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Gene: APOA2 (apolipoprotein A2) Chlorocebus sabaeus

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Symbol:

APOA2

Name:

apolipoprotein A2

RGD ID:

18599160

Description:

ENCODES a protein that exhibits cholesterol transfer activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH APOLIPOPROTEIN A-II DEFICIENCY (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

apolipoprotein A-II

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	APOA2 (apolipoprotein A2)	NCBI	Ortholog
Mus musculus (house mouse):	Apoa2 (apolipoprotein A-II)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Apoa2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Apoa2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	APOA2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	APOA2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Apoa2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	APOA2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Apoa2 (apolipoprotein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,757,939 - 2,760,356 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,759,237 - 2,760,686 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	1,806,549 - 1,808,724 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

APOLIPOPROTEIN A-II DEFICIENCY (ISO)

autoimmune interstitial lung, joint, and kidney disease (ISO)

coronary artery disease (ISO)

Diabetic Nephropathies (ISO)

familial combined hyperlipidemia (ISO)

familial hypercholesterolemia (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

Hyperlipoproteinemia Type II (ISO)

hyperthyroidism (ISO)

Hypertriglyceridemia (ISO)

Insulin Resistance (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

parathyroid carcinoma (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

cellular response to lipoprotein particle stimulus (IEA)

cholesterol efflux (IEA)

cholesterol homeostasis (IEA,ISO)

cholesterol metabolic process (IEA,ISO)

cholesterol transport (IEA,ISO)

diacylglycerol catabolic process (IEA)

high-density lipoprotein particle assembly (IEA)

high-density lipoprotein particle clearance (IEA)

high-density lipoprotein particle remodeling (IEA)

lipid transport (IEA,ISO)

lipoprotein metabolic process (IEA,ISO)

low-density lipoprotein particle remodeling (IEA)

negative regulation of cholesterol import (IEA)

negative regulation of cholesterol transport (IEA)

negative regulation of cholesterol transporter activity (ISO)

negative regulation of cytokine production involved in immune response (IEA)

negative regulation of lipase activity (ISO)

negative regulation of lipid catabolic process (IEA)

negative regulation of very-low-density lipoprotein particle remodeling (IEA)

peptidyl-methionine modification (ISO)

phosphatidylcholine biosynthetic process (IEA)

phospholipid catabolic process (IEA)

phospholipid efflux (IEA)

positive regulation of CoA-transferase activity (ISO)

positive regulation of interleukin-8 production (IEA)

positive regulation of lipid catabolic process (IEA)

positive regulation of phagocytosis (IEA,ISS)

protein oxidation (ISO)

protein stabilization (IEA,ISS)

regulation of intestinal cholesterol absorption (IEA,ISO)

regulation of protein stability (IEA)

response to estrogen (ISO)

response to glucocorticoid (ISO)

response to glucose (IEA)

response to xenobiotic stimulus (ISO)

reverse cholesterol transport (IEA)

signal transduction (IEA)

triglyceride-rich lipoprotein particle remodeling (IEA)

Cellular Component

chylomicron (IEA)

extracellular region (IEA)

extracellular space (IEA,ISO)

high-density lipoprotein particle (IEA)

spherical high-density lipoprotein particle (IEA)

very-low-density lipoprotein particle (IEA)

Molecular Function

apolipoprotein receptor binding (IEA)

cholesterol binding (IEA)

cholesterol transfer activity (IEA,ISO)

enzyme binding (IEA)

heat shock protein binding (IEA)

high-density lipoprotein particle binding (IEA)

high-density lipoprotein particle receptor binding (IEA)

lipase inhibitor activity (IEA)

lipid binding (IEA)

lipid transporter activity (IEA)

phosphatidylcholine binding (IEA)

phosphatidylcholine-sterol O-acyltransferase activator activity (IEA)

phospholipid binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

protein homodimerization activity (IEA)

receptor ligand activity (IEA)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

lipoprotein metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

APOA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,757,939 - 2,760,356 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,759,237 - 2,760,686 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	1,806,549 - 1,808,724 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

APOA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,222,292 - 161,223,628 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,222,290 - 161,223,631 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	161,192,082 - 161,193,418 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,458,707 - 159,460,042 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	158,005,155 - 158,006,491	NCBI
Celera	1	134,259,238 - 134,260,561 (-)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,549,030 - 132,550,353 (-)	NCBI		HuRef
CHM1_1	1	162,588,335 - 162,589,660 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,359,748 - 160,361,078 (-)	NCBI		T2T-CHM13v2.0

Apoa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	171,049,133 - 171,053,948 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	171,052,623 - 171,053,948 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	171,221,564 - 171,226,379 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,225,054 - 171,226,379 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	173,155,185 - 173,156,510 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	173,061,764 - 173,063,045 (+)	NCBI		MGSCv36	mm8
Celera	1	173,673,195 - 173,674,520 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.22	NCBI

Apoa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,176,767 - 86,178,819 (+)	NCBI		GRCr8
mRatBN7.2	13	83,644,460 - 83,646,358 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,644,470 - 83,646,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	86,150,563 - 86,152,200 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,548,803 - 87,550,440 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,780,423 - 84,782,059 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,596,872 - 89,598,805 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,597,138 - 89,598,802 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	94,223,741 - 94,225,670 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	87,114,734 - 87,116,372 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	87,303,617 - 87,305,256 (+)	NCBI
Celera	13	83,275,901 - 83,277,538 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

Apoa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	12,977,956 - 12,979,753 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	12,977,956 - 12,979,282 (-)	NCBI	ChiLan1.0	ChiLan1.0

APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,627,887 - 88,629,720 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	88,318,208 - 88,320,039 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	136,634,754 - 136,636,122 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,546,591 - 140,547,959 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,546,591 - 140,547,959 (-)	Ensembl	panpan1.1		panPan2

