particle assembly  (IBA,IEA)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IBA,IEA)
intermembrane lipid transfer  (IEA)
lipid transport  (ISO)
lipoprotein metabolic process  (IBA,IEA,ISO)
low-density lipoprotein particle remodeling  (IBA,IEA)
negative regulation of cholesterol import  (IEA)
negative regulation of cholesterol transport  (ISO)
negative regulation of cholesterol transporter activity  (IEA)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of lipase activity  (IBA,IEA,ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
peptidyl-methionine modification  (IEA)
phosphatidylcholine biosynthetic process  (IEA)
phospholipid catabolic process  (IEA)
phospholipid efflux  (IEA)
positive regulation of cholesterol esterification  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of lipid catabolic process  (IEA)
positive regulation of phagocytosis  (IEA)
protein oxidation  (IEA)
protein stabilization  (IEA)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of protein stability  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (IEA)
reverse cholesterol transport  (IEA)
triglyceride-rich lipoprotein particle remodeling  (IBA,IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:27296287  


Genomics

Comparative Map Data
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,320 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1161,222,292 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBImm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21383,644,460 - 83,646,358 (+)NCBI
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0panPan3
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBI
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBI
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBI
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBI
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBI
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBI
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBI
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)Ensembl
Apoa2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system respiratory system
High
Medium
Low 1 1 4 2 2
Below cutoff 3 1 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006964   ⟹   ENSSSCP00000006775
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,237,511 - 89,239,009 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000091550   ⟹   ENSSSCP00000069906
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,237,515 - 89,240,320 (+)Ensembl
RefSeq Acc Id: NM_001186294   ⟹   NP_001173223
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001173223 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD91908 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001173223   ⟸   NM_001186294
- Peptide Label: precursor
- UniProtKB: F1S1A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000006775   ⟸   ENSSSCT00000006964
RefSeq Acc Id: ENSSSCP00000069906   ⟸   ENSSSCT00000091550


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006355 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025918 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006775 UniProtKB/TrEMBL
  ENSSSCP00000069906 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070043887 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006964 UniProtKB/TrEMBL
  ENSSSCT00000091550 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070051871 UniProtKB/TrEMBL
InterPro ApoA-II UniProtKB/TrEMBL
  ApoA-II_sf UniProtKB/TrEMBL
KEGG Report ssc:100153243 UniProtKB/TrEMBL
NCBI Gene APOA2 ENTREZGENE
PANTHER PTHR11027 UniProtKB/TrEMBL
Pfam ApoA-II UniProtKB/TrEMBL
Superfamily-SCOP SSF82936 UniProtKB/TrEMBL
UniProt A0A481BCM9_PIG UniProtKB/TrEMBL
  A0A4X1VK69_PIG UniProtKB/TrEMBL
  F1S1A9 ENTREZGENE, UniProtKB/TrEMBL
  Q7YRR7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85416 ENTREZGENE