APOA2 (apolipoprotein A2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: APOA2 (apolipoprotein A2) Canis lupus familiaris
Analyze
Symbol: APOA2
Name: apolipoprotein A2
RGD ID: 12144182
Description: ENCODES a protein that exhibits cholesterol transfer activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cholesterol homeostasis (ortholog); cholesterol metabolic process (ortholog); PARTICIPATES IN lipoprotein metabolic pathway; ASSOCIATED WITH APOLIPOPROTEIN A-II DEFICIENCY (ortholog); autoimmune interstitial lung, joint, and kidney disease (ortholog); coronary artery disease (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Apo-AII; ApoA-II; apolipoprotein A-II
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to lipoprotein particle stimulus  (IEA)
cholesterol efflux  (IEA)
cholesterol homeostasis  (IBA,IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IBA,ISO)
diacylglycerol catabolic process  (IEA)
high-density lipoprotein particle assembly  (IEA)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IEA)
lipid transport  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
low-density lipoprotein particle remodeling  (IEA)
negative regulation of cholesterol import  (IEA)
negative regulation of cholesterol transport  (IEA)
negative regulation of cholesterol transporter activity  (ISO)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of lipase activity  (ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
peptidyl-methionine modification  (ISO)
phosphatidylcholine biosynthetic process  (IEA)
phospholipid catabolic process  (IEA)
phospholipid efflux  (IEA)
positive regulation of CoA-transferase activity  (ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of lipid catabolic process  (IEA)
positive regulation of phagocytosis  (IEA,ISS)
protein oxidation  (ISO)
protein stabilization  (IEA,ISS)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of protein stability  (IEA)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (IEA)
response to xenobiotic stimulus  (ISO)
reverse cholesterol transport  (IEA)
signal transduction  (IEA)
triglyceride-rich lipoprotein particle remodeling  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16341006   PMID:20483223   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APOA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,263,641 - 21,265,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBIUU_Cfam_GSD_1.0
APOA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,222,292 - 161,223,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,222,290 - 161,223,631 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,192,082 - 161,193,418 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,458,707 - 159,460,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 341158,005,155 - 158,006,491NCBI
Celera1134,259,238 - 134,260,561 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,549,030 - 132,550,353 (-)NCBIHuRef
CHM1_11162,588,335 - 162,589,660 (-)NCBICHM1_1
T2T-CHM13v2.01160,359,748 - 160,361,078 (-)NCBIT2T-CHM13v2.0
Apoa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,049,133 - 171,053,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,052,623 - 171,053,948 (+)EnsemblGRCm39 Ensembl
GRCm381171,221,564 - 171,226,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,225,054 - 171,226,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,155,185 - 173,156,510 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,061,764 - 173,063,045 (+)NCBIMGSCv36mm8
Celera1173,673,195 - 173,674,520 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.22NCBI
Apoa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,176,767 - 86,178,819 (+)NCBIGRCr8
mRatBN7.21383,644,460 - 83,646,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,644,470 - 83,646,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,150,563 - 86,152,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,548,803 - 87,550,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,780,423 - 84,782,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,596,872 - 89,598,805 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,597,138 - 89,598,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,223,741 - 94,225,670 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,114,734 - 87,116,372 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,303,617 - 87,305,256 (+)NCBI
Celera1383,275,901 - 83,277,538 (+)NCBICelera
Cytogenetic Map13q24NCBI
Apoa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,977,956 - 12,979,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,977,956 - 12,979,282 (-)NCBIChiLan1.0ChiLan1.0
APOA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,627,887 - 88,629,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,318,208 - 88,320,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,634,754 - 136,636,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,546,591 - 140,547,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,546,591 - 140,547,959 (-)Ensemblpanpan1.1panPan2
Apoa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,311,984 - 7,313,278 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903520,650 - 521,910 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903520,420 - 521,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,237,511 - 89,240,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,237,514 - 89,239,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,094,196 - 97,095,808 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,757,939 - 2,760,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl202,759,237 - 2,760,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660381,806,549 - 1,808,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624794164,370 - 166,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624794164,351 - 165,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in APOA2
72 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 5 3 15 15 13 6 6 6 3 23 12 9 12 7

Sequence


Ensembl Acc Id: ENSCAFT00000020461   ⟹   ENSCAFP00000018988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3821,262,789 - 21,265,887 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000085695   ⟹   ENSCAFP00000054407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3821,262,789 - 21,265,787 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051946   ⟹   ENSCAFP00845040756
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,727 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845051966   ⟹   ENSCAFP00845040771
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3821,380,609 - 21,383,627 (+)Ensembl
RefSeq Acc Id: NM_001313799   ⟹   NP_001300728
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13821,263,641 - 21,265,887 (+)NCBI
Dog10K_Boxer_Tasha3821,338,500 - 21,340,743 (+)NCBI
ROS_Cfam_1.03821,381,461 - 21,383,727 (+)NCBI
UMICH_Zoey_3.13821,278,560 - 21,279,234 (+)NCBI
UNSW_CanFamBas_1.03821,683,795 - 21,686,027 (+)NCBI
UU_Cfam_GSD_1.03822,092,910 - 22,095,161 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001300728   ⟸   NM_001313799
- Peptide Label: precursor
- UniProtKB: E2RAK7 (UniProtKB/Swiss-Prot),   A0A8C0JHW7 (UniProtKB/TrEMBL),   A0A8C0RNZ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000018988   ⟸   ENSCAFT00000020461
Ensembl Acc Id: ENSCAFP00000054407   ⟸   ENSCAFT00000085695
Ensembl Acc Id: ENSCAFP00845040756   ⟸   ENSCAFT00845051946
Ensembl Acc Id: ENSCAFP00845040771   ⟸   ENSCAFT00845051966


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012886 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030019630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805025679 UniProtKB/Swiss-Prot
  ENSCAFG00845029343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020461.5 UniProtKB/Swiss-Prot
  ENSCAFT00000085695.2 UniProtKB/TrEMBL
  ENSCAFT00030036082.1 UniProtKB/Swiss-Prot
  ENSCAFT00030036132.1 UniProtKB/TrEMBL
  ENSCAFT00030036201.1 UniProtKB/Swiss-Prot
  ENSCAFT00030036225.1 UniProtKB/TrEMBL
  ENSCAFT00805046550 UniProtKB/Swiss-Prot
  ENSCAFT00845051946 ENTREZGENE
  ENSCAFT00845051946.1 UniProtKB/Swiss-Prot
  ENSCAFT00845051966.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApoA-II_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:478982 UniProtKB/Swiss-Prot
NCBI Gene APOA2 ENTREZGENE
PANTHER APOLIPOPROTEIN A-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ApoA-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82936 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JHW7 ENTREZGENE
  A0A8C0NTI6_CANLF UniProtKB/TrEMBL
  A0A8C0RNZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QJD2_CANLF UniProtKB/TrEMBL
  APOA2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:37992 ENTREZGENE