Idh3a (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha) - Rat Genome Database

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Gene: Idh3a (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha) Rattus norvegicus
Analyze
Symbol: Idh3a
Name: isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
RGD ID: 70889
Description: Enables isocitrate dehydrogenase (NAD+) activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: isocitrate dehydrogenase (NAD(+)) 3 alpha; isocitrate dehydrogenase 3 (NAD+) alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8863,867,882 - 63,887,223 (+)NCBIGRCr8
mRatBN7.2854,971,694 - 54,991,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,971,740 - 54,991,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,505,281 - 60,524,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,784,271 - 58,803,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,648,509 - 56,667,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,164,601 - 59,183,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,164,572 - 59,183,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,745,463 - 57,764,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,135,412 - 58,156,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,154,465 - 58,175,073 (+)NCBI
Celera854,460,353 - 54,479,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlormidazole  (ISO)
clofibrate  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoxastrobin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin RR  (ISO)
mitoxantrone  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
Propiverine  (EXP)
pyridaben  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tebufenpyrad  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):634-8.
12. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, etal., J Biol Chem. 2003 Dec 26;278(52):52146-53. doi: 10.1074/jbc.M306178200. Epub 2003 Oct 10.
Additional References at PubMed
PMID:2252888   PMID:14651853   PMID:17634366   PMID:18614015   PMID:21630459   PMID:25931508   PMID:26316108   PMID:28098230   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Idh3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8863,867,882 - 63,887,223 (+)NCBIGRCr8
mRatBN7.2854,971,694 - 54,991,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,971,740 - 54,991,084 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx860,505,281 - 60,524,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,784,271 - 58,803,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,648,509 - 56,667,913 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,164,601 - 59,183,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,164,572 - 59,183,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,745,463 - 57,764,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,135,412 - 58,156,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,154,465 - 58,175,073 (+)NCBI
Celera854,460,353 - 54,479,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
IDH3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,149,362 - 78,171,945 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,131,498 - 78,171,945 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,441,704 - 78,464,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,228,774 - 76,249,939 (+)NCBINCBI36Build 36hg18NCBI36
Build 341576,228,773 - 76,249,938NCBI
Celera1555,378,247 - 55,399,414 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,199,257 - 55,220,449 (+)NCBIHuRef
CHM1_11578,559,625 - 78,580,790 (+)NCBICHM1_1
T2T-CHM13v2.01576,011,920 - 76,034,530 (+)NCBIT2T-CHM13v2.0
Idh3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,493,795 - 54,511,946 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,493,618 - 54,511,945 (+)EnsemblGRCm39 Ensembl
GRCm38954,586,511 - 54,604,662 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,586,334 - 54,604,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,434,318 - 54,452,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,384,648 - 54,402,799 (+)NCBIMGSCv36mm8
Celera951,829,728 - 51,847,959 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.7NCBI
Idh3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450685,905 - 703,586 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450685,905 - 703,593 (+)NCBIChiLan1.0ChiLan1.0
IDH3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,362,996 - 67,384,370 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,528,667 - 71,550,063 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,078,588 - 57,099,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,043,311 - 76,064,634 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,043,311 - 76,064,634 (+)Ensemblpanpan1.1panPan2
IDH3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1358,301,982 - 58,318,925 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl358,302,001 - 58,318,248 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,993,181 - 61,010,332 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0358,769,639 - 58,786,830 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,748,159 - 58,786,830 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1358,266,135 - 58,283,304 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,474,154 - 58,491,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,823,194 - 58,840,363 (+)NCBIUU_Cfam_GSD_1.0
