Gene: Hpse (heparanase) Rattus norvegicus
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Symbol: Hpse
Name: heparanase
Description: ENCODES a protein that exhibits heparanase activity; protein dimerization activity (ortholog); syndecan binding (ortholog); INVOLVED IN angiogenesis involved in wound healing (ortholog); cell-matrix adhesion (ortholog); heparan sulfate proteoglycan catabolic process (ortholog); PARTICIPATES IN syndecan signaling pathway; glycosaminoglycan degradation pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); IgA glomerulonephritis (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); lysosome (ortholog); membrane raft (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
AGR Description: Exhibits heparanase activity; predicted to be involved in several processes, including cell-matrix adhesion, heparan sulfate proteoglycan catabolic process, and positive regulation of blood coagulation; predicted to localize to the extracellular matrix, intracellular organelle, and membrane raft; orthologous to human HPSE (heparanase).
Merged Description: Exhibits heparanase activity; predicted to be involved in several processes, including cell-matrix adhesion, heparan sulfate proteoglycan catabolic process, and positive regulation of blood coagulation; predicted to localize to the extracellular matrix, intracellular organelle, and membrane raft; orthologous to human HPSE (heparanase); PARTICIPATES IN syndecan signaling pathway; glycosaminoglycan degradation pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endo-glucoronidase; Hep; heparanase-like; Hpa; LOC100362546
Orthologs:
Homo sapiens (human) : HPSE (heparanase)  HGNC  Alliance
Mus musculus (house mouse) : Hpse (heparanase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hpse (heparanase)
Pan paniscus (bonobo/pygmy chimpanzee) : HPSE (heparanase)
Canis lupus familiaris (dog) : HPSE (heparanase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hpse (heparanase)
Sus scrofa (pig) : HPSE (heparanase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01410,534,358 - 10,576,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01410,483,116 - 10,523,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41410,144,322 - 10,185,115 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11410,144,321 - 10,185,115NCBI
Celera149,005,457 - 9,045,081 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hpse
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61969
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.