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Gene: Cxcl14 (C-X-C motif chemokine ligand 14) Rattus norvegicus

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Symbol:

Cxcl14

Name:

C-X-C motif chemokine ligand 14

RGD ID:

1307406

Description:

Predicted to enable chemokine activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of another organism. Predicted to act upstream of or within inner ear development; negative regulation of myoblast differentiation; and positive regulation of natural killer cell chemotaxis. Predicted to be located in Golgi apparatus. Orthologous to human CXCL14 (C-X-C motif chemokine ligand 14); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BRAK; C-X-C motif chemokine 14; chemokine; chemokine (C-X-C motif) ligand 14; LOC306748; MGC124510

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CXCL14 (C-X-C motif chemokine ligand 14)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Cxcl14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cxcl14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CXCL14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CXCL14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cxcl14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CXCL14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CXCL14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cxcl14 (C-X-C motif chemokine ligand 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CXCL14 (C-X-C motif chemokine ligand 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cxcl14 (C-X-C motif chemokine ligand 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cxcl14 (chemokine (C-X-C motif) ligand 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cxcl14	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	8,323,150 - 8,331,176 (+)	NCBI		GRCr8
mRatBN7.2	17	8,317,930 - 8,325,956 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	8,317,933 - 8,324,839 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	8,334,039 - 8,342,060 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	9,867,177 - 9,875,163 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	8,330,434 - 8,338,451 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,109,731 - 9,117,754 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,109,731 - 9,117,750 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	11,271,210 - 11,279,233 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	14,286,747 - 14,295,502 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	14,286,946 - 14,294,385 (+)	NCBI
Celera	17	8,404,203 - 8,412,194 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

Chemical and Drug Induced Liver Injury (ISO)

contact dermatitis (ISO)

endometriosis (ISO)

familial adenomatous polyposis 1 (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

liver cirrhosis (ISO)

Lung Neoplasms (ISO)

Neurodevelopmental Disorders (ISO)

substance-related disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-benzothiazole-2-thiol (ISO)

1,4-phenylenediamine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-Nitrobenzanthrone (ISO)

3-phenylprop-2-enal (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxy-TEMPO (ISO)

4-hydroxynon-2-enal (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

9-cis-retinoic acid (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-hexylcinnamaldehyde (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

butanal (ISO)

cadmium atom (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chloromethylisothiazolinone (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

curcumin (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

diallyl disulfide (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

diethylstilbestrol (EXP,ISO)

Diisodecyl phthalate (ISO)

dimethyl sulfoxide (ISO)

dimethylarsinous acid (ISO)

dioxygen (ISO)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethylene glycol dimethacrylate (ISO)

fenvalerate (EXP)

flutamide (EXP)

folic acid (ISO)

fonofos (ISO)

fumonisin B1 (ISO)

genistein (ISO)

indometacin (ISO)

iron(2+) sulfate (anhydrous) (ISO)

ketoconazole (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

lycopene (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

methimazole (EXP)

methotrexate (ISO)

methyl methacrylate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (EXP)

microcystin-LR (ISO)

N-Acetyl-S-(1,2-dichlorovinyl)-cysteine (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosomorpholine (EXP)

naphthalene (ISO)

nickel dichloride (ISO)

O-acetyl-L-carnitine (ISO)

ozone (ISO)

paclitaxel (EXP)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

parathion (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

phenyl benzoate (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulfadimethoxine (EXP)

terbufos (ISO)

tetrachloromethane (EXP,ISO)

thiram (ISO)

titanium dioxide (ISO)

toluene (EXP)

tributylstannane (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

zinc dichloride (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

cell chemotaxis (IEA)

immune response (IEA)

inner ear development (ISO)

killing of cells of another organism (ISO)

negative regulation of myoblast differentiation (ISO)

positive regulation of natural killer cell chemotaxis (ISO)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Golgi apparatus (ISO)

Molecular Function

chemokine activity (IEA)

cytokine activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

cytokine mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12949249	PMID:19109182	PMID:20974226	PMID:21462317	PMID:21795542	PMID:23688424	PMID:23844157	PMID:31640472	PMID:33070779	PMID:38750454

Genomics

Comparative Map Data

Cxcl14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	8,323,150 - 8,331,176 (+)	NCBI		GRCr8
mRatBN7.2	17	8,317,930 - 8,325,956 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	8,317,933 - 8,324,839 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	8,334,039 - 8,342,060 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	9,867,177 - 9,875,163 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	8,330,434 - 8,338,451 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	9,109,731 - 9,117,754 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	9,109,731 - 9,117,750 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	11,271,210 - 11,279,233 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	14,286,747 - 14,295,502 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	14,286,946 - 14,294,385 (+)	NCBI
Celera	17	8,404,203 - 8,412,194 (+)	NCBI		Celera
Cytogenetic Map	17	p14	NCBI

CXCL14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	135,570,679 - 135,578,991 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	135,570,679 - 135,579,279 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	134,906,369 - 134,914,681 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	134,934,274 - 134,942,868 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	134,934,273 - 134,942,868	NCBI
Celera	5	131,030,125 - 131,038,702 (-)	NCBI		Celera
Cytogenetic Map	5	q31.1	NCBI
HuRef	5	130,094,056 - 130,102,631 (-)	NCBI		HuRef
CHM1_1	5	134,338,974 - 134,347,553 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	136,097,821 - 136,106,134 (-)	NCBI		T2T-CHM13v2.0

Cxcl14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	56,436,456 - 56,444,624 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	56,436,456 - 56,444,364 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	56,288,643 - 56,296,811 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	56,288,643 - 56,296,551 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	56,390,004 - 56,397,912 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	56,298,266 - 56,306,173 (-)	NCBI		MGSCv36	mm8
Celera	13	57,348,344 - 57,356,250 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	30.06	NCBI

Cxcl14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	30,733,079 - 30,740,854 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	30,733,079 - 30,740,854 (-)	NCBI	ChiLan1.0	ChiLan1.0

CXCL14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	130,854,528 - 130,862,843 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	128,994,088 - 129,002,350 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	130,960,143 - 130,967,365 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	137,100,019 - 137,108,336 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	137,100,019 - 137,108,336 (-)	Ensembl	panpan1.1		panPan2

CXCL14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	23,598,640 - 23,606,850 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	23,599,645 - 23,606,823 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	22,347,471 - 22,355,658 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	24,415,392 - 24,423,551 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	24,410,494 - 24,423,570 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	23,103,462 - 23,111,609 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	22,969,182 - 22,977,337 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	23,619,246 - 23,627,406 (-)	NCBI		UU_Cfam_GSD_1.0

Cxcl14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	123,722,562 - 123,729,168 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	2,746,296 - 2,754,716 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	2,746,415 - 2,754,169 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCL14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	137,803,992 - 137,813,118 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	137,803,988 - 137,813,118 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	143,444,416 - 143,453,547 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCL14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	38,355,340 - 38,363,905 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	38,355,341 - 38,363,680 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	39,552,142 - 39,560,916 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cxcl14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	11,455,047 - 11,463,176 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	11,455,166 - 11,463,086 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cxcl14
33 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	277
Count of miRNA genes:	174
Interacting mature miRNAs:	208
Transcripts:	ENSRNOT00000016009
Prediction methods:	Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	4299130	35837242	Rat
631499	Stl1	Serum triglyceride level QTL 1	3.6		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	3271398	27389946	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4354487	27028127	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2115149	34551001	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	4299130	21293263	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	1	31990913	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7979968	16317111	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	37830672	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31701463	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4354487	27028127	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2115149	21881669	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22871563	Rat

Markers in Region

RH128165

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	8,325,626 - 8,325,806 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	9,117,425 - 9,117,604	NCBI	Rnor6.0
Rnor_5.0	17	11,278,904 - 11,279,083	UniSTS	Rnor5.0
RGSC_v3.4	17	14,295,173 - 14,295,352	UniSTS	RGSC3.4
Celera	17	8,411,865 - 8,412,044	UniSTS
Cytogenetic Map	17	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	45	113	77	76	45	25	45	6	200	93	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF488348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016009 ⟹ ENSRNOP00000016009

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	8,317,933 - 8,324,839 (+)	Ensembl
Rnor_6.0 Ensembl	17	9,109,731 - 9,117,750 (+)	Ensembl

RefSeq Acc Id:

NM_001013137 ⟹ NP_001013155

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	8,323,150 - 8,331,176 (+)	NCBI
mRatBN7.2	17	8,317,930 - 8,325,956 (+)	NCBI
Rnor_6.0	17	9,109,731 - 9,117,754 (+)	NCBI
Rnor_5.0	17	11,271,210 - 11,279,233 (+)	NCBI
RGSC_v3.4	17	14,286,747 - 14,295,502 (+)	RGD
Celera	17	8,404,203 - 8,412,194 (+)	RGD

Sequence:

show sequence

CGCAGCACCCAGCGCCAAGCGCAGCGCAGCACCGCGACAGACGGCAGGAGCACCCATCGACGGG
CGCAGCTGGAGAGAGCCCAGCATAGAGAGGCGGGCTCAAAACCGAGAACCCTGCCGGGCGGCAT
CCCCCGGCCGCCGCACGCACAGGCCGGCGCCCTCCTCGCCTCCCTGCTCCCCACCGCGCCCCTC
CGGCCAGCATGAGGCTCCTGGCGGCCGCGCTGCTCCTGCTGCTCCTGGCGCTGTGCGCCTCGCG
CGTGGACGGGTCCAAGTGTAAGTGTTCCCGGAAGGGGCCCAAGATCCGCTACAGCGACGTGAAG
AAGCTGGAAATGAAGCCAAAGTACCCACACTGCGAGGAGAAGATGGTTATCATAACCACCAAGA
GCATGTCCAGGTACCGCGGCCAGGAGCACTGCCTGCATCCTAAGCTGCAAAGTACCAAGCGCTT
CATCAAATGGTACAACGCCTGGAACGAGAAACGCAGGGTCTACGAAGAGTAGGGTGGACGATCT
TGGAAAGAAAACCTCCAGGCCAGTTGAGAGACTTCAGCAGAGGACTTTGCAGATTAAAAATAAA
AGCCCTTTCTTTCTCACAAGCATAAGACAAATTATATATTGCTGTGAAGCTCTTCTTACCAGGG
TCAGTTTTTACATTTTATAGCTGTGTGCGAAAGCCTTCCAGATGTGAGATCCAGCTCTCCTGCG
TACCAGACTTCATTACAAGTGGCTTTTTGCCGGGGGTTGGGGGGTTGGGGGTGGGCCCAAGCCT
TTCCTTTTTAAAATAAGGGTTTTTGTATTTGTCCATATGTCACCACACATCTGAACTTTATAAG
CGCCTGGAAGGAGCAATCAGTATGGTTCAGGCAATTCATTGCACTGTTGCTCCGGTCCAGGCTT
TCGAAGCTTCCTCTCAGAGAGCCTGGCGCCTCGGCACAGCTGCCACAGGCTCTCCTGGGCTTAT
GACTGGTCAAGAGTTTCGGTGTGGCTCCACCATGGCCCCTGTTGCAGGGCAATTGGGAACAAGT
CCTTCTGCATCTGTGCCTAGAGGAACTCAATCTACTTCCCAGGATGAGCTTCATGCCCCCACCC
CAGCCCCACCCCCACCCCAGCTCATTCCCCTATCCCAACCAGGCAAGCGATCCTTAAAGGAGCT
GGGTCTTTCTCTCGCAACCTCTGAGGGTTTCTGAAAGGCTCACTGCTTTGGTAGATGATGCTTC
TGAAGCATCAGAAGCCCCCGGCAGCGTGAGAAAACTGTGTGGAGGAAAAGGGGAAAATTCAGGA
CTCAATGCATGACATCCAGCCAGAGCTACACATCCTACTGGCATGGGGAGACCCACGTAGCTCT
GTTCCCCTCGCCCCCACAGAAAGCGCACTCCCCCTTCGGTGCATATGCAAACAGCGAGGTCCTC
TTTTGGAGTTAGGATGACCCTGCACCCTCTCCTGTGTACATATTGCTTCAGTACCCGCCCCTGC
CACACGCTGCCCCTCAGTAGAGGCCGCACTGGACGGCTGTGAATCTGCTATGTAAGTGCTGAGA
TTCATGAGTGCTGCATGCGGGTTTCATGTTCTTTCTAAGATGAAAAAGAAAGTAATAAAAATAT
ATTTGAAGTTACCAAAAAAAAAAAAAAAATAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013155	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI01897	(Get FASTA)	NCBI Sequence Viewer
	AAM74057	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016009.6
	ENSRNOP00000111202

RefSeq Acc Id:	NP_001013155 ⟸ NM_001013137
- Peptide Label:	precursor
- UniProtKB:	Q8K453 (UniProtKB/TrEMBL), D4A5S7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRLLAAALLLLLLALCASRVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSMS RYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE hide sequence

Ensembl Acc Id:

ENSRNOP00000016009 ⟸ ENSRNOT00000016009

Protein Domains

Chemokine interleukin-8-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K453-F1-model_v2	AlphaFold	Q8K453	1-99	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700292

Promoter ID:

EPDNEW_R10816

Type:

initiation region

Name:

Cxcl14_1

Description:

C-X-C motif chemokine ligand 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	9,109,721 - 9,109,781	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307406	AgrOrtholog
BioCyc Gene	G2FUF-10253	BioCyc
Ensembl Genes	ENSRNOG00000011984	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016009.6	UniProtKB/TrEMBL
	ENSRNOT00000169308	ENTREZGENE
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7932648	IMAGE-MGC_LOAD
InterPro	Chemokine_IL8	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:306748	UniProtKB/TrEMBL
MGC_CLONE	MGC:124510	IMAGE-MGC_LOAD
NCBI Gene	306748	ENTREZGENE
Pfam	IL8	UniProtKB/TrEMBL
PhenoGen	Cxcl14	PhenoGen
PRINTS	INTERLEUKIN8	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011984	RatGTEx
Superfamily-SCOP	Chemokine_IL8	UniProtKB/TrEMBL
UniProt	A0A8J8XEY2_RAT	UniProtKB/TrEMBL
	D4A5S7	ENTREZGENE
	Q8K453	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	D4A5S7	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-08	Cxcl14	C-X-C motif chemokine ligand 14	Cxcl14	chemokine (C-X-C motif) ligand 14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Cxcl14	chemokine (C-X-C motif) ligand 14	Cxcl14_predicted	chemokine (C-X-C motif) ligand 14 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cxcl14_predicted	chemokine (C-X-C motif) ligand 14 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)