Idh3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,974,940 - 118,994,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,822,971 - 36,842,610 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,823,003 - 36,842,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,759,439 - 47,778,956 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,759,436 - 47,778,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,312,283 - 53,330,719 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,183,470 - 5,205,385 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,184,991 - 5,205,384 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,598,251 - 136,620,304 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,662,434 - 2,679,232 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248942,661,509 - 2,679,071 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idh3a
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:105
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000015102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1300150Cm3Cardiac mass QTL 33.97heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)85423781455523877Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat

Markers in Region
RH127975  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,990,700 - 54,990,905 (+)MAPPERmRatBN7.2
Rnor_6.0859,183,518 - 59,183,722NCBIRnor6.0
Rnor_5.0857,764,380 - 57,764,584UniSTSRnor5.0
RGSC_v3.4858,155,638 - 58,155,842UniSTSRGSC3.4
Celera854,479,274 - 54,479,478UniSTS
RH 3.4 Map8600.8UniSTS
Cytogenetic Map8q24UniSTS
AA957451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,990,169 - 54,990,270 (+)MAPPERmRatBN7.2
Rnor_6.0859,182,987 - 59,183,087NCBIRnor6.0
Rnor_5.0857,763,849 - 57,763,949UniSTSRnor5.0
RGSC_v3.4858,155,107 - 58,155,207UniSTSRGSC3.4
Celera854,478,743 - 54,478,843UniSTS
RH 3.4 Map8599.4UniSTS
Cytogenetic Map8q24UniSTS
AU049801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,970,149 - 54,970,333 (+)MAPPERmRatBN7.2
Rnor_6.0859,162,970 - 59,163,153NCBIRnor6.0
Rnor_5.0857,743,565 - 57,743,748UniSTSRnor5.0
RGSC_v3.4858,133,781 - 58,133,964UniSTSRGSC3.4
Celera854,458,722 - 54,458,905UniSTS
Cytogenetic Map8q24UniSTS
RH124560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2854,990,187 - 54,990,269 (+)MAPPERmRatBN7.2
Rnor_6.0859,183,005 - 59,183,086NCBIRnor6.0
Rnor_5.0857,763,867 - 57,763,948UniSTSRnor5.0
RGSC_v3.4858,155,125 - 58,155,206UniSTSRGSC3.4
Celera854,478,761 - 54,478,842UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015102   ⟹   ENSRNOP00000015102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl854,971,740 - 54,991,084 (+)Ensembl
Rnor_6.0 Ensembl859,164,572 - 59,183,908 (+)Ensembl
RefSeq Acc Id: NM_053638   ⟹   NP_446090
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8863,867,882 - 63,887,223 (+)NCBI
mRatBN7.2854,971,740 - 54,991,084 (+)NCBI
Rnor_6.0859,164,601 - 59,183,899 (+)NCBI
Rnor_5.0857,745,463 - 57,764,761 (+)NCBI
RGSC_v3.4858,135,412 - 58,156,019 (+)RGD
Celera854,460,353 - 54,479,655 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080661   ⟹   XP_038936589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8863,867,908 - 63,887,221 (+)NCBI
mRatBN7.2854,971,694 - 54,991,085 (+)NCBI
RefSeq Acc Id: NP_446090   ⟸   NM_053638
- Peptide Label: precursor
- UniProtKB: Q99NA5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015102   ⟸   ENSRNOT00000015102
RefSeq Acc Id: XP_038936589   ⟸   XM_039080661
- Peptide Label: isoform X1
Protein Domains
Isopropylmalate dehydrogenase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99NA5-F1-model_v2 AlphaFold Q99NA5 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695981
Promoter ID:EPDNEW_R6505
Type:multiple initiation site
Name:Idh3a_1
Description:isocitrate dehydrogenase 3 (NAD+) alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0859,164,595 - 59,164,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70889 AgrOrtholog
BioCyc Gene G2FUF-30395 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000010277 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015102.5 UniProtKB/TrEMBL
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isocitrate_DH_NAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114096 UniProtKB/Swiss-Prot
NCBI Gene 114096 ENTREZGENE
PANTHER DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Idh3a PhenoGen
PROSITE IDH_IMDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010277 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6J4L7_RAT UniProtKB/TrEMBL
  A6J4L8_RAT UniProtKB/TrEMBL
  A6J4L9_RAT UniProtKB/TrEMBL
  A6J4M0_RAT UniProtKB/TrEMBL
  A6J4M1_RAT UniProtKB/TrEMBL
  A6J4M2_RAT UniProtKB/TrEMBL
  F1LNF7_RAT UniProtKB/TrEMBL
  IDH3A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh3a  isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha  Idh3a  isocitrate dehydrogenase (NAD(+)) 3 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-29 Idh3a  isocitrate dehydrogenase (NAD(+)) 3 alpha  Idh3a  isocitrate dehydrogenase 3 (NAD+) alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Idh3a  isocitrate dehydrogenase 3 (NAD+) alpha      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brown adipose tissue but not in white adipose tissue 70770