APOA2 (apolipoprotein A2) - Rat Genome Database

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Gene: APOA2 (apolipoprotein A2) Sus scrofa
Analyze
Symbol: APOA2
Name: apolipoprotein A2
RGD ID: 13894749
Description: ENCODES a protein that exhibits cholesterol transfer activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH APOLIPOPROTEIN A-II DEFICIENCY (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apolipoprotein A-II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to lipoprotein particle stimulus  (IEA)
cholesterol efflux  (IEA)
cholesterol homeostasis  (IBA,IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IBA,ISO)
diacylglycerol catabolic process  (IEA)
high-density lipoprotein particle assembly  (IEA)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IEA)
lipid transport  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
low-density lipoprotein particle remodeling  (IEA)
negative regulation of cholesterol import  (IEA)
negative regulation of cholesterol transport  (IEA)
negative regulation of cholesterol transporter activity  (ISO)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of lipase activity  (ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
peptidyl-methionine modification  (ISO)
phosphatidylcholine biosynthetic process  (IEA)
phospholipid catabolic process  (IEA)
phospholipid efflux  (IEA)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of lipid catabolic process  (IEA)
positive regulation of phagocytosis  (IEA)
protein oxidation  (ISO)
protein stabilization  (IEA)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of protein stability  (IEA)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (IEA)
response to xenobiotic stimulus  (ISO)
reverse cholesterol transport  (IEA)
signal transduction  (IEA)
triglyceride-rich lipoprotein particle remodeling  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:27296287   PMID:30032202  


Genomics

Comparative Map Data
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,222,290 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
T2T-CHM13v2.01160,359,748 - 160,361,078 (-)NCBIT2T-CHM13v2.0
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)EnsemblGRCm39 Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBIMGSCv36mm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,176,767 - 86,178,819 (+)NCBIGRCr8
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903520,650 - 521,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,806,549 - 1,808,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794164,370 - 166,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in APOA2
51 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 1 11 1 2 4 4 4 11 1 3

Sequence


Ensembl Acc Id: ENSSSCT00000006964   ⟹   ENSSSCP00000006775
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,237,511 - 89,239,009 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000091550   ⟹   ENSSSCP00000069906
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl489,237,515 - 89,240,319 (+)Ensembl
RefSeq Acc Id: NM_001186294   ⟹   NP_001173223
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001173223   ⟸   NM_001186294
- Peptide Label: precursor
- UniProtKB: A0A481BCM9 (UniProtKB/TrEMBL),   A0A4X1VK69 (UniProtKB/TrEMBL),   A0A480TEQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000006775   ⟸   ENSSSCT00000006964
Ensembl Acc Id: ENSSSCP00000069906   ⟸   ENSSSCT00000091550


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006355 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015048011 UniProtKB/TrEMBL
  ENSSSCG00025004777 UniProtKB/TrEMBL
  ENSSSCG00035071578 UniProtKB/TrEMBL
  ENSSSCG00040055404 UniProtKB/TrEMBL
  ENSSSCG00045031833 UniProtKB/TrEMBL
  ENSSSCG00050029379 UniProtKB/TrEMBL
  ENSSSCG00055001950 UniProtKB/TrEMBL
  ENSSSCG00065024674 UniProtKB/TrEMBL
  ENSSSCG00070025918 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006964.4 UniProtKB/TrEMBL
  ENSSSCT00000091550 ENTREZGENE
  ENSSSCT00000091550.2 UniProtKB/TrEMBL
  ENSSSCT00015064098.1 UniProtKB/TrEMBL
  ENSSSCT00025006477.1 UniProtKB/TrEMBL
  ENSSSCT00035096803.1 UniProtKB/TrEMBL
  ENSSSCT00040075063.1 UniProtKB/TrEMBL
  ENSSSCT00045054338.1 UniProtKB/TrEMBL
  ENSSSCT00050039494.1 UniProtKB/TrEMBL
  ENSSSCT00055003630.1 UniProtKB/TrEMBL
  ENSSSCT00065032974.1 UniProtKB/TrEMBL
  ENSSSCT00070051871.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.100 UniProtKB/TrEMBL
InterPro ApoA-II UniProtKB/TrEMBL
  ApoA-II_sf UniProtKB/TrEMBL
KEGG Report ssc:100153243 UniProtKB/TrEMBL
NCBI Gene APOA2 ENTREZGENE
PANTHER APOLIPOPROTEIN A-II UniProtKB/TrEMBL
  PTHR11027 UniProtKB/TrEMBL
Pfam ApoA-II UniProtKB/TrEMBL
Superfamily-SCOP SSF82936 UniProtKB/TrEMBL
UniProt A0A480TEQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A481BCM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VK69 ENTREZGENE, UniProtKB/TrEMBL
  F1S1A9_PIG UniProtKB/TrEMBL
  Q7YRR7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85416 ENTREZGENE