APOA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,263,641 - 21,265,887 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	21,262,789 - 21,265,887 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,338,500 - 21,340,743 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,381,461 - 21,383,727 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	21,380,609 - 21,383,727 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	21,278,560 - 21,279,234 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,683,795 - 21,686,027 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,092,910 - 22,095,161 (+)	NCBI		UU_Cfam_GSD_1.0

Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,311,984 - 7,313,278 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936903	520,650 - 521,910 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936903	520,420 - 521,726 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APOA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	89,237,511 - 89,240,319 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	89,237,514 - 89,239,126 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	97,094,196 - 97,095,808 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Apoa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	164,370 - 166,248 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	164,351 - 165,676 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in APOA2
63 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
49	28	20	34	34	35	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007976408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000000691 ⟹ ENSCSAP00000015372

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	2,759,237 - 2,760,686 (+)	Ensembl

RefSeq Acc Id:

XM_007976408 ⟹ XP_007974599

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	2,757,939 - 2,760,356 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	1,806,549 - 1,808,724 (+)	NCBI

Sequence:

show sequence

AAACAAACAAAAAAACCTGCACATATACTTCTGAATTTAAAACAAAAGTTAAAAAACAAAGATT
TCTTGGTCTTTGGTCACTACCTCCCTCATTAGCTCTGCGCCTCCTCTCTCACCTCTCAGGAATG
TTCCATATACTCAGGGAGTATGCTTGGGGGGGCAAAAGGGTGAAAGATACAAATGCTTCTGATA
TCTATTTAACTGATTTCACCCAAATGCTTTGAACCTGAGAATGTACCTATCCCCCTCCCCTACC
CCCAACAGGAGTGAGACAAGGGCCAGGGCTATTGCCCCTGCTGACTCAGTATTGGCTGATCACT
GCCTAGAACTGATAAGGTGATCAAATGACCAGGCACCTTCAACCTTTACCCTGGCAGAAGCCTC
TTGTTCACCCCTTTTCCTGCCAGAGCCCTCCATTGGGAGGGGATGGGCGGAAGCTGTTTTCTGA
ATTTGTTTTACTGGGGGTAGGGTATGTTCACTGATCAGCATCCAGGTCATTCTGGGCTCTCCTG
TTTTCTCCCCATCTCATTACACATTAACTCAAAAATGGACAAAATCATTTACACTTGCCTCTTA
CCCGACCCTCATTTTCGTAACCCCCATAGCCGTCAACCCTGTCCCTGATTTCAATTCCTTTCTC
CTTTCTTCTGCTCCCCAATATCTCTCTGCCAAATTGCAGTAAAGTGGGATAAGGTTGAGAGATG
AGATCTACCCACAATGGAATAAAGATACCATGAGCTTTCCATGGTATGATGGGTTGATGGTATC
CCATGGGTTGATATATCAGAGCTTTCCAGAGAAGTAACTTGGAAATCCTGCTTCCTGCTGCATT
CAAGTCCAAGGACCTCAGATCTCAAAAGAATGAACCTCAAATATACCTGAAGTGTACCCTCTTA
GCCTCCACTAAGGGCTGTACCCCCTGCCTCTCACCCCATCACCATGAGTCTTCCATGTGCTTGT
CCTCTCCTCCCCCATCTGTCCAACTTGTTTATCCTAACATAATCCCTGTCCCACTGGACCCATC
ATAGTTCCTGTCACCTGACAGGGGGTGGGTAAACAGACAGGTATATAGCCCCTACCTCTCCAGC
CAGGGCAGGCACAGACGCCAAGGACAGACACGCTGACTAGGCCGCTTTCCCCACTGTCACCAAC
ATGAAGCTGCTCGCAGCAACTGTGCTGCTTCTCACCGTCTGCAGCCTTGAAGGAGCTTTGGTTC
GGAGACAGGCAGAGGAGCCAAGTGTGGAGAGCCTGGTTTCTCAGTACTTCCAGACGGTGACTGA
CTACGGCAAGGACCTGATGGAGAAGGTCAAGAGCCCAGAGCTTCAGGCCCAGGCCAAGGCTTAC
TTTGAAAAGTCAAAGGAGCAGCTGACACCTCTGGTCAAGAAGGCTGGAACGGATCTGGTTAACT
TCTTGAGCTATTTCGTGGAACTTAGAACACAGCCTGCCACCCAGTGAGGTGTCCAGATCATTGT
CTTCCAACCCCAGCTGGCCTCTAGAATACCCACTGGCCAGGCCTGGAGCTCCTCTCCCTACCCA
CTCTTTGCTACAATAAATGCTGAATGAATCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007974599	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015372
	ENSCSAP00000015372.1
GenBank Protein	P0DP84	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_007974599 ⟸ XM_007976408
- UniProtKB:	P0DP84 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSCSAP00000015372 ⟸ ENSCSAT00000000691

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002673	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSCSAT00000000691.1	UniProtKB/Swiss-Prot
Gene3D-CATH	6.10.250.100	UniProtKB/Swiss-Prot
InterPro	ApoA-II	UniProtKB/Swiss-Prot
	ApoA-II_sf	UniProtKB/Swiss-Prot
KEGG Report	csab:103223686	UniProtKB/Swiss-Prot
NCBI Gene	APOA2	ENTREZGENE
PANTHER	APOLIPOPROTEIN A-II	UniProtKB/Swiss-Prot
	PTHR11027	UniProtKB/Swiss-Prot
Pfam	ApoA-II	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF82936	UniProtKB/Swiss-Prot
UniProt	APOA2_CHLSB	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations