Ints15 (integrator complex subunit 15) - Rat Genome Database

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Gene: Ints15 (integrator complex subunit 15) Rattus norvegicus
Analyze
Symbol: Ints15
Name: integrator complex subunit 15
RGD ID: 1584479
Description: Predicted to be part of integrator complex. Orthologous to human INTS15 (integrator complex subunit 15); INTERACTS WITH thioacetamide; (S)-colchicine (ortholog); adenine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC683674; similar to Protein C7orf26 homolog; uncharacterized protein C7orf26 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,358,644 - 16,373,763 (+)NCBIGRCr8
mRatBN7.21211,245,045 - 11,260,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,245,842 - 11,260,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,053,126 - 12,067,490 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,676,410 - 12,690,774 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,702,786 - 11,716,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,299,651 - 13,313,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,299,859 - 13,313,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,340,436 - 15,354,557 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1213,039,384 - 13,053,326 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ints15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,358,644 - 16,373,763 (+)NCBIGRCr8
mRatBN7.21211,245,045 - 11,260,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,245,842 - 11,260,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,053,126 - 12,067,490 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,676,410 - 12,690,774 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,702,786 - 11,716,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,299,651 - 13,313,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,299,859 - 13,313,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,340,436 - 15,354,557 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1213,039,384 - 13,053,326 (+)NCBICelera
Cytogenetic Map12p11NCBI
INTS15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,590,021 - 6,608,726 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,590,021 - 6,608,726 (+)EnsemblGRCh38hg38GRCh38
GRCh3776,629,652 - 6,648,357 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,596,440 - 6,614,880 (+)NCBINCBI36Build 36hg18NCBI36
Build 3476,403,154 - 6,421,595NCBI
Celera76,086,824 - 6,105,263 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,502,397 - 6,520,738 (+)NCBIHuRef
CHM1_176,629,541 - 6,647,974 (+)NCBICHM1_1
T2T-CHM13v2.076,709,194 - 6,727,910 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,676,974 - 6,695,409 (+)NCBI
Ints15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,286,827 - 143,301,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,286,950 - 143,301,115 (-)EnsemblGRCm39 Ensembl
GRCm385143,301,072 - 143,315,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,301,195 - 143,315,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,062,751 - 144,077,039 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,566,348 - 143,580,500 (-)NCBIMGSCv36mm8
Celera5140,346,063 - 140,360,351 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.07NCBI
Ints15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,104,112 - 13,118,530 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,106,906 - 13,118,531 (-)NCBIChiLan1.0ChiLan1.0
INTS15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,063,706 - 11,082,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,388,416 - 59,407,080 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v076,835,964 - 6,854,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,782,966 - 6,801,636 (+)NCBIpanpan1.1PanPan1.1panPan2
INTS15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,910,812 - 11,924,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,893,081 - 11,924,929 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,535,776 - 13,549,851 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,913,000 - 11,927,095 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,913,048 - 11,927,091 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,788,667 - 11,802,741 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,767,733 - 11,781,834 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,995,119 - 12,009,213 (+)NCBIUU_Cfam_GSD_1.0
Ints15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,121,571 - 140,134,654 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936765112,637 - 125,711 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936765112,637 - 125,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INTS15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,610,700 - 4,626,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,610,701 - 4,626,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INTS15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,805,068 - 15,821,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666102214,405 - 237,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ints15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,743,068 - 30,757,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,743,218 - 30,757,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ints15
130 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:95
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000039191
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat

Markers in Region
RH137324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,259,879 - 11,260,097 (+)MAPPERmRatBN7.2
Rnor_6.01213,313,441 - 13,313,658NCBIRnor6.0
Rnor_5.01215,354,267 - 15,354,484UniSTSRnor5.0
RGSC_v3.41211,620,098 - 11,620,315UniSTSRGSC3.4
Celera1213,053,034 - 13,053,251UniSTS
Cytogenetic Map12p11UniSTS
RH141332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,244,571 - 11,244,785 (+)MAPPERmRatBN7.2
Rnor_6.01213,298,193 - 13,298,406NCBIRnor6.0
Rnor_5.01215,339,000 - 15,339,213UniSTSRnor5.0
RGSC_v3.41211,605,526 - 11,605,739UniSTSRGSC3.4
Celera1213,037,835 - 13,038,048UniSTS
Cytogenetic Map12p11UniSTS
UniSTS:235357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,259,945 - 11,260,073 (+)MAPPERmRatBN7.2
Rnor_6.01213,313,507 - 13,313,634NCBIRnor6.0
Rnor_5.01215,354,333 - 15,354,460UniSTSRnor5.0
RGSC_v3.41211,620,164 - 11,620,291UniSTSRGSC3.4
Celera1213,053,100 - 13,053,227UniSTS
Cytogenetic Map12p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 30 23 10 23 2 66 27 34 4
Low 17 27 18 9 18 8 9 8 8 7 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000039191   ⟹   ENSRNOP00000037318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,245,842 - 11,260,166 (+)Ensembl
Rnor_6.0 Ensembl1213,299,859 - 13,313,358 (+)Ensembl
RefSeq Acc Id: NM_001398880   ⟹   NP_001385809
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,359,627 - 16,373,763 (+)NCBI
mRatBN7.21211,246,032 - 11,260,169 (+)NCBI
RefSeq Acc Id: XM_017598485   ⟹   XP_017453974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,358,644 - 16,373,763 (+)NCBI
mRatBN7.21211,245,045 - 11,260,170 (+)NCBI
Rnor_6.01213,299,651 - 13,313,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089852   ⟹   XP_038945780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,360,004 - 16,373,763 (+)NCBI
mRatBN7.21211,246,396 - 11,260,170 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385809 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453974 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945780 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037318
  ENSRNOP00000037318.4
RefSeq Acc Id: XP_017453974   ⟸   XM_017598485
- Peptide Label: isoform X1
- UniProtKB: F1M0G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037318   ⟸   ENSRNOT00000039191
RefSeq Acc Id: XP_038945780   ⟸   XM_039089852
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001385809   ⟸   NM_001398880
- UniProtKB: A6K1L7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0G5-F1-model_v2 AlphaFold F1M0G5 1-437 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698442
Promoter ID:EPDNEW_R8966
Type:single initiation site
Name:E130309D02Rik_1
Description:RIKEN cDNA E130309D02 gene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,299,914 - 13,299,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584479 AgrOrtholog
BioCyc Gene G2FUF-20001 BioCyc
Ensembl Genes ENSRNOG00000024567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039191.4 UniProtKB/TrEMBL
InterPro DUF4507 UniProtKB/TrEMBL
KEGG Report rno:683674 UniProtKB/TrEMBL
NCBI Gene 683674 ENTREZGENE
PANTHER PTHR14540 UniProtKB/TrEMBL
  SIMILAR TO PROTEIN C7ORF26 HOMOLOG UniProtKB/TrEMBL
Pfam DUF4507 UniProtKB/TrEMBL
PhenoGen Ints15 PhenoGen
RatGTEx ENSRNOG00000024567 RatGTEx
UniProt A6K1L7 ENTREZGENE, UniProtKB/TrEMBL
  F1M0G5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-10 Ints15  integrator complex subunit 15  LOC683674  similar to Protein C7orf26 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683674  similar to Protein C7orf26 